Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use

The Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use opportunity is a forecasted federal funding initiative issued by the Centers for Disease Control and Prevention within the U.S. Department of Health and Human Services. This program is administered through the National Center for HIV, Viral Hepatitis, STD, and TB Prevention and is aligned with federal public health priorities to address infectious disease risks among people who use drugs. The initiative is structured as a cooperative agreement, indicating substantial federal involvement in program implementation, oversight, and technical guidance throughout the project period. The primary purpose of this funding opportunity is to strengthen services that prevent infectious disease transmission associated with drug use, particularly in high impact service settings that interact with people who use drugs. The program is divided into two components. The first component focuses on improving the quality and availability of service data through the administration of biennial surveys. These surveys are designed to assess capacity, identify service gaps, and document access to prevention and treatment services. It also includes a biobehavioral survey conducted every two years to generate timely local data on infectious disease outcomes and the utilization of testing, treatment, and prevention services. The second component emphasizes expanding the availability and use of infectious disease services, including testing, treatment, and prevention interventions, within these high impact settings. Funding under this opportunity supports a broad scope of activities related to public health surveillance, data collection, service delivery expansion, and program evaluation. Allowable uses include conducting surveys, improving data infrastructure, enhancing service delivery systems, and increasing access to testing and treatment for hepatitis B, hepatitis C, and HIV. The program does not require cost sharing or matching contributions from applicants. Applicants may choose to apply for one component or both, depending on their organizational capacity and alignment with program goals. Eligibility for this opportunity is extensive and inclusive of a wide range of entity types. Eligible applicants include state governments, county and city governments, tribal governments and organizations, public and private institutions of higher education, nonprofit organizations with and without 501(c)(3) status, small businesses, for profit organizations, independent school districts, and public housing authorities. This broad eligibility reflects the national scope of the initiative and its emphasis on reaching diverse service providers that operate in high impact environments serving people who use drugs. The application process is expected to be conducted electronically through standard federal submission systems, with applications due by May 24, 2027 at 11:59 PM Eastern Time. The opportunity is currently in a forecasted stage, with an estimated posting date of March 24, 2027. There are no pre application requirements such as letters of intent specified in the forecast. Applicants will need to prepare a comprehensive application that addresses the selected component or components, outlines program design, and demonstrates capacity to achieve the stated outcomes. Evaluation will likely focus on the ability to improve data systems, expand service delivery, and contribute to measurable increases in testing, treatment initiation, and engagement in care. The expected timeline indicates that awards will be made by August 30, 2027, with project activities beginning on September 30, 2027. The program anticipates making two awards with a total estimated funding pool of 82,500,000 dollars. Expected outcomes include increased testing rates for hepatitis and HIV among people who use drugs, higher rates of treatment initiation for hepatitis C, and improved engagement in HIV care. The program also aims to enhance both national and local capacity to use data for improving prevention and treatment services. For additional information or inquiries, applicants may contact Monica Adams at the Centers for Disease Control and Prevention via email at ydy7@cdc.gov or by phone at 404-718-5092. As a forecasted opportunity, applicants are encouraged to monitor updates and prepare in advance for the formal release of the notice of funding opportunity.