Somatic Mosaicism across Human Tissues (SMaHT) Program: Experimental and Computational Technology Development (RM1 Clinical Trial Not Allowed)

The Somatic Mosaicism across Human Tissues (SMaHT) Program: Experimental and Computational Technology Development (RM1 Clinical Trial Not Allowed) is a forecasted federal grant opportunity from the U.S. Department of Health and Human Services through the National Institutes of Health. The opportunity number is RFA-RM-28-017, and the Assistance Listing is 93.310, Trans-NIH Research Support. The opportunity is categorized as discretionary funding in the Health funding activity category. The SMaHT Network is intended to advance discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from standardized human tissues spanning all three germ layers. Building on the Stage 1 foundation, the National Institutes of Health intends to issue a Notice of Funding Opportunity supporting Stage 2 of the SMaHT Experimental and Computational Technology Development initiative. The initiative is designed to support multidisciplinary development, optimization, validation, benchmarking, and dissemination of rigorous and cost-effective technologies for somatic mutation detection and functional interpretation. Awardees are expected to collaborate with other SMaHT Stage 2 initiatives so that validated technologies can be incorporated into production workflows, pipelines, data releases, and community resources. The forecast identifies the funding instrument as a grant but does not provide an estimated total program funding amount, award ceiling, award floor, or expected number of awards. Consequently, no specific award amount or program funding estimate can be established from the available forecast. Cost sharing or matching is explicitly identified as not required. The forecast also does not provide a period of performance, indirect cost limitation, subaward limitation, or other detailed spending rules. Those details may be provided when the National Institutes of Health publishes the full Notice of Funding Opportunity. Eligible applicants listed in the forecast include city or township governments, county governments, state governments, special district governments, independent school districts, public housing authorities and Indian housing authorities, federally recognized Native American tribal governments, Native American tribal organizations other than federally recognized tribal governments, public and state controlled institutions of higher education, private institutions of higher education, nonprofits with 501(c)(3) status other than institutions of higher education, nonprofits without 501(c)(3) status other than institutions of higher education, small businesses, and for profit organizations other than small businesses. Additional eligible applicants include Indian or Native American tribal governments other than federally recognized governments, eligible agencies of the Federal Government, U.S. territories or possessions, faith-based or community-based organizations, regional organizations, and non-domestic entities or foreign institutions. The inclusion of U.S. and foreign entities without a stated U.S. state restriction supports nationwide U.S. eligibility. This opportunity remains in the forecast stage and is not yet accepting applications based on the dates supplied. The forecasted date and last updated date are September 14, 2026. The estimated posting date is May 1, 2027, and the estimated application due date is July 1, 2027. No letter of intent, concept paper, pre-proposal, notice of intent, or other pre-application gating requirement is identified in the forecast. The source also does not provide application questions, required proposal components, required uploads, evaluation criteria, submission instructions beyond the Grants.gov opportunity context, or an application preparation estimate. These details should not be inferred before the full Notice of Funding Opportunity is issued. The estimated award date is May 1, 2028, and the estimated project start date is also May 1, 2028, for fiscal year 2028. No archive date is provided. The source does not state that this opportunity recurs annually, biennially, quarterly, or according to another repeating schedule, so it is treated as non-recurring based on the available forecast. The listed program contact is the SMaHT Program, which instructs applicants to make contact by email at smaht@od.nih.gov. No individual grantor contact name or telephone number is supplied. Because this is a forecast, dates and other program details are estimates and may be refined when the full Notice of Funding Opportunity is published.

Align proposed work with multidisciplinary development, optimization, validation, benchmarking, and dissemination of rigorous, cost-effective technologies for somatic mutation detection and functional interpretation, and address collaboration with other SMaHT Stage 2 initiatives for incorporation of validated technologies into production workflows, pipelines, data releases, and community resources.