Science and Technology Grants

The purpose of the RRTCs, which are funded through the Disability and Rehabilitation Research Projects and Centers Program, is to achieve the goals of, and improve the effectiveness of, services authorized under the Rehabilitation Act through well-designed research, training, technical assistance, and dissemination activities in important topical areas as specified by NIDILRR. These activities are designed to benefit people with disabilities, family members, rehabilitation service providers, policymakers and other research stakeholders. The purpose of this particular RRTC is to conduct research, training, technical assistance, and related activities to contribute to improved health and function among people with physical disabilities. NIDILRR plans to make one grant under this opportunity. The grant will have a 60-month project period, with five 12-month budget periods.

This is a Request for Information (RFI) only. This RFI is not accepting applications for financial assistance. The purpose of this RFI is solely to solicit input for ARPA-E consideration to inform the possible formulation of future programs. The purpose of this Request for Information (RFI) is to solicit input for a potential ARPA-E program focused on leveraging material, process, equipment, and cross-supply chain manufacturing innovations to catalyze domestic production of cathode active materials (CAMs) and their precursors (pCAMs). Most commercial lithium-ion batteries employ graphite anodes and layered transition metal oxide cathodes. CAMs can account for approximately 50% of total battery cost, while CAM chemistry determines overall battery performance and safety.5 To date, commercial cell-level energy densities exceeding 280 watt-hour per kilogram (Wh/kg) are achievable in batteries where NMC is used as the CAM in combination with a graphite anode.6 Recent optimization efforts have focused on innovations in chemistry to decrease cobalt content and increase nickel content thus simultaneously increasing energy density and reducing cost. Moreover, significant government and private sector research funding has been allocated to develop alternative lithium-based battery chemistries. Thus far, LFP is the most commercially successful nickel-free and cobalt-free cathode to be developed with notable attributes in cost, safety, and cycle life. Recent gains in market share suggest that LFP batteries may become the dominant chemistry for compact, economy EVs, while NMC is likely to continue to be the preferred cathode chemistry for vehicles where torque response and range are priorities. To view the RFI in its entirety, please visit https://arpa-e-foa.energy.gov.

This grant invites government, academic, and industry collaborators to propose innovative research projects that enhance air warfare and weapons technology for the Navy and Marine Corps.

The project seeks to support engagement with target / priority countries in, at, and around UN fora and events to support responsible, inclusive, and rights-respecting development, deployment, use, and governance of AI technologies. The project will seek to leverage existing work underway in the UN system and with partner countries, including but not limited to UNESCOs Recommendation on the Ethics of AI, Readiness Assessment Methodology (RAM), and Ethical Impact Assessment (EIA); Office of the United Nations High Commissioner for Human Rights (OHCHR) initiatives such as B-Tech; International Telecommunication Unions (ITU) AI for Good Global Summit; United Nations Development Programmes (UNDP) readiness assessment initiative; and USAIDs activities on AI capacity building, including support for the Global Index on Responsible AI.

The City of Arlington is offering grants to public and non-profit agencies for projects that foster economic development and tourism within the city. This grant program aims to enhance the local economy and promote Arlington as a desirable destination. The funding available for these grants is $175,000, and awards will be allocated proportionally based on application scores, with higher-scoring projects receiving a larger share of the total funding. The primary beneficiaries of this grant are public and non-profit agencies that can demonstrate projects promoting economic growth and tourism. The impact goals are centered around increasing tourism, supporting local events, and improving tourism-related facilities. This will ultimately benefit the City of Arlington by boosting its economy and improving the quality of life for its residents through enhanced amenities and attractions. The program prioritizes several key areas for funding. These include tourism marketing initiatives, the marketing and operations of special events and festivals, the operation of tourism-related facilities owned by non-profit organizations, and the operations and capital expenditures of tourism-related facilities owned by municipalities. These focus areas are designed to directly contribute to the program's overarching goals of economic development and tourism promotion. Expected outcomes include a measurable increase in tourism activity, successful execution of special events and festivals, and the improved operation or development of tourism-related infrastructure. While specific measurable results are not explicitly detailed beyond the proportional funding allocation based on points, the requirement for a 25% project cost match indicates a commitment to projects with significant investment and potential for impact. Applicants are expected to provide details that will allow for the evaluation of the proposed project's benefits.

The DoD Breast Cancer, Clinical Research Extension Award aims to enhance the impact of breast cancer clinical studies by extending or expanding data collection, follow-up, and analysis, with a focus on deeper molecular analysis, biomarker validation, and patient follow-up, while encouraging collaboration between investigators and involving breast cancer consumer advocates, with a budget not exceeding $5M for single PI applications or $6M for Partnering PI applications.

The Era of Hope Scholar Award supports individuals early in their careers who have demonstrated significant potential to effect meaningful change in breast cancer. These individuals should be exceptionally talented scientists who have shown that they are the best and brightest in their field(s) through extraordinary creativity, vision, innovation, and productivity. They should have demonstrated experience in forming effective partnerships and collaborations and must exhibit strong potential for future leadership in breast cancer research.As the intent of the Era of Hope Scholar Award is to recognize creative and innovative individuals rather than projects, the central features of the award are the demonstrated ability of the individual named as the Principal Investigator (PI) in the application to go beyond conventional thinking in their field and the innovative contribution that the PI can make toward ending breast cancer. The application should articulate a vision that challenges current dogma and demonstrates an ability to look beyond tradition and convention.Experience in breast cancer research is not required; however, the application must focus on breast cancer, and the PI must commit a minimum of 25% level of time and effort during the period of performance to conduct breast cancer research under this award. Individuals from other disciplines who apply novel concepts to breast cancer are encouraged to submit.The PI is encouraged to assemble a research team that will provide the necessary expertise and collaborative efforts toward accomplishing the research goals. The PIs research team must include two or more breast cancer consumer advocates. As lay representatives, the consumer advocates must be individuals who have been diagnosed with breast cancer and are actively involved in a breast cancer advocacy organization. Their role should be independent of their employment, and they may not be employees of any organizations participating in the application. The consumer advocates should have a high level of knowledge of current breast cancer issues and the appropriate background and/or training in breast cancer research to contribute to the project. Their role should be focused on providing objective input throughout the research effort and its potential impact for individuals with, or at risk for, breast cancer.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 BCRP priorities.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women’s health outcomes and/or advancing knowledge for women’s health.The proposed research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public. Collaborations between researchers at military or Veteran institutions and non-military institutions are strongly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the partners bring to the research effort, ultimately advancing cancer research that is of significance to the Warfighter, military Families, and the American public.Clinical trials are allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated direct costs budgeted for the entire period of performance for an FY24 Era of Hope Scholar Award should not exceed $3.5M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $5.4M to fund approximately one Era of Hope Scholar Award application. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

This funding opportunity supports projects that enhance the preservation and accessibility of humanities collections, particularly those addressing challenges like technological obsolescence and climate change impacts.

The Asheville Area Arts Council's Arts for Schools grant program aims to provide in-school arts programming for students attending economically disadvantaged schools in Buncombe County and the City of Asheville K-12 public school system. This initiative aligns with the foundation's mission to support arts education and ensure access to enriching artistic experiences for all students, particularly those in underserved communities. For a limited time, the program also extends support to arts-focused after-school and camp programs, demonstrating a broader commitment to arts accessibility outside of traditional school hours. The target beneficiaries of this grant are K-12 students in Buncombe County and City of Asheville public schools, with a specific focus on those attending economically disadvantaged schools. The program seeks to impact students by providing free arts-focused performances, workshops, residencies, and field trips. The ultimate goal is to enhance arts education and foster artistic engagement among students who might otherwise lack such opportunities due to economic barriers. The extension to after-school and camp programs further broadens the reach and potential impact on youth development through the arts. The program prioritizes applicants located in Buncombe County for at least one year and requires them to be either a 501c3 nonprofit arts organization or a qualified teaching artist. Qualified teaching artists must possess a BA or BFA in their specific art form, or equivalent training and experience, along with at least five years of experience in arts education. All programs must serve students in Buncombe County or City of Asheville K-12 public schools, be free for students and schools, and align with North Carolina’s Common Core curriculum and Essential Standards. These criteria ensure that the funding supports high-quality, accessible, and educationally relevant arts programming. Expected outcomes include an increase in arts participation and appreciation among students, improved access to arts education in economically disadvantaged schools, and the development of artistic skills and creative thinking. Measurable results for in-school programs range from $500-$2,000, and for out-of-school programs, from $500-$5,000. Programs must take place between July 1, 2024, and June 30, 2025. For in-school programs, a school partnership agreement form is required. For out-of-school programs, applicants are ineligible if they already receive funding for the proposed arts-focused program from Dogwood Health Trust’s WNC After 3pm initiative. For camps, only 501c3 nonprofit arts organizations may apply. The Asheville Area Arts Council's strategic priorities are centered on fostering a vibrant arts community and ensuring equitable access to arts education. Their theory of change posits that by investing in arts programming for students, particularly in underserved areas, they can contribute to positive educational outcomes, personal development, and community enrichment. The emphasis on qualified artists and alignment with educational standards underscores their commitment to effective and impactful arts interventions. This grant program is a direct manifestation of their belief in the transformative power of the arts for young people.

The Seeds of Sustainability Grant Program, offered by the Western New York Foundation, aims to bolster nonprofit organizations working within the food system. This program aligns with the foundation's mission by supporting efforts to improve organizational capacity and drive transformative work. Through this initiative, the foundation seeks to empower nonprofits to achieve their objectives and contribute to a more sustainable and resilient food system in the region. The target beneficiaries of this grant program are small to mid-size nonprofit organizations with budgets between $100,000 and $6,000,000, operating within Allegany, Cattaraugus, Chautauqua, Erie, Genesee, Niagara, and Wyoming counties in New York. The program's impact goals center on enhancing the operational effectiveness and sustainable growth of these organizations. It seeks to equip them with the necessary skills, knowledge, and resources to amplify their impact on local and regional food systems. The program prioritizes several key areas to achieve its objectives. These include supporting strategic leadership development, fostering collaboration among community stakeholders, strengthening communication efforts to raise awareness and attract resources, expanding resources to stabilize financials, promoting programming excellence, and enhancing overall operational effectiveness. These focuses are designed to address the multifaceted needs of nonprofits and build a robust foundation for long-term success. Expected outcomes and measurable results include improved board and staff leadership, stronger community engagement and expanded services through collaborative efforts, increased awareness and resource attraction due to enhanced communications, greater financial stability and long-term sustainability, more effective program delivery and evaluation, and improved day-to-day operational productivity in areas such as administration, grant management, finance, human resources, technology, and facility management. The foundation's strategic priorities and theory of change are evident in its commitment to capacity building, believing that by strengthening the internal capabilities of nonprofits, they can more effectively drive transformative change in the food system. To be eligible, applicants must be 501(c)(3) tax-exempt nonprofit organizations, demonstrate a commitment to transformative change in the food system, and have three years of 990 filings. The program's detailed approach, from leadership support to operational enhancements, reflects the Western New York Foundation's comprehensive strategy for fostering sustainable growth and impactful work within the vital food sector of the region.

The POISE Foundation's Community Impact Grants are designed to support the Black community in achieving self-sustaining practices through strategic leadership, collective giving, grantmaking, and advocacy. This aligns directly with the foundation's mission to empower and uplift the Black community. The program offers small grants, typically between $1,000-$5,000, to nonprofit organizations in the Pittsburgh Region. These grants are generally for one-year durations and are specifically targeted at Black-led, Black-serving organizations. The target beneficiaries of these grants are nonprofit organizations serving the Black community in the Pittsburgh Region, with a focus on programs that lead to empowerment and self-sufficiency. The impact goals are broad, aiming to foster pathways from poverty to prosperity, advance educational achievement, create and develop Black businesses, support the well-being of young ladies, and strengthen Black families. This is achieved by investing in programs that build capacity, engage in civic participation, make decisions, and advocate for the well-being of Black communities and residents. The program prioritizes several key areas: Community & Economic Development, Education, Entrepreneurial Activities, Young Ladies, and Strengthening Black Families. Within these areas, there's a strong focus on community engagement, understanding issues, and promoting economic, social, environmental, political, and psychological well-being. For Strengthening Black Families, specific priorities include being family-driven, building family development, increasing family interaction, being culturally responsive, assisting with support networks, providing advocacy tools, and promoting family healing and wellness. Expected outcomes include increased civic participation, improved educational achievement for Black youth, growth in Black businesses and cooperatives, enhanced well-being for young ladies, and the restoration of the Black family as a core, thriving institution in Pittsburgh. While specific measurable results are not explicitly detailed in terms of quantifiable metrics, the foundation's theory of change is evident in its investment in programs that provide direct services and seek to bring about change that leads to empowerment and self-sufficiency within the Black community. The preference for Black-led organizations further demonstrates their strategic priority of empowering community-driven solutions.

This grant provides funding for research and development of advanced technologies in military communications, information operations, and cybersecurity, targeting organizations and researchers focused on enhancing defense capabilities.

This program provides funding to federally recognized Tribal Colleges and Universities, Alaska Native-serving institutions, and Native Hawaiian-serving institutions to improve STEM education, research capacity, and community outreach.

The Community Funds, managed by the Grand Traverse Regional Community Foundation (GTRCF), are designed to broadly support the region by funding a diverse array of organizations, including environmental nonprofits, arts and culture groups, Tribal organizations, and educational institutions. This program aligns with the GTRCF's mission to strengthen the community by providing financial resources to a wide range of initiatives that address various needs and opportunities within its service area. The foundation aims to foster a vibrant and thriving community by empowering organizations that contribute to the region's overall well-being. The target beneficiaries for these grants include nonprofit, educational, governmental, and Tribal entities operating across Antrim, Benzie, Grand Traverse, Kalkaska, and Leelanau Counties in Michigan. The impact goals are to support projects that have a significant community benefit, can leverage other funding sources, and ultimately contribute to the region's development. The program encourages organizations to apply for amounts ranging from $1,000 to $30,000, with a total of $300,000 available for Community Funds grants in 2024, indicating a commitment to flexible and accessible funding. A key priority for the GTRCF in this grant program is to provide unrestricted general operating support, allowing recipient organizations the flexibility to allocate funds where they are most needed. Furthermore, consideration is given to grant awards that can demonstrate a larger impact for the grant partner and the community. Grant requests that are informed by data on the Community Development Regional Scorecard or address community issues highlighted on this scorecard are prioritized in the review process. This strategic focus ensures that funding is directed towards evidence-based needs and initiatives that are aligned with documented regional challenges and opportunities. The expected outcomes include strengthened community organizations, significant community benefits, and the ability of grant partners to leverage additional funding. By prioritizing data-informed requests and those addressing issues on the Community Development Regional Scorecard, the GTRCF aims for measurable results that contribute to tangible improvements in the region. This approach reflects the foundation's strategic priorities, which likely involve a theory of change centered on empowering local organizations to drive positive change and address critical community issues through targeted and impactful investments.

The Western New York Foundation’s Impact Capacity Assessment Program Core (iCAP Core) is a tailored program specifically designed for emerging and smaller nonprofits in the region. Its primary objective is to provide a comprehensive understanding of capacity building and its influence on both internal and external facets of these organizations. This aligns directly with the foundation's mission to foster effective organizations, which are defined as those that fulfill their mission through sound management, strong governance, and a persistent rededication to assessing and achieving results. The iCAP Core program is a 6-month initiative aimed at addressing the complexities of capacity-related opportunities and challenges, reflecting the foundation's strategic priority to invest in organizational development. The target beneficiaries of the iCAP Core program are non-profit organizations that have obtained tax-exempt status under Section 501(c)(3) or are fiscally sponsored, have been in operation for at least two years with at least $50,000 in annual revenue, and are specifically food system, arts and culture, or rural organizations. These organizations must be headquartered within the seven counties of Western New York: Allegany, Cattaraugus, Chautauqua, Erie, Genesee, Niagara, and Wyoming. The impact goals are to strengthen leadership, enhance board effectiveness, improve overall organizational development, and create a sustainable capacity-building plan. The program prioritizes several key elements. A significant focus is placed on leadership, specifically the relationship between the Executive Director and Board Chair, providing one-on-one consultation and coaching to strengthen their skills and vision. Board training is another core priority, equipping members with knowledge for effective governance, strategic decision-making, and resource mobilization. Comprehensive organizational development covers a wide array of areas including leadership structure, financial management, fundraising, communications, marketing, and IT systems. Expected outcomes include enhanced leadership skills, a more informed and skilled board, improved organizational infrastructure across various functions, and the creation of a detailed 1 to 2-year organizational capacity-building plan with actionable goals and progress measurements. Measurable results will be derived from the implementation and assessment of this capacity-building plan, which will also inform future foundation investment in the organizations' capacity development. A $10,000 stipend is provided to offset administrative expenses during iCAP, further supporting the participating nonprofits in achieving these outcomes.

The DoD Breast Cancer, Transformative Breast Cancer Consortium Development Award is a funding opportunity aimed at providing resources to establish a multi-institutional research team, including scientists, clinicians, and breast cancer advocates, to conduct preliminary research and develop a consortium framework for future application to a full Transformative Breast Cancer Consortium Award, with a focus on innovative research for early diagnosis and effective treatment of breast cancer relevant to active-duty Service Members, Veterans, military beneficiaries, and the American public.

The Piper Fellows program, funded by the Virginia G. Piper Charitable Trust, is designed to support and revitalize nonprofit leaders. This initiative directly aligns with the foundation's mission by acknowledging the demanding nature of nonprofit leadership and offering opportunities for professional development. The program provides up to six fellowship awards annually, each offering up to $30,000 for professional development to outstanding leaders of nonprofit 501(c)(3) organizations. This direct investment in leadership aims to strengthen the nonprofit sector within Maricopa County, Arizona, which is a key strategic priority for the Piper Charitable Trust. The primary target beneficiaries are experienced leaders of nonprofit organizations serving Maricopa County, specifically those that have been operating for a minimum of 10 years in critical sectors such as human services, health, education, arts and culture, or religious organizations. The impact goal is to enhance the professional capabilities of these leaders, thereby strengthening their organizations and ultimately improving the quality and reach of services provided to the community. By fostering individual growth, the program seeks to create a ripple effect that benefits the wider community served by these organizations. The program prioritizes a personalized approach to professional development, encouraging Fellows to design their own plans that can include educational programs, visits to model sites, and meetings with leaders across the nation. This focus on tailored development ensures that the learning is relevant and impactful for each individual and their organization. Additionally, the fellowship includes a $10,000 grant for staff and board development within the Fellow's organization, and eligibility for an Organizational Enhancement Award of up to $50,000 after fellowship completion. These additional grants underscore the foundation's commitment to holistic organizational improvement alongside individual leadership development. Expected outcomes include enhanced leadership skills, improved organizational management, and increased capacity for innovation within participating nonprofits. Measurable results would be reflected in the successful completion of professional development plans, the effective utilization of staff and board development grants, and the successful application and implementation of Organizational Enhancement Awards. The foundation's theory of change posits that by investing in the professional growth and organizational capacity of established nonprofit leaders, they can foster more resilient, effective, and impactful organizations that better address the needs of Maricopa County residents. The program emphasizes that continued employment of the Fellow is crucial for the grant-related awards, ensuring the investment benefits the organization long-term.

The van Ameringen Foundation focuses on improving mental health services, particularly for those with limited financial means, within New York City and Philadelphia, and through national advocacy. Its mission is to increase accessibility to mental health services, offer preventive and early-intervention strategies, and advocate for systemic change. The foundation offers both general support and project-specific grants, aligning its funding directly with its core mission of fostering a more equitable and effective mental healthcare system for underserved populations. The primary beneficiaries of these grants are individuals and communities confronting significant mental illness, particularly those with limited financial means and opportunities. This includes people needing direct services like case management, counseling, psychotherapy, and psychiatric care, as well as those who benefit from systemic changes in law, public policy, and public perception. The impact goals are to enhance the mental health safety net, improve access to services, and create lasting, positive changes in mental healthcare delivery and perceptions. The foundation's priorities and focuses are clearly delineated into two main categories: Direct Service Grants and Non-Direct Service Grants. Direct Service Grants support programs that provide immediate and tangible assistance to individuals, such as housing, jobs, and various forms of mental health treatment. Non-Direct Service Grants encompass advocacy efforts to change policies, media/dissemination projects to share best practices and research, and training initiatives for mental health providers, advocates, and community members. The foundation explicitly does not fund programs for intellectual or physical disabilities, direct grants to individuals, endowment campaigns, capital projects, annual fundraising drives, or international activities. Expected outcomes include increased accessibility of mental health services, successful implementation of preventive and early-intervention strategies, and significant systemic changes with local or national impact. Measurable results could include the number of individuals served, improvements in patient outcomes, policy changes enacted, increased public awareness, and the number of mental health professionals trained. The foundation encourages innovative and practical proposals that demonstrate a clear path to achieving these outcomes. The foundation's strategic priorities are centered on fostering innovation and practical solutions within the mental health sector. Its theory of change posits that by investing in direct services, advocating for policy reforms, disseminating knowledge, and building capacity through training, it can effectively address disparities in mental healthcare access and quality. This multi-pronged approach aims to create both immediate relief for individuals and long-term structural improvements in the mental health landscape, primarily within its specified geographic areas and at a national advocacy level.

LIGHT intends to shine a light on the lymphatic system, illuminating the unseen both literally via novel diagnostic approaches and figuratively through insight gained into the critical role the lymphatic system plays in health as well as its impacts when dysfunctional. LIGHT aims to improve the lives of tens of millions of Americans by creating agile tools that are scalable, accessible, accurate and clinically useful to detect lymphatic structure and function. Multiple diagnostic technologies will enable targeted interventions that result in better patient outcomes and reduced treatment costs, and will advance our understanding of lymphatic dysfunction, a key factor in the pathophysiology of many important diseases. Signs and symptoms of lymphatic dysfunction do not manifest until the disease has progressed, and current assessment tools neither adequately appraise lymphatic anatomy nor measure lymphatic function. The Government reserves the right to select for negotiation all, some, one, or none of the proposals received in response to this ISO. If warranted, portions of resulting awards may be segregated into prepriced options. In the event the Government desires to award only portions of a proposal, negotiations will commence upon selection notification. The Government reserves the right to fund proposals in phases with options for continued work, as applicable. The Government reserves the right to request any additional, necessary documentation to support the negotiation and award process. The Government reserves the right to remove a proposal from award consideration should the parties fail to reach agreement on award terms, conditions, cost, and/or if the proposer fails to provide requested additional information in a timely manner. In all cases, the Government will have sole discretion to negotiate all instrument terms and conditions with selectees. ARPA-H will apply publication or other restrictions, as necessary, if it is determined that the research resulting from the proposed effort will present a high likelihood of disclosing sensitive information including Personally Identifiable Information (PII), Protected Health Information (PHI), financial records, proprietary data, any information marked Sensitive but Unclassified (SBU), etc. Any award resulting from such a determination will include a requirement for ARPA-H concurrence before publishing any information or results on the effort. ARPA-H seeks proposals from all eligible entities (see Section 2 Eligibility Information) to accomplish the LIGHT Program goals as described in this solicitation package. Ultimately, ARPA-H intends to negotiate multiple Other Transaction agreements (OTs) and/or Cooperative Agreements (CAs) with proposers whose proposals are most advantageous to the Government and are poised to meet the goals of the LIGHT program. Proposals are expected to use innovative approaches that may include both existing and novel technology, enabling revolutionary advances in medicine and healthcare. The LIGHT program aims to develop a comprehensive diagnostic toolkit to assess lymphatic structure and function, and potential performers should consider an approach to ensure the final technology includes an imaging modality plus biomarkers and/or genetic integration. Initially proposers should consider primary lymphatic 5 diseases as the targeted disease state; however, consideration of other chronic conditions associated with lymphatic dysfunction is encouraged. Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art, including clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

The Impact 100 Ozark grant program seeks to provide transformational grants to organizations serving eastern Christian County, Missouri. The foundation's mission is deeply aligned with this program, aiming to empower women to significantly improve community lives through generosity and by funding impactful grants. This strategic approach ensures that the grants have a lasting positive effect within the specified geographic area, reflecting Impact 100 Ozark's commitment to community betterment through focused financial support. The target beneficiaries for these grants are 501(c)3 organizations or other IRS-approved entities, including government entities, school districts, and churches, that specifically serve the eastern Christian County area. The primary impact goal is to fund significant initiatives that dramatically improve lives. While not explicitly stated as a "theory of change," the foundation's approach suggests that by empowering local organizations with substantial funding, they can address critical community needs and foster sustainable improvements. The program prioritizes proposals that avoid funding day-to-day operations, scholarships, or the start-up of new nonprofit agencies, indicating a focus on established organizations and projects with a clear, transformative scope. This ensures that the grants are directed towards initiatives that can create a significant, rather than incremental, impact. The available funding includes two grants totaling $49,000, with one grant of $35,000 and another of $14,000, underscoring the "significant grants" aspect of their mission. Expected outcomes and measurable results are inherent in the program's design, aiming for "lasting impact." While specific metrics are not detailed in the provided information, the emphasis on "transformational grants" implies a desire for substantial and demonstrable change within the community. The foundation's strategic priority is clearly to harness generosity to fund these impactful projects, thereby improving the lives of individuals and families in eastern Christian County.