Grants for For profit organizations other than small businesses - Science and Technology

The FY24 DMDRP CTRA mechanism supports advanced translational research that will accelerate the movement of promising ideas in DMD research into clinical applications. Translational research may be defined as an integration of basic science and clinical observations. However, applicants should not view translational research as a one-way continuum from bench to bedside. The research plan must involve a reciprocal flow of ideas and information between applied and clinical research. As such, applications must include preliminary and/or published data relevant to DMD to support the proposed research project.This mechanism is intended to support established projects that have moved beyond the realm of basic research and proof of concept studies and have the potential to result in a near-term impact in clinical research or the clinic. Research projects investigating therapies that will be efficacious across the life span, including infants, toddlers, and non-ambulatory individuals, are strongly encouraged. Pilot, proof-of-principle clinical trials, and correlative studies to better inform development of drugs, devices, and other interventions are allowed.Early-Career Partnering PI Option: The FY24 DMDRP encourages applications that include meaningful and productive collaborations between investigators. In an effort to promote enhanced research capacity within the DMD field, the FY24 CTRA includes an option for an Early-Career Partnering Principal Investigator (PI). The Partnering PI Option is structured to accommodate two PIs. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The Early-Career PI will be identified as the Partnering PI. Both PIs should contribute significantly to the development and execution of the proposed research project. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PI, refer to Section II.D.2, Content and Form of the Application Submission.The FY24 DMDRP CTRA offers two funding levels (refer to Section II.D.5 Funding Restrictions). Only one funding level category may be chosen per application, and the choice of application category is at the discretion of the applicant. The following are generalized descriptions of the scope of the research appropriate for each funding level:Funding Level 1: Funding Level 1 is intended to support smaller, less complex preclinical and/or clinical research. Pilot clinical trials are allowed. The proposal/applications direct costs budgeted for the entire period of performance should not exceed $650,000.Funding Level 2: Funding Level 2 is intended to support larger, more complex preclinical and/or clinical research. Pilot clinical trials are allowed. The proposal/applications direct costs budgeted for the entire period of performance should not exceed $1.35M.Additionally, both funding levels will support an Early-Career Partnering PI Option at the same maximum direct costs and periods of performance, respectively.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Both pilot clinical trials and clinical research are permitted under this mechanism.A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.All investigators applying to FY24 DMDRP funding opportunities and conducting clinical research are encouraged to consult the Strategies to Promote Diversity in Muscular Dystrophy Research Participation developed by the MDCC.

This funding opportunity provides financial support for the design and operation of a facility that extracts and refines rare earth elements from unconventional sources, aimed at strengthening domestic supply chains and reducing reliance on foreign materials.

This funding opportunity provides $100,000 to established for-profit businesses in Cook County, Illinois, to support their growth through capital investments in workforce expansion, equipment, and facility upgrades.

Project is to increase the capacity of partner countries to develop, adopt, and implement legal frameworks that protect individual data privacy while educating key stakeholders and enabling trusted cross-border data flows and digital trade.

This funding opportunity supports Arizona-based institutions conducting clinical research on ibogaine's potential therapeutic uses for neurological diseases, encouraging collaboration among academic, nonprofit, and private sectors.

This funding supports Southern nonprofit organizations and government entities in enhancing their artistic programming and professional development through travel and training opportunities.

The Alaska Community Foundation (ACF) is seeking applications for its Kodiak Community Foundation Grants program, targeting charitable organizations and programs within the Kodiak Archipelago Area. This grant opportunity aligns with the ACF's broader mission to support diverse community needs, with a focus on local impact in the Kodiak region. The program aims to address a wide range of needs, ensuring that funding contributes to the well-being and development of the community. The target beneficiaries of these grants are charitable organizations and programs operating in the Kodiak Archipelago. The impact goals are broad, encompassing health and wellness, education, outdoor activities, arts and culture, and community development. The foundation's strategic priority is to empower local initiatives that directly benefit the residents of the Kodiak area, reflecting a theory of change that grassroots efforts are crucial for sustainable community growth. The program prioritizes projects that address a broad spectrum of community needs. While specific outcomes are not rigidly defined beyond these categories, the expectation is that funded projects will contribute to an improved quality of life, enhanced community resources, and increased opportunities for residents in the aforementioned areas. Measurable results would likely be defined by individual grant recipients based on their specific project goals, within the broader framework of the foundation's focus areas. Funding information indicates average awards range from $1,000 to $3,000, with a potential for higher or lower amounts, and grant projects must be completed within one year of the award. The eligibility criteria emphasize support for 501(c)(3) public charitable organizations, faith-based organizations providing social services, federally recognized Tribes or Tribal non-profit organizations, and city or borough governments. This structured approach ensures that resources are directed towards credible and impactful entities capable of delivering on the grant's objectives.

This program provides financial assistance to small, independently owned businesses in Wakefield, Massachusetts, to help them enhance their digital marketing efforts and expand their online presence.

This grant provides funding for research and development projects aimed at improving the equipment and support systems for U.S. Army soldiers, focusing on enhancing their survivability, mobility, and overall effectiveness in the field.

This funding opportunity supports collaborative research projects that aim to develop clinical applications addressing health issues related to military toxic exposures, targeting independent researchers and their partners.

This funding opportunity supports clinical research aimed at improving burn care for military personnel, focusing on practical applications that enhance treatment in challenging environments.

This grant provides financial assistance to municipalities, non-profit land conservation organizations, and water companies in Connecticut for acquiring land to preserve open spaces and protect water supplies.

The "DoD Bone Marrow Failure, Investigator-Initiated Research Award" is a grant that provides two levels of funding: one for expanding mature research ideas and key discoveries in bone marrow failure, and another for supporting the development of new drugs for bone marrow failure treatment, with the ultimate goal of improving patient care and finding effective treatments and cures.

The DoD Peer Reviewed Cancer, Impact Award is a grant aimed at funding advanced research projects that can quickly translate promising findings into clinical applications, with the goal of making a significant, near-term impact on critical cancer issues and improving patient outcomes.

The National Bycatch Reduction Engineering Program (BREP) - FY2025 aims to fund innovative research and development projects that reduce bycatch of non-target species in fisheries, promoting sustainable practices and protecting marine ecosystems.

The DoD Kidney Cancer, Academy of Kidney Cancer Investigators - Early-Career Scholar Award is a grant aimed at supporting early-career scholars in conducting kidney cancer research, providing them with funding, networking, and collaborative opportunities, and mentorship for a period of four years, with the ultimate goal of advancing kidney cancer research and developing highly productive kidney cancer researchers.

This funding opportunity supports innovative research and development in biological technologies that enhance national security, targeting universities, nonprofits, small businesses, and industry participants, particularly those with commercial potential.

This funding opportunity provides financial support to organizations working to prevent the misuse of biological weapons and enhance global biosecurity standards, targeting both state and non-state threats.

This program provides essential financial support to small businesses in Pennsylvania that have been negatively affected by the COVID-19 pandemic, helping them access working capital to sustain their operations.

This funding program provides financial support to community-based organizations in the Pacific Northwest working to address environmental justice and public health challenges in historically underinvested communities.