Controlling and Preventing STIs in US Health Departments (CAP-STIs)

Controlling and Preventing STIs in US Health Departments (CAP-STIs) is a forecasted federal cooperative agreement from the U.S. Department of Health and Human Services through the Centers for Disease Control and Prevention, NCHHSTP. The opportunity number is CDC-RFA-PS-27-0008, and the Assistance Listing is 93.977, Sexually Transmitted Diseases (STD) Prevention and Control Grants. CDC describes the program as supporting health departments that track, prevent, and control sexually transmitted infections. The forecast identifies an estimated total program funding level of $500,000,000 and an expected 59 awards. The source reports no cost sharing or matching requirement. The purpose of CAP-STIs is to track, prevent, and control three common sexually transmitted infections: syphilis, gonorrhea, and chlamydia. The program supports goals associated with preventing new STIs, reducing adverse health outcomes, accelerating implementation of STI prevention technologies and innovations, reducing the impact of STIs in disproportionately affected areas or populations, and achieving integrated and coordinated responses to the STI epidemic. Local surveillance data are expected to determine priority populations, and each funded program should focus on populations disproportionately affected by STI transmission. CDC also states that successful implementation will require collaboration with partners to address interconnected comorbidities and sexual health. Eligibility includes all fifty states, the District of Columbia, the U.S. Virgin Islands, and Puerto Rico. CDC intends to fund these jurisdictions non-competitively according to a formula based on jurisdiction population and morbidity associated with chlamydia, gonorrhea, and primary and secondary syphilis. The notice also permits funding of political subdivisions and states that CDC may competitively fund a limited number of cities. Directly funded cities must demonstrate the capacity to report chlamydia, gonorrhea, and syphilis surveillance data to CDC and must have an agreement with their parent state to apply separately and coordinate following an award. City eligibility also depends on 2024 metropolitan statistical area data meeting at least one stated threshold: at least 500 syphilis cases among persons aged 15-44, at least 7,500 gonorrhea cases among persons aged 15-44, at least 15,000 chlamydia cases among persons aged 15-44, or at least 4 million estimated residents. Cities applying for funding must submit their 2024 surveillance summary demonstrating the applicable case or population threshold and documentation addressing coordination with the state. The latter may be a joint statement of collaboration and coordination with the respective state or a letter indicating that the city notified the state of its application. If cities do not compete successfully for direct funding, the notice states that all funds will be provided to the state, which will then be responsible for distributing funds to constituent cities as appropriate. The forecast does not provide additional application forms, narrative questions, page limits, budget instructions, allowable cost details, indirect cost restrictions, or other complete submission requirements. The opportunity is currently in the forecast stage rather than accepting applications. The forecast was dated May 11, 2026 and was last updated September 2, 2026. The estimated posting date is November 10, 2026, and the estimated application deadline is January 11, 2027. Electronically submitted applications must be submitted no later than 11:59 p.m. Eastern Time on the listed application due date. No separate letter of intent, concept paper, pre-proposal, notice of intent, or other pre-application gating deadline is identified in the supplied forecast. No recurring or annually repeating application cycle is stated. CDC estimates an award date of February 1, 2027 and a project start date of March 1, 2027. The fiscal year is 2027, and the listed archive date is February 10, 2027. Although Grants.gov displays award ceiling and award floor values of zero, those values are treated as missing rather than valid award amounts because they do not establish meaningful minimum or maximum awards. The forecast does not state the period of performance. The listed grantor contact is Mary McFarland at 404.639.8309. The source also identifies Luke Shouse with the displayed email address zxz3@cdc.gov and phone number 404-639-4678. No explicit direct PDF URL for the NOFO, RFA, guidelines, or application is provided in the supplied source.

Use local surveillance data to identify populations disproportionately impacted by STI transmission; demonstrate capacity to report chlamydia, gonorrhea, and syphilis surveillance data to CDC when seeking direct city funding; document state coordination for city applications; demonstrate collaboration with partners addressing interconnected comorbidities and sexual health.