NIDDK Multi-Purpose Resource-Related, Multi-Component Research Services Centers Cooperative Agreement (U2C - Clinical Trial Optional)

The NIDDK Multi-Purpose Resource-Related, Multi-Component Research Services Centers Cooperative Agreement is a federal funding opportunity administered by the National Institutes of Health within the U.S. Department of Health and Human Services. Specifically, it is issued through the National Institute of Diabetes and Digestive and Kidney Diseases, which supports research aimed at improving the understanding, prevention, and treatment of diseases such as diabetes, obesity, and digestive and kidney disorders. This opportunity is structured as a cooperative agreement, indicating substantial involvement by the federal agency in programmatic oversight and collaboration throughout the lifecycle of the funded projects. The primary purpose of this funding opportunity is to support the establishment and operation of multi-component research service centers that provide highly specialized, resource-related services to external investigators and institutions. These centers are intended to enhance research rigor, reproducibility, and cost efficiency by offering access to expertise and technical capabilities that may not be available at individual institutions. The services provided can include hands-on technical support, consulting, data coordination, research support, and other specialized functions aligned with the scientific mission of the NIDDK. The program emphasizes enabling high-impact research across areas such as integrative physiology, metabolic phenotyping, nutrition, community engagement, communications, and research data coordination. Funding under this program is expected to support approximately seven awards, with an estimated total program funding of nine million dollars. While specific award ceilings and floors are not defined in the forecast, the funding is intended to support complex, multi-component center structures that may include core facilities, service units, and optional pilot and feasibility programs. These centers are expected to serve a broad network of clients, including consortia, research partners, and individual investigators, and must incorporate experiential training opportunities in at least one of the service areas offered. Eligibility for this opportunity is broad and inclusive, reflecting the federal nature of the program. Eligible applicants include a wide range of entities such as state and local governments, public and private institutions of higher education, nonprofit organizations with and without 501(c)(3) status, for-profit organizations including small businesses, tribal governments and organizations, independent school districts, and public housing authorities. Additional eligible entities include federal agencies, U.S. territories, faith-based organizations, and regional organizations. This broad eligibility framework supports the program’s goal of fostering collaboration and expanding access to specialized research resources across diverse institutional settings. The application process is expected to follow standard NIH submission procedures, although specific application components and requirements will be detailed upon formal release of the Notice of Funding Opportunity. As a forecasted opportunity, the estimated application due date is January 28, 2027, with an anticipated posting date in late November 2026. Applicants will likely be required to submit detailed proposals outlining the structure of the proposed center, the services to be provided, management plans, and alignment with NIDDK research priorities. Evaluation criteria are expected to focus on scientific merit, the value and uniqueness of the proposed services, the capability of the team, and the potential to enhance research productivity and collaboration. The projected award date for this opportunity is November 1, 2027, with a planned project start date of December 1, 2027. While no cost sharing or matching requirement is indicated, recipients will be expected to adhere to NIH cooperative agreement terms, including active engagement with program staff. Interested applicants may direct inquiries to the Division of Diabetes, Endocrinology and Metabolic Diseases at the provided program email. As a forecasted funding opportunity, applicants are encouraged to begin early planning and monitor updates for the official release and detailed guidance.

Emphasize specialized service capabilities, demonstrate national impact, and align closely with NIDDK research priorities focusing on rigor and reproducibility.