Limited Competition: Superfund Hazardous Substance Research and TrainingProgram (P42 Clinical Trial Optional)

The Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) is a discretionary grant opportunity administered by the National Institutes of Health (NIH), specifically the National Institute of Environmental Health Sciences (NIEHS). This program is designed to support research and training activities focused on hazardous substances and their impact on human health and the environment. The opportunity is offered under the authority provided by Section 311(a)(3) of the Superfund Amendments and Reauthorization Act (SARA), which stipulates that only accredited higher education institutions are eligible to apply. The primary purpose of this funding opportunity is to advance understanding and improve strategies related to the detection, assessment, evaluation, and treatment of hazardous substances. The program encourages multidisciplinary research efforts that address the complex challenges posed by hazardous waste sites and contaminated environments. Applicants are permitted to engage in partnerships and subcontract with a variety of public and private organizations, both domestic and international, to fulfill portions of the research. These may include universities, hospitals, laboratories, faith-based organizations, governmental units, and entities involved in hazardous waste management. The scope of funding includes research and education activities that contribute to basic scientific knowledge and practical applications concerning hazardous substances. Funds may be used to support clinical trials, although participation is optional. There are no stated restrictions on specific categories of allowable expenses, but all spending must align with the overall goals of the Superfund Hazardous Substance Research and Training Program. Eligibility is strictly limited to accredited higher education institutions, both public and private. This limitation is mandated by the legislative authority governing the program. However, eligible institutions are encouraged to collaborate with a broad array of partners through subcontracts to enhance the breadth and impact of their research. There is no cost-sharing or matching requirement for applicants. The application process will open on October 13, 2025, with a final submission deadline of March 12, 2026. Awards are expected to be announced by May 1, 2027, which is also the anticipated project start date. The estimated total program funding is $22 million, with approximately 10 awards to be granted. The grant notice is currently in a forecasted state, and potential applicants should monitor Grants.gov for updates and the official posting of the funding opportunity. For additional information, applicants may contact Danielle Carlin, PhD, DABT, at the National Institute of Environmental Health Sciences. She can be reached by phone at 984-287-3244 or by email at danielle.carlin@nih.gov. Interested applicants should prepare to align their proposals with the stated goals of the program and ensure compliance with all eligibility and submission requirements.