Grants for For profit organizations other than small businesses - Science and Technology

The intent of the Breakthrough Award is to support promising research that has high potential to lead to or make breakthroughs in breast cancer. The critical components of this award mechanism are:Impact: Research supported by the Breakthrough Award will have the potential for a major impact and accelerate progress toward ending breast cancer. The impact may be near-term or long-term but must move beyond a minor advancement and have the potential to lead to a fundamentally new approach that is significantly more effective than interventions already approved or in clinical development. Applications are expected to identify the breast cancer patients or at-risk individuals who would ultimately benefit from the proposed research.Research Scope: The Breakthrough Award is structured with four different funding levels. The levels are designed to support major (but not all) stages of research that will lead to clinical application. Each level has a defined research scope. It is the responsibility of the Principal Investigator (PI) to select the level that aligns with the scope of the proposed research. The funding level should be selected based on the research scope defined in the program announcement, and not on the amount of the budget.The current program announcement discusses the Breakthrough Award Levels 1 and 2. Funding Levels 3 and 4 are available under other program announcements (HT942524BCRPBTA3 and HT942524BCRPBTA4, respectively). The PI is strongly encouraged to review the research scope defined under each funding level as described in the corresponding Breakthrough Award program announcement before submitting the pre-application. An application that does not meet the intent of the funding level selected will not be recommended for funding, even if it might meet the intent of a different funding level.The following are general descriptions, although not all-inclusive, of the scope of research projects that would be appropriate to propose under the current program announcement: Funding Level 1: Innovative, high-risk/high-reward research that is in the earliest stages of idea development or is an untested theory that addresses an important problem. To foster research that yields new avenues of investigation, preliminary data are not required. Proof of concept is the anticipated outcome. Funding Level 2: Research that is already supported by substantial preliminary or published data and strongly validates clinical translation in a well-defined context within thebreast cancer landscape. Funding Level 2: Population Science and Prevention Studies: Population Science and Prevention Studies should involve investigations into why certain human patient populations differ in cancer risk or clinical prognosis. The studies should focus on the analysis of human data and biospecimens. Research should be already supported by substantial preliminary or published data and strongly validate clinical translation in a well-defined context within the breast cancer landscape. With compelling justification, population science and prevention studies may request higher levels of funding and an additional year in the period of performance.Partnering PI Option: The Breakthrough Award encourages applications that include meaningful and productive partnerships between investigators. The Partnering PI Option is structured to accommodate two PIs. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other PI will be identified as a Partnering PI. Both PIs should contribute significantly to the development of the proposed research project, including the Project Narrative, Statement of Work (SOW), and other required components. The PIs may have expertise in similar or disparate scientific disciplines, but each PI is expected to bring distinct contributions to the application. The application should clearly demonstrate that both PIs have equal intellectual input into the design of the project and will devote similar and appropriate levels of effort to the conduct of the project. It is expected that funding will be balanced between both PIs unless appropriately justified. New partnerships are encouraged, but not required. The application is expected to describe how the PIs unique expertise combined as a partnership will better address the research question, how the unique expertise that each individual brings to the application is critical for the research strategy and completion of the SOW, and why the work should be done together rather than through separate efforts. To meet the intent of the Partnering PI Option, applicants are discouraged from being named as a Partnering PI on multiple Breakthrough Award Levels 1 and 2 applications unless they are clearly unique, meaningful partnerships addressing distinct research questions. Applications in which a mentor and their current postdoctoral fellow or junior investigator are named as Initiating and Partnering PIs do not meet the intent of the Partnering PI Option. Applications where one PI is providing samples, animal models, or investigational agents while the other PI is conducting most, or all of the experiments and analyses, do not meet the intent of the Partnering PI Option. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PIs, refer to Section II.D.2, Content and Form of the Application Submission.Personnel: Applications are expected to include an appropriate and robust research team with the combined backgrounds and breast cancer-related expertise to enable successful conduct of the project.Research involving human subjects and research involving human anatomical substances and data is permitted; however, clinical trials are not allowed under this funding opportunity.Applications seeking support for a clinical trial may be submitted to the FY24 BCRP Breakthrough Award Level 3 and Level 4 program announcements (HT942524BCRPBTA3 and HT942524BCRPBTA4, respectively).A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 BCRP priorities.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.The proposed research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public. Collaborations between researchers at military or Veteran institutions and non-military institutions are strongly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the partners bring to the research effort, ultimately advancing cancer research that is of significance to the Warfighter, military Families, and the American public.Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated direct costs budgeted for the entire period of performance for an FY24 BCRP Breakthrough Award Funding Level 1 should not exceed $450,000 for applications with a single PI or $750,000 if applying under the Partnering PI Option.The anticipated direct costs budgeted for the entire period of performance for an FY24 BCRP Breakthrough Award Level 2 should not exceed $1.0M for applications with a single PI or $1.5M if applying under the Partnering PI Option.The anticipated direct costs budgeted for the entire period of performance for an FY24 BCRP Breakthrough Award Funding Level 2, Population Science and Prevention Studies, should not exceed $1.5M for applications with a single PI or $2.0M if applying under the Partnering PI Option. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $20.9M to fund approximately 14 Breakthrough Award Levels 1 and 2 applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

This funding opportunity provides additional financial support to active health services research projects facing unforeseen costs, helping researchers continue their work effectively.

This funding opportunity is designed to support researchers and organizations developing advanced communication and networking technologies to enhance the operational capabilities of the Navy and Marine Corps.

The OCRP Investigator-Initiated Research Award is intended to support high-impact research that addresses a critical need and has the potential to make an important contribution to ovarian cancer or patient/survivor care. Research projects may focus on any phase of research, from basic laboratory research through translational research, excluding clinical trials. The application must demonstrate logical reasoning and a sound scientific rationale established through a critical review and analysis of the literature for the application to be competitive. Applications must include preliminary data that are relevant to ovarian cancer and support the proposed research project. These data may be unpublished or from the published literature.

This funding opportunity provides financial support to organizations working to combat forced labor and illegal fishing in seafood supply chains, particularly in East Asia and the Pacific and the Western Hemisphere, excluding Indonesia and the Philippines.

This funding opportunity provides financial support for researchers at domestic institutions to study atmospheric processes using data from the Department of Energy's ARM facility, with a focus on improving climate models and understanding critical environmental factors.

Through the support of the Centers for Disease Control and Prevention (CDC), the Urban Indian Health Institute (UIHI) launched a nationwide initiative to not only enhance evidence-based culturally rigorous chronic disease prevention programs but also to enhance public health infrastructure among urban Indian organizations. This initiative aligns with UIHI's mission to serve urban Indian communities by promoting health and preventing chronic diseases through culturally appropriate approaches. The grant program, called Sweetgrass funds, focuses on Indigenous approaches to preventing chronic diseases. The target beneficiaries of this grant are Urban Indian Organizations (UIOs) as defined by the Indian Health Service (Title V programs), members of the National Urban Indian Family Coalition (NUIFC), and not-for-profit urban Indian organizations whose leadership and board are majority urban Indian, and whose mission is to provide public health services to urban Indians. The impact goals are to address and prevent chronic diseases such as obesity, commercial tobacco use, Type 2 Diabetes, and heart disease and stroke within these communities. The program encourages the use of AI/AN traditional, cultural, and regional knowledge in developing and implementing chronic disease education, prevention, and management initiatives. The program prioritizes expanding previous projects related to obesity prevention, commercial tobacco use prevention and cessation promotion, Type 2 Diabetes prevention, and heart disease and stroke prevention. Specific approaches include using cultural or regional adaptations of chronic disease prevention education program components, reclaiming traditional knowledge of nutrition and first foods, promoting access to physical activity and lifestyle modifications, engaging Native youth and elders, addressing perceptions and beliefs, promoting traditional values, and emphasizing community-driven planning for chronic disease prevention and control, such as community needs assessments. Expected outcomes include enhanced evidence-based and culturally rigorous chronic disease prevention programs, improved public health infrastructure among urban Indian organizations, and a reduction in the prevalence of chronic diseases within urban Indian communities. Applicants are required to participate in performance measurement, evaluation activities, and a chronic disease community of practice, which includes annual webinar-based trainings and optional technical assistance services, all coordinated by UIHI. This structured approach ensures measurable results and continuous improvement in addressing chronic diseases with a broad reach across the United States.

The DOD Pancreatic Cancer, Focused Pilot Award is a grant that supports innovative research projects aimed at improving the quality of life for pancreatic cancer patients, with a focus on areas such as healthcare access, mental health, psycho-social issues, nutrition, education, and symptom management.

The "ROSES 2024: A.41 SERVIR Applied Sciences Team" grant is a funding opportunity supported by NASA and USAID, aiming to enhance the use of Earth observations to address environmental and developmental challenges in Africa, Asia, and Latin America by co-developing practical applications of satellite data to support decision-making in areas like agriculture, water security, and climate resilience.

This challenge invites engineers and materials innovators worldwide to create a cost-effective, corrosion-resistant lining for flow meters used in harsh industrial environments, with the potential for significant monetary awards and collaboration opportunities with a leading automation company.

This funding opportunity invites a wide range of organizations, including academic institutions and businesses, to propose innovative research and technology projects that enhance naval aviation capabilities for the U.S. Navy.

This grant provides funding for innovative research projects aimed at improving the understanding and treatment of eye injuries and visual dysfunction related to military service.

This funding opportunity supports community-based healthcare organizations in implementing educational initiatives and system-level changes to improve care for patients with relapsed or refractory multiple myeloma, particularly through the use of bispecific antibody therapies.

The Massachusetts Clean Energy Technology Center (MassCEC) is offering Climate-Critical Workforce Training, Equipment, and Infrastructure Grants (“Climate Training Grants”) to increase access to modern, relevant training equipment and infrastructure. These grants provide direct funding and technical assistance to organizations that can build and scale career pathways and upskilling programs. The core mission alignment is to help Massachusetts residents access and advance in climate-critical priority occupations, thereby addressing clean energy and climate tech employer needs and providing high-quality training and support opportunities across the Commonwealth. The target beneficiaries for these grants are Massachusetts residents who can benefit from career pathways and upskilling programs in climate-critical priority occupations. The impact goals are to fill workforce gaps in climate-critical sectors, expand recruitment pipelines, and create new or expand existing technical and job readiness training opportunities. This initiative also aims to create and expand career advancement programming and upskilling training for incumbent workers, ensuring businesses can grow to support the state’s climate goals. The program prioritizes several key areas, including expanding recruitment pipelines to broaden access to climate-critical priority occupations, creating and expanding technical and job readiness training, and fostering career advancement and upskilling opportunities. It also focuses on leveraging effective workforce development models like registered apprenticeships and pre-apprenticeships, developing new relationships with employers for job placements, and establishing wraparound and retention support services to address barriers to entry and advancement. Furthermore, a significant focus is on expanding the availability and effectiveness of climate-critical training by securing modern equipment and infrastructure resources. Expected outcomes include a more robust workforce for climate-critical sectors, increased access for residents to high-quality training and job opportunities, and businesses expanding their capacity to meet climate goals. Measurable results will likely involve the number of residents trained, placed in climate-critical occupations, and upskilled, as well as the expansion of training programs, equipment, and infrastructure. The overall theory of change is that by investing in workforce development, equipment, and infrastructure, MassCEC can directly support the state's clean energy and climate tech employer needs while creating equitable access to career advancement for Massachusetts residents.

This grant provides funding for independent documentary films that explore the Asian American experience, intended for broadcast on public television.

This funding opportunity supports nonprofit organizations in New Jersey that are dedicated to improving the social, economic, and educational outcomes of Hispanic communities through various initiatives.

This grant provides funding to organizations that create and distribute accessible educational videos for children and youth with disabilities, ensuring they have equal access to high-quality learning materials.

This grant provides funding and support to early-stage U.S. startups developing innovative technologies that can meet critical needs of the Department of Defense.

This funding opportunity supports organizations in conducting research and developing resources to improve hiring, retention, and advancement practices for people with disabilities in the workforce, particularly focusing on small and medium-sized businesses.

This program provides funding for researchers and innovators to develop advanced technologies for rapidly identifying and sequencing complex protein-based biothreats, enhancing national security and defense capabilities.