Grants for State governments - Health

This Funding Opportunity Announcement (FOA) supports applications to develop and implement investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or implementation research clinical trials. These trials may include ones that test different therapeutic, behavioral, and/or prevention strategies. Trials for which this FOA applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This FOA will utilize a bi-phasic, milestone-driven mechanism of award. The objective of the application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The multiple PD/PI model is strongly encouraged but not required. Applicants are encouraged to include a PD/PI with expertise in biostatistics, clinical trial design, and coordination.

This funding opportunity provides financial support to a variety of organizations, including nonprofits and educational institutions, to strengthen public health systems and workforce capabilities in Nigeria, focusing on local implementation of health regulations and emergency preparedness.

This FOA solicits applications for new Behavioral and Social Sciences Research (BSSR) predoctoral training programs that focus on innovative computational and/or data science analytic approaches and their incorporation into training for the future BSSR health research workforce. The vision of the Advanced Data Analytics for BSSR training program is to support the development of a cohort of specialized predoctoral candidates who will possess advanced competencies in data science analytics to apply to an increasingly complex landscape of behavioral and social health-related big data. This Notice of Funding Opportunity (NOFO) does not allow appointed Trainees to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

The purpose of the Black Lung Data and Resource Center (BLDRC) program is to improve health care in rural areas by supporting patient-level data collection and analysis, clinic operations, and the quality and breadth of services provided by recipients of Black Lung Clinics Program (BLCP) funding. For the purposes of this Notice of Funding Opportunity, BLCP award recipients are referred to as BLCP recipients. Additional details about the program requirements and expectations for BLCP recipients can be found in HRSA-25-040. Our goal is to strengthen BLCP recipients ability to examine and treat respiratory diseases and pulmonary impairments in active and inactive U.S. coal miners. To that end, the BLDRC provides programmatic assistance and resources to help BLCP recipients use data analysis to better understand the health status and needs of U.S. coal miners. BLDRC support and data analysis contributes to advancing evidence-based models of health care for rural health care providers, including BLCP recipients and other health care providers serving rural populations. The BLDRC will work with BLCP recipients and stakeholders to address long-standing challenges and barriers to medical, outreach, educational, and benefits counseling services for U.S. coal miners. The BLDRC will also help collect and analyze information on the demographics and clinical status of coal miners with Coal Mine Dust Lung Diseases (CMDLD), or black lung diseases, especially Coal Workers Pneumoconiosis (CWP) and its most severe form, Progressive Massive Fibrosis (PMF). The BLDRC supports BLCP recipients, including rural health providers, in discerning effective methods to address challenges, analyzing best practices, and informing lessons learned that translate across rural and non-rural health care settings. These methods also expand and further enhance support for health care delivery in rural areas.

This funding opportunity provides financial support to organizations that help young adults aged 16-25 with serious emotional or mental health challenges access culturally and developmentally appropriate services as they transition into adulthood.

This grant provides financial support and mentorship for early-career clinician-scientists to develop their research skills in pain management, focusing on innovative approaches to understanding and treating pain without leading clinical trials.

This funding opportunity supports early-stage researchers and those new to Alzheimer's Disease and related dementias research, providing resources to develop innovative pilot projects aimed at improving prevention, diagnosis, treatment, and care strategies.

This funding opportunity supports diverse institutions and researchers in conducting innovative research to promote health equity and improve health outcomes for all individuals, particularly by addressing social determinants of health and eliminating health disparities.

This program provides funding to local organizations in EPA Region 3 for projects that address environmental and health challenges in historically underserved communities.

Reissue of RFA-MH-22-115 to comply with DMSP policy. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits and provide insights into cellular interactions that underlie brain function. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways. Clinical intervention with novel cell and circuit specific tools will require extensive focused research designed to remove barriers to delivery of gene therapies. In addition to identification and removal of barriers, the need to specifically target dysfunctional circuitry poses additional challenges. Neuroscience has experienced an impressive influx of exciting new research tools in the past decade, especially since the launch of the BRAIN Initiative. However, the majority of these cutting edge tools have been developed for use in model organisms, primarily rodents, fish and flies. These cutting edge tools, such as viral delivery of genetic constructs, are increasingly adaptable to large brains and more importantly are emerging as potential human therapeutic strategies for brain disorders. A pressing need to develop tools for use in large brains, more directly relevant to the human brain is the focus of this initiative. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application.

This funding opportunity supports researchers in planning high-risk, multi-center clinical studies focused on kidney, digestive, diabetes, and metabolic disorders, helping them develop essential protocols and administrative frameworks before conducting the actual trials.

This funding opportunity supports research to improve cancer care and outcomes for sexual and gender minority survivors by addressing their unique challenges and engaging community partners in the process.

This grant provides funding for researchers to evaluate community and societal programs aimed at preventing adverse childhood experiences and addressing social and health inequities.

This funding opportunity provides financial support to community organizations and health facilities to deliver hepatitis C treatment in accessible, non-traditional settings for people who inject drugs, aiming to eliminate health disparities and improve health equity.

This grant provides funding to support postdoctoral researchers from underrepresented backgrounds in transitioning to independent cancer research roles, with a focus on clinical trials and addressing cancer health disparities.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage pilot and/or feasibility research in the following areas: 1) the development and pilot testing of new or adapted interventions to prevent or delay the initiation of substance use and/or the progression from use to misuse or disorder and 2) pre-trial feasibility and acceptability testing of services and service system research relevant to the prevention of substance use. In addition to the prevention of substance use, misuse and disorder, other outcomes of interest for the research supported through FOA include a reduction in negative sequalae such as deaths related to impaired driving, suicidal behavior (e.g., nonfatal and fatal attempts), and drug- or alcohol-related acquisition or transmission of HIV infection and viral hepatitis among diverse populations and settings.

This grant provides funding to institutions and organizations for establishing a centralized data coordination center that will manage and share research data on how socioenvironmental factors influence neurocognitive development and addiction risk.

This funding opportunity supports multi-site clinical trials for innovative treatments and interventions aimed at preventing or alleviating symptoms of Alzheimer's disease and related dementias, inviting applications from a diverse range of organizations and institutions.

This funding opportunity supports innovative research projects aimed at developing tools and treatments for diagnosing and mitigating injuries from radiation exposure during public health emergencies.

The ODAC Grant Program, part of the SFY 2025 initiative by the Governor's Office of Crime Prevention and Policy, is designed to decrease the number of fatal and non-fatal overdoses stemming from substance use. The program emphasizes the coordination of law enforcement and public health efforts to combat the substance abuse epidemic through enhanced investigative strategies, data sharing, and community outreach. The ODAC initiative aligns with the state's goals to improve public health and safety by addressing the root causes of drug abuse and facilitating access to treatment and support services.