Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Infrastructure Clinical Enrollment Hubs

The Strategies to Innovate EmeRgENcy Care Clinical Trials Network Infrastructure - Clinical Enrollment Hubs opportunity is a forecasted federal cooperative agreement from the U.S. Department of Health and Human Services through the National Institutes of Health. The opportunity number is RFA-NS-28-004, and the listed Assistance Listing is 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders. The National Institute of Neurological Disorders and Stroke, in conjunction with the National Heart, Lung and Blood Institute, intends to continue supporting infrastructure for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network, known as SIREN. The opportunity is categorized by Grants.gov as a discretionary Health funding activity. The purpose of the forecasted opportunity is to encourage applications for network clinical enrollment hubs that will support the NIH SIREN clinical trial network. SIREN performs clinical trials intended to affect the care of individuals experiencing non-stroke neurological and cardiovascular emergencies in pre-hospital or emergency department settings. The stated goal of SIREN is to improve patient outcomes by identifying effective treatments that can be administered during the earliest stages of care. The forecast specifically concerns infrastructure for clinical enrollment hubs rather than announcing a currently open application competition. Applications are not being solicited at this time. NIH states that the forecast notice is being provided so that potential applicants have sufficient time to develop meaningful collaborations and responsive applications for centers. The source does not provide detailed allowable or prohibited expenditures, application questions, required attachments, evaluation criteria, indirect cost restrictions, project period, or other detailed spending rules. It does state that there is no cost sharing or matching requirement. Because this is a forecast rather than the posted funding announcement, prospective applicants should rely on the future solicitation for complete application requirements and submission mechanics. Eligible applicants are broad and include public and state controlled institutions of higher education, private institutions of higher education, state governments, county governments, city or township governments, special district governments, independent school districts, public housing authorities and Indian housing authorities, federally recognized Native American tribal governments, Native American tribal organizations other than federally recognized tribal governments, nonprofits with or without 501(c)(3) status other than institutions of higher education, for profit organizations other than small businesses, and small businesses. Additional eligible applicants identified in the source include eligible agencies of the federal government, U.S. territories or possessions, faith-based or community-based organizations, regional organizations, and non-domestic entities or foreign institutions. No state-specific restriction is identified. The forecast lists an estimated post date of January 4, 2027 and an estimated application due date of March 4, 2027. Because the notice states that applications are not currently being solicited, the opportunity is in an early engagement stage rather than accepting applications. The estimated award date is December 7, 2027, and the estimated project start date is March 4, 2028, for fiscal year 2028. The source does not state that the opportunity is rolling or recurring and does not identify a letter of intent, concept paper, pre-proposal, notice of intent, or other pre-application gating deadline. The forecast anticipates 15 awards but does not provide an estimated total program funding amount, award ceiling, or award floor. No previous recipients are identified in the provided source. The source also does not provide enough application components to support a reliable application preparation time estimate or a detailed list of application questions. Questions regarding the forecast may be directed to the NINDS Department of Emergency Medicine through the program email address NINDS_SIREN@ninds.nih.gov. No telephone number or direct PDF URL is provided in the source.

Use the forecast period to develop meaningful collaborations and a responsive clinical enrollment hub application. Align the proposed center with the SIREN network focus on clinical trials addressing non-stroke neurological and cardiovascular emergencies in pre-hospital or emergency department settings and treatments delivered in the earliest stages of care.