Grants for Private institutions of higher education - Science and Technology

This funding opportunity supports research on the origins, evolution, and distribution of life in the universe, primarily aimed at U.S.-based institutions and eligible international collaborators.

This grant provides funding for research projects that advance scientific and engineering knowledge to support military and civil missions, targeting a wide range of eligible applicants including educational institutions, non-profits, small businesses, and minority-serving organizations.

This program provides funding for predoctoral and postdoctoral researchers to advance the understanding and treatment of spinal cord injuries through innovative research.

Supports applications for innovative research projects addressing critically important questions that will significantly advance knowledge of the causes, risk factors, molecular and clinical characteristics, prevention, and/or treatment of early-onset cancers. • Applicants may request a maximum of $300,000 per year for a 3-year period. • Multi-Principal Investigators (MIs) are allowed under this Request for Applications (RFA). See the Information for Applicants (IFA) document for definition and eligibility of MIs. See application limitations for Principal Investigators (PIs)/MIs, regardless of whether the MI is from the primary institution or a subcontracted institution. • Note that CPRIT does not allow the use of the term Co-PI. • Minimum effort for the PI and/or MIs throughout the project period is required. • FY25 salary cap has been set at $225,000 per year.

This funding opportunity is designed to support innovative research and development projects that enhance military logistics, supply chain resilience, and operational readiness for the Department of Defense.

This grant provides funding to U.S. universities to support early-career faculty members in developing innovative research related to space technology, specifically in advanced diagnostics for spacecraft atmospheric entry and autonomous spacecraft navigation using machine learning.

LIGHT intends to shine a light on the lymphatic system, illuminating the unseen both literally via novel diagnostic approaches and figuratively through insight gained into the critical role the lymphatic system plays in health as well as its impacts when dysfunctional. LIGHT aims to improve the lives of tens of millions of Americans by creating agile tools that are scalable, accessible, accurate and clinically useful to detect lymphatic structure and function. Multiple diagnostic technologies will enable targeted interventions that result in better patient outcomes and reduced treatment costs, and will advance our understanding of lymphatic dysfunction, a key factor in the pathophysiology of many important diseases. Signs and symptoms of lymphatic dysfunction do not manifest until the disease has progressed, and current assessment tools neither adequately appraise lymphatic anatomy nor measure lymphatic function. The Government reserves the right to select for negotiation all, some, one, or none of the proposals received in response to this ISO. If warranted, portions of resulting awards may be segregated into prepriced options. In the event the Government desires to award only portions of a proposal, negotiations will commence upon selection notification. The Government reserves the right to fund proposals in phases with options for continued work, as applicable. The Government reserves the right to request any additional, necessary documentation to support the negotiation and award process. The Government reserves the right to remove a proposal from award consideration should the parties fail to reach agreement on award terms, conditions, cost, and/or if the proposer fails to provide requested additional information in a timely manner. In all cases, the Government will have sole discretion to negotiate all instrument terms and conditions with selectees. ARPA-H will apply publication or other restrictions, as necessary, if it is determined that the research resulting from the proposed effort will present a high likelihood of disclosing sensitive information including Personally Identifiable Information (PII), Protected Health Information (PHI), financial records, proprietary data, any information marked Sensitive but Unclassified (SBU), etc. Any award resulting from such a determination will include a requirement for ARPA-H concurrence before publishing any information or results on the effort. ARPA-H seeks proposals from all eligible entities (see Section 2 Eligibility Information) to accomplish the LIGHT Program goals as described in this solicitation package. Ultimately, ARPA-H intends to negotiate multiple Other Transaction agreements (OTs) and/or Cooperative Agreements (CAs) with proposers whose proposals are most advantageous to the Government and are poised to meet the goals of the LIGHT program. Proposals are expected to use innovative approaches that may include both existing and novel technology, enabling revolutionary advances in medicine and healthcare. The LIGHT program aims to develop a comprehensive diagnostic toolkit to assess lymphatic structure and function, and potential performers should consider an approach to ensure the final technology includes an imaging modality plus biomarkers and/or genetic integration. Initially proposers should consider primary lymphatic 5 diseases as the targeted disease state; however, consideration of other chronic conditions associated with lymphatic dysfunction is encouraged. Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art, including clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

This funding opportunity supports early-career researchers and medical residents conducting impactful cancer research relevant to military health, with a focus on improving the quality of life for service members and their families.

This grant provides funding for researchers investigating the causes and effects of social, political, and economic inequalities in the United States, focusing on various factors such as race, gender, and immigration status.

This funding opportunity supports small research projects that explore how immigrants integrate into American society, focusing on their legal status and economic advancement.

This funding opportunity is designed to support domestic industrial facilities in recovering critical minerals and materials from byproducts, enhancing the U.S. supply chain and reducing reliance on foreign sources.

The Confronting Hazards, Impacts and Risks for a Resilient Planet Program (CHIRRP) invites projects focusing on innovative and transformative research that advances Earth system hazard knowledge and risk mitigation in partnership with affected communities. Hazards compounded by changing climates, rising populations, expanding demands for resources, aging infrastructure, and increasing reliance on technology are putting our economy, well-being, and national security at risk. Researchers, academics, and community leaders will work together to develop community-driven research questions and actionable, science-based solutions that increase community resilience now and in the future. CHIRRP projects are expected to advance understanding, forecasting and/or prediction of future Earth system hazards and risks, engage communities in development of research questions and approaches, and produce actionable, science-based solution pathways for adaptation methodologies, products, and services. CHIRRP projects may evaluate a single or system of cascading hazards, impacts, and risks at a local, regional, or global scale through the lens of transformative earth system science research. Competitive projects will engage community partners at all stages of a project from development to implementation. CHIRRP currently supports planning, conference, RCNs, EAGER, and RAISE proposals that support development of community partnerships, provide training for effective community engagement, catalyze ideas, and/or support the initial conceptualization, planning and collaboration activities aimed at formulating new and sound plans for future large-scale projects. CHIRRP Elements CHIRRP projects will demonstrate convergence of three essential elements: (1) Equitable Community Partnerships; (2) an Earth System Science approach to advance knowledge of hazards, impacts, and risks and (3) Actionable Solutions that increase resilience. The initiative seeks solutions to existing as well as next-generation Earth system hazards1. Build Equitable Community Partnerships: CHIRRP projects will serve a community and equitably co-produce project research questions and solutions. CHIRRP teams will bring together community members with direct knowledge of hazard impacts and community priorities and researchers with expertise in the natural and human dimensions of the Earth system. Partners may include, but are not limited to, local governments, Tribal Nations, civil society organizations, youth groups, and non-government organizations (NGOs). Robust partnerships are responsive to community priorities, may involve a social science component, and lead to actionable solutions that increase community resilience. Advance Earth System Science: Generating practical and foundational knowledge on many of the nation's most urgent challenges requires a systems approach to understand the highly interdependent and complex natural and human components of the Earth system. CHIRRP projects will innovate and advance Earth System Science approaches that explore dynamic interactions and couplings among natural and social processes that affect Earths capacity to sustain the well-being of communities, infrastructure, and national security.Evaluate Actionable Science-Based Solutions: CHIRRP deliverables include co-produced innovative, science-based actionable solution pathways that mitigate future hazards, impacts, and risks. Multiple solutions may exist, and new solutions may emerge in the future. CHIRRP projects will inform pathways to resilience through evaluation of different solutions informed by the advancement of earth systems knowledge delivered from the project. An understanding of risk, vulnerability and resilience necessarily entails an understanding of relevant social dynamics including methods and analysis to identify how the impacts of hazards may disproportionately affect specific segments of a community or region. Solutions should be responsive to community priorities, including objectives such as reducing Earth system hazard related risk, increasing resilience, and advancing equity.1National Academies of Sciences, Engineering, and Medicine. 2022. Next Generation Earth Systems Science at the National Science Foundation. Washington, DC: The National Academies Press. https://doi.org/10.17226/26042 [placeholder to add URL link in the text]. [Placeholder to insert CHIRRP image here.]

This funding opportunity supports U.S.-based researchers and institutions in advancing space weather science and its operational applications, with a focus on transitioning research findings into practical use.

The DoD Bone Marrow Failure, Idea Development Award is a funding opportunity aimed at supporting innovative and scientifically sound research ideas that contribute to understanding and curing bone marrow failure diseases, with a particular emphasis on hypothesis-driven studies linked to clinical trials, open to both established and early-career investigators.

This funding opportunity supports U.S. and eligible foreign institutions in developing innovative analysis tools and improving data accessibility for heliophysics research.

The 2025 Arts & History Re-Grant Program, administered by the Cape May County Government in New Jersey, offers funding to support arts and history-related projects and ongoing programs within Cape May County. The program's mission aligns with fostering community engagement and increasing exposure to arts and history. It aims to support a diverse range of initiatives, from single events to sustained programming, ultimately enriching the cultural landscape of the county. The program targets organizations and groups located within Cape May County that are involved in arts or history. This includes civic organizations, social organizations, community theater groups, dance companies, museums, galleries, orchestras, and singing groups. The impact goals are to support and sustain arts and history projects, programs, and general operations, thereby enhancing cultural offerings and community participation in these areas. There are three distinct categories of funding: Special Project, General Programming Support (GPS), and General Operating Support (GOS). Special Project funding is for single, specific arts or history-related events. GPS supports major, ongoing arts programs with multiple events or activities throughout the year. GOS is designed for organizations whose primary charter is arts or history-related, providing general operating support to groups that consistently increase exposure to art/history in the community. The program prioritizes projects and programs that take place within Cape May County and, for General Operating Support, requires the applying organization to be located within the county. Expected outcomes include a more vibrant cultural scene in Cape May County, increased opportunities for residents to engage with arts and history, and the sustained operation of local arts and history organizations. Measurable results would involve the number and diversity of projects funded, the reach and attendance of programs, and the organizational stability of grant recipients. The strategic priorities revolve around making arts and history accessible, supporting the infrastructure of cultural organizations, and ensuring fiscal responsibility, particularly for General Operating Support grants. The program's theory of change posits that by providing targeted financial support, local cultural initiatives will thrive, leading to a more enriched and engaged community.

This grant provides funding for researchers studying the physical properties and processes of the Earth, including earthquakes, volcanoes, and the structure of the Earth's interior.

This funding opportunity supports interdisciplinary research projects that integrate human behavior into epidemiological models, targeting U.S. higher education institutions to improve public health responses based on insights from the COVID-19 pandemic.

The FY24 PCRP Idea Development Award is intended to support new ideas that represent innovative approaches to prostate cancer research and have the potential to make an important contribution to the PCRP mission. The key components of this award mechanism are: Innovation: Research deemed innovative may represent a new paradigm, challenge current paradigms, look at existing problems from new perspectives, leverage unique study populations, or exhibit other highly creative qualities. Research that is an incremental advance upon published data is not considered innovative. Projects involving multidisciplinary and/or data science approaches are especially encouraged. Impact: Applications are required to address and provide a solution to one or more of the FY24 PCRP Overarching Challenges. The potential impact of the research, both short-term and long-term, in addressing the FY24 PCRP Overarching Challenge(s) should be clearly described. High-impact research will, if successful, significantly advance prostate cancer research and/or patient care. Preliminary Data: Due to this awards emphasis on innovation, the presentation of preliminary data relevant to prostate cancer and the proposed project is encouraged, but not required. Any unpublished, preliminary data provided should originate from the laboratory of the Principal Investigator (PI) or a member(s) of the research team. Regardless of whether preliminary data are included, applications should be based on a sound scientific rationale that is established through logical reasoning and/or critical review and analysis of the literature.New Investigator category: The FY24 PCRP Idea Development Award mechanism encourages research ideas from investigators in the early stages of their careers. The New Investigator category of this award mechanism is designed to allow applicant organizations to name PIs who are early in their faculty appointments or in the process of developing independent research careers. Applications submitted to the New Investigator category will be assessed using different review criteria for personnel (refer to Section II.E.1.a., Peer Review) and are required to include a collaborator (or collaborators) who has (have) experience in prostate cancer research, as demonstrated by a record of funding and publications. The application must describe the potential of the collaboration(s) to be successful and how the collaboration(s) will augment the PIs expertise to better address the research question. In addition, applicants are strongly encouraged to provide a letter of collaboration from the collaborator(s) describing the collaborator(s) involvement in the proposed work. All applicants for the New Investigator category must meet specific eligibility criteria described in Section II.C, Eligibility Information.Multidisciplinary projects are encouraged, and multi-institutional projects are allowed. Each proposed study must include a clearly stated plan for interactions among all team members and organizations involved. The plan must include communication, coordination of research progress and results, and data transfer. Additionally, multi-institutional applications must provide an intellectual property plan to resolve potential intellectual and material property issues and to remove institutional barriers that might interfere with achieving high levels of cooperation to ensure the successful completion of this award.Investigators are strongly encouraged to incorporate the following components into their study design, where appropriate, in order to maximize the potential impact of the proposed research project: authentication of proposed cell lines; statistical rigor of preclinical animal experiments; and incorporation of experiments to assess clinical relevance and translatability of findings. Studies utilizing data that are derived from large patient studies that include long-term health records, biospecimen repositories, and pre-existing research and apply state-of-the-art genomic and/or proteomic analysis, bioinformatics, and/or mathematical models to such data are also encouraged. Investigators are highly encouraged to provide a letter of support indicating access to and the availability of any resources required to support the study.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 PCRP priorities.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more-effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 https://www.nature.com/nature/ journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated direct costs budgeted for the entire period of performance for an FY24 PCRP Idea Development Award should not exceed $1.2M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $53.76M to fund approximately 28 Idea Development Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

This funding opportunity supports innovative basic research in behavioral and social sciences to improve the Army's ability to develop and retain professional Soldiers, targeting universities, nonprofits, and commercial organizations.