PRIMED-AI: Logistics Center (U24 Clinical Trial Not Allowed)

The National Institutes of Health (NIH) through the Common Fund, in collaboration with other NIH Institutes and Centers, is planning to release a Notice of Funding Opportunity (NOFO) titled PRIMED-AI: Logistics Center under the cooperative agreement mechanism U24. This initiative is designed to provide administrative infrastructure to support the broader PRIMED-AI program, which focuses on developing artificial intelligence tools that integrate clinical imaging with multimodal health data to advance precision medicine. The program is particularly aimed at improving personalized approaches to chronic and other complex health conditions. The Logistics Center will be structured around three integrated cores: Administration, Evaluation, and Outreach. These cores will manage key functions including consortium governance, steering committee operations, workshops, hackathons such as code-a-thons, and activities designed to foster community engagement and cross-team collaboration. The center will play a central role in ensuring efficient communication, oversight, and program impact by coordinating governance boards, outreach interfaces, and evaluation mechanisms. This approach is intended to create a robust framework that supports the diverse teams participating in PRIMED-AI. The funding opportunity is forecasted and applications are not currently being accepted. The estimated posting date for the NOFO is December 18, 2025, with a projected application due date of February 18, 2026. Awards are expected to be announced by December 1, 2026, and funded projects are planned to begin on the same date. The total estimated program funding is $2,750,000, though the award ceiling and floor for individual applications have not yet been defined. Cost sharing or matching is not required for this opportunity. Eligibility for this program is broad, reflecting NIH’s commitment to fostering diverse collaborations across sectors. Eligible applicants include public and state-controlled institutions of higher education, private higher education institutions, nonprofit organizations with 501(c)(3) status, independent school districts, public housing authorities, Native American tribal governments and organizations, small businesses, for-profit organizations other than small businesses, state governments, and county governments. This wide eligibility ensures that a range of expertise and institutional structures may contribute to the goals of the PRIMED-AI program. Applications must demonstrate capacity to manage and integrate administrative structures across multiple stakeholders while also supporting innovative research infrastructure. Although the forecast does not yet specify detailed application instructions or evaluation criteria, investigators with expertise in building and managing consortia and fostering effective scientific collaboration are strongly encouraged to begin preparing partnerships and organizational plans. For more information about this forecasted opportunity, interested applicants may contact the designated NIH program official, Dr. Sahana N. Kukke at the Office of the Director, NIH Common Fund, Division of Program Coordination, Planning, and Strategic Initiatives. She may be reached by phone at 301-402-3756 or by email at ODPRIMED-AI@od.nih.gov. As the NOFO is currently at the forecast stage, NIH encourages potential applicants to use the additional preparation time to develop meaningful collaborations and responsive projects aligned with the program’s objectives.