Kidney Precision Medicine Project Recruitment Sites (U01 Clinical Trial Not Allowed)

The Kidney Precision Medicine Project Recruitment Sites funding opportunity is issued by the National Institutes of Health within the U.S. Department of Health and Human Services. This initiative is part of a broader federal research effort to advance precision medicine approaches in kidney disease. The NIH, through its institutes and centers, supports biomedical and public health research designed to improve health outcomes nationwide. This specific opportunity contributes to the agency’s mission by enabling the development of a comprehensive kidney tissue atlas and advancing understanding of kidney disease mechanisms. The purpose of this funding opportunity is to support Recruitment Sites that will enroll participants diagnosed with acute kidney injury and chronic kidney disease into a longitudinal cohort study. These sites are responsible for recruiting, consenting, and managing participants, as well as conducting protocol-driven kidney biopsies. The data and biospecimens collected will contribute to a coordinated national effort to better characterize kidney disease at a cellular and molecular level, with the goal of identifying disease subtypes and novel therapeutic targets. Funded entities will collaborate closely with other components of the Kidney Precision Medicine Project, including Tissue Interrogation Sites, the Kidney Tissue Atlas Coordinating Center, and a Central Hub. Together, these entities will process and analyze kidney biopsy samples to construct a detailed kidney tissue atlas. The research scope includes identifying key cellular structures, interstitial components, biological pathways, and disease mechanisms. Funding is provided through a cooperative agreement mechanism, indicating substantial involvement from NIH program staff throughout the project period. Eligible applicants include a broad range of organizations across public, private, nonprofit, and governmental sectors. These include institutions of higher education, state and local governments, tribal organizations, small and large businesses, and nonprofit entities both with and without 501(c)(3) status. Federal agencies, U.S. territories, and non-domestic institutions are also eligible. This inclusive eligibility framework reflects the collaborative and interdisciplinary nature of the project and supports participation from diverse research and clinical environments. The application process is expected to follow standard NIH submission procedures via Grants.gov, requiring applicants to prepare detailed research proposals, institutional documentation, and compliance materials. While specific application components are not outlined in the forecast notice, NIH cooperative agreement applications typically require a comprehensive research plan, budget justification, biosketches, and institutional assurances. There is no cost sharing or matching requirement associated with this funding opportunity. The estimated timeline indicates that the opportunity will be posted in July 2026, with applications due in early October 2026. Awards are expected to be made by June 2027, with project activities beginning in July 2027. Approximately seven awards are anticipated, with total program funding estimated at four million dollars. Applicants may contact the listed NIH program official for additional guidance. As a forecasted opportunity, details may be subject to change upon official release of the full funding announcement.