Grants for Nonprofits - Health

Notice of Funding Opportunity Description Background The accumulation of misprocessed and aberrant proteins is a defining characteristic of various neurodegenerative conditions, such as AD and frontotemporal lobar degeneration (FTLD). These atypical proteins may arise from various factors, such as somatic mutations, environmental changes, genomic instability, irregular RNA processing, and proteolytic cleavages, as well as incorrect folding and post-translational modifications. For instance, many recent proteome and transcriptome profiling of AD brains reveals RNA splicing dysfunction and abnormal accumulation of U1 small nuclear ribonucleoprotein (snRNP) and transactive response DNA-binding protein 43 (TDP-43). In AD, U1-70K and its N-terminal 40-KDa fragment (N40K) is one of the most abundant proteins in the insoluble fraction of cell lysates. TDP-43 is an RNA-binding protein. In AD, TDP-43 pathology is observed in approximately 25-50% of cases, particularly in cases with co-morbidities such as Lewy body dementia or hippocampal sclerosis. However, the relationship between U1snRNP/TDP-43 and AD pathology is complex and not fully understood. The disruption of RNA processing is thought to be one possible mechanism to cause the accumulation of misprocessed proteins, which can lead to altered expression of genes involved in AD pathology, including amyloid precursor protein (APP), tau, and synaptic proteins. Understanding the mechanisms underlying the dysregulation of misprocessed proteins in neurodegenerative diseases will be important for developing effective therapies. Approaches that target the production or aggregation of misprocessed proteins, or that promote their clearance or degradation, may be effective in preventing or slowing disease progression. Purpose This NOFO invites innovative research proposals to explore the accumulation of misprocessed proteins in Tauopathies within specific brain regions and cell types. This NOFO encourages collaborative efforts to create advanced single-cell or single-cell type proteogenomic platforms. These platforms aim to shed light on dynamic changes in protein-misfolding responses in neuronal proteomes and their potential biological consequences during aging and the development of AD/ADRD. Research Objectives This NOFO aims to provide a proof-of-principal for a novel strategy to identify misprocessed and aberrant proteins in Tau diseases using the proteogenomic approach. Proteogenomics is an integrated approach that combines proteomics and genomics data. In proteogenomics, genomic and transcriptomic experiments are more closely integrated to identify potential protein coding and non-coding regions in the genome. These regions are then validated using mass spectrometry-based proteomics. Proteogenomics has emerged as a powerful tool for investigating the role of protein homeostasis in AD pathogenesis, especially in the context of mis-translated and mis-repaired proteins. However, relying solely on misprocessed protein levels to draw conclusions about biological processes is unlikely to be reliable. Therefore, an intermediate layer of functional validation is essential to transform proteogeomic data into meaningful biological information. As a result, the objective of this NOFO is not only to confirm changes in protein abundance using other methods, but also to assess the biological effects of those changes in some model systems, especially in the area of tauopathies, to ensure high interlaboratory reproducibility. Using the proteogenomics approach, this NOFO aims to accomplish the following: Create a comprehensive database of misprocessed and aberrant proteins in selected mouse models of human Tau diseases. Cross-validate the presence of misprocessed and aberrant proteins in human AD/ADRD brains. Identify new molecular pathways and novel misprocessed protein-protein interaction networks that are not currently in most datasets. Define novel mechanisms through which misprocessed and aberrant proteins influence the onset and progression of neurodegeneration in tauopathies. Identify disease specific therapeutic targets in neurodegenerative diseases. It is expected that applications responding to this initiative will use the latest cell-type-specific labeling and proteogenomic techniques with suitable model systems to understand the etiology of tauopathies in aging and AD.

Through Illinois General Review Funds, funds will be appropriated for expenses related to Suicide Prevention, Education, and Treatment Program pursuant to Public Act 101-0331. The Illinois Department of Public Health (IDPH) will provide funding to expand the implementation of strategies in the Illinois Suicide Prevention Strategic Plan. At the recommendation of the Illinois Suicide Prevention Alliance (ISPA), the IDPH Violence and Injury Prevention Section will provide funding to one entity for the purpose to organize and implement workforce development opportunities through implementing the ECHO approach, a Community of Practice (CoP), and offering evidence-based trainings to build workforce development for professionals.

This funding opportunity provides financial support to community-based organizations in Minnesota to deliver job training, mentorship, and entrepreneurial skills development for individuals from communities of color and low-income backgrounds, focusing on high-growth industries.

The L&M Medical Needs Fund Grants, offered by the Community Foundation of Greene County, provide financial assistance for medical needs in Greene County, Pennsylvania. Funded by an endowed gift from an anonymous donor, these grants are available to nonprofit charitable organizations serving individuals in need of medical services, such as prescriptions, hospice care, and other medical services. Eligibility is limited to 501(c)(3) organizations in good standing with the IRS and registered with the Pennsylvania Bureau of Charitable Organizations. The grants focus on aiding individuals who struggle to afford medical services due to being uninsured or facing high costs not covered by insurance. While priority is given to lower-income families, other cases with well-documented need may also be considered. Grant amounts vary annually. Grant renewed every year. Grant Spring Annual deadline: June 1st

This funding opportunity supports researchers exploring the mechanisms of Treponema pallidum, the bacteria responsible for syphilis, to address the rising rates of sexually transmitted infections and improve understanding of its pathogenesis.

This grant provides funding for research projects that test strategies to reduce suicide risk by promoting safe storage of lethal means, such as firearms, in healthcare and community settings.

This funding opportunity supports innovative research projects that utilize genomic data from a specific cloud-based platform to answer important biological questions and improve data accessibility for the scientific community.

The San Francisco Bay Restoration Authority, a regional government agency, allocates funds for restoring and enhancing wetland and wildlife habitats along the San Francisco Bay shoreline. Grants exceeding $1 million are available for projects lasting up to five years, with a deadline of September 20, 2024. Eligible projects must be located within the nine Bay Area counties—Alameda, Contra Costa, Marin, Napa, San Francisco, San Mateo, Santa Clara, Solano, and Sonoma—and align with priorities outlined in Measure AA. These priorities include maximizing positive environmental impacts, ensuring geographic distribution, leveraging additional resources, and benefiting economically disadvantaged communities. The Authority funds various project phases, including planning, construction, and scientific studies, provided they support habitat restoration, flood management, or public access initiatives. Projects must meet specific criteria related to improving water quality, enhancing wildlife habitats, providing flood protection, and improving public access. Eligible applicants include federal, state, and local agencies, tribal governments, nonprofits, and shoreline parcel owners in the San Francisco Bay Area. For more information, visit the San Francisco Bay Restoration Authority website.

This grant provides funding to establish Trauma Recovery Centers in Arizona, aimed at supporting survivors of crime and underserved populations through holistic, trauma-informed services.

The City of Kettering Demolition Grant Program provides financial assistance to commercial and residential property owners for the demolition of structures and clearance of sites for redevelopment, economic development, and removal of blight. The program aims to eliminate existing or potential blighting influences, encourage property maintenance, promote sustainable reuse of properties, and ensure compliance with the city's zoning code. Grants cover up to 50% of demolition costs, not exceeding $25,000. Applications are accepted year-round, with funding contingent on the city's budget.

This grant provides funding to nonprofit organizations in Erie County to support projects that improve the lives of women and children by addressing critical issues such as transportation, healthcare, education, housing, childcare, and food insecurity.

This funding opportunity provides up to $2 million to a single organization to enhance statewide tobacco prevention efforts in California through communication, technical assistance, and support for local initiatives targeting high-risk populations.

The City of Newark's Love Your Block (LYB) Mini-Grants Program is a community-driven initiative aimed at fostering neighborhood beautification and community building through collaborative projects between residents, city departments, and local organizations. This program aligns with a broader mission of empowering residents to actively shape their communities, promoting a sense of ownership and pride, and ultimately creating cleaner, greener, and healthier neighborhoods. The underlying theory of change suggests that by providing accessible funding and technical support, resident-led initiatives will lead to tangible improvements and stronger community ties. The primary beneficiaries of this program are individuals, resident groups, and community organizations within the City of Newark who are passionate about enhancing their local environments. The program's impact goals are centered on reducing litter, improving waste management, revitalizing underutilized properties, and enhancing green spaces. By engaging residents directly in these efforts, the program aims to cultivate a more vibrant and engaged citizenry, leading to sustainable community improvements and a better quality of life for all residents. The program's priorities and focuses are clearly delineated into three grant categories: Community clean-ups, Minor exterior home repairs & curb appeal, and Enhancing Green Spaces and Activating Vacant Lots. These categories reflect the city's strategic priorities in addressing key challenges such as litter, property blight, and underutilized public spaces. The emphasis on these areas is designed to produce visible and impactful results that resonate with residents' everyday experiences and contribute to the overall aesthetic and environmental health of the city. Expected outcomes include a noticeable reduction in litter and an improvement in recycling efforts, the repurposing of dormant or underutilized properties, and the enhancement of community advantages around parks and open areas. Measurable results will likely be observed through the number of successful clean-up events, the completion of home repair and curb appeal projects, and the transformation of vacant lots into valuable community assets. The program's reimbursement-based funding of up to $5,000 per project, coupled with targeted technical assistance, is designed to ensure that these initiatives are achievable and produce meaningful, lasting change within the designated project period of September 2024 to November 15, 2024.

The "Innovation Grants to Nurture Initial Translational Efforts (IGNITE)" program supports the development of in vitro and ex vivo assays to identify and characterize new therapeutic agents for neurological and neuromuscular disorders, with a focus on creating robust screening methods for promising neurotherapeutics.

The Denver Foundation's Care Fund invites qualified Colorado nonprofits to apply for funding to support the well-being of people with low incomes who also live with developmental, intellectual, or physical disabilities, or who are visually impaired or blind. This grant program directly aligns with the Foundation's mission to address critical community needs and improve the quality of life for vulnerable populations within the state. The primary beneficiaries of the Care Fund are individuals with low incomes who face the dual challenges of disability or visual impairment. The program's impact goals are centered on enhancing the well-being and support systems for these specific groups. The Foundation prioritizes organizations whose work directly connects with the purpose of the Care Fund, ensuring that grants are awarded to initiatives that can effectively serve these target populations. Grants from the Care Fund will range between $10,000 and $20,000. While the grant duration is not explicitly mentioned, the focus is on supporting programs that offer tangible benefits and positive outcomes for the beneficiaries. Expected outcomes include improved access to services, enhanced quality of life, and greater support for individuals with disabilities and visual impairments. The eligibility criteria emphasize that applicant organizations must be 501(c)(3) nonprofits or have a 501(c)(3) fiscal sponsor, and must be located in and conduct work within Colorado. This ensures that the Foundation's strategic priorities are met by investing in local organizations that have a direct impact on Colorado communities. While a formal "theory of change" is not detailed, the program's structure indicates a belief that targeted funding to qualified nonprofits serving specific vulnerable populations will lead to improved well-being and support for those individuals.

This funding opportunity supports exploratory preclinical studies to evaluate the effectiveness of therapeutic agents for rare diseases affecting fewer than 200,000 people in the U.S., aiming to advance these treatments toward clinical trials.

The "NIDCD's Mentoring Networks to Enhance Clinician-Scientists' Participation in Research" grant aims to support educational and mentoring activities that encourage individuals, especially those from diverse backgrounds, to pursue research careers in biomedical, behavioral, and clinical sciences, with a particular focus on improving the recruitment, preparation, and retention of clinician investigators.

This grant provides funding to early-career researchers in mental health to support innovative projects that advance the understanding and treatment of mental illnesses.

This program will constitute a national CBA Provider Network (CPN) to deliver CBA services to an interdisciplinary HIV prevention workforce (e.g., professional, technical, clinical, and managerial staff) within CDC-funded state and local health departments and CBOs. In the United States, an estimated 1.2 million people are living with HIV. In recent years, the number of people with HIV (PWH) has increased while deaths have declined. Of PWH, about 87% were aware of their HIV status. In 2021, among people with diagnosed HIV, an estimated 75% received HIV medical care and 66% were virally suppressed. Promising progress has been made in HIV prevention as the estimated annual new HIV infections were 12% lower in 2021 (32,100 infections) compared to 2017 (36,500 infections). This decline was largely driven by a substantial decrease (34%) in new infections among 13- to 24-year-olds, mostly among gay and bisexual males. However, HIV prevention efforts must go further, and progress must be faster, for gains to equitably reach all populations and end the HIV epidemic. The National HIV/AIDS Strategy (NHAS) for the United States focuses on four goals: preventing new HIV infections, improving HIV-related health outcomes of people with HIV, reducing HIV-related disparities and health inequities, and achieving integrated, coordinated efforts that address the HIV epidemic among all partners. Successful HIV programs must recognize the syndemics that affect the people and places disproportionately affected by HIV. A syndemic is population-level clustering of social and health problems. In the context of HIV, a syndemic is when HIV clusters with one or more other diseases or health conditions within a specific population, driven by the contextual, structural and social factors that increase the adverse effects on the health of people and communities. Syndemics may include HIV, STIs, TB, viral hepatitis, overdose, and substance use, and other existing and emerging conditions or factors that may be related to or impact HIV. The Ending the HIV Epidemic in the US (EHE) initiative focuses on scaling up four sciencebased strategies in communities most affected by HIV across the country. The strategies are to diagnose all people with HIV as early as possible; treat people with HIV rapidly and effectively to result in sustained viral suppression; prevent new HIV transmissions by using proven interventions, including condom distribution, pre-exposure prophylaxis (PrEP), postexposure prophylaxis (PEP), and syringe services programs (SSP); and respond quickly to potential HIV outbreaks to get vital prevention and treatment services to people who need them. Toward achieving national HIV prevention goals, the Centers for Disease Control and Prevention (CDC) funds state and local health departments and community-based organizations (CBOs) to plan, integrate, implement, evaluate, and sustain HIV prevention and surveillance programs, prioritizing people disproportionately affected by HIV including gay, bisexual, and other men who have sex with men, in particular Black, Latino, and American Indian/Alaska Native men, Black women, transgender women, youth aged 13-24, and people who inject drugs. Racism, HIV stigma, discrimination, homophobia, poverty, and barriers to health care continue to drive disparities in HIV prevention. Building individual competencies and technical expertise among staff, strengthening organizational capacities, and enabling supportive structural environments are critical strategies Page 5 of 81 in addressing operational challenges for more effective HIV prevention and surveillance programs. Reflecting CDC’s continued investment in improving the performance of the nation’s HIV workforce, this NOFO will support the provision of capacity building assistance (CBA) services, including training and technical assistance (TA).

This grant from Sanofi's Rare Blood Disorders Medical Affairs department focuses on medical education programs addressing Immune Thrombocytopenia (ITP). The grant aims to support independent medical education (IME) activities that recap highlights from EHA 2024 and ISTH 2024 conferences on ITP, emphasizing enduring programs, accredited or non-accredited IME activities, and digital or omnichannel formats. Proposals should address existing healthcare gaps in the treatment and management of ITP, improving clinician knowledge and patient outcomes. The maximum grant request is $150,000, with a focus on comprehensive interventions that address knowledge and performance gaps in ITP treatment. Proposals should cover target audience generation, learning objectives, educational methods, faculty recruitment, program evaluation, and budget planning.