Grants for Small businesses - Health

This funding opportunity is designed for U.S.-based small businesses to develop innovative, cost-effective drug detection devices that can quickly identify both known and new drugs without relying on traditional antibody-based methods.

This funding opportunity is designed to establish a center that will coordinate and manage data for collaborative research on rare diseases, supporting various research consortia and engaging stakeholders to improve diagnosis and treatment.

This ISO seeks solution summaries and proposals for projects that fall within the general scope of the ARPA-H Scalable Solutions mission office. SSO expands what is technically possible by developing approaches that will leverage an interdisciplinary approach and collaborative networks to address challenges of geography, distribution, manufacturing, data and information, thereby improving health care access and affordability. In the United States, many communities and remote areas lack access to timely and quality health care, which leads to disparities in health outcomes for those populations. Bottlenecks during the manufacturing processes of products and health technologies also lead to delays and limited availability, preventing effective distribution of health care solutions to areas of need, especially in emergencies.ARPA-H SSO seeks solutions to improve the scalability and affordability of health care solutions, bridge gaps in underserved areas, and extend remote access to expertise by developing location-specific interventions, telemedicine solutions, and mobile health clinics. Solutions should focus on rapid innovation and the use of partnerships, as well as flexible distribution networks and streamlined manufacturing processes. The following SSO interest areas categorize the ground-breaking solutions we seek to support:Scalable Technologies and Interventions: Approaches to improve affordability and equitable access to health care that are adaptable to various geographic, demographic, economic contexts and can be rapidly deployed at scale (e.g., drug-repurposing*, telemedicine, point-of-care diagnostics, and modular health care infrastructure). Tailored solutions for the pediatric population that provide parity in access to treatments and other health care interventions with the adult population and adapt to the pediatric patients changing physiology and developmental status over the course of years. Transformational approaches to reduce or eliminate health disparities, including tools and models for product design and care delivery that scale novel approaches in human factors and human-centered design to respond to full diversity of patients. Tools to enable the scaling of provider and institutional capabilities (e.g., school nurses and schools, walk-in clinics, homesteading care) to address unmet health care access needs and expand availability of critical services. Foundational capabilities to accelerate diagnoses and reduce the cost of treatments for rare diseases wherever patients are, without the need for specialized facilities or healthcare expertise.* Solution summaries and proposals that focus on testing drugs for effectiveness for other disease states or use cases, are unlikely to be funded unless including additional R, or providing gains in cost reduction, accessibility, and/or equity.Collaborative Distribution Networks: Methods for standardization, automation, and democratization of complex procedures 5 including, but not limited to, histopathology, rare disease diagnosis and treatment, and surgical interventions to ensure access and delivery to populations diverse in demographics, geographies, and resources at scale. Approaches to enhance delivery of effective healthcare solutions in rural or low resource settings, including but not limited to "last mile delivery, at-home monitoring, imaging, drug delivery, telehealth augmentation, and support for remote medical procedures with limited need for specialized training. Technologies to enable the deployment of critical healthcare resources rapidly, equitably, and securely at scale to the point of need in permissive and non-permissive (i.e., damaged infrastructure, cyber-denied) environments during a public health crisis or natural disaster. Solutions to scale education and training of critical healthcare resources for health care providers and patients to ensure information integrity to prevent negative impacts to resource use/uptake. Innovative information technology, data and analytic products and technologies to enable ordering, inventory management, situational awareness, allocation planning and demand forecasting of critical healthcare resources during a public health crisis or natural disaster.Biomanufacturing Innovations*: Innovative manufacturing technologies and approaches that reduce cost, shorten the timeline for production, advance domestic competitiveness and reduce supply chain risk of biologics, cellular and gene therapies, pharmaceuticals, medical devices and personal protective equipment. New approaches to support predictable, programable biological production of conventional and novel materials reliability at scale in a cost-effective sustainable manner. Novel solutions to reduce the reliance on specialized handling and cold chain management of pharmaceuticals and biologics. Scalable innovations to advance and strengthen biomanufacturing supply chain and resolve bottlenecks including:o Advances in production of active pharmaceutical ingredients, process consumables, and other critical materials (i.e., enzymes, cell lines, etc);o Novel biomanufacturing-related data products, technologies or models to integrate into supply chain situational awareness systems;o Alternative materials and new manufacturing capabilities for personal protective equipment; ando Improvement of capabilities sustainably re-shore manufacturing and utilize a broad array of readily accessible and cost-efficient feedstocks as part of strengthening the local and national industry base. Analytics and novel sensor systems to precisely manage bioproduction, real-time release assays, and predictive capabilities to inform tuning of biological chassis for efficient and effective scale-up of manufacturing to industrial scale.*ARPA-H is not interested in approaches that merely increase capacity reservation.Other high-quality submissions that propose revolutionary technologies that meet the goals of SSO will be considered even if they do not address the topics listed above.Proposals are expected to use innovative approaches to enable revolutionary advances in medicine and healthcare, and the science and technology underlying these areas. While approaches that are disease agnostic are encouraged, ARPA-H welcomes proposals that bring radically new insights to address specific diseases including, but not limited to, cancer, diabetes, neurological diseases, pediatric and maternal/fetal health, infectious diseases, and cardiovascular disease.Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art or technology that has reached the clinical trial stage. An example of this type of proposal might include the request to fund clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

The "Single Source for the Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D)" grant is intended to fund the University of Pennsylvania's ongoing research into understanding and combating Type 1 Diabetes, by studying human pancreatic tissues and immune cells, and sharing their findings through an open-access database.

The OneOhio Recovery Foundation’s first round of grants will be awarded to eligible organizations that apply and are selected for funding by one of the 19 OneOhio Regions. To be considered for funding, applicants must demonstrate the program or services intended for funding align with the Approved Purposes and the Ohio Abatement Strategies detailed in the OneOhio Memorandum of Understanding (MOU).

This grant provides funding to a wide range of organizations, including NGOs and private sector entities, to strengthen local health systems in Guinea, focusing on improving healthcare quality and accessibility in targeted regions.

This funding opportunity supports innovative research projects that aim to improve HIV prevention and care strategies, targeting a wide range of organizations and individuals involved in health and social sciences.

All work supported under this Grant will focus on reducing health disparities for the populations across the state impacted by the high prevalence of cardiovascular (CVD), exacerbated by health inequities and disparities, social determinants, such as low incomes, poor health care, and unfair opportunity structures.  Financial Notes: Funds for the Umbrella Hub Arrangement come from the Centers for Disease Control and Prevention (CDC), A Strategic Approach to Advancing Health Equity for Priority Populations with or at Risk for Diabetes CDC-RFA-DP-23-0020 grant (230020).

This grant provides funding to organizations in India to improve the quality and accessibility of HIV and STI testing services through enhanced laboratory networks and continuous quality improvement initiatives.

This funding opportunity supports a variety of organizations in developing technology-based training programs for healthcare providers to improve patient care and workforce capacity in underserved communities.

This funding opportunity provides financial support to organizations working to improve HIV prevention, care, and treatment services for key populations in Central America, aiming to achieve significant health outcomes by 2030.

This funding opportunity supports innovative research projects that address social factors affecting health to reduce disparities and promote health equity among underserved populations in the U.S.

This initiative provides financial incentives to nonprofit nursing organizations and educational institutions to recruit and retain registered nurses in nursing homes across the U.S. to improve care quality and compliance.

This funding opportunity supports innovative cancer research projects that explore new treatments, diagnostics, and strategies to reduce disparities in cancer care, targeting a wide range of researchers and institutions.

This funding opportunity provides $6 million to the University of South Florida to continue managing the TEDDY study's Data Coordinating Center, which investigates the environmental causes of type 1 diabetes in children.

This funding opportunity provides financial support for small businesses to develop innovative e-learning training products that enhance the safety and health training of workers dealing with hazardous materials and emergency response situations.

This funding opportunity supports research projects aimed at improving the management of multiple chronic diseases in low- and middle-income countries and American Indian/Alaska Native populations in the U.S. through innovative, community-centered healthcare strategies.

This funding opportunity supports the establishment of a Data Coordinating Center to manage and analyze data for multi-site clinical trials focused on heart, lung, and blood health research, aimed at a wide range of eligible organizations including universities and nonprofits.

This funding opportunity supports research to implement and evaluate a fall prevention program for older adults in assisted living facilities, particularly targeting vulnerable populations at higher risk of falls.

This funding opportunity supports diverse institutions and researchers in conducting innovative research to promote health equity and improve health outcomes for all individuals, particularly by addressing social determinants of health and eliminating health disparities.