Enhancement and Management of Established Biomedical Data Repositories and Knowledgebases (R24 Clinical Trial Not Allowed)

The Enhancement and Management of Established Biomedical Data Repositories and Knowledgebases (R24 Clinical Trial Not Allowed) is a federal funding opportunity administered by the National Institutes of Health, within the Department of Health and Human Services. This program is managed through the Office of Data Science Strategy in collaboration with participating NIH Institutes and Centers. It is part of NIH’s broader effort to support data-driven biomedical research by ensuring that high-value data repositories and knowledgebases remain accessible, sustainable, and impactful for the scientific community. The primary purpose of this funding opportunity is to provide continued support for established biomedical data repositories and knowledgebases that have already demonstrated significant scientific impact. Rather than funding the creation of new resources, this program focuses on maintaining and enhancing existing data infrastructures that serve defined research communities. Applicants must demonstrate that their data resources are actively used, scientifically valuable, and capable of delivering ongoing benefits to researchers and stakeholders. Eligible projects under this program must involve data repositories or knowledgebases that are already operational and have a proven track record of contributing to biomedical research. Applicants are required to document prior impact, including how the resource has advanced scientific understanding, facilitated collaboration, or supported innovation. Additionally, proposals must outline plans for continued improvement, management, and sustainability of the resource, ensuring that it remains relevant and accessible over time. The funding opportunity is structured as a grant mechanism and does not allow clinical trials. It does not specify total program funding, award ceilings, or award floors in the forecast notice, indicating that funding levels may vary depending on the scope and merit of submitted applications. There is no cost-sharing or matching requirement, which allows applicants to focus resources on maintaining and enhancing their data systems. The absence of predefined funding levels suggests a flexible approach to supporting a range of high-impact data resources. Eligibility for this program is broad and includes a wide range of entity types, such as state and local governments, institutions of higher education (both public and private), nonprofit organizations with and without 501(c)(3) status, for-profit organizations, small businesses, and tribal entities. Additional eligible applicants include federal agencies, regional organizations, faith-based and community-based organizations, and non-U.S. entities. This inclusive eligibility framework is designed to encourage participation from diverse sectors involved in biomedical data management and research. The application timeline includes an estimated posting date in July 2026 and an application deadline in September 2026, with awards anticipated in July 2027. Project activities are expected to begin immediately following award announcements. However, the notice specifies that no applications are currently being solicited, indicating that this forecast serves as an advance notice to allow potential applicants to prepare for a future funding cycle. Applicants are encouraged to use this time to develop strong proposals aligned with the program’s objectives. Applications must be submitted electronically and are expected to include detailed documentation of the existing data resource, evidence of impact, and plans for continued management and enhancement. NIH will evaluate proposals based on scientific merit, demonstrated impact, and the potential for continued benefit to the biomedical research community. This opportunity is not identified as recurring but reflects NIH’s ongoing commitment to sustaining critical data infrastructure that underpins modern biomedical research.