Grants for State governments - Education

The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial and microbiome therapies). Applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in manufacturing, scaling, pharmacokinetics, toxicology, and Phase I clinical testing. BPN-Biologics awardee institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN-Biologics contractors (and thereby control the patent prosecution and licensing negotiations) for biotherapeutic candidates developed in this program.

The Learning Landscapes Challenge, sponsored by Siegel Family Endowment (SFE) and the Walton Family Foundation (WFF), aims to integrate social, digital, and physical infrastructure to bridge current and future learning paradigms. This initiative aligns with the foundations' broader missions to support changemakers and foster innovative approaches to education. By focusing on infrastructure, the challenge seeks to create more connected and effective learning environments, reflecting a strategic priority to enhance educational ecosystems through systemic improvements. The challenge targets "changemakers," including individuals, groups, or entities with innovative ideas, particularly those operating in the United States, as lead individuals or entities must maintain a primary place of operations there to be eligible for monetary prizes. The impact goal is to achieve tangible, transformative effects in learning, extending beyond single communities. The program prioritizes solutions that incorporate multiple dimensions of infrastructure or utilize infrastructure in novel ways to create scaled impact. The Learning Landscapes Challenge is structured in three phases to identify and support infrastructural concepts. Phase 1 is open to all eligible entrants, with up to 40 winners receiving $5,000 and an invitation to the Phase 2 accelerator. Phase 2 is exclusively for Phase 1 winners, with up to five recipients each receiving $200,000 and an invitation to the Phase 3 incubator. Finally, Phase 3 is for Phase 2 winners, with up to two grand-prize winners each receiving $500,000. These phased awards, totaling up to $2.2 million, are designed to progressively refine and scale solutions. Expected outcomes include the development and implementation of innovative learning solutions that integrate various infrastructures, leading to more accessible and effective learning experiences. Measurable results are tied to the progression through the phases and the successful scaling of these solutions beyond initial communities. The foundations' theory of change suggests that by supporting the development of robust and integrated learning infrastructures, they can catalyze significant improvements in educational access, quality, and adaptability, ultimately preparing learners for future challenges and opportunities.

The purpose of this notice of funding opportunity (NOFO) is to solicit applications proposing innovative transdisciplinary research that integrates approaches across social/cognitive neuroscience and other social sciences and will lead to a testable conceptual or computational model that provides mechanistic insights into social behavior and its relationships with the onset, trajectory and impact of Substance Use Disorders (SUD) and comorbidities. This NOFO is specifically soliciting applications proposing BESH research, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Application budgets are not limited but need to reflect the actual needs of the proposed project.

This funding opportunity provides financial support to licensed organizations that offer long-term foster care and related services for unaccompanied minors without legal immigration status in the U.S.

This grant provides funding to educational institutions to create programs that support and encourage undergraduate students from diverse and underrepresented backgrounds to pursue advanced degrees and careers in neuroscience research.

This funding opportunity supports postdoctoral researchers in biomedical and behavioral fields, providing mentorship and resources to help them develop into independent scientists.

This funding opportunity provides financial support for researchers to quickly evaluate new policies or programs aimed at influencing behaviors related to obesity, such as diet and physical activity, to help prevent or reduce obesity rates.

This grant provides funding to educational institutions and organizations to train professionals in vocational rehabilitation, specifically to support individuals who are hard of hearing, addressing workforce shortages in this field.

This funding opportunity is designed to help libraries in Ohio create innovative projects that address specific community needs while aligning with the State Library's strategic goals.

This funding opportunity provides financial support for organizations to implement school feeding programs and improve nutrition and education for children, particularly girls, in developing countries.

This funding opportunity supports doctoral candidates conducting research on substance use and substance use disorders, helping them complete their dissertation projects while fostering new talent in the field.

This grant provides funding to partnerships of employers, educational institutions, and community organizations to develop cybersecurity workforce training programs that address local labor market needs.

This funding opportunity supports U.S. institutions and organizations in developing animal models and biological resources to advance research on Down syndrome and its related health conditions.

This funding opportunity provides support for the ongoing development and maintenance of valuable informatics tools and resources that enhance cancer research and management, benefiting researchers and the broader cancer community.

The purpose of the NIH Midcareer Investigator Award in Patient-Oriented Research (K24) is to provide support to mid-career health-professional doctorates for protected time to devote to patient-oriented research (POR) and to act as research mentors primarily for clinical residents, clinical fellows and/or junior clinical faculty. Section I. Funding Opportunity Description The overall goal of the NIH Research Career Development program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's biomedical, behavioral, and clinical research needs. NIH Institutes and Centers (ICs) support a variety of mentored and non-mentored career development award programs designed to foster the transition of new investigators to research independence and to support established investigators in achieving specific objectives. Candidates should review the different career development (K) award programs to determine the best program to support their goals. More information about Career programs may be found at the NIH Extramural Training Mechanisms website. The NIH Midcareer Investigator Award in Patient-Oriented Research (K24) is designed to enable mid-career clinician-scientists to: Devote more time to augment their capabilities in Patient-Oriented Research (POR); and Provide mentoring to junior clinical investigators in the conduct of POR (see below for definition). The K24 award is intended to provide protected time to mid-career clinical investigators to provide mentoring to junior clinical investigators, particularly K23 grantees, in POR and to stabilize the careers of these investigators. The intent is to allow these investigators to continue to conduct POR and be available as mentors in POR. It is expected that K24 recipients will obtain new or additional independent, peer-reviewed funding for POR as PD/PI and establish and assume leadership roles in collaborative POR programs. In addition, it is expected that there will be an increased effort and commitment to act as a mentor to beginning clinician investigators in POR to enhance the research productivity of both the K24 investigator and increase the pool of well-trained clinical researchers of the future. For the purposes of the K24 award, Patient-Oriented Research is defined as research conducted with human subjects (or on material of human origin such as tissues, specimens and cognitive phenomena) for which an investigator (or colleague) directly interacts with human subjects. This area of research includes: (1) mechanisms of human disease; (2) therapeutic interventions; (3) clinical trials, and; (4) the development of new technologies. Excluded from this definition are in vitro studies that utilize human tissues but do not deal directly with patients. In other words, patient-oriented research is research in which it is necessary to know the identity of the patients from whom the cells or tissues under study are derived. Studies falling under Exemption 4 for human subjects research are not included in this definition. See also the NIH Director's Panel on Clinical Research Report. NIH defines a clinical trial as "A research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes." (NOT-OD-15-015). NIH not only supports trials of safety and efficacy, it also supports mechanistic exploratory studies that meet the definition of a clinical trial and are designed to explore or understand a biological or behavioral process, the pathophysiology of a disease, or the mechanism of action of an intervention. These studies may focus on basic and/or translational discovery research in healthy human subjects and in human subjects who are affected by the pathophysiology of diseases and disorders. By addressing basic questions and concepts in biology, behavior, and pathophysiology, these studies may provide insight into understanding human diseases and disorders along with potential treatments or preventive strategies. NIH also supports biomarker studies that meet the definition of a clinical trial and that may provide information about physiological function, target engagement of novel therapeutics, and/or the impact of therapeutics on treatment response. NIH thus supports studies that meet the definition of clinical trials (as noted above) but do not seek to establish safety, clinical efficacy, effectiveness, clinical management, and/or implementation of preventive, therapeutic, and services interventions. Note: This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary clinical trial, as part of their research and career development. Applicants not planning an independent clinical trial, or proposing to gain research experience in a clinical trial led by another investigator, must apply to companion FOA Special Note: Because of the differences in individual Institute and Center (IC) program requirements for this FOA, prospective candidates are strongly encouraged to consult the Table of IC-Specific Information, Requirements and Staff Contacts, to make sure that their application is appropriate for the requirements of one of the participating NIH ICs. See Section VIII. Other Information for award authorities and regulations. Section II. Award Information Funding Instrument Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Application Types Allowed New Resubmission Revision Renewal The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this FOA. Clinical Trial? Required: Only accepting applications that propose an independent clinical trial(s) Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Award Budget Award budgets are composed of salary and other program-related expenses, as described below. Award Project Period The total project period may not exceed 5 years.

This funding opportunity supports nonprofit organizations and public agencies in their efforts to combat poverty through community empowerment and sustainable solutions in areas such as economic opportunity, education, and environmental stewardship, with a focus on advancing racial equity and serving underserved communities.

Substance use needs to be better incorporated into interventions for the engagement and retention of sexual minority persons in prevention and care with attention to emergent interventions such as long-acting PrEP. Social determinants of health associated with HIV and problematic substance use such as homelessness and criminal justice involvement also demonstrate disproportionate impact among sexual and gender minorities and need attention. Changing self-definition of sexual minority status has implications for outreach and provider stigma and needs to be better integrated into interventions. This initiative will address these gap areas and support epidemiologic, intervention, and implementation research that incorporates attention to HIV as a syndemic including comorbidities such as STIs, HCV, and psychiatric disorder.

This funding opportunity supports innovative research projects that aim to improve the use of genomic information in clinical care, particularly for diverse and underrepresented populations, while addressing health disparities and enhancing the integration of genomic medicine into healthcare practices.

This funding opportunity provides financial support for research on the role of inflammasomes in the brain related to HIV and substance use disorders, targeting innovative studies that explore their impact on inflammation and neurocognitive health.

This grant provides funding for interdisciplinary research teams to explore the ethical implications of new neurotechnologies and brain science advancements, focusing on issues like data privacy, informed consent, and public attitudes toward brain research.