Grants for Native American tribal organizations - Health

This funding opportunity supports researchers in developing innovative animal models and biological resources to advance the understanding of Down syndrome and its related health conditions.

The National Cancer Institute (NCI) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the RNA Modifications Driving Oncogenesis (RNAMoDO) Initiative. It aims to promote mechanistic research in the emerging area of RNA modifications that drive oncogenesis, with a focus on the central role of RNA modifications in translational reprogramming of cancer cells. RNA modifications have been recognized to exert a substantial impact on gene expression and function and their de-regulation has been linked to the cancer phenotype. In particular, recent insights point to a crucial role for mRNA, tRNA, and rRNA modifications in translational reprogramming during tumor initiation, progression, and adaptation to therapy. However, the molecular mechanisms underlying this reshaping of the translatome caused by dynamic changes in RNA modifications, and especially the interplay between different RNA modifications within and across RNA molecules during translation, are not understood and represent the focus of this initiative. Historically, the research community has largely pursued investigations of RNA modifications by studying single RNA species and modification types. However, elucidating how dysregulation of mRNA, tRNA, and rRNA modifications reprograms translation to drive oncogenesis is not likely feasible for any single research laboratory, but will require the combination of expertise in mRNA, tRNA and rRNA biology, translational regulation, and cancer research. To stimulate progress in this emerging field, the RNAMoDO program will support collaborative research projects, preferably using an MPI structure, on how modifications in mRNA, tRNA, and rRNA molecules can drive the oncogenic process through translational reprogramming. To be responsive to the NOFO, each project will also explore the impact of interactions between modifications residing on the same or different RNA molecules during translation. This Notice of Intent to Publish (NOITP) is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in the early Fall of 2024, with an expected application due date in November 2024. The NOFO will utilize the U01 mechanism for Research Project Cooperative Agreement (Clinical Trial Not Allowed). Potential applicants are encouraged to view the presentation of this initiative to the NCI Board of Scientific Advisors (BSA), available at: (https://videocast.nih.gov/watch=54423) beginning at 1 hour, 32 minutes, 52 seconds. Presentation slides are downloadable at https://deainfo.nci.nih.gov/advisory/bsa/0324/Maas.pdf.

This funding opportunity supports researchers from various fields in developing innovative methods to study brain changes over time, focusing on both healthy individuals and those with specific cognitive or emotional challenges.

This funding opportunity supports researchers exploring heart, lung, and blood diseases and sleep disorders by providing access to valuable biospecimen collections for preliminary data generation.

This grant provides financial support for senior graduate students from diverse backgrounds to complete their dissertations in aging research, promoting a more inclusive scientific workforce.

This funding opportunity supports physician-scientists with clinical doctorate degrees who are transitioning to independent research careers in non-malignant hematology, enabling them to advance their research on blood disorders.

This funding opportunity supports research projects that develop and test strategies to overcome barriers to HIV prevention for individuals who use substances, particularly focusing on marginalized groups such as women, transgender individuals, and those involved in the criminal justice system.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs.The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. To accomplish the stated overarching goal, this FOA will provide support to recipients of Clinical and Translational Science Awards (CTSA) for creative educational activities with a primary focus on research experiences designed to ensure that the participants receive exposure to the scientific and operational principles underlying each step of the translational process so that they can apply these principles to clinical and translational science research areas such as: 1) pre-clinical research, 2) clinical research, 3) clinical implementation, and 4) public health.

This grant provides funding for innovative technology development projects that aim to create new tools and methods for advancing biomedical research, focusing on prototypes that address significant technical challenges.

This funding opportunity provides resources for Arizona-based organizations to conduct integrated testing for HIV, Hepatitis C, and Syphilis, aiming to improve early detection and linkage to care in diverse community settings.

This funding opportunity supports U.S. higher education institutions and nonprofits in training predoctoral and postdoctoral researchers to advance interdisciplinary research on Alzheimer's Disease and related dementias.

This funding opportunity supports early-career researchers from diverse backgrounds in advancing their studies on Alzheimer's Disease-Related Dementias, helping them transition from mentored postdoctoral positions to independent faculty roles.

This grant provides funding to organizations that support programs helping older adults and individuals with disabilities manage chronic diseases while improving their behavioral health through education and community partnerships.

This funding opportunity supports federally recognized American Indian and Alaska Native tribes and organizations in creating culturally relevant mental health and wellness programs for children and youth facing historical and systemic challenges.

The "Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH)" grant aims to support research that develops new behavioral measures and data infrastructure to improve the diagnosis, prognosis, and treatment of mental disorders.

This Notice of Funding Opportunity (NOFO) requests applications to explore human pancreatic tissues and the immune compartment for the discovery of specific signaling or processing pathways that may contribute to the asymptomatic phase of T1D, the discovery of early biomarkers of T1D pathogenesis, the development of diagnostic tools for the detection and staging of early T1D in at-risk or recently-diagnosed individuals, and/or the identification and biological validation of therapeutic targets for the development of preventative or early treatment strategies. Successful applicants will join the Consortium on Beta Cell Death and Survival (CBDS), whose mission is to better define and detect the mechanisms of beta cell stress and destruction central to the development of T1D in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and of preventing the progression to autoimmunity. The CBDS is part of a collaborative research framework, the Human Islet Research Network (HIRN, https://hirnetwork.org/), whose overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This NOFO will only support studies with a primary focus on increasing our understanding of human disease biology (as opposed to rodent or other animal models). This NOFO will not accept applications proposing a clinical trial.

This funding opportunity supports a wide range of research projects aimed at improving the understanding, prevention, diagnosis, and treatment of Alzheimer's Disease and related dementias, particularly focusing on underserved populations and health disparities.

The Rose Foundation for Communities and the Environment, in partnership with the Bay Foundation of Morro Bay, is offering a grant opportunity through the Central Coast Community-Based Water Quality Grants Program. This initiative focuses on supporting water quality-related projects within the Central Coast Regional Water Quality Control Board’s jurisdiction. The program's core mission aligns with the Rose Foundation's broader goals of fostering environmental health and community well-being, specifically by addressing critical water issues in California's Central Coast. The program primarily targets projects that advance environmental justice and provide water quality benefits to underrepresented communities. This focus aims to address historical inequities and ensure that all communities have access to clean and safe water. The expected outcomes include tangible improvements in water quality, enhanced environmental justice outcomes, and increased resiliency for communities facing water-related challenges. Measurable results will likely involve reductions in pollutant loading, progress toward water quality objectives, and the preservation and restoration of watershed functions. Key priorities and preferred topic areas for this grant include the human right to water, environmental justice capacity building, and understanding the water quality impacts of climate change. The program also emphasizes drought-related water supply resiliency, climate adaptation and mitigation, sustainable drinking water and wastewater treatment, and sustainable groundwater management strategies. Additionally, projects that benefit marine habitats in San Luis Obispo County, reduce pollutant loading to meet Central Coast Basin Plan objectives, restore impaired waterbodies, implement on-farm Best Management Practices to reduce salt and nitrate, and prevent or address Harmful Algal Blooms are highly encouraged. The grant offers two funding tracks: a Large Grant Track for requests up to $200,000 (with most awards between $100,000-$200,000) and a Small Grant Track for requests up to $50,000 (with most awards between $20,000-$50,000). Eligible applicants include 501(c)(3) nonprofit organizations, federally recognized and State Indian tribes, and public agencies with jurisdiction over water resources management. All projects must be conducted within the Central Coast Water Board's Region 3 jurisdiction, encompassing Southern Santa Clara, Santa Cruz, San Benito, Monterey, San Luis Obispo, Santa Barbara, and portions of Ventura, Kern, and San Mateo Counties. The foundation's strategic approach underscores a commitment to community-driven solutions and measurable environmental impact through collaborative partnerships.

This funding opportunity supports research partnerships between technology developers and academic researchers to optimize and evaluate digital mental health interventions, particularly for underserved populations.

This funding opportunity supports research projects aimed at developing safe and effective medications for treating substance use disorders, particularly for substances like cocaine, methamphetamine, and cannabis, and is open to a wide range of eligible institutions and organizations.