Protecting and Improving Global Public Health: Strengthening and Sustaining Public Health Systems in Ghana

The U.S. Centers for Disease Control and Prevention (CDC), operating under the Department of Health and Human Services, has forecasted a grant opportunity titled “Protecting and Improving Global Public Health: Strengthening and Sustaining Public Health Systems in Ghana.” This initiative falls under the assistance listing 93.318 and is part of CDC’s ongoing commitment to advancing global health security. The CDC has a long-standing presence in Ghana and other partner countries, working to improve local public health systems and their capacity to detect and respond to health threats. This grant opportunity represents the next phase in a series of investments designed to build resilience in public health infrastructure, systems, and workforce capabilities. The primary objective of this grant is to continue strengthening the Ghanaian public health system by enhancing capabilities in disease prevention, surveillance, laboratory capacity, emergency response, and bioinformatics. The scope includes a targeted expansion of surveillance and laboratory networks in border districts, with an emphasis on sequencing and bioinformatics to improve early detection and tracking of infectious diseases. This aligns with broader CDC strategies to mitigate global pandemic threats and build self-sustaining health systems that can respond to both endemic and emerging diseases. Applicants awarded under this cooperative agreement will collaborate closely with CDC personnel, reflecting the nature of the funding instrument which anticipates substantial federal involvement. Funding may be used to support workforce development, enhance disease surveillance infrastructure, implement data systems for early detection, and improve laboratory networks. The grant builds upon previous CDC investments and will complement the efforts of other multilateral and multisectoral partners engaged in Ghana’s health sector. The program does not require cost sharing or matching funds from the recipients, making it accessible to a broader array of applicants, including smaller organizations and institutions that may lack significant financial resources. Eligible entities include a wide range of public and private institutions such as local governments, tribal organizations, nonprofit entities, higher education institutions, and small businesses. The grant is open to both 501(c)(3) and non-501(c)(3) nonprofit organizations. The estimated total funding for this grant is $125 million, with four awards expected. While no specific award ceiling or floor is published, recipients are encouraged to propose funding levels commensurate with their scope of work and capacity. The forecasted application window opens on January 19, 2026, and closes on March 20, 2026, with all electronic submissions due by 11:59 PM ET. Awards are anticipated by August 31, 2026, with funded projects expected to commence by September 30, 2026. No pre-application steps such as a Letter of Intent are required. The grant is forecasted and has not yet opened for applications. Prospective applicants are encouraged to monitor the grants.gov page for updates. For questions regarding this opportunity, applicants may contact Broderick Yoerg at 404-234-0666 or via email at DGHPNOFOs@cdc.gov. There is currently no PDF guideline or NOFO available for download, as this is a forecasted opportunity.