Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)

The Silvio O. Conte Digestive Diseases Research Core Centers funding opportunity is issued by the National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases. This program supports the development and operation of Digestive Diseases Research Core Centers that bring together multidisciplinary teams of basic and clinical investigators focused on digestive and liver diseases. The initiative is designed to strengthen collaborative research environments by providing shared infrastructure and resources that enhance productivity, promote innovation, and accelerate scientific discovery aligned with the mission of the NIDDK. The primary purpose of this funding opportunity is to support integrated centers that are organized around a unifying scientific theme within digestive or liver diseases. These centers are expected to facilitate communication and collaboration among investigators and to provide shared core resources that improve efficiency and foster new research directions. The program emphasizes cost-effective use of resources and encourages synergy among investigators with existing peer-reviewed funding. A strong research base is required, including a minimum level of direct-cost funding and a significant proportion of support from NIDDK, ensuring alignment with the institute’s priorities. Funding supports several core components within each center, including an Administrative Core, Biomedical Research Cores, and a Pilot and Feasibility Program. The Administrative Core is responsible for oversight, coordination, and evaluation of center activities, as well as supporting governance structures such as advisory committees. Biomedical Research Cores provide specialized services, technologies, and expertise that are not readily accessible or cost-effective through other means. The Pilot and Feasibility Program offers limited funding to support innovative, early-stage research projects, particularly for new investigators or those transitioning into digestive disease research. The program allows for an optional Clinical Component, which facilitates the translation of basic research findings into clinical applications. This component may provide support for clinical study design, subject recruitment, data analysis, and specimen storage, among other services. Additionally, a Scientific Catalyst Program is required to promote collaboration, training, and knowledge exchange through seminars, workshops, and other activities. These elements collectively aim to enhance the overall impact of the research center and contribute to advancements in prevention, diagnosis, and treatment of digestive and liver diseases. Eligible applicants include a wide range of U.S.-based organizations, such as higher education institutions, nonprofits, for-profit entities, and government agencies at various levels. However, applicants must demonstrate a robust and relevant research base and meet specific funding thresholds. Foreign organizations and non-U.S. components are not eligible. Applications must follow NIH submission procedures using systems such as ASSIST or institutional system-to-system solutions, and must comply with detailed application instructions and formatting requirements outlined in the NIH Application Guide. The application process includes multiple required components, such as detailed descriptions of the research base, core facilities, and administrative structure. Applications undergo a rigorous peer review process followed by advisory council review. Key dates include an open date in late August 2026 and multiple submission deadlines, with review cycles extending into 2027. Awards are expected to support projects for up to five years, with funding levels based on justified needs and subject to NIH policies.

Prioritize strong existing research base, clear thematic focus, and demonstrated collaboration among investigators; ensure core resources are justified and widely utilized