Kidney Precision Medicine Project Tissue Interrogation Sites (U01 Clinical Trial Not Allowed)

The Kidney Precision Medicine Project Tissue Interrogation Sites opportunity is a federal funding initiative issued by the National Institutes of Health within the U.S. Department of Health and Human Services. This program is part of a broader effort to advance biomedical research in kidney disease through precision medicine approaches. The funding is delivered as a cooperative agreement, indicating substantial involvement and collaboration between the NIH and award recipients. The initiative aligns with the mission of the National Institute of Diabetes and Digestive and Kidney Diseases to support research that improves understanding, diagnosis, and treatment of kidney-related conditions. The primary purpose of this funding opportunity is to support Tissue Interrogation Sites that will analyze human kidney tissue samples as part of the Kidney Precision Medicine Project. These sites will work collaboratively with Recruitment Sites, the Kidney Tissue Atlas Coordinating Center, and a Central Hub. The overall goal is to generate a comprehensive Kidney Tissue Atlas, identify disease subgroups, and better understand cellular and molecular mechanisms underlying acute kidney injury and chronic kidney disease. The work will contribute to identifying therapeutic targets and advancing personalized treatment strategies. Funding under this opportunity is intended to support the infrastructure, personnel, and technical capabilities required to perform detailed tissue analysis. Activities may include collecting and processing kidney biopsy samples, conducting advanced molecular and cellular analyses, integrating data across collaborating sites, and contributing to shared data resources. The cooperative nature of the agreement requires awardees to actively coordinate with NIH-designated partners and adhere to project-wide protocols and data-sharing expectations. Eligibility for this opportunity is broad and inclusive, encompassing a wide range of entity types. Eligible applicants include federal agencies, state and local governments, public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations, small businesses, tribal governments and organizations, and foreign institutions. Additional eligible entities include faith-based and community-based organizations, regional organizations, and U.S. territories or possessions. This inclusive eligibility structure reflects the collaborative and interdisciplinary nature of the project. The application process will follow NIH standard submission procedures, typically requiring submission through Grants.gov and NIH systems. Applicants should expect to prepare detailed research plans, organizational and personnel information, budgets, and compliance documentation. While no specific pre-application requirements such as letters of intent are identified in the forecast, applicants should monitor updates for any additional requirements as the opportunity progresses from forecast to official posting. Applications will be evaluated based on scientific merit, feasibility, collaborative capacity, and alignment with project goals. The timeline for this opportunity indicates that it is currently in a forecast stage, with an estimated posting date in July 2026 and an application due date in October 2026. Awards are expected to be made in June 2027, with project start dates in July 2027. The total estimated program funding is $6,000,000 with approximately seven awards anticipated. Interested applicants are encouraged to prepare early and engage with program contacts for clarification. The listed contact for this opportunity is Debbie S. Gipson, who can be reached via email or phone for additional information and guidance.