Grants for Native American tribal organizations - Education

This notice of funding opportunity (NOFO) will support projects proposing mechanistic studies that will transform our understanding of polysubstance use in addiction. These hypothesis-based, exploratory projects may investigate mechanisms of polysubstance use at the behavioral, cognitive, cellular, circuit, genetic, epigenetic, pharmacological and/or computational levels. Research on substance use disorders (SUDs) has primarily focused on individual substances although polysubstance use is prevalent. Polysubstance use is the use of more than one addictive substance within a defined interval; the use may be sequential (use of multiple substances on separate occasions), or concurrent/simultaneous. Limiting studies to an individual addictive substance overlooks potential interactions between substances and could influence the translational potential of preclinical research findings. Results from several studies have demonstrated that the use of multiple addictive substances produces pharmacokinetic and behavioral profiles that are distinct from those produced by a single substance. Despite this recognition, little is known about the precise pharmacological mechanisms and interactions that may contribute to such outcomes, or co-morbidities resulting from co-use. There is also a significant lack in our understanding of how the activity of discrete cells, genes, circuits, expression of receptors, ion channels, intrinsic excitability or signaling mechanisms in the reward systems synergize when exposed to distinct classes of drugs simultaneously or sequentially. Even less is known about these mechanisms in brain regions and circuits that underlie negative reinforcement, or how neurotransmitters, neuromodulators or stress interact within these circuits to contribute to the behavioral and pharmacological profiles observed following polysubstance use. In addition, there is a need for behavioral models of polysubstance use that have translational potential. Research Objectives: The National Institute on Drug Abuse (NIDA) seeks to stimulate innovative research that will transform our understanding of the basic mechanisms that underlie polysubstance use in addiction. These studies will investigate novel neurobiological, pharmacological and/or behavioral mechanisms underlying the biobehavioral outcomes of polysubstance use. Research areas and questions of programmatic interest include, but are not limited to: Identification and/or characterization of molecules, genes, cells (including non-neuronal cells), neural pathways, circuits, receptors, ion channels, intrinsic excitability, pharmacological and signaling mechanisms mediating the effects of polysubstance use. Mechanisms underlying the association of early adolescent polysubstance use with SUD’s in adulthood. Sex differences in the development and trajectory of polysubstance use. What are the roles of organizational and activational effects of sex steroids on discrete brain regions and neural circuits, and how is this altered with exposure to polysubstance use? What are the developmental determinants? Are there developmental windows during which polysubstance use would be facilitated? What are the pharmacologic, pharmacokinetic and pharmacodynamic interactions that can impact toxicity, or the SUD trajectory? How do environmental factors interact with brain circuits to influence the development and trajectory of SUDs involving polysubstance use? How does stress interact with brain circuits to influence the development and trajectory of SUDs involving polysubstance use? Are there neurobehavioral risk phenotypes for progression to polysubstance use? What are the neurocognitive and neurobehavioral changes that occur through experience with different patterns of polysubstance use? Applications Not Responsive to this Notice of Funding Opportunity (NOFO) The following types of studies are not responsive to this NOFO and will not be reviewed: The major goal of the project is not targeted at delineating the basic mechanisms underlying polysubstance use in addiction. Projects limited exclusively to the phenomenology of polysubstance use, consequences of polysubstance use, or those focused exclusively on the development of tools or animal models. Projects that do not focus on combinations of two or more addictive substances with well-justified translational and public health relevance. Projects that do not include a psychostimulant, opioid, or cannabinoid in the polysubstance combination. Alcohol may be included in the polysubstance combination. Research that does not pertain to at least one of the stages of the substance use trajectory, including, but not limited to initiation, escalation, withdrawal and/or relapse. Other application considerations: Collaborative research teams to foster the sharing of conceptual and/or technical expertise are strongly encouraged. Applicants using animal models are encouraged to use models reflective of chronic and voluntary drug intake. Preliminary data are not required but may be included if available. In the absence of preliminary data, a strong premise should be provided for testing a novel hypothesis based upon the scientific literature as well as evidence of the team’s ability to carry out the proposed studies through published or technical preliminary data.

This funding opportunity supports early-stage researchers in cancer control and population sciences to explore innovative ideas that can significantly advance cancer research and improve healthcare delivery.

This funding opportunity supports researchers conducting basic science studies to explore how sleep and circadian rhythms are connected to substance use disorders, aiming to improve understanding and treatment of these issues.

This grant provides funding for researchers to explore the complex interactions between the brain and immune system in the context of HIV and substance use disorders, aiming to identify new therapeutic targets and improve understanding of related neurological issues.

Reissue of RFA-MH-20-128 This Funding Opportunity Announcement (FOA) solicits applications to develop standards that describe experimental protocols that are being conducted as part of the BRAIN Initiative. It is expected that applications will solicit community input at all stages of the process. It is recommended that the first step of standard development will involve sharing data between different key groups in the experimental community in order to ensure that the developing standard will cover the way that all of those groups are collecting data. The developed standard is expected to be made widely available.

This funding opportunity provides financial support to community-based organizations in Seattle to improve health and educational outcomes for pregnant individuals, infants, and toddlers, particularly in marginalized communities.

Public Health – Seattle & King County is offering a grant of $100,000 to $500,000 for projects that support diverse youth mental health providers, particularly those connected to LGBTQIA and BIPOC communities, with the aim of increasing access to mental health resources, improving retention, and supporting diverse providers in King County, Washington.

This funding opportunity supports researchers exploring the use of microorganisms, like bacteria and viruses, to develop innovative methods for cancer imaging, diagnosis, and treatment.

This funding opportunity provides financial support to Tribal Colleges and Universities for planning initiatives that transition their campuses to clean energy solutions.

This funding opportunity supports researchers in developing and testing innovative devices for diagnosing and treating disorders of the nervous system through small clinical studies and safety assessments.

This grant provides funding for researchers to explore how diet and lipid metabolism influence tumor growth and progression, encouraging innovative studies that connect nutrition science with cancer biology.

The Mississippi Humanities Council offers grants to support projects that engage communities in meaningful dialogue, attract diverse audiences, and are participatory and engaging, applying humanities to everyday life. Grants support public humanities programs, exhibits, planning of larger projects, and the development of original productions in various media. Regular grants : start at $2,500 to $10,000. Regular grants applications are accepted on May 1st and September 1st Grant renewed every year.

This grant provides funding for small-scale cancer research projects that can be completed in two years, aimed at supporting innovative studies and methodologies in various areas of cancer research.

This funding opportunity supports researchers working to identify and address health and healthcare disparities affecting sexual and gender minority populations, particularly those from racial/ethnic minority and lower socioeconomic backgrounds.

This grant provides funding for research centers to improve gifted education and explore the use of generative artificial intelligence in postsecondary instruction, targeting partnerships between higher education institutions and state educational agencies.

The purpose of this Request for Applications (RFA) is to solicit applications from eligible Tribal Groups or Incorporated American Indian Associations for grants to operate American Indian Education Centers (AIEC) authorized by sections 33370 and 33380–33385 of the California Education Code (EC). It is anticipated that the Budget Act will allocate approximately $5.1 million for the fiscal year (FY) 2024-25. The California Department of Education (CDE) anticipates that similar amounts will be allocated for each year during this five-year cycle. This award is made contingent upon the availability of funds. If the Legislature takes action to reduce or defer the funding upon which this award is based, then this award will be amended accordingly. The AIEC grant funds may be used for any of the purposes specified in the authorizing legislation and the program regulations (California Code of Regulations, Title 5 [5 CCR], Section 11996) to promote the academic and cultural achievement of the students. The AIEC grant funds may be used, on the basis of established priority needs, to accomplish the following: • Improve the academic achievement of American Indian pupils in kindergarten and grades one to twelve, inclusive.• Improve the self-concept and sense of identity of American Indian pupils and adults.• Serve as a center for related community activities.• Provide individual and group counseling to pupils and adults related to personal adjustment, academic progress, and vocational planning.• Create and offer coordinated programs with the public schools.• Provide a focus for summer cultural, recreational, and academic experiences.• Create and offer adult classes and activities that benefit parents or guardians of pupils in its programs.• Provide training programs to develop pathways to college and the workplace for American Indian pupils.• Provide American Indian educational resource materials to pupils, their parents, and the schools they attend in order to ensure appropriate tribal histories and cultures is made available.

The Welch Charitable Fund, administered by the Maine Community Foundation, supports organizations within the Greater Portland area, specifically Cumberland County, Maine. This grant program aligns with the foundation's mission to foster community well-being by prioritizing nonprofits dedicated to youth, education, healthcare, alcohol and substance abuse rehabilitation, and arts and culture. The fund aims to provide grants that either increase the scope (number of people or services) or improve the efficiency and effectiveness of organizations, as well as support new or expanded projects that address community needs in these focus areas. The target beneficiaries of the Welch Charitable Fund are individuals residing in the Greater Portland area, with a particular focus on youth. The fund seeks to impact these beneficiaries by supporting projects that promote their development, health, and access to educational and cultural opportunities. Through strategic funding, the foundation aims to contribute to a healthier, more educated, and culturally enriched community, ultimately addressing critical social issues such as substance abuse. The priorities and focuses of the Welch Charitable Fund are clearly defined: education, health care, youth development, recovery from substance use disorder, and arts and culture. The foundation's strategic priorities are evident in its commitment to funding initiatives that directly address these areas, recognizing their interconnectedness in fostering a vibrant and resilient community. The theory of change behind this grant program is that by investing in these key sectors, the foundation can empower local organizations to deliver vital services and programs, leading to positive and lasting changes for individuals and the community as a whole. The expected outcomes of the grants include an expanded reach of services, improved organizational efficiency, and the successful implementation of new projects. While specific measurable results are not explicitly detailed beyond the scope and effectiveness improvements, the focus on increased numbers of people served and enhanced organizational performance suggests a commitment to tangible impact. Eligible organizations include 501(c)(3) nonprofits, municipalities, public schools, public agencies, and Indian tribal governments, with a grant size ranging from $1,000 to $10,000, underscoring the foundation's dedication to supporting a diverse array of community-serving entities.

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Funding Opportunity Announcement (FOA) invites researchers to submit applications for support of clinical projects that address critical needs for clinical trial readiness in Down syndrome. This initiative seeks applications that are intended to facilitate Down syndrome research by enabling efficient and effective movement of candidate therapeutics or diagnostics towards clinical trials for Down syndrome and its co-occurring conditions, and to increase their likelihood of success through development and testing of biomarkers and clinical outcome assessment measures, development and testing of novel trial methods and recruitment strategies, or by defining the presentation and course of the co-occurring conditions in individuals with Down syndrome to enable the design of future clinical trials.

This funding opportunity provides financial support to exceptional clinician scientists who contribute to the development and implementation of NCI clinical trials, ensuring their continued involvement in cancer research without being principal investigators on research project grants.

This grant provides funding for research on how HIV and substance use affect placental health and maternal outcomes, targeting a wide range of institutions and researchers focused on these critical health issues.