Centers for Structural Biology of HIV and other Infectious Diseases

The National Institutes of Health (NIH), through the National Institute of Allergy and Infectious Diseases (NIAID), has forecasted the "Centers for Structural Biology of HIV and other Infectious Diseases" funding opportunity. This initiative supports multidisciplinary research centers focused on determining the three-dimensional (3D) structures of molecules and molecular complexes relevant to priority infectious diseases. These centers will play a crucial role in advancing structural biology methodologies and technologies with the objective of discovering novel diagnostics, treatments, and preventive tools, particularly in the context of HIV and other pressing infectious diseases. By investing in structural biology, NIAID aims to enhance our understanding of the molecular underpinnings of infections and facilitate the design of targeted medical interventions. The scope of the program is expansive, encompassing high-resolution structural analysis, computational molecular dynamics, functional and mechanistic studies at both molecular and cellular levels, and atomic-level visualization of molecular complexes within cells and tissues. Furthermore, the program encourages advanced structure-guided design of therapeutic molecules. A core aim is to promote shared infrastructure and collaborative research efforts among investigators, maximizing resource efficiency and scientific output. The initiative places significant emphasis on mentoring the next generation of structural biologists, thereby ensuring long-term impact and sustainability in this critical research field. Funding will be distributed via cooperative agreements, emphasizing a collaborative relationship between the recipients and NIAID. While the estimated total program funding, award ceilings, and floors are not specified in this forecast notice, the mechanism implies active involvement from the federal agency throughout the funded projects. There is no cost-sharing or matching requirement for applicants. The grant opportunity falls under the broader discretionary funding category, and it is classified under the health domain, consistent with NIAID’s mission and the scope of activities described. Eligibility for this opportunity is notably inclusive. A wide range of entities are eligible to apply, including nonprofit organizations (both with and without 501(c)(3) IRS status), state, local, tribal, and territorial governments, public and private institutions of higher education, independent school districts, public housing authorities, for-profit entities, and faith-based or community-based organizations. Foreign institutions are also eligible, provided they meet the program's objectives and comply with applicable regulations. This wide eligibility ensures that research centers from various organizational types and geographic contexts can contribute to the overarching goals of the initiative. The estimated timeline for this funding opportunity begins with an anticipated post date of August 18, 2026. Applications will be due by December 18, 2026, with awards expected to be announced around July 1, 2027, and projects starting the same day. Although no pre-application submission such as letters of intent or concept papers is required at this stage, applicants are encouraged to monitor the NIAID website and Grants.gov for further updates once the Notice of Funding Opportunity (NOFO) is officially released. For any inquiries or additional information, applicants are directed to contact the Division of AIDS at NIAID via the provided email address: sciops@niaid.nih.gov. This forecasted opportunity demonstrates the federal commitment to advancing biomedical research infrastructure, particularly in areas of urgent public health importance, and reflects the strategic direction of NIAID to address emerging and existing infectious disease threats through structural biology innovation.