Grants for Public and State controlled institutions of higher education - Science and Technology

This funding opportunity supports U.S. and Canadian organizations in creating public diplomacy projects that foster mutual understanding and cooperation between the two countries, focusing on shared interests like innovation, security, and cultural exchange.

The U.S. National Science Foundations Directorate for Technology, Innovation and Partnerships (TIP) is charged with accelerating use-inspiredand translationalresearch and development (R) to advance U.S. competitiveness in key technology focus areas. The Advancing Cell-Free Systems Toward Increased Range of Use-Inspired Applications (CFIRE) initiative will accelerate the adoption of cell-free systems, enable new applications of this technology and contribute to the growth of the U.S. bioeconomy. A nascent industry has formed around the ability to carry out biochemical processes, such as DNA transcription/translation, in cell-free in-vitro systems instead of in traditional cell-based in-vivo bio-reactors. This approach has a number of potential advantages, including rapid turn-around, distributed and highly retargetable manufacturing, high-fidelity instrumentation and control of the manufacturing environments without the constraints of biological growth and the interference caused by cell biomass and cell membranes during product purification. Furthermore, cell-free systems can produce products that are challenging to manufacture in cell-based cultures, such as those inherently toxic to cells or hydrocarbon products that are consumed by the cellular machinery. Despite these advantages, present-day cell-free manufacturing is significantly more expensive than cell-based methods and cell-free systems have a limited range of applications. CFIRE aims to: 1. Reduce the cost of cell-free systems; 2. Increase the range and capabilities of cell-free systems; and 3. Develop and demonstrate cost-effective use-inspired applications. CFIRE will address the key limitations of cell-free technology by identifying technical approaches that can enable ongoing cycles of improvement. The objective is to place cell-free technology on an exponential growth path in which reduced costs lead to increasing adoption which, in turn, generates the learning and investment required to further reduce costs. In order to keep the work focused and to stimulate increasing adoption, efforts funded through this initiative will focus on one or more specific use cases. CFIRE seeks significant breakthroughs that will accelerate the adoption of cell-free systems by: (a) Demonstrating the feasibility and advantages of cell-free systems through use-inspired applications with specific emphasis on applications beyond human therapeutics; (b) Creating infrastructure components, such as tools, protocols, kits, datasets, and characterization services that can readily be accessed by third parties; and (c) Investing in workforce components focused on the training of translational talent with the skills and passion to engage in use-driven cell-free applications. CFIRE will use the Ideas Lab process (see PAPPG Chapter II.F.6), starting with an intensive meeting that brings together multiple diverse perspectives. The primary objectives of this Ideas Lab workshop will be to: identify specific opportunities to significantly reduce the cost of cell-free systems; establish acceptable standards for the fidelity and reproducibility; expand the range of capabilities in order to facilitate broader adoption of the technology; and identify and prioritize use-driven applications beyond human therapeutics.

This program provides quick funding to researchers at North Carolina universities and nonprofit institutes to develop innovative life sciences projects that show strong commercial potential.

The long-range goal of the Research Training Groups in the Mathematical Sciences (RTG) program is to strengthen the nation's scientific competitiveness by increasing the number of well-prepared U.S. citizens, nationals, and permanent residents who pursue careers in the mathematical sciences, be they in academia, government, or industry. The RTG program supports efforts to improve graduate student research training and professional development through structured groups pursuing collaborative research. In addition to graduate student trainees working with faculty members, RTG supported research teams may, but are not required to, include undergraduate or postdoctoral trainees. The RTG program invites submissions in all fields within mathematical sciences; especially encouraged in 2024-2025 are those that align and integrate research in mathematics and statistics with emerging areas such asArtificial Intelligence, Biotechnology,Quantum Computing, and Cybersecurity.

This funding opportunity provides financial support for New Jersey-based nonprofit organizations and government entities to implement public humanities projects that engage local audiences through activities like exhibitions, oral history projects, and community programs.

The subrecipient shall access the current utilization of CHWs in the State of Arizona. The subrecipient shall use results to inform and develop a statewide CHW workforce development plan to expand CHW curricula, training delivery, career ladders, integration of CHWs, promotion of CHW voluntary certification, and/or sustainable payment mechanisms for CHW services. Financial Notes: Funds for the Clinical Health Worker (CHW) Sustainability come from the Centers for Disease Control and Prevention (CDC), A Strategic Approach to Advancing Health Equity for Priority Populations with or at Risk for Diabetes (Part A) CDC-RFA-DP-23-0020 grant (230020).

The key aspects of this award are: Impact: The SRA is intended to support research designed to have a major impact on the health and well-being of melanoma survivors, their families, and/or caregivers. Impactful research will accelerate the movement of promising ideas into clinical applications or other real-world applications and advance the field of melanoma-specific quality of life and survivorship. Study Design: Applications should clearly articulate and justify the chosen study design. Studies proposing retrospective analyses or prospective enrollment should clearly describe the architecture of the study (e.g., descriptive, correlational, field experimental, meta-analyses) and the study population(s). The study population(s) should be representative of the people who are anticipated to benefit from the research. If applicable, questionnaires should be described in sufficient detail to justify interpretation of potential results. Melanoma Consumer Collaboration: For the purposes of the SRA, a melanoma consumer is defined as a melanoma survivor, family member, and/or caregiver who can provide lived experience expertise to the research project team. Applicants to the SRA are required to establish a collaborative research approach with the melanoma consumer community to maximize the impact and translatability of the research for the benefit of the intended melanoma community(ies). The research team must include at least one melanoma consumer or a melanoma-community supporting organization who will be integral to the planning, execution, and implementation of the proposed research. The role of the melanoma consumer collaborator(s) should include providing objective input on the research question being addressed; the study design, execution, and evaluation; and the potential impact of the research outcomes on the health and well-being of melanoma survivors, their families, and/or their caregivers. The melanoma consumer collaborator(s) should be active participants and integrated into the research team; their participation should not be limited only to passive activities (e.g., attending seminars or quarterly team meetings). Additional information and resources for establishing a collaborative research approach with the melanoma consumer community is provided below.Other Important Considerations:Collaborative Research Approaches: Collaborative research approaches create partnerships between scientific researchers and, for the purposes of the SRA, melanoma consumers to create knowledge useable by both sets of stakeholders. Recognizing the strengths of each partner, scientific researchers and melanoma consumers collaborate and contribute equitably on all aspects of the project, which may include needs assessment, planning, research intervention design, implementation, evaluation, and dissemination. Collaborative research approaches feature shared responsibility and ownership for the research project to ensure non-tokenistic involvement of the melanoma consumers within the research team. Research results are jointly interpreted, disseminated, and fed back to affected communities and in some instances may be translated into interventions or policy.Collaborative relationships with the melanoma consumer community may be established through integrating melanoma consumers and/or melanoma-community supporting organizations into research teams as co-researchers, advisors, and/or consultants. Examples for implementing collaborative research approaches are listed below, but each research team may pursue other options as appropriate for the proposed research: The research team includes at least one melanoma consumer who will provide advice and consultation throughout the planning and implementation of the research project. The consumer(s) should be able to speak to the needs of the melanoma consumer community, not just speak to their own personal experiences. The research team establishes partnerships with at least one community-supporting organization that provides advice and consultation throughout the planning and implementation of the research project. Community-supporting organizations may include advocacy groups or other formal organizational stakeholders that can speak to the needs of the melanoma consumer community. The research team assembles a melanoma consumer community advisory board. The advisory board may include melanoma consumers, a coalition of community-supporting organizations, or any combination thereof that provides advice and consultation throughout the planning and implementation of the overall program and/or individual research projects.

This funding opportunity supports not-for-profit organizations and educational institutions in the UAE to develop programs that strengthen U.S.-UAE relations through cultural events, space exploration initiatives, and entrepreneurship activities.

NASA has released a Research Announcement for the Human Exploration Research Opportunities (HERO) program, inviting U.S. institutions to submit proposals for applied research projects aimed at enhancing human health and performance for space exploration, with grants ranging from under $100K to $1.2M per year, for a period of one to five years.

This award is to support community development and resilience with geospatial data and digital technology by engaging university-aged youth. The activities anticipated as part of this award will add valuable, free and openly accessible data to digital ecosystems of lower and middle income countries, which in turn can be used by USAID programs and humanitarian assistance activities. The award will specifically focus on youth training, geospatial data collection, and analysis to help communities address local development challenges. Activities will also engage marginalized populations to ensure representation of the diversity of partner country populations. USAID anticipates awarding one to three grants and/or cooperative agreements under this Addendum. Issuance of this Addendum does not constitute an award or commitment on the part of the U.S. Government to make an award, nor does it commit the U.S. Government to pay for costs incurred in the preparation and submission of a Concept Note or Application(s). The actual number of assistance awards is subject to the availability of funds, as well as the viability of eventual full Applications received.

This grant seeks innovative proposals from a wide range of organizations, including universities and small businesses, to develop advanced technologies that enhance national defense capabilities.

This grant provides funding for collaborative research projects that explore innovative ideas in computing and information science, requiring teams of experts from multiple disciplines to tackle complex problems.

This funding opportunity supports researchers studying the formation and transformation of Earth through the analysis of rocks and minerals, as well as the development of new analytical tools and techniques in petrology and geochemistry.

This funding opportunity supports various mentoring and intervention programs aimed at reducing violence and fostering positive relationships among youth and families in the community.

The MBRP TTDA is a product-driven award mechanism intended to provide support for the translation of promising preclinical findings into products for clinical application in resource-limited settings, particularly within the pre-hospital, or early, acute phase of care environments. Applications must address one or more of the critical gaps included in the FY24 MBRP TTDA Focus Areas. Products under development must address the needs of military Service Members, Veterans, their beneficiaries, and the American public.The product(s) to be developed may be a tangible item such as a medical device or pharmacologic agent (including, but not limited to, drugs or biologics). Knowledge products may be considered, provided that the knowledge is applicable to a technology or therapeutic under development. (A knowledge product is a non-materiel product that addresses an identified need in one or more of the FY24 MBRP TTDA Focus Areas. A knowledge product is based on current evidence, aims to transition clinical practice standards, training, or tools into clinical practice, or supports materiel solutions [systems to develop, acquire, provide, and sustain medical solutions and capabilities], and educates or impacts behavior throughout the continuum of care, including primary prevention of negative outcomes.)At the time of pre-application submission the proposed product must have achieved a minimum technology readiness level (TRL) or knowledge readiness level (KRL) of 3 (Appendix II).Proof-of-concept AND a prototype/preliminary version of the proposed product demonstrating its potential utility must be established at the time of pre-application submission. Applications must include relevant data that support the rationale for the proposed study. These data may be unpublished and/or from the published literature.This award mechanism is intended to facilitate progression of research that is supported by significant preliminary data but has not yet advanced to the level of clinical use. Examples of the types of research that may be supported include, but are not limited to: Testing new therapeutic or technologic modalities (e.g., agents, delivery systems, chemical modification of lead compounds, device testing and/or validation) using established or validated preclinical systems Designing pilot or full-scale Good Manufacturing Practice (GMP) production of therapeutics and/or technologies for use in advanced preclinical studies Developing pharmacologic agents through absorption, distribution, metabolism, excretion, and toxicity studies Investigational New Drug- or Investigational Device Exemption-enabling studiesClinical trials and clinical research studies ARE NOT PERMITTED under this award mechanism. Projects involving limited use of commercially available human cells or anatomical specimens are permitted, provided that the use of such specimens is necessary for device or product development. Applicants interested in proposing clinical research should consider submitting to the FY24 MBRP Patient-Centered Research Award mechanism (HT942524MBRPPCRA).A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.Impact: The overall impact of the proposed research is a key component of this award mechanism. High-impact research will, if successful, lead to the development and translation of therapeutic or technologic advances for clinical application in the care of burn-injured casualties, such as detection, diagnosis, treatment, or burn complication prevention.Relevance to Military Health: Relevance to the health care needs of burn-injured military Service Members is a key feature of this award.Use of DOD or Department of Veterans Affairs (VA) Resources: Applications involving multidisciplinary collaborations among academia, industry, the military Services, the VA, and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Applicants are encouraged to integrate and/or align their research projects with DOD and/or VA research laboratories and programs. Collaboration with DOD or VA investigators is also encouraged. A list of websites that may be useful in identifying additional information about ongoing DOD and VA areas of research interest or potential opportunities for collaboration can be found in Appendix IV.Rigor of Experimental Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Projects that include research on animal models are required to submit Attachment 8, Animal Research Plan, as part of the application package to describe how these standards will be addressed. Applicants should consult the ARRIVE guidelines 2.0 (Animal Research: Reporting In Vivo Experiments) to ensure relevant aspects of rigorous animal research are adequately planned for and, ultimately, reported. The ARRIVE guidelines 2.0 can be found at https://arriveguidelines.org/arrive-guidelines.The CDMRP expects to allot approximately $4.4M to fund approximately two MBRP Technology/Therapeutic Development Award applications. Funding of applications received is contingent upon the availability of federal funds for this program as well as the number of applications received, the quality and merit of the applications as evaluated by scientific and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.The funding instrument for awards made under the program announcement will be assistance agreements, contracts, or Other Transactions. The type of instrument used to reflect the business relationship between the organization and the government is at the discretion of the government, in accordance with the Federal Grant and Cooperative Agreement Act of 1977, as amended, 31 USC 6301-6308, which provides the legal criteria to select a procurement contract or an assistance agreement. The USAMRDC will also consider the use of Other Transactions (OTs) as a vehicle for award, in accordance with the conditions in 10 USC 4021 and 10 USC 4022.An assistance agreement can take the form of a grant or cooperative agreement. The level of government involvement during the projects period of performance is the key factor in determining whether to award a grant or cooperative agreement. If no substantial government involvement is anticipated, a grant will be made (31 USC 6304). Conversely, if substantial government involvement is anticipated, a cooperative agreement will be made (31 USC 6305). Substantial involvement means that members of the U.S. government will assist, guide, coordinate, or participate in project activities.A contract is required when the principal purpose of the instrument is to acquire property or services for the direct benefit or use of the U.S. government.An Other Transaction will also be considered as a vehicle for award under this BAA, in accordance with 10 USC 4021 and 10 USC 4022. The OT authorities were created to give DOD the flexibility necessary to adopt and incorporate business practices that reflect commercial industry standards and best practices into its award instruments. When leveraged appropriately, OTs provide the government with access to state-of-the-art technology solutions from traditional and non-traditional defense contractors (NDCs), through a multitude of potential teaming arrangements tailored to the particular project and the needs of the participants. OTs can help to foster new relationships and practices involving traditional and NDCs, especially those that may not be interested in entering into FAR-based contracts with the government; broaden the industrial base available to government; support dual-use projects; encourage flexible, quicker, and cheaper project design and execution; leverage commercial industry investment in technology development and partner with industry to ensure DOD requirements are incorporated into future technologies and products; and collaborate in innovative arrangements. OTs are not FAR-based procurement contracts, grants, cooperative agreements, or cooperative research and development agreements.The award type, along with the start date, will be determined during the negotiation process.The anticipated total costs budgeted for the entire period of performance for an FY24 MBRP Technology/Therapeutic Development Award should not exceed $2.2M. Refer to Section II.D.6, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025. For additional information refer to Section II.F.1, Federal Award Notices.

This grant provides funding for U.S. universities to conduct collaborative, basic research in science and engineering that addresses complex challenges relevant to national security.

This initiative provides up to $10 million in prizes to innovators developing advanced LED lighting solutions that improve energy efficiency, quality, and accessibility for commercial use.

This grant provides funding for U.S.-based organizations to conduct research and develop technologies for future planetary exploration by utilizing Earth-based environments that simulate conditions on other planets.

The Tourist Development Council Arts, Culture & Heritage (ACH) funding program, administered by the St. Johns Cultural Council, aims to bolster the economic impact of local tourism. Its core mission is to encourage exceptional arts, culture, and heritage programming while enhancing advertising and promotion for these tourism opportunities. This aligns with a broader strategy to position St. Johns County as a culturally rich and vibrant destination, utilizing a portion of the Tourist Development Tax to support relevant operations and promotions that specifically attract visitors. The program targets organizations and events within St. Johns County that are dedicated to arts, culture, or heritage and primarily seek to draw tourists. Beneficiaries include for-profit businesses, private institutions of higher education, and municipalities that are qualified to operate in Florida. The ultimate impact goal is to increase the positive economic contributions of tourism through cultural engagement. The ACH Grant Program prioritizes activities that attract visitors, evidenced by promotion to tourists. It offers two main funding options: "Out-of-Area Marketing Support" for existing, unchanged events or programs, and "Program and Marketing Support" for new or significantly improved programs/events. A significant focus is on marketing efforts that reach audiences outside St. Johns, Flagler, Putnam, Clay, Duval, and Nassau counties, with reimbursement based on the percentage of documented out-of-area reach. Expected outcomes include enhanced advertising and promotion of St. Johns County's cultural offerings, leading to a greater influx of tourists. Measurable results will likely be tied to the documented out-of-area reach of marketing campaigns and the overall increase in tourism-related economic activity within the county. The program's strategic priority is to leverage arts, culture, and heritage as key drivers for tourism, thereby contributing to the county's economic vitality.

The Department of Energys (DOE), National Nuclear Security Administrations (NNSA) Office of Defense Programs, directs research and development activities to maintain the safety, security, and effectiveness of the nations nuclear weapons stockpile. This nuclear deterrent remains a vital part of our national security infrastructure. It maintains strategic stability, deters potential adversaries, and reassures our allies and partners of our security commitments. Since 1992, the United States has observed the moratorium on underground nuclear testing while significantly decreasing the size of its nuclear arsenal. National Policy required NNSA and its weapons laboratories to institute the science-based Stockpile Stewardship Program (SSP) to ensure the safety, security, and effectiveness of the stockpile, while allowing the country to pursue a variety of nonproliferation and disarmament goals. The SSP combines sophisticated experiments, highly accurate physics modeling, and improved computational power to simulate and predict nuclear weapon performance over a wide range of conditions and scenarios. The Stewardship Science Academic Alliances (SSAA) Program was established in 2002 to support state-of-the-art research at U.S. academic institutions in areas of fundamental physical science and technology of relevance to the SSP mission. The SSAA Program provides the research experience necessary to maintain a cadre of trained scientists and engineers at U.S. universities to meet the nations current and future SSP needs, with a focus on those areas not supported by other federal agencies. It supports the DOE/NNSAs priorities both to address the workforce specific needs in science, technology, engineering, and mathematics and to support the next generation of professionals who will meet those needs. The Office of Defense Programs announce their interest in receiving applications for new or renewal financial assistance awards for research grants in the SSAA Program. Researchers seeking renewals of their current SSAA grant should apply to this NOFO. The research areas of interest in the SSAA Program for this announcement are properties of materials under extreme conditions and material processing, low energy nuclear science, and radiochemistry. Questions regarding the content of the announcement must be submitted through the FedConnect portal. You must register with FedConnect FedConnect - Gateway to Government Opportunities (test instance) to respond as an interested party to submit questions, and to view responses to questions. It is recommended that you register as soon after release of the NOFO as possible to have the benefit of all responses. DOE/NNSA will try to respond to a question within 3 business days unless a similar question and answer have already been posted on the website. All applications must be submitted through Grant.gov. Questions and comments concerning this NOFO shall be submitted not later than 5 calendar days prior to the application due date. Questions submitted after that date may not allow the Government sufficient time to respond. Questions relating to the registration process, system requirements, how an application form works, or the submittal process must be directed to Grants.gov at 1-800-518-4726 or support@grants.gov. DOE/NNSA cannot answer these questions. Name: Kristee Hall, Grants Management Specialist Via: https://www.fedconnect.net/FedConnect/default.htm SSAA Program Contact: Terri Stone via: terri.stone@nnsa.doe.gov