Grants for Small businesses - Science and Technology

This funding opportunity supports clinical trials aimed at improving the treatment and management of multiple sclerosis, targeting researchers and organizations focused on innovative therapeutic strategies for affected individuals, including Service Members and Veterans.

The FY24 DMDRP CTRA mechanism supports advanced translational research that will accelerate the movement of promising ideas in DMD research into clinical applications. Translational research may be defined as an integration of basic science and clinical observations. However, applicants should not view translational research as a one-way continuum from bench to bedside. The research plan must involve a reciprocal flow of ideas and information between applied and clinical research. As such, applications must include preliminary and/or published data relevant to DMD to support the proposed research project.This mechanism is intended to support established projects that have moved beyond the realm of basic research and proof of concept studies and have the potential to result in a near-term impact in clinical research or the clinic. Research projects investigating therapies that will be efficacious across the life span, including infants, toddlers, and non-ambulatory individuals, are strongly encouraged. Pilot, proof-of-principle clinical trials, and correlative studies to better inform development of drugs, devices, and other interventions are allowed.Early-Career Partnering PI Option: The FY24 DMDRP encourages applications that include meaningful and productive collaborations between investigators. In an effort to promote enhanced research capacity within the DMD field, the FY24 CTRA includes an option for an Early-Career Partnering Principal Investigator (PI). The Partnering PI Option is structured to accommodate two PIs. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The Early-Career PI will be identified as the Partnering PI. Both PIs should contribute significantly to the development and execution of the proposed research project. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PI, refer to Section II.D.2, Content and Form of the Application Submission.The FY24 DMDRP CTRA offers two funding levels (refer to Section II.D.5 Funding Restrictions). Only one funding level category may be chosen per application, and the choice of application category is at the discretion of the applicant. The following are generalized descriptions of the scope of the research appropriate for each funding level:Funding Level 1: Funding Level 1 is intended to support smaller, less complex preclinical and/or clinical research. Pilot clinical trials are allowed. The proposal/applications direct costs budgeted for the entire period of performance should not exceed $650,000.Funding Level 2: Funding Level 2 is intended to support larger, more complex preclinical and/or clinical research. Pilot clinical trials are allowed. The proposal/applications direct costs budgeted for the entire period of performance should not exceed $1.35M.Additionally, both funding levels will support an Early-Career Partnering PI Option at the same maximum direct costs and periods of performance, respectively.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Both pilot clinical trials and clinical research are permitted under this mechanism.A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.All investigators applying to FY24 DMDRP funding opportunities and conducting clinical research are encouraged to consult the Strategies to Promote Diversity in Muscular Dystrophy Research Participation developed by the MDCC.

This funding opportunity provides financial support for the design and operation of a facility that extracts and refines rare earth elements from unconventional sources, aimed at strengthening domestic supply chains and reducing reliance on foreign materials.

This funding opportunity provides $100,000 to established for-profit businesses in Cook County, Illinois, to support their growth through capital investments in workforce expansion, equipment, and facility upgrades.

This funding opportunity supports innovative research projects aimed at advancing the understanding and treatment of post-traumatic epilepsy, particularly for Service Members, Veterans, and their families.

The Oregon Community Foundation is offering a grant of $10,000 to $100,000 for projects that enhance economic vitality and workforce development in specified Oregon counties, with priority given to initiatives that improve prosperity, tax base, competitiveness, workforce skills, and image of the region, and can be used for equipment, facility upgrades, start-up costs, and other necessary services.

This funding opportunity provides financial support for research and management projects focused on conserving Chinook and Chum salmon in the Yukon River, with an emphasis on community engagement and capacity building among local residents.

This program provides financial assistance to small, independently owned businesses in Wakefield, Massachusetts, to help them enhance their digital marketing efforts and expand their online presence.

This grant provides funding for research and development projects aimed at improving the equipment and support systems for U.S. Army soldiers, focusing on enhancing their survivability, mobility, and overall effectiveness in the field.

This funding opportunity supports clinical research aimed at improving burn care for military personnel, focusing on practical applications that enhance treatment in challenging environments.

The "DoD Bone Marrow Failure, Investigator-Initiated Research Award" is a grant that provides two levels of funding: one for expanding mature research ideas and key discoveries in bone marrow failure, and another for supporting the development of new drugs for bone marrow failure treatment, with the ultimate goal of improving patient care and finding effective treatments and cures.

The National Bycatch Reduction Engineering Program (BREP) - FY2025 aims to fund innovative research and development projects that reduce bycatch of non-target species in fisheries, promoting sustainable practices and protecting marine ecosystems.

This grant provides financial support to non-profit organizations and local entities in Bergen County, New Jersey, to promote and preserve local history through various programs and projects.

The DoD Kidney Cancer, Academy of Kidney Cancer Investigators - Early-Career Scholar Award is a grant aimed at supporting early-career scholars in conducting kidney cancer research, providing them with funding, networking, and collaborative opportunities, and mentorship for a period of four years, with the ultimate goal of advancing kidney cancer research and developing highly productive kidney cancer researchers.

This funding opportunity supports innovative research and development in biological technologies that enhance national security, targeting universities, nonprofits, small businesses, and industry participants, particularly those with commercial potential.

This program provides essential financial support to small businesses in Pennsylvania that have been negatively affected by the COVID-19 pandemic, helping them access working capital to sustain their operations.

This program provides funding for innovative research in advanced technologies related to energy systems, robotics, and networked multi-agent systems, focusing on improving decision-making, resource allocation, and resilience in the face of uncertainty.

CDPs Foreign Assistance Leveraged for Cybersecurity Operational Needs FALCON project is intended to establish and maintain a reservoir of primarily commercial cybersecurity and technology capabilities that CDP can draw upon in short order and in a wide variety of situations to support U.S. allies and partners to effectively prevent, respond to, mitigate, and recover from cybersecurity incidents. The objective of the project is to support partner governments, their subordinate agencies and critical infrastructure operators and partners in their efforts to identify, prevent, respond to, mitigate and recover from cybersecurity incidents.

This funding opportunity provides financial support for research projects aimed at improving earthquake safety and preparedness across the United States, targeting a wide range of eligible applicants including universities, nonprofits, and local governments.

The PRMRP Investigator-Initiated Research Award (IIRA) supports fundamental research studies that will make an important contribution toward research, patient care, and/or quality of life for a disease or condition related to one of the FY24 PRMRP Topic Areas and one of the FY24 PRMRP Strategic Goals. This award mechanism is intended to support basic research that is exploratory in nature and seeks to further or validate preliminary findings for short- or long-term impact. Research projects may focus on any stage of basic laboratory research, ranging from fundamental research for the generation of knowledge, hypothesis, or models, to expansion of mature data.The rationale for a research idea may be derived from a laboratory discovery, population-based studies, a clinicians first-hand knowledge of patients, or anecdotal data. The project should include a well-formulated testable hypothesis based on existing evidence. Applications must include relevant preliminary data that support the rationale and feasibility for the proposed study. These data may be unpublished or from the published literature.This award mechanism is not intended to support translational research. Applicants seeking funding for projects that have progressed beyond the realm of basic research should consider one of the other FY24 PRMRP program announcements being offered. For information about these award mechanisms, see Section II.A.1, FY24 PRMRP Research Development Pipeline.