Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Infrastructure Clinical Coordinating Center (CCC) and Data Coordinating Center (DCC)

The Strategies to Innovate EmeRgENcy Care Clinical Trials Network Infrastructure - Clinical Coordinating Center and Data Coordinating Center opportunity is a forecasted federal cooperative agreement from the National Institutes of Health within the U.S. Department of Health and Human Services. The opportunity number is RFA-NS-28-001, and the Assistance Listing is 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders. The National Institute of Neurological Disorders and Stroke, in conjunction with the National Heart, Lung and Blood Institute, seeks to continue support for the infrastructure of the Strategies to Innovate EmeRgENcy Care Clinical Trials Network, known as SIREN. The opportunity is categorized as Health funding and is expected to result in two awards. The SIREN Network performs clinical trials intended to affect the care of individuals experiencing non-stroke neurological and cardiovascular emergencies in pre-hospital or emergency department settings. Its stated goal is to improve outcomes by identifying effective treatments that can be given during the earliest stages of care. Through this forecasted opportunity, NIH plans to encourage applications for a Clinical Coordinating Center and a Data Coordinating Center to support the SIREN clinical trial network. The source does not provide specific allowable or prohibited spending categories, budget limitations, indirect cost restrictions, subaward limitations, or other detailed funding-use rules. It also does not provide an estimated total program funding amount, award ceiling, or award floor. A broad range of applicants is identified as eligible. These include public housing authorities and Indian housing authorities, special district governments, state governments, independent school districts, public and state controlled institutions of higher education, private institutions of higher education, county governments, city or township governments, small businesses, for-profit organizations other than small businesses, federally recognized Native American tribal governments, Native American tribal organizations other than federally recognized tribal governments, nonprofits with 501(c)(3) status other than institutions of higher education, and nonprofits without 501(c)(3) status other than institutions of higher education. Additional eligible applicants include other Indian or Native American tribal governments, eligible agencies of the federal government, U.S. territories or possessions, faith-based or community-based organizations, regional organizations, and non-domestic entities or foreign institutions. No cost sharing or matching requirement is stated. This notice is a forecast rather than an open solicitation. Applications are explicitly not being solicited at this time. NIH states that the advance notice is intended to give potential applicants sufficient time to develop meaningful collaborations and responsive applications for centers. The source does not provide application forms, narrative questions, required attachments, submission portal instructions beyond the Grants.gov context, letters of intent, concept papers, pre-proposals, or other pre-application gating requirements. It also does not provide formal evaluation or scoring criteria. Accordingly, applicants should not treat the forecast as authorization to submit an application and should await the posted funding opportunity for complete application requirements. The forecast was issued on August 13, 2026 and was last updated on August 13, 2026. The estimated posting date is January 4, 2027, which places the opportunity in an Early Engagement stage as of August 14, 2026. The estimated application due date is March 4, 2027. The estimated award date is December 7, 2027, and the estimated project start date is March 4, 2028. The fiscal year is 2028. No recurring schedule, rolling application process, archive date, or separate pre-application deadline is stated, so recurrence should not be inferred from the forecast. The grantor contact information identifies the NINDS Department of Emergency Medicine and directs interested parties to communicate by email at NINDS_SIREN@ninds.nih.gov. No individual contact person or telephone number is provided. Because this is only a forecast, significant application details remain unavailable, including funding amounts, application components, evaluation criteria, detailed spending restrictions, and a performance period. Potential applicants can use the advance notice to develop meaningful collaborations and prepare applications aligned with the anticipated Clinical Coordinating Center or Data Coordinating Center roles while awaiting the formal solicitation.

Use the forecast period to develop meaningful collaborations and prepare a responsive application for the anticipated Clinical Coordinating Center or Data Coordinating Center role. Align the proposed center with SIREN's clinical trial network mission and its focus on treatments delivered during the earliest stages of care for non-stroke neurological and cardiovascular emergencies.