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Grants for Small businesses - Science and Technology

Explore 1,385 grant opportunities

Notice of Intent to Issue Infrastructure Investment and Jobs Act (IIJA): Mines and Metals Capacity Expansion Piloting By-Product Critical Minerals and Materials Recovery at Domestic Industrial Facilities
$50,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Dec 15, 2025

Date Added

Aug 14, 2025

This funding opportunity is designed to support domestic industrial facilities in recovering critical minerals and materials from byproducts, enhancing the U.S. supply chain and reducing reliance on foreign sources.

Energy
For profit organizations other than small businesses
NIJ FY25 Research and Evaluation for the Testing and Interpretation of Physical Evidence in Publicly Funded Forensic Laboratories
$1,500,000
U.S. Department of Justice (National Institute of Justice)
Federal

Application Deadline

Jun 3, 2026

Date Added

May 4, 2026

This funding opportunity provides financial support for research projects aimed at improving the testing and interpretation of physical evidence in publicly funded forensic laboratories across the United States.

Science and Technology
State governments
Microsystems Technology Office (MTO) Office-wide
$2,000,000
U.S. Department of Defense (DARPA - Microsystems Technology Office )
Federal

Application Deadline

Mar 2, 2026

Date Added

May 10, 2024

This funding opportunity supports innovative research in microsystems technology, targeting a wide range of applicants including universities, small businesses, and minority institutions, to develop advanced microelectronic systems that enhance U.S. national security.

Science and Technology
For profit organizations other than small businesses
Cognitive Terrain Flight Model Development
$250,000
U.S. Department of Defense (DoD)
Federal

Application Deadline

Not specified

Date Added

Feb 19, 2025

This funding opportunity is designed to support small businesses in developing advanced AI and machine learning technologies that enhance the safety and effectiveness of Army aviation operations in challenging terrain.

Science and Technology
Small businesses
Activate AI: Economic Opportunity Challenge
$115,000
data.org
Private

Application Deadline

Jan 8, 2026

Date Added

Dec 30, 2025

This grant provides funding and support to organizations worldwide that use artificial intelligence to create job opportunities, enhance workforce development, and promote climate resilience.

Employment Labor and Training
Nonprofits
Pennsylvania Technical Assistance Program (PennTAP)
Contact for amount
Pennsylvania Department of Community and Economic Development
State

Application Deadline

Not specified

Date Added

Mar 23, 2024

This program provides free technical assistance to small Pennsylvania businesses to help them improve their operations and competitiveness by connecting them with expert resources and solutions for specific technical challenges.

Science and Technology
Small businesses
Stimulate Utilization of Plentiful Energy in Rocks through High-temperature Original Technologies SBIR/STTR (SUPERHOT SBIR/STTR)
$4,505,859
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Mar 5, 2026

Date Added

Jan 29, 2026

This funding opportunity provides financial support to small businesses developing innovative technologies to harness superhot geothermal energy, aiming to create sustainable and cost-effective electricity generation systems.

Opportunity Zone Benefits
Small businesses
Vast x Explorers Club Grant
$25,000
Vast
Private

Application Deadline

Feb 15, 2026

Date Added

Dec 29, 2025

This grant provides funding to researchers and innovators focused on advancing human habitation in space, supporting projects related to life-support systems, habitat construction, space medicine, and psychological aspects of long-duration isolation.

Science and Technology
Individuals
North Sacramento Business Investment Program
$240,000
City of Sacramento
Local

Application Deadline

Not specified

Date Added

Feb 12, 2025

This program provides financial assistance to local businesses and property owners in North Sacramento to improve storefronts, purchase equipment, and restore vacant buildings, particularly those affected by the COVID-19 pandemic.

Business and Commerce
For profit organizations other than small businesses
BROAD AGENCY Announcement (BAA) FOR THE PROTECTION OF DEPLOYED MILITARY PERSONNEL FROM THREATS POSED BY ARTHROPOD DISEASE VECTORS
$975,000
DOD (Department of Defense)
Federal
Rolling

Application Deadline

Not specified

Date Added

Mar 8, 2024

07 March 2024 Update: Please see instructions for full proposal instructions and general submission instructions within the attached documents to this announcement.****CURRENTLY ACCEPTING WHITE PAPER SUBMISSIONS ONLY - DEADLINE FOR WHITE PAPER SUBMISSIONS is 12 DEC 2023*********The pre-proposal (a.k.a. white paper) form and submission instructions is available at the hyperlink below:https://www.acq.osd.mil/eie/afpmb/docs/dwfp/FY24_DWFP_Form.pdf.Applicants should follow the instructions in the pre-proposal form to complete both the form and a separate project summary slide (quad chart). The pre-proposal form and quad chart are submitted as two separate files and also as one combined file, for a total of 3 PDF files. Submissions are due to the AFPMB Webmaster no later than December 12, 2023 (11:59pm EDT). Late submissions will not be considered.Full details are available at related documents tab see downloadable PDF file entitled "BAA Version 1 dated 19 Oct 2023". Note: This document references 3 pages for a white paper/preproposal submission however this should instead reference 3 PDF files make up a preproposal/white paper submission.The U. S. Army Contracting Command, Aberdeen Proving Ground Edgewood Contracting Division, Fort Detrick, invites applications for funding opportunities for the Fiscal Year 2024 Deployed War Fighter Protection (DWFP) Research Program, renewable for up to 3 years, administered by the Armed Forces Pest Management Board (AFPMB). The AFPMB is soliciting pre-proposals for original, innovative research designed to develop new interventions to protect deployed U. S. Department of Defense (DoD) personnel from medically relevant pests, including arthropod disease vectors of mosquito-borne arboviruses and tick-borne pathogens, as well as fly-borne bacterial pathogens. The DWFP Program supports the development of: new toxicants or the adaptation of existing toxicants to medically relevant pests; new insecticide application techniques; new personal protection tools that prevent human-vector contact; new decision support tools; and new vector surveillance tools that focus on improving vector control outcomes. The proposed research should: support the Advanced Technology Development of new insecticides, or improved formulations of existing insecticides for vector control, new technology or enhanced modalities of personal protection from biting arthropods, or improved efficacy and sustainability of equipment for application of pesticides (for more information, see Budget Activity 3 in the DoD Financial Management Regulation Volume 2B, Chapter 5); be product-oriented, consisting of advanced research related to a particular technology or new capability, field evaluation of products, or research directed towards the development of an existing prototype product for commercialization; include semi-field or field evaluation of prototype products; be applicable for both military and civilian uses, including military operational environments with limited logistical support; focus on multiple target vectors; and outline a strategy for subsequent registration by the U. S. Environmental Protection Agency (EPA) for the development of products containing a pesticide(s).The program does not support: basic research; vector pathogen research; clinical, diagnostic, therapeutic or vaccine research in humans; testing to measure acute oral, dermal and/or inhalation toxicity; EPA registration costs; testing and evaluation of products previously registered with the EPA, unless they are being developed for a new use; testing and evaluation of commercial products, unless they are tested in comparison with prototype products; or manufacturing, packaging and production costs.Up to $4,500,000 may be awarded in FY24, with future years subject to the availability of funds. The total proposed cost cannot exceed $975,000, i.e. a maximum of $325,000 per year for up to 3 years, inclusive of all direct and indirect costs. Funding is intended to be provided during August-October 2024. Projects will be selected on the basis of peer-reviewed scientific merit and programmatic relevance. Pre-proposals will be accepted from investigators who are employed by or affiliated with an eligible institution. Eligible institutions include for-profit, non-profit, public, and private organizations. Examples include universities, hospitals, laboratories, companies, and agencies of local, state government. Federal Agencies may also respond to this request; however, federal submissions will be processed in accordance with applicable regulations. Funding for federal agencies is provided subject to an appropriate interagency agreement.The estimated timeline for the FY24 DWFP Program is as follows: December 12, 2023 Deadline for pre-proposal submissions Mid-January 2024 Invitation to submit full proposals Mid-March 2024 Deadline for full proposal submissions Late April/early May 2024 Notification of full proposal selections August/September 2024 Awards funded

Science and Technology
City or township governments
DoD Prostate Cancer, Clinical Consortium Award
$10,500,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Sep 2, 2025

Date Added

May 28, 2025

This grant provides funding to research institutions for collaborative clinical trials focused on innovative prostate cancer treatments, particularly targeting high-risk populations, including military personnel and veterans.

Health
Public and State controlled institutions of higher education
Arizona Innovation Challenge 2024
$100,000
Arizona Commerce Authority
Private

Application Deadline

Aug 30, 2024

Date Added

Aug 8, 2024

The Arizona Innovation Challenge (AIC) is the largest business plan competition in the country, designed to advance innovation and technology commercialization opportunities in Arizona. Its mission aligns with supporting early-stage ventures in scaling their operations. The program is specifically structured to identify and nurture promising startups, providing them with the resources and guidance necessary to grow and succeed within the state's innovation ecosystem. The primary goal is to foster a vibrant technology and entrepreneurial landscape in Arizona, contributing to economic development and job creation. The target beneficiaries of the AIC are early-stage technology companies and startups based in Arizona. The program aims to support ventures that demonstrate potential for innovation and commercialization, helping them overcome common challenges associated with early-stage development, such as securing funding and gaining market traction. The impact goals include increasing the number of successful technology companies in Arizona, enhancing the state's reputation as a hub for innovation, and ultimately generating significant economic value through new businesses and advanced technologies. The AIC prioritizes ventures that are innovative and have a clear path to commercialization, focusing on sectors that can drive economic growth and technological advancement in Arizona. The program offers a two-tiered support system: semifinalists gain access to Venture Raise, a twelve-week hybrid accelerator designed to prepare startups for funding. This initial phase focuses on refining business models, pitch development, and investor readiness. Following Venture Raise, ten finalists are awarded $100,000 and enter Venture Scale, a six-month accelerator. This advanced phase provides customized support and one-on-one matching with ACA Entrepreneurs-in-Residence, focusing on strategic growth, market penetration, and long-term sustainability. The expected outcomes include a higher success rate for participating startups, increased investment in Arizona's technology sector, and the creation of high-quality jobs. Measurable results are tied to the number of companies funded, the amount of follow-on investment secured by participants, and the sustained growth of businesses emerging from the program. The Arizona Commerce Authority's strategic priority through the AIC is to build a robust and competitive innovation economy. Their theory of change posits that by providing targeted financial awards, comprehensive accelerator programs, and expert mentorship, early-stage ventures can significantly de-risk their growth trajectory and achieve commercial success. This, in turn, creates a virtuous cycle of innovation, attracting further talent and investment to the state and solidifying Arizona's position as a leader in technology and entrepreneurship.

Business and Commerce
Small businesses
DoD Peer Reviewed Medical, Clinical Trial Award
$90,000,000
Department of Defense - Dept. of the Army -- U.S.AMRAA
Federal

Application Deadline

Aug 19, 2024

Date Added

Mar 27, 2024

The FY24 PRMRP Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of a disease or condition addressed in one of the congressionally directed FY24 PRMRP Topic Areas and FY24 PRMRP Strategic Goals. Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept trials (e.g., pilot, first in human, phase 0) to demonstrate the feasibility or inform the design of more advanced trials through large-scale phase 1 to phase 3 trials to determine efficacy in relevant patient populations.Applications from investigators within the military Services and applications involving multidisciplinary collaborations among academia, industry, the military Services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health.Funding from this award mechanism must support a clinical trial. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes. Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.

Science and Technology
Nonprofits
ROSES 2025: A.5 Earth Venture Suborbital-4 Snow4Flow Science Team
$5,000,000
National Aeronautics & Space Administration (NASA Headquarters)
Federal

Application Deadline

Sep 9, 2025

Date Added

Jul 12, 2025

This funding opportunity is designed for researchers and teams focused on improving our understanding of snow accumulation and ice flow dynamics in glaciers across the Northern Hemisphere, with an emphasis on airborne and ground-based observations, modeling, and data synthesis.

Environment
Public and State controlled institutions of higher education
COVID-19 ARPA Digital Connectivity Technology Program
$20,000,000
Pennsylvania Department of Community and Economic Development
State

Application Deadline

Dec 31, 2026

Date Added

May 15, 2024

This program provides funding for community organizations and local governments to acquire technology devices to help bridge the digital divide for those facing affordability challenges.

Health
City or township governments
Department of Army Energetics Basic Research Center (EBRC) Fiscal Year 2025
$500,000
U.S. Department of Defense (Dept of the Army -- Materiel Command)
Federal

Application Deadline

Apr 7, 2025

Date Added

Oct 1, 2024

This funding opportunity is designed to support research institutions and organizations in developing innovative energetic materials and methods to enhance the Army's capabilities in weapon systems and multi-domain operations.

Science and Technology
Public and State controlled institutions of higher education
Workforce and Business Development
$28,000,000
California Department of Forestry and Fire Protection
State
Rolling

Application Deadline

Not specified

Date Added

Sep 18, 2023

CAL FIRE's Wood Products and Bioenergy team seeks to maintain and enhance the wood products infrastructure of California to promote healthy resilient forests throughout the state by supporting a diverse set of business development and workforce development projects.  ; Eligible business development projects include facilities, operations, and professional services that support the restoration of healthy, resilient forests.   Eligible workforce development projects include universities, colleges, government and community organizations, and businesses that aim to increase workforce capacity in the fields of logging, fuels treatment, transportation, manufacturing, or other support services that bolster the development of a resilient forest sector workforce.   Research and development projects related to both business and workforce development will also be considered. Check out the Wood Products website and subscribe for updates.     

Diversity Equity and Inclusion
Small businesses
University Leadership Initiative (ULI)
Contact for amount
NASA-HQ (NASA Headquarters)
Federal

Application Deadline

May 29, 2024

Date Added

Mar 1, 2024

Amendment 2 to the NASA ARMD Research Opportunities in Aeronautics (ROA) 2024 NRA has been posted on the NSPIRES web site. University Leadership Initiative (ULI) provides the opportunity for university teams to exercise technical and organizational leadership in proposing unique technical challenges in aeronautics, defining multi-disciplinary solutions, establishing peer review mechanisms, and applying innovative teaming strategies to strengthen the research impact.Research proposals are sought in six ULI topic areas in Appendix D.4.Topic 1: Safe, Efficient Growth in Global Operations (Strategic Thrust 1)Topic 2: Innovation in Commercial High-Speed Aircraft (Strategic Thrust 2)Topic 3: Ultra-Efficient Subsonic Transports (Strategic Thrust 3) Topic 4: Safe, Quiet, and Affordable Vertical Lift Air Vehicles (Strategic Thrust 4)Topic 5: In-Time System-Wide Safety Assurance (Strategic Thrust 5)Topic 6: Assured Autonomy for Aviation Transformation (Strategic Thrust 6)This NRA will utilize a two-step proposal submission and evaluation process. The initial step is a short mandatory Step-A proposal due May 29, 2024. Those offerors submitting the most highly rated Step-A proposals will be invited to submit a Step-B proposal. All proposals must be submitted electronically through NSPIRES at https://nspires.nasaprs.com.An Applicants Workshop will be held on Thursday Apr 3, 2024; 1:00-3:00 p.m. ET (https://uli.arc.nasa.gov/applicants-workshops/workshop8).An interested partners list for this ULI is at https://uli.arc.nasa.gov/partners. To be listed as an interested lead or partner, please send electronic mail to hq-univpartnerships@mail.nasa.gov with "ULI Partnerships" in the subject line and include the information required for the table in that web page.

Science and Technology
Nonprofits
Spinal Cord Injury and Traumatic Brain Injury Research Grant Program - Tier 2 Standard Research Grant
$250,000
Minnesota Office of Higher Education
State

Application Deadline

May 22, 2024

Date Added

Apr 19, 2024

This grant option, part of the Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program, aims to support early-stage research into innovative treatments and rehabilitative techniques for spinal cord and traumatic brain injuries. The Tier 1 Pilot Project Grant does not require preliminary data but encourages it, reflecting early investment as researchers prepare to seek larger grants. The funding amount can reach up to $125,000 for a project duration of two years with an additional one-year no-cost extension.

Health
Nonprofits
Legacy Business Recovery Grant Program
$20,000
Economic & Workforce Development Department (EWDD)
Local

Application Deadline

Sep 15, 2024

Date Added

Aug 8, 2024

The Legacy Business Recovery Grant Program, funded by the American Rescue Plan Act (ARPA) allocation to the City of Los Angeles, offers grants of up to $20,000 to eligible Legacy Businesses. This initiative is designed to provide crucial financial assistance to aid these businesses in their recovery from the economic impacts of the COVID-19 pandemic. The program's core mission aligns with broader efforts to support local economies and preserve established community businesses, recognizing their historical and cultural value. It underscores a commitment to helping businesses adapt, reopen, and sustain operations in a challenging economic landscape. The primary beneficiaries of this program are Legacy Businesses listed on the Legacy Business Registry, operating within Los Angeles city limits, and functioning from commercial, industrial, or manufacturing locations with a valid commercial lease. Home-based businesses are not eligible, and annual revenue cannot exceed $3 million. The impact goal is to facilitate the recovery and continued operation of these vital businesses, ensuring their survival and contribution to the local economy and community fabric. Businesses must demonstrate how the funds will be used for COVID-19 recovery expenses, with a focus on necessary expenditures. Funding priorities emphasize equitable distribution across finalists, with a particular focus on City of Los Angeles geographic diversity and low-to-moderate income neighborhoods. Grant application submissions from businesses located in or owned by individuals in low- and moderate-income communities (50% and 80% of Area Median Income as defined by HUD) are more heavily weighted, as are businesses facing an imminent threat of displacement. This weighted selection process reflects a strategic priority to support businesses in areas with greater need and vulnerability, aligning with a theory of change that targeted investment can produce more equitable and impactful recovery outcomes. Expected outcomes include the sustained operation of Legacy Businesses, job retention, and economic stabilization within affected communities. Measurable results will be tied to how grant funds are utilized, with eligible uses encompassing employee payroll, rent, utilities, insurance, working capital for reopening or continued operations, adapting to new technologies, payment of outstanding business expenses incurred after March 3, 2021, adaptive business practices, and legal fees for lease negotiations. Grant amounts are tiered based on employee count: $10,000 for businesses with one to five employees and $20,000 for those with six or more. This structure ensures that assistance is tailored to the operational scale of the businesses, contributing to their effective recovery and resilience.

Business and Commerce
Small businesses