Grants for County governments - Health

The purpose of this Notice of Funding Opportunity (NOFO) is to support milestone-driven projects focused on developing and utilizing novel predictive models, assays, tools, and/or platforms based on penetration and efflux of small molecules to facilitate therapeutic discovery for select Gram-negative bacterial pathogens: carbapenem-resistant Acinetobacter, carbapenem-resistant Enterobacteriaceae (CRE), and multidrug-resistant Pseudomonas aeruginosa. A number of Gram-negative bacterial pathogens are associated with the alarming increase in rates of drug resistance in healthcare and community settings. This group includes carbapenem-resistant Acinetobacter , carbapenem-resistant Enterobacterales (CRE), and MDR Pseudomonas aeruginosa that have been designated as “urgent” or “serious” threats in a recent report by the Centers for Disease Control and Prevention (CDC). A significant threat arises from the lack of effective therapeutic options available to treat some of these infections and is exacerbated by the scarcity of novel compounds effective against antimicrobial resistant (AR) and multidrug-resistant (MDR) Gram-negative bacteria in the discovery and development pipeline. In recent years, several public forums (including NIAID-sponsored workshops) identified the lack of understanding of the principles that govern compound penetration into, and efflux out of, Gram-negative bacteria as a key bottleneck for the rational discovery of novel lead therapeutic compounds. The paucity of suitable assays/tools/models to inform structure-activity relationships and guide optimization of whole cell penetration (and efflux avoidance) is reflected in the failure of medicinal chemistry efforts to advance novel chemical classes of compounds with Gram-negative activity. As more Gram-negative bacteria become resistant to antimicrobials and therapeutic options become limited or nonexistent, it becomes imperative to understand and rationalize the principles that allow molecules to penetrate Gram-negative bacteria, while avoiding efflux and overt toxicity toward eukaryotic cells. Therefore, developing new assays, tools, and models is paramount for overcoming this key bottleneck and facilitating the development of novel compounds targeting Gram-negative pathogens. Research Objectives and Scope The objective of this NOFO is to support milestone-driven projects focused on developing and utilizing novel predictive models, assays, tools, and/or platforms aimed at gaining a better understanding of the rules and compound properties that govern the penetration and efflux of drug-like small molecules into Gram-negative bacterial pathogens. This NOFO also supports the preclinical development of novel Gram-negative antibacterial therapeutics based on the tools and models hereby developed. Applications must focus on one or more of the following Gram-negative bacterial pathogens: carbapenem-resistant Acinetobacter, carbapenem-resistant Enterobacterales (CRE), and/or MDR Pseudomonas aeruginosa. Projects should complete assay/tool/model development prior to the end of the third year of the project period and initiate discovery activities to demonstrate its utility in supporting a corresponding medicinal chemistry program to generate a lead chemical series with demonstrated activity against one or more targeted Gram-negative bacteria. This NOFO will also support subsequent preclinical development of a promising lead antibacterial. Given the complex challenges of this research, this initiative encourages applications from multi-disciplinary teams composed of relevant experts in areas such as bacterial physiology, microbiology, bacterial membrane biology, medicinal chemistry, pharmacology, computation, and specialized technologies (microscopy, spectroscopy, electrophysiology, machine learning, etc.), as appropriate. Collaboration with, and utilization of, the NIAID Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB), is recommended for completion of project relevant medicinal chemistry tasks. Close collaboration between academic and industry partners is highly encouraged to optimally combine innovative basic science with drug discovery expertise and proper access to compound libraries more typically available from industry. Examples of assay and model development activities include, but are not limited to: Quantitative cellular (or model system) assays to measure drug penetration and efflux, independent from standard minimum inhibitory concentration (MIC) testing; Innovative quantitative assays to measure drug concentrations in the bacterial cytoplasm and/or periplasmic space; Innovative technologies for dissecting and assessment of the kinetics of drug penetration and efflux from bacteria; and Computational algorithms for describing/predicting physical-chemical properties/guidelines needed by small molecules for optimal Gram-negative penetration and efflux avoidance. Applicants should demonstrate the utility of the developed tools and/or assays to predict and measure potency of candidate therapeutics against Gram-negative targets through one or more approaches. For example, using the developed models and/or assays to guide a medicinal chemistry campaign aimed at producing a novel chemical series with Gram-negative activity; screening existing libraries using the computational algorithms developed as a tool to find compounds with Gram-negative activity; or profiling existing libraries of compounds with known Gram-negative activity. Applications including the following will be considered non-responsive and will not be reviewed: Projects that do not focus on at least one select Gram-negative pathogen (carbapenem-resistant Acinetobacter, carbapenem-resistant Enterobacterales, or MDR Pseudomonas aeruginosa); Projects focused only on Gram-positive bacteria or Mycobacterium tuberculosis; Projects that do not focus on penetration and efflux of small molecules; Applications not containing a Milestone and Timeline attachment; Applications proposing Clinical trials; and Research on HIV/AIDS.

This funding opportunity supports researchers in developing innovative animal models and biological tools to advance the understanding of Down syndrome and its related health conditions.

This funding opportunity supports innovative research projects that explore how climate change affects cancer risks, treatment, and survivorship, with a focus on developing solutions to mitigate these impacts and address health inequities.

The "Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research" grant aims to fund exploratory research projects that further develop and validate innovative technologies for analyzing molecular and cellular aspects of cancer, with the goal of improving cancer research, detection, diagnosis, treatment, and understanding of health disparities.

This grant provides funding for researchers to investigate the biological mechanisms behind adverse effects related to anti-beta-amyloid immunotherapy in Alzheimer's disease, with the goal of developing strategies to protect the blood-brain barrier and improve treatment safety.

This funding opportunity supports U.S.-based organizations in developing and testing effective cancer interventions that improve health outcomes for diverse populations across the entire cancer control continuum, particularly in under-resourced communities.

The Michigan Office of the Environmental Justice Public Advocate in the Department of Environment, Great Lakes and Energy (EGLE) offers the Environmental Justice (EJ) Impact Grant program. This program is designed to reduce environmental health burdens and impacts within Michigan’s Environmental Justice communities. The core mission of this grant aligns with the broader goal of promoting environmental equity and public health, particularly in areas disproportionately affected by environmental issues. The primary target beneficiaries of this program are residents within Michigan’s Environmental Justice communities. The overarching impact goal is to positively affect these residents by funding place-based and equity-focused projects. This direct focus on communities facing environmental injustice ensures that the grant addresses critical needs where they are most prevalent, aiming for tangible improvements in their living environments and health outcomes. The program prioritizes several key areas for funding. These include community improvement projects aimed at enhancing public health, initiating or expanding monitoring of background pollution levels in air, water, or soil (with air monitoring equipment classified as air quality sensors and not for regulatory use), new or improved equipment or management techniques to improve indoor air quality in schools, and the remediation/redevelopment of contaminated or blighted sites. These priorities reflect a comprehensive approach to environmental justice, addressing both pollution and its direct impacts on community well-being. Expected outcomes include measurable improvements in public health through community projects, enhanced understanding of pollution levels via monitoring, better indoor air quality in schools, and the revitalization of environmentally degraded areas. The program has a total of $20,000,000 available, with a maximum of $500,000 per applicant. This substantial funding allows for significant, impactful projects. Eligible applicants include federally recognized Tribes, community-based non-profit organizations (including grassroots and frontline organizations), schools, institutions of higher education, and local governments, reflecting a strategic approach to engage diverse stakeholders in achieving environmental justice.

The purpose of this NOFO is to support projects to test prospective multi-sectoral preventive interventions that address social determinants of health in populations that experience health disparities. These research projects will be part of the Multi-Sectoral Preventive Interventions (MSPI) Research Network, which will also include a Coordinating Center (NOFO xxx). Funded under a cooperative agreement, projects participating in the MSPI Research Network will collaborate to share approaches, methods, and data, working closely with NIH Institutes, Offices and Centers. Applicants applying to this NOFO are encouraged to review the Coordinating Center NOFO to fully understand the MSPI Research Network structure and activities. This NOFO solicits bi-phasic research projects proposed in UG3/UH3 Phased Innovation Awards Cooperative Agreement applications. Funding for the UG3 phase (phase I) will be used to demonstrate sufficient preparation, feasibility and capacity to meet foundational milestone targets specific to the work proposed. A UG3 project that meets its milestones will be administratively considered by NIH and prioritized for transition to the UH3 award (phase II). Applicants responding to this NOFO must address specific aims and milestones for both the UG3 and UH3 phases.

This funding opportunity is designed to improve the health of refugees and immigrants in the U.S. by supporting initiatives that enhance healthcare access, provider training, and health education for these vulnerable populations.

This funding opportunity supports researchers at various institutions to conduct basic experimental studies involving human participants, aimed at advancing our understanding of fundamental biological and behavioral processes.

This program provides funding to various organizations for research projects that improve workplace safety and health by identifying and reducing occupational hazards.

The "Effectiveness of School-Based Health Centers to Advance Health Equity" grant aims to fund research into how school-based health centers can effectively address the health needs of underserved school-aged children, particularly in managing and preventing chronic illnesses and understanding how these centers can improve health outcomes for at-risk groups such as immigrant youth and those in rural areas.

This funding opportunity supports projects that improve public health and the environment in communities disproportionately affected by pollution and environmental issues across Colorado.

This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) and related assays that replicate complex nervous system architectures and physiology with improved fidelity over current capabilities. Supported projects will be expected to enable future studies of complex nervous system development, function and aging in healthy and disease states.

This funding opportunity provides financial support to community-based organizations in California to improve behavioral health services for children aged 0-5 and mothers, focusing on collaboration and early intervention to enhance overall health outcomes.

This funding opportunity provides financial support to Ohio's county Alcohol, Drug Addiction, and Mental Health Services boards to develop and implement comprehensive disaster preparedness plans that integrate behavioral health services into emergency response efforts.

This funding opportunity provides financial support for new and at-risk researchers from diverse backgrounds to conduct independent scientific studies, particularly in areas addressing health disparities and underrepresented populations.

This funding opportunity supports nonprofit organizations and government entities in Philadelphia to plant and care for at least 35,000 trees by 2035, focusing on community engagement and environmental equity.

This program provides funding to local organizations in Iroquois County to enhance their existing food, shelter, and emergency assistance services for individuals and families in need.

This funding opportunity supports researchers and institutions in conducting early-phase clinical trials for innovative cancer treatments and diagnostic tools to improve patient care and address unmet needs in cancer research.