Somatic Mosaicism across Human Tissues (SMaHT) Program: National Somatic Mosaicism Commons Data Analysis Organizational Center (UM1 Clinical Trial Not Allowed)

The Somatic Mosaicism across Human Tissues Program National Somatic Mosaicism Commons Data Analysis and Organizational Center is a forecasted federal cooperative agreement opportunity from the U.S. Department of Health and Human Services through the National Institutes of Health. The opportunity number is RFA-RM-28-016, and the Assistance Listing is 93.310, Trans-NIH Research Support. The SMaHT Network is intended to advance discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized collection of human tissues spanning all three germ layers. The forecast describes a planned Stage 2 funding opportunity that will build on this Stage 1 foundation. The planned National Somatic Mosaicism Commons Data Analysis and Organizational Center will combine data management and analysis functions with network governance, coordination, outreach, and training. Its work is intended to support both SMaHT Network members and the wider clinical and research communities in investigating and using the complex datasets generated by the program. The Center will be responsible for managing network data and providing access to data analysis tools developed through the program. Specific responsibilities identified in the forecast include building the SMaHT data portal, Variant Catalog, variant browser, visualization tools, and analysis-ready releases. The Center will also conduct outreach to clinical and research communities and provide training in the use of SMaHT resources. These responsibilities establish a scope encompassing data infrastructure, data management, analytical resources, visualization, access, organizational coordination, outreach, and training. The forecast does not state an award ceiling, award floor, estimated total program funding, expected number of awards, detailed allowable or prohibited cost rules, indirect cost limitations, subaward limitations, or a defined period of performance. Cost sharing or matching is expressly identified as not required. Because the opportunity remains forecasted, applicants should not infer funding amounts or detailed spending rules that are not provided in the current notice. Eligibility is broad. Listed eligible applicants include state governments, county governments, city or township governments, special district governments, independent school districts, public housing authorities and Indian housing authorities, federally recognized Native American tribal governments, Native American tribal organizations, small businesses, other for-profit organizations, public and state controlled institutions of higher education, private institutions of higher education, and nonprofit organizations both with and without 501(c)(3) status when they are not institutions of higher education. Additional eligible applicants include other Indian or Native American tribal governments, eligible agencies of the federal government, U.S. territories or possessions, faith-based or community-based organizations, regional organizations, and non-domestic entities or foreign institutions. No state-specific restriction is stated. The opportunity is currently a forecast rather than an open application solicitation. The forecast was issued and last updated on September 14, 2026. The estimated posting date is May 1, 2027, and the estimated application due date is July 1, 2027. No separate letter of intent, concept paper, pre-proposal, notice of intent, or other pre-application gating deadline is identified in the provided forecast. The estimated award date is May 1, 2028, and the estimated project start date is also May 1, 2028, for fiscal year 2028. The source does not state that this opportunity is rolling or recurring, and no future recurrence schedule is provided. The current forecast also does not provide application questions, required proposal attachments, submission forms, evaluation or scoring criteria, review priorities, or a detailed application procedure beyond indicating that a future Notice of Funding Opportunity is intended. Those details should therefore be treated as unavailable until the full funding opportunity is posted. The program contact is identified as the SMaHT Program, with applicants instructed to make contact by email at smaht@od.nih.gov. No individual contact person or telephone number is provided. Because this is a forecasted opportunity, the estimated posting, application, award, and project start dates may be refined when the full Notice of Funding Opportunity becomes available.

Align the proposed Center approach with the stated responsibilities for network data management, access to program-developed analysis tools, the SMaHT data portal, Variant Catalog, variant browser, visualization tools, analysis-ready releases, outreach to clinical and research communities, and training in SMaHT resources.