Grants for Nonprofits - Science and Technology

Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at sara@nasa.gov, but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

The intent of the FY24 Transforming Care Award (TrCA) is to support research that provides answers and solutions in critical areas to improve quality of life, reduce caregiver burden and stress, reduce health disparities, and increase support for the individual with a diagnosis of Alzheimers disease and related dementias (AD/ADRD), their care partner/caregiver, and/or both, as well as the impact on families and/or communities. For this mechanism, family is broadly defined as the family of choice and/or the family of origin. Additionally, the TrCA definition of care does not include medical care (such as medical interventions administered by a physician), as the care landscape extends beyond that of medical interventions to be inclusive of research into integration, education, and support. The PRARP requires projects to ensure strategies maintain the dignity of the individual living with a dementia diagnosis and their family/care/social communities. All applications submitted to this funding opportunity must clearly indicate how the project addresses a critical unmet need, explain how the research will be representative of the population it intends to benefit, and demonstrate cultural competence. Culturally competent research factors the cultural background and diversity of the intended beneficiaries of the research outcomes when developing research ideas, conducting research, and implementing the research findings. Cultural competency in research is critical in reducing health disparities and enhancing the quality and impact of research by ensuring inclusivity, understanding, and responsiveness to the needs of diverse populations. The TrCA targets research that includes, but is not limited to, improvements in long-term care, quality of life, psychosocial wellness, and supporting aging-in-place, belonging, and community living for individuals, care partners, and families living with a dementia diagnosis. Studies may include, but are not limited to, topics such as considerations for dementia care that are specific to military Service Members and/or Veterans and their Families, navigating the AD/ADRD diagnosis and care path, and overcoming care partner/caregiver stress. Projects may address knowledge gaps, interventions, strategies, technologies, and/or tools. Clinical research and clinical trials are allowed, however, clinical trials solely testing or evaluating pharmacological interventions do not meet the intent of this funding opportunity. Key elements of this award mechanism are: Person-centered research: All applications to the FY24 PRARP TrCA should be person- centered. This mechanism is intended to provide answers and solutions in critical areas to improve quality of life, reduce burden and stress, and increase support for individuals living with a diagnosis, their families, and their care partners (hereafter referred to as Community(ies) in this Funding Opportunity). The research should have near-immediate impact on the intended beneficiaries. To facilitate success, the TrCA requires Community collaboration for all projects. Focus on outcomes: The intent of the TrCA is to advance knowledge and capacity in the AD/ADRD care field. As such, applicants should clearly articulate outcomes, clearly demonstrate a pathway of feasibility, and identify realistic approaches to scaling and Community level implementation for widespread use. Additionally, applications should plan for and describe how the research will be manualized (i.e., compiled in a manual) and fed back into the research, lived experience, and care communities. See Attachment 6, Research Manual and Progression Plan. Representation: Awards supported by the PRARP are expected to address gaps in representative AD/ADRD data sets. Applicants must prioritize diversity and equity in clinical study populations including, but not limited to, social and structural determinants of health such as sex, gender, ethnicity, culture, socioeconomic status, geography, and health care access, are expected. Projects supported by this mechanism must represent a non-incremental advance in the care field. Preliminary data are required. For this mechanism, studies utilizing animal models do not meet the intent of the mechanism and are not allowed. Milestone meeting: The Principal Investigator (PI) will be required to present an update on progress toward accomplishing the goals of the award at a Milestone Meeting to be held in the National Capital Area during years 2-4 of the period of performance. The PI may bring up to three additional members of the research team, including their Community partner, to the meeting. The Milestone Meeting will be attended by members of the PRARP Programmatic Panel, CDMRP staff, the USAMRAA Grants/Contracts Officer, and other stakeholders. Optimizing research impact through Community collaboration: Research funded by the FY24 PRARP should be responsive to the needs of Communities in the remainder of the Funding Opportunity, maximizes the translational and impact potential of the proposed research. Establishing and utilizing effective and equitable collaborations and partnerships with members of the AD/ADRD lived experience Communities is essential to maximize the translational and impact potential of the proposed research. Collaborative research approaches feature shared responsibility and ownership for the research project to ensure fully integrated involvement of Community members within the research team. Collaborative research approaches such as Community-based participatory research, participatory action research, and integrated knowledge transition, generate partnerships between scientific researchers and Community members to create knowledge useable by both sets of stakeholders. Recognizing the strengths of each partner, scientific researchers and Community members must collaborate and contribute their expertise equitably on all aspects of the project, which may include needs assessment, planning, research intervention design, implementation, evaluation, and dissemination. Research results are jointly interpreted, disseminated, fed back to affected communities, and may be translated into interventions or policy. These methods are critically important for Community-level interventions and can also augment the potential impact of a research program on people living with dementia, their families, and/or their care partners. These collaborative relationships are often established through integrating Community members into research teams as co-researchers, advisors, and consultants. Some examples for Community collaborations include: Lived Experience Consultation: The research team includes at least one project advisor with AD/ADRD lived experience who will integrate with the research team to provide consultation throughout the planning, implementation, and dissemination of the research project. Lived experience consultants (LECs) may include individuals with an AD/ADRD diagnosis, their family members, care partners, or others as appropriate. Partnership with a Community-Based Organization: The research team establishes partnerships with at least one Community-based organization that provides consultation throughout the planning, implementation, and dissemination of the research project. Community-based organizations may include advocacy groups, service providers, policymakers, or other formal organizational stakeholders. Community Advisory Board (CAB): A CAB is composed of multiple Community stakeholders and can take many forms, from a board of LECs to a coalition of Community-based organizations, or any combination thereof. As with LECs and organizational partners, the CAB provides consultation throughout the planning, implementation, and dissemination of the research project. Career Initiation or Transition (CIT) Partnership Option: The FY24 PRARP encourages applications that include meaningful and productive collaborations between two principal investigators. To promote enhanced research capacity within the AD/ADRD field, the FY24 TrCA includes an option for a CIT Principal Investigator (PI) to partner with an experienced investigator to jointly address a research question. The CIT PI must have nominal, if any, research support in the field and may be either one of the following: The Career Initiation PI must be an early-career researcher, at least 3 years post their terminal degree but no more than 7 years into their independent position. Both PIs may have similar or disparate expertise, but each PI is expected to bring distinct and complimentary contributions to the application. The Career Transition PI must be an investigator (at any stage) who is new to the military health, TBI, or AD/ADRD field(s). New to the field is defined as having only nominal, if any, publications in the field. The other partnering investigator must have complimentary experience (as evidenced by publications) in military health, TBI, and/or AD/ADRD field(s). The CIT is structured to accommodate two PIs. One PI will be identified as the Initiating PI and will be responsible for most of the administrative tasks associated with application submission. The other will be identified as a Partnering PI. Either PI can be the CIT PI. Both PIs should contribute significantly to the development of the proposed research project, including the Project Narrative, Statement of Work (SOW), and other required components. Both PIs may have experience in similar or disparate scientific disciplines, but each PI is expected to bring distinct and complimentary contributions to the application. If recommended for funding, each PI will be named to an individual award within the recipient organization(s). For individual submission requirements for the Initiating and Partnering PI, refer to Section II.D.2, Content and Form of the Application Submission.

The Devices Grants program, supported by the KC Digital Inclusion Fund (DIF), aims to bridge the digital divide by providing essential devices like computers, laptops, tablets, and smartphones. This initiative directly aligns with the DIF's broader mission to advance a systemic strategy for digital equity, fill programmatic gaps, attract new funding, and strengthen Kansas City’s competitiveness for state and federal dollars. The program emphasizes supporting user interface devices to overcome technology barriers, rather than focusing on connectivity infrastructure or data plans. The target beneficiaries for this grant are individuals in need within the 9-county Greater Kansas City region, encompassing Cass, Clay, Jackson, Platte, and Ray counties in Missouri, and Johnson, Leavenworth, Miami, and Wyandotte counties in Kansas. The program specifically targets populations with limited access to technology and digital resources, aiming to empower them to access the internet and enhance their digital literacy. The impact goals include increasing access to technology for underserved communities, improving digital literacy, and fostering better internet connectivity solutions. The funding priorities for Devices Grants are centered around projects that provide access to technology, offer digital literacy training, and implement internet connectivity solutions. Priority is given to projects that are aligned with a specific program, rather than just an organization or population, and that help outcome-oriented direct-service organizations fulfill their mission by overcoming technology barriers. The core focus area is "Access to Network." Eligible applicants are direct-serving 501(c)(3) public charities, educational or governmental entities serving people in need within the specified 9-county region. While the grant size ranges from $10,000 to $100,000, the available funding is up to $75,000 with an award range of $1,000 to $20,000. The grant period is up to 6 months, with all projects expected to be completed by March 31, 2025. Grantees are notified of award status via email around August 26, 2024. The expected outcomes are that recipient organizations will be better equipped to serve their communities by providing necessary devices, ultimately leading to increased digital inclusion and improved access to digital resources for vulnerable populations.

This grant provides funding for researchers and organizations to conduct observations and studies related to the solar system, supporting a wide range of scientific investigations in space and planetary sciences.

This program provides financial support to practicing, professional, and emerging artists in Wichita to help them pursue professional development and skill-building opportunities that enhance their careers.

This funding opportunity is designed for researchers and organizations developing innovative methods to produce nitric acid more efficiently and sustainably, reducing reliance on traditional ammonia-based processes.

The Community Foundation San Luis Obispo County's "Access for All Fund" is dedicated to supporting charitable organizations that primarily benefit San Luis Obispo County residents, aligning directly with the foundation's overarching mission. This grant program specifically targets the disability community within the county, aiming to advance access and promote inclusion across several critical areas. The foundation's strategic priority is to foster a more equitable and accessible community for individuals with disabilities, with the Access for All Fund serving as a key mechanism to achieve this. The program's focus areas include advancing access to Health & Wellness, expanding capacity for Housing & Home Access, creating and supporting Community Participation/Inclusion, and promoting Accessible Workspaces and growing Employment Opportunities. For Health & Wellness, the goal is to improve access to healthcare services, equipment, and activities promoting physical and mental health. In terms of Housing & Home Access, the program seeks to increase options for accessible and affordable housing, along with modifications and equipment for independent living. Community Participation/Inclusion aims to ensure accessible events, physical and virtual spaces, inclusive programming, and accessible transportation. Finally, Accessible Workspaces and Employment Opportunities look to foster inclusive work environments through educational outreach, needs assessments, employee training, and improved access to services. The expected outcomes and measurable results of the Access for All Fund are directly tied to these focus areas. For example, increased access to health services and wellness activities, a greater number of accessible and affordable housing options, enhanced community participation through accessible events and spaces, and improved employment opportunities for individuals with disabilities. The foundation prioritizes one-year grants ranging from $1,000 to $10,000, with a specific amount of $5,000 available to award during the 2024 grant-making cycle. This funding approach is designed to support impactful, focused projects that can demonstrate tangible progress within a year. The Community Foundation San Luis Obispo County's theory of change through the Access for All Fund is that by investing in organizations that address the specific needs of the disability community, they can significantly improve the quality of life, independence, and overall inclusion of these residents. By supporting programs that advance access in health, housing, community participation, and employment, the foundation believes it can create a more equitable and supportive environment, leading to long-term positive societal impacts within San Luis Obispo County. Eligibility criteria mandate tax-exempt status under Section 501(c)(3) or a fiscal sponsorship, ensuring that funds are directed to legitimate charitable endeavors.

The "DoD Multiple Sclerosis, Clinical Trial Award" is a grant that funds the implementation of clinical trials aimed at significantly impacting the treatment or management of multiple sclerosis, ranging from small proof-of-concept trials to large-scale trials, with the expectation that the proposed trial will begin within 12 to 18 months after the award date.

This program provides $2 million in funding to support manufacturing and research organizations in Washington, encouraging innovation and job creation in key sectors like aerospace, clean technology, and advanced manufacturing.

The Clean Power Alliance (CPA) offers Community Benefits Grants (CBG) to support organizations that are advancing clean energy, fostering green jobs, promoting environmental education and stewardship, and championing energy equity and diversity within the communities served by CPA. This grant program directly aligns with CPA's mission to drive sustainability and resiliency through various pathways, reflecting their strategic priority to invest in community-level initiatives that complement their core energy services. The CBG program targets several key beneficiaries, particularly focusing on environmental and social justice communities. These include areas predominantly inhabited by communities of color or low-income populations, those underrepresented in policy and decision-making processes, and communities disproportionately affected by environmental hazards. Specifically, targeted communities include disadvantaged communities (based on CalEnviroScreen scores), all Tribal lands, and low-income households or census tracts. The impact goals are to alleviate environmental burdens, promote equitable access to clean energy benefits, and empower these communities through education and workforce development. The program prioritizes projects and organizations that advance clean energy, sustainability, and resiliency through specific focus areas: Research, Environmental and Social Justice Communities, Workforce Development, and Education. These priorities are designed to address systemic inequalities and foster a just transition to a clean energy economy. The expected outcomes include increased community engagement in clean energy initiatives, the development of a skilled green workforce, improved environmental literacy, and a reduction in environmental disparities in historically underserved areas. Awards for this grant range from $15,000 to $30,000, with a grant duration of one year. Eligible applicants must be IRS-designated 501(c)(3) non-profit organizations operating within the CPA service territory, which encompasses numerous cities and unincorporated areas in Los Angeles and Ventura Counties. While previous grant recipients can apply for the 2024-2025 cycle, they are ineligible to receive funds for more than two consecutive years. This structure aims to ensure a broad reach of funding and sustainable impact across the service areas.

This funding opportunity provides financial support for organizations to develop and evaluate innovative technologies and environments that promote accessibility and usability for individuals with disabilities.

We are pleased to announce that U.S. Mission Morocco is considering proposals for American Spaces Support Funding ranging from $5,000 to $30,000 USD to carry out programming at one or both of Mission Moroccos two American Spaces. American Spaces serve as the primary cultural and information hubs established by the U.S. government abroad, offering free and open access to communities worldwide with an interest in gaining insights into the United States. In Morocco, there are two such spaces: Dar America, located in Casablanca, and the American Space Oujda (ASO), situated in Oujda. Dar America and the ASO have the responsibility of providing vibrant programming that fosters stability and prosperity in Morocco, all while engaging a wide range of audiences. The programming goals from the previous year encompassed the enhancement of soft skills, entrepreneurship, and climate change training. In the fiscal year 2023, the programming extended to over 332 virtual and in-person initiatives and events, drawing in up to 15,466 attendees, both virtually and in-person, across the two spaces. Please read this document carefully and follow all instructions. This notice is subject to the availability of funding. B. PROGRAM OBJECTIVES: For FY2024, American Spaces Morocco wish to continue to implement impactful programs focused on English language learning, digital transformation empowerment, soft skills development, STEAM training, countering disinformation, and environment and climate change awareness. Key Programming descriptions: Enhancing English Language Learning: Implement a comprehensive English Language Learning (ELL) program designed to empower individuals from diverse communities toacquire and improve their English language learning. The aim is to create an inclusive and immersive learning environment, addressing the linguistic needs of participants while fostering cultural understanding. Digital Transformation Empowerment: Provide individuals and small businesses with the knowledge, skills, and tools necessary to navigate the digital landscape, fostering innovation, economic growth, and digital inclusion. Professional Development for Moroccan Youth: Promote professional and soft skills development, entrepreneurship and innovation through mentoring and training to promote positive community engagement and increase employability. Science, Technology, Engineering, arts, and Math (STEAM) Programming: Create innovative STEAM programs to engage youth at Moroccos American Spaces while utilizing the existing Makerspaces. Environment and Climate Programming: Expand understanding of environmental and climate change challenges through engaging and hands-on programming. Countering Disinformation: Promote media literacy and other skills to help young people effectively identify online disinformation. The primary target audience is young Moroccans, aged 18 30 and the principal method of engagement will be through in-person programming at the American Spaces. Virtual engagement may be a part of the overall strategy, augmenting in-person programming, when possible, and acting as the primary method of engagement, when necessary. Preference will be given to proposals that prioritize and maximize the needs of the audience while limiting overhead, equipment, and other expenses that do not directly support program participants. A successful proposal will develop a robust monthly calendar of activities spanning at least eight months and directly address at least one of the six key programming areas. Prospective grantees may plan programming activities at one or both American Spaces. Please see below an example of a monthly calendar.See attached copy of the NOFO for full information.

This grant provides funding to nonprofit organizations and government entities for projects that improve the quality of life in Franklin County, focusing on areas such as arts, education, health, and community development.

This program provides financial assistance to low-income families to improve their homes' energy efficiency, helping them save on energy costs while ensuring their health and safety.

This funding opportunity supports public agencies in California to create regional conservation plans that protect and restore habitats for vulnerable species through collaborative efforts and the use of scientific data.

This grant provides funding to support professional development and networking opportunities for teaching artists in the Philadelphia area, enabling them to deliver high-quality, inclusive arts education programs for youth.

The City of Champaign's Community Matters youth program, founded in 2007, offers funding for the 2024-2025 program year. This initiative aligns with the city's mission to address critical areas such as safety, academic support, technology, recreation, career exploration, and employment among its youth. The program seeks to support public or private non-profit agencies that provide services meeting the needs of Pre-K through 18-year-old students residing within Champaign. The primary beneficiaries of this grant are youth from low-income families within the City of Champaign. The program's impact goal is to have a lasting positive effect on the community by fostering well-rounded development in its youth. While open to low-income youth from any Champaign neighborhood as space and funding allow, a key prioritization is given to programs serving youth from specific target areas: Beardsley Park, Bristol Park, Garden Hills, and Douglass Park, ensuring that resources are directed where they are most needed for community transformation. Proposals should focus on activities that can be carried out with Community Development Block Grant (CDBG) funds. These activities are broad and include the rehabilitation of residential and non-residential structures, building demolition, construction and rehabilitation of public facilities, and public services. However, activities related to the general conduct of government, political activities, and new housing construction are generally ineligible. This focus ensures that the funded programs directly contribute to community improvement and youth development. The expected outcomes include enhanced safety, improved academic performance, increased technological literacy, greater recreational opportunities, and better career exploration and employment prospects for the youth participants. While specific measurable results for the 2024-2025 allocation are dependent on the yet-to-be-announced CDBG annual allocation, the previous year's public service allocation of approximately $133,000 provides an indication of the funding scale. This funding, limited to 15% of the City of Champaign’s total CDBG award, underscores the strategic priority of public services within the broader community development framework, aiming for a significant impact despite funding constraints. The funding period runs from July 1, 2024, to June 30, 2025.

This funding opportunity provides financial support and resources to help immigrants and individuals with limited English proficiency in California start or grow small businesses that address social challenges in their communities.

The FY24 Transformative Breast Cancer Consortium Award is designed to support collaborations and ideas that will transform the lives of individuals with, and/or at risk for, breast cancer and will significantly accelerate progress toward ending breast cancer. Applicants must bring together different perspectives to develop new paradigms that will solve fundamental yet overarching problems in breast cancer. This award requires a team-based approach by a consortium of exceptional researchers and advocates, whose collaborative efforts will make a transformative impact in breast cancer. The transformation intended by the consortium must be in peoples lives, and not in the healthcare or research system.This funding opportunity is a separate mechanism from the Transformative Breast Cancer Consortium Development Award, which is intended to provide successful applicants the time and resources needed to bring investigators and breast cancer advocates together to establish a consortium framework and conduct preliminary research to support application to a future, full Transformative Breast Cancer Consortium Award (pending availability of funds). For FY24, investigators may be named as Consortium Director on an application submitted to either (but not both) of these mechanisms. It is not necessary to receive a development award in order to apply for the current funding opportunity or anticipated full consortium awards in the future. Detailed information on the FY24 Transformative Breast Cancer Consortium Development Award is available under a separate program announcement (HT942524BCRPTBCCDA).For the FY24 Transformative Breast Cancer Consortium Award, the consortium should have at least four, but no more than five, project teams, each investigating different projects under a central hypothesis. No more than two project teams may be based at one institution. Each teams work must be integrated within the consortium so that every component is working toward the consortiums central hypothesis. Note: This award is not intended to replace, supplement, duplicate, or compete with other collaborative research efforts, such as the National Cancer Institute (NCI) Specialized Programs of Research Excellence (SPOREs), and it should not represent a collection of related Program Project grants or subprojects.The proposed consortiums overall work is expected to be innovative. In addition, the Transformative Breast Cancer Consortium Award will include funds for seed projects to pursue brand-new, high-risk/high-reward concepts that arise from the work, during the award period.DOD FY24 Transformative Breast Cancer Consortium Award 5The Breast Cancer Landscape describes the reality of breast cancer and identifies overarching challenges to progress the field. Research funded under this award mechanism should result in answers that will fundamentally and significantly transform and disrupt the present landscape.Applications submitted to the Transformative Breast Cancer Consortium Award must include the following: Research that includes truly innovative and brand-new, paradigm-shifting work in breast cancer that will address vital issues in a unique way. The issues may be one (or more) of the FY24 BCRP Overarching Challenges or, with justification, may be a different issue that meets the intent of the award mechanism and addresses the mission of ending breast cancer. If the application identifies a different fundamental issue, it must be coupled with at least one of the FY24 BCRP Overarching Challenges. Research that includes different disciplines that come together to address ending breast cancer with an ecologic approach. The consortiums proposed research must look at all aspects of the disease and bring together these different perspectives into one overarching plan for a deep, definitive dive into the FY24 BCRP Overarching Challenge(s) or other fundamental issue identified in the application. The plan also should include issues related to the hypothesis that have not been previously addressed or answered. A plan that describes in detail the integration across the consortium in all aspects, including administration, logistics, and substance. Applications must describe the substantive integration across and among teams that are necessary for the work. The required communication plan and administrative management plan will not suffice to show integration, nor will identifying individual team members who will cross teams. A detailed explanation of the substantive research processes that will be integrated is required.Synergistic, highly integrated, multidisciplinary, and multi-institutional research teams of leading scientists, clinicians, and consumer advocates must be assembled into a consortium to address a major problem in a way that could not be accomplished by a single investigator or group. While the project teams are made up of different groups, each with its own Principal Investigator (PI), the teams must be working on the major problem identified in the Transformative Breast Cancer Consortium Award application and under the leadership of the Consortium Director. The research proposed in Transformative Breast Cancer Consortium Award applications may include phase 1 clinical trials and collaborations with pharmaceutical or biotechnology industry scientists and/or companies, as appropriate. However, a clinical trial is not required, and the primary thrust of the application should not be a clinical trial.Although not all-inclusive, applications that propose the following as the primary effort(s) or central hypothesis of the consortium will not meet the intent of this award mechanism: NCI Program Project or SPORE grants or applications Conducting drug screens or testing a cocktail of therapeutics Targeting a single gene or protein Developing a new derivative or formulation of an old drug Conducting genomic landscape mapping analyses Seeking to improve existing technologies (e.g., mammography or magnetic resonance imaging screening)All applications submitted to the Transformative Breast Cancer Consortium Award must address the following key features:1. IMPACTDemonstrate potential to transform or improve the lives of individuals with, and/or at risk for, breast cancer. The time to the final impact may vary, but the outcomes of the effort must be transformative and significantly advance the BCRPs mission of ending breast cancer. A clear and compelling presentation of how the effort will be transformative for individuals with, and/or at risk for, breast cancer must be provided. Applications proposing research that represents an incremental advance in breast cancer do not meet the intent of this award mechanism.2. INNOVATIONPursue innovative, high-risk/high-reward research that has the potential to change existing paradigms, or develop new paradigms. Innovative research may introduce a new paradigm, look at existing problems from new perspectives, or exhibit other highly creative qualities. In addition to the requirement that the consortiums overall research be innovative, applications must describe a plan to support the pursuit of innovative concepts through seed projects, i.e., the development of new concepts that emerge during the course of the award. These seed projects should enable the research team to explore new avenues of high-risk/high-reward ideas that were not part of the original application, but that develop during the project and are within the scope of the overall vision of the research. A portion of the total direct budget costs (no more than 5%) must be reserved to support the seed projects, and these funds may not be used for equipment or travel.3. CONSORTIUMIntegrate project teams consisting of preeminent investigators and advocates from appropriate disciplines and institutions. Applications should include a robust consortium of researchers with the combined backgrounds and breast cancer-related expertise to enable successful conduct of the proposed research. Emphasis must be placed on integrating the most highly qualified investigators and advocates to focus on the research problem, regardless of their location. These investigators must include highly accomplished scientists, clinicians, and promising young investigators in the targeted areas of research who collectively represent the best team to solve the problem(s) identified. The proposed research effort should be broad enough to require a multidisciplinary approach that is reflected in the composition of the consortium team. Inclusion of scientists from nontraditional disciplines is encouraged.The award mechanism is structured with a Consortium Director and at least three, but no more than four, Project Team PIs representing at least two institutions. The Consortium Director is responsible for the day-to-day management of the consortium, as well as for leading their own project team. The Consortium Director, together with the Project Team PIs, are jointly responsible for leading and executing the proposed research projects that are integrated into a central hypothesis and will result in answers that will fundamentally and significantly transform and disrupt the present breast cancer landscape. Please see the top of this section, Section II.B, Award Information, for more details.Incorporate breast cancer consumer advocates into every aspect of the proposed consortiums activities. Applications are required to include consumer advocate involvement. The consortium team must include at least one breast cancer consumer advocate per project team. The consumer advocates are expected to represent the perspective of the patient population(s) that are most relevant to the consortiums proposed research. Breast cancer consumer advocates must have an active role in every aspect of the proposed consortiums work including consortium conception and design, ongoing discussion, decisions and oversight, program evaluation, and dissemination of information to the public. Consumer advocates must be integrated into and play an active role in the leadership and decision-making committees for the consortium at each participating institution. Examples of appropriate integration include membership on the advisory board(s) and steering committee(s), participation in each project team, and attendance at all consortium-related meetings. As lay representatives, the consumer advocates must be individuals who have been diagnosed with breast cancer, they should be part of a breast cancer advocacy organization, and their role in the project should be independent of their employment. They cannot be employees of any of the institutions participating in the application. They must have a high level of familiarity and training involving science and current issues in breast cancer research.4. INTEGRATIONProvide a plan that describes in detail the integration across the consortium in all aspects, including administration, logistics, and substance. Applications must demonstrate the substantive integration across and among teams that are necessary for the work. The integration plan must provide a detailed explanation of the substantive research processes that will be integrated.5. IMPLEMENTATIONProvide a strategy for implementation. Projects must demonstrate solid scientific rationale, and applications must include published and/or preliminary data that support the feasibility of their hypotheses and/or approaches. The application must include a detailed research management plan that identifies critical milestones, outlines the innovations and technical solutions that will be implemented to accomplish the milestones, and explains how these solutions will ultimately be translated to individuals with, and/or at risk for, breast cancer. It is expected that the proposed plan will present an exceptional level of innovation and creativity.Accelerate research progress through communication. Communication between and among consortium team members is essential to the success of the consortium. Applications must include a strategy for sharing data in real time and using information technologies to facilitate timely and effective communication and cooperation. The communication plan should specify the processes and tools to be used for regular and structured communication. The consortium should take full advantage of state-of-the-art communication and data sharing tools in addition to formal and informal meetings. The framework for the communication plan must be part of the application and the individual(s) who will maintain the data sharing and communications technologies must be identified.Provide an effective, coordinated administrative management plan that integrates and optimizes the research and collaborations. The Consortium Director is required to commit a minimum level of time and effort of 25% to direct and manage an initiative of this magnitude, as well as lead their own project team. The Consortium Director must have the scientific ability and proven administrative ability to oversee large research programs and a proven record of leadership, including experience in the effective use of communication tools and the management of multifaceted and multidisciplinary projects. The administrative management plan must explain how the consortium will be organized and managed, and specify the processes and tools to be used for project meeting scheduling, reviews of research findings, ensuring multidisciplinary authorship of all publications arising from the consortiums work, and other issues of common concern to the consortium and its investigators. The administrative management plan also must describe procedures and processes that will be used to maximize the resources (e.g., databases, animal models) and products (e.g., antibodies) generated by the consortium and how these resources and products will be made available to the scientific community. A portion of the total direct budget costs must be reserved for a program manager.Award Structure: The Transformative Breast Cancer Consortium Award is structured to accommodate up to five PIs (the Consortium Director and three or four Project Team PIs). The Consortium Director will be responsible for the majority of the administrative tasks associated with application submission and the day-to-day management of the consortium. In addition, the Consortium Director will be responsible for leading their own project team. The Consortium Director and Project Team PIs each have different submission requirements; however, all PIs should contribute significantly to the development of the proposed research project, including the Project Narrative, Statement of Work (SOW), and other required components. If recommended for funding, each PI will be named on separate awards to the recipient organizations. For individual submission requirements for the Consortium Director and Project Team PIs, refer to Section II.D.2, Content and Form of the Application Submission.The Consortium Director, Project Team PIs, and consumer advocates will be required to present an update on progress toward accomplishing research milestones and goals of the consortium and each project at an annual In-Progress Review (IPR) Meeting for the Transformative Breast Cancer Consortium Award. The intent of the IPR Meeting is to assess research progress, address problems, and define future directions. Annual IPR Meetings will be held at the conclusion of year 1 and every subsequent year in the period of performance and will be attended by members of the BCRP Programmatic Panel, CDMRP staff, and the USAMRAA Grants Officer to facilitate oversight and provide feedback to the consortium. IPR Meetings will either be held in person in the National Capital Region or virtually, at the discretion of the government. Continued funding may be contingent upon the successful completion of specific research milestones and goals. Research milestones from the approved SOW will be determined during the award negotiation process.In addition to IPR Meetings, each consortium must hold biannual workshops, which may be held at the PIs institutions or virtually, to facilitate ongoing communication and exchange of information within the consortium, as well as with advisory board(s) and/or steering committee(s).

This funding opportunity supports U.S. institutions in establishing a national center to coordinate and enhance research on Alzheimer's Disease and related dementias through data collection, integration, and collaboration efforts.