Science and Technology Grants

The FY 2024 Multicultural Summer Youth Employment Program (SYEP) is a grant initiative by the Executive Office of Mayor Muriel Bowser and the Mayor’s Office on Latino Affairs (MOLA). This program seeks applications from qualified Community-Based Organizations (CBOs) serving the District of Columbia’s Latino Youth community. The core mission of this grant is to provide meaningful and structured summer experiences and career readiness opportunities for District of Columbia youth aged 14-24, aligning with MOLA’s commitment to empowering the Latino community through impactful programs. The primary beneficiaries of this grant are Latino youth residents in the District of Columbia, specifically those between the ages of 14 and 24. The impact goal is to foster career readiness and provide valuable summer experiences that contribute to their overall development and future success. The program aims to achieve significant, lasting change by engaging youth in activities that enhance their well-being and prepare them for future opportunities. The grant prioritizes six key areas: Downtown Comeback, Public Safety, Recreation & All Students on Pathways to Success, Workforce Development, Highlight East of the River, and More Democracy. These priorities reflect the broader strategic goals of the District of Columbia, focusing on urban revitalization, violence reduction, comprehensive youth development, economic empowerment, equitable investment in underserved communities, and civic engagement. Organizations applying for the grant must demonstrate how their proposed services align with at least one of these critical areas. Expected outcomes include increased participation of Latino youth in structured summer programs, enhanced career readiness skills, and improved engagement in community-based initiatives aligned with the funding priorities. The grant's duration is less than one year, with a project period from June 17, 2024, to August 23, 2024. Eligible organizations can receive up to $15,000, which is intended to facilitate the provision of direct services and programming within the District of Columbia. MOLA's theory of change is rooted in the belief that investing in youth, particularly through structured employment and development programs, leads to stronger individuals and more vibrant communities. To be eligible, CBOs must have a Federal 501(c)(3) tax-exempt status, be licensed in the District of Columbia, have their principal place of business in the District, and provide direct services to District residents. Additionally, applicants must be in good standing with the Department of Licensing and Consumer Protection (DLCP) and the Office of Tax and Revenue (OTR), and current grantees must be current on MOAA reporting obligations and reflect substantial progress towards their grant agreement goals. This rigorous eligibility ensures that funds are directed to reputable organizations capable of delivering impactful programs.

This grant aims to assist businesses in Goshen County to diversify and enhance their online presence, a critical factor due to the growing importance of e-commerce post-COVID-19. Funding covers website creation, e-commerce platform set-up, app creation, POS system upgrades necessary for e-commerce integration, and other related online business development tools. Projects require multiple bids and give preference to local contractors. Deadlines: Applications due first Friday of November, February, May, August

The Alachua County Small Farmer Grant Program is a mini-grant initiative funded by the County Commission, designed to support Alachua County-based small farms and ranches. The program aims to promote local food system economic resilience and equity, particularly for marginalized communities. This grant differs from traditional reimbursement models by offering an immediate infusion of funds upon award, recognizing that small producers may lack the immediate cash flow for capital equipment. The total funding available for this mini-grant is approximately $100,000, with individual grant requests not exceeding $5,000. The primary target beneficiaries are small producers (farms, ranches, or other agricultural operations) within Alachua County that produce foodstuffs for human consumption and have annual gross cash income between $1,000 and $250,000. There is a strong prioritization for small producers with an annual gross cash income of no more than $75,000. Furthermore, the program specifically prioritizes black, women, indigenous, and persons-of-color owned agricultural operations, aligning with broader goals of economic equity and community support. The program's key priorities and focuses include assisting Alachua County residents and supporting the immediate acquisition of capital infrastructure and equipment. This direct funding approach is intended to enhance the farm's productive capability and financial expansion, addressing a critical need for small producers who may struggle with upfront costs. The grant is not a cost reimbursement grant, emphasizing its role in providing immediate financial support. Expected outcomes and measurable results revolve around improving the economic viability of these small producers and increasing the resiliency of local food production. The program also aims to expand the production of related value-added farm products. Ultimately, these efforts are designed to achieve the Board's policies related to economic development, specifically by increasing economic prosperity, economic equity, and fostering a diverse tax base within Alachua County.

The Maryland Department of Housing and Community Development (DHCD) provides the Main Street Improvement Program (MIP) Grant, designed to bolster community revitalization and economic development in Maryland's designated and affiliate Main Street communities, as well as Baltimore City's designated Main Street neighborhoods. This program aligns with the DHCD's broader mission of fostering sustainable communities throughout the state by building local capacity and supporting initiatives that contribute to economic growth and community well-being. The grants aim to empower these communities to achieve their strategic goals, as outlined in their annual work plans, directly contributing to the transformation strategies of these areas. The target beneficiaries of the MIP Grant are the 34 designated and 9 affiliate Main Street Maryland communities, along with 8 Baltimore City's designated Main Street neighborhoods. The impact goals are centered on improving business districts, supporting local businesses, and enhancing the overall vitality of these communities. By providing financial assistance, the program seeks to facilitate a range of activities that will lead to tangible improvements and sustainable growth within these designated areas. The foundation's strategic priorities are evident in its focus on supporting established Main Street programs, recognizing their proven framework for community development. The program prioritizes activities that have been identified in the applicant's work plans as key to their Main Street efforts. Eligible activities are broad and include staff and consultant services, general operating expenses, market and business recruitment strategies, street furniture, advertising, and façade improvements. This flexibility ensures that communities can address their unique needs and challenges. The grants are intended to directly support the goals and outcomes of annual work plans and contribute to the community's transformation strategy. All projects and activities funded are expected to be completed within one year, encouraging timely and efficient implementation. Expected outcomes include enhanced business districts, increased economic activity, improved community aesthetics, and strengthened organizational capacity within the Main Street programs. While specific measurable results like job creation numbers or increased sales figures are not explicitly detailed as requirements for this summary, the allocation of funds to specific Main Street categories ($25,000 for Designated Main Street Maryland Communities, $10,000 for Main Street Maryland Affiliates, and $8,000 for Baltimore City Main Street Neighborhoods) provides a clear framework for resource distribution. The absence of a funding match requirement further facilitates access for eligible communities, simplifying the application and implementation process and accelerating their progress towards revitalization goals.

This is a competitive renewal, supporting a single Collaborative Action Program to Reduce Liver Cancer Mortality in Texas: Collaborative Action Center (CAP:CAC). • A competitive renewal application will address the expansion of administrative services, resources, and support to funded hepatocellular carcinoma research projects along with strong justification for the continuation of the FY19.2 CAP:CAC award. • Applicants may request a maximum of $3,000,000 in total costs for a period of 5 years. • Multi-Principal Investigators (MIs) are allowed under this Request for Applications (RFA). See the Information for Applicants (IFA) document for definition and eligibility of MIs. • See application limitations for Principal Investigators (PIs)/MIs, regardless of whether the MI is from the prime institution or a subcontracted institution. • Note that CPRIT does not allow the use of the term Co-PI. • Minimum effort for the PI and/or MIs throughout the project period is required. • FY25 salary cap is $225,000 per year. • Competitive renewals are not subject to preliminary evaluation. Renewal applications move directly to the full peer review phase.

The Golden LEAF Foundation's Open Grants Program is designed to strengthen North Carolina's economy, particularly in tobacco-dependent, economically distressed, and/or rural communities. This program aligns directly with the foundation's mission to use its entrusted funds for projects with the highest potential for economic impact. The grants, ranging from $100,000 to $500,000, are available to governmental entities and 501(c)(3) nonprofit organizations across all North Carolina counties. The program targets communities and organizations capable of driving economic development in three priority areas: Job Creation and Economic Investment, Workforce Preparedness, and Agriculture. The impact goals are to foster economic growth and create opportunities in these specific sectors, ultimately benefiting the residents and businesses within the designated communities. The foundation's strategic priority is to invest in projects that demonstrate a clear potential for strengthening the state's economy. Competitive projects are those that seek funds to develop new workforce training programs, implement career pathways in high schools for high-demand fields, extend infrastructure to enable industrial development and job creation, or support new crops, expand agricultural markets, and provide farmer training. These focuses reflect the foundation's theory of change, which posits that targeted investments in these areas will lead to measurable economic improvements. While most awards are expected to be $200,000 or less, projects eligible for grants over $200,000 must demonstrate additional outcomes commensurate with the increased funding, result from multi-organizational planning with continued community engagement, build on a history of success to scale projects, be collaborative with innovative or regional features, leverage significant funding from other organizations, or be from applicants with limited resources where phased implementation would compromise outcomes. The expected outcomes are the creation of full-time jobs, enhanced workforce skills, improved agricultural practices, and overall economic revitalization in North Carolina.

The Maryland Agricultural Education and Rural Development Assistance Fund (MAERDAF) provides grants to rural-serving nonprofit organizations, as well as rural community colleges, that promote statewide and regional planning, economic and community development, and agricultural and forestry education. The core mission of this program is to increase the overall capacity of these organizations and community colleges to address a wide array of rural development challenges. A key aspect of the fund's strategy is to help these entities establish new public/private partnerships, which are crucial for leveraging non-state sources of funding and ensuring long-term sustainability. The Rural Maryland Council (RMC) serves as the administrative agency for this grant, managing applications and disbursing funds. The target beneficiaries of MAERDAF are rural-serving nonprofit organizations and rural community colleges. These entities work with communities across Maryland's state-determined rural counties, including Allegany, Calvert, Caroline, Carroll, Cecil, Charles, Dorchester, Frederick, Garrett, Harford, Kent, Queen Anne’s, St. Mary’s, Somerset, Talbot, Washington, Wicomico, and Worcester. The overarching impact goal is to strengthen rural Maryland through enhanced education, economic opportunities, and community development. By supporting organizations that directly serve these areas, MAERDAF aims to foster a more resilient and prosperous rural landscape. For Fiscal Year 2025, the RMC has outlined several key priority areas for applications. These include Agriculture & Forestry (Agricultural Education, Regional Food System Development, Forest Industry Development), Energy (Combined Heat Power, Energy Efficiency, Biomass), Rural Broadband (Rural Broadband Expansion Efforts, Digital Inclusion Programs), Youth Engagement & Leadership Development (Career Technology Centers, Youth Enrichment Programs), Economic Development (Entrepreneurship Ecosystem Development, Education & Workforce Development, Regional Marketing Efforts & Tourism Projects), and Community Development (Rural Transportation, Housing repairs, Housing counseling, Poverty Alleviation Efforts). These focus areas reflect the most pressing needs and strategic opportunities for rural growth and improvement in Maryland. The expected outcomes and measurable results from MAERDAF grants are multifaceted, aiming for tangible improvements in rural areas. Projects are expected to contribute to the growth of agricultural and forestry sectors, increase energy efficiency, expand rural broadband access, and enhance youth engagement and leadership. In economic development, anticipated outcomes include the creation of entrepreneurship ecosystems, improved workforce development, and increased regional tourism. Community development efforts are designed to result in better rural transportation, improved housing conditions, and a reduction in poverty. While specific metrics are not detailed in the provided information, the focus on these clear outcome areas indicates an expectation of measurable progress in each. MAERDAF's strategic priorities are deeply aligned with a theory of change that posits that by empowering and funding rural-serving organizations and community colleges, a ripple effect of positive development will occur. The funding, budgeted at $878,964 for Fiscal Year 2025 with a maximum grant amount of $45,000, is intended to build the capacity of these local entities. The encouragement of new public/private partnerships further demonstrates a belief that diversified funding and collaborative efforts are essential for long-term impact. The emphasis on a broad range of development areas reflects a holistic approach to rural well-being, recognizing the interconnectedness of agriculture, education, economy, and community health.

The Arc Fund, an initiative by CultureSource, is a $1.5 million grant program designed to support culture-workers of color in Southeast Michigan. Its core mission aligns with addressing historical disadvantages, underrepresentation, and oppression faced by these professionals due to their race. The fund aims to spur growth and provide opportunities for career advancement, contributing to a more equitable and vibrant arts and culture ecosystem in the region. The program specifically targets culture-workers of color living and working full-time in Livingston, Macomb, Monroe, Oakland, St. Clair, Washtenaw, and Wayne counties in Southeast Michigan. Eligible beneficiaries include arts administrators, artists, arts organizers, curators, and arts programmers whose primary professional focus is advancing arts and culture in the region. The impact goal is to empower these individuals to make significant career leaps, fostering professional development and reducing financial or other obligations that limit their flexibility and growth. The Arc Fund prioritizes individuals prepared to invest in new skills, pursue novel artistic endeavors, or address financial burdens that hinder their career trajectory. It focuses on providing unrestricted awards, professional development experiences, and social networking opportunities. This comprehensive approach reflects a strategic priority to not only offer financial support but also to build capacity and community among culture-workers of color. The expected outcomes include the distribution of 74 unrestricted awards of $15,000 each, enabling recipients to fund various aspects of their professional growth. Measurable results will likely involve tracking the number of awards distributed, the engagement in professional development, and the overall career advancement reported by the awardees. While a formal theory of change is not explicitly detailed, the initiative implicitly operates on the theory that targeted financial support, skill-building, and networking will directly counter historical inequities, leading to significant career progression and a more inclusive cultural landscape.

The Priddy Foundation seeks grant applications to bolster programs in human services, education, the arts, and health, all with a significant focus on fostering individual development and community improvement. This aligns directly with the foundation's mission to create lasting and favorable impact on individuals and organizations. The foundation offers various types of grants, including Program Grants for expanding services, Operating Grants with an emphasis on achieving self-sufficiency, Capital Grants for buildings and equipment, and Organizational Development Support Grants to enhance organizational capacity. The overall goal is to support initiatives that address identified problems and opportunities, and that are sustainable beyond the grant period. Target beneficiaries for these grants span a wide range, as the foundation supports programs in human services, education, arts, and health. This implies a focus on individuals and communities benefiting from improved access to these essential services. The impact goals are centered on individual development and community improvement, aiming for measurable positive change. For instance, program requests are expected to deal effectively with identified problems and opportunities, and organizations should be able to evaluate results against defined standards of measurement. For operating grants, a practicable plan to achieve self-sufficiency is often required, demonstrating a long-term impact objective. The foundation's priorities and focus areas are clearly delineated, encompassing Arts and Culture, Civic/Government, Education, Health, Human Services, Other, and Youth. Within these areas, there's a strong interest in requests that create or expand program services, enhance organizational capacity, and support capital projects that have broad community backing. Geographically, the foundation concentrates on specific counties in Texas (Archer, Baylor, Childress, Clay, Cottle, Foard, Hardeman, Haskell, Jack, King, Knox, Montague, Stonewall, Throckmorton, Wichita, Wilbarger, Wise, and Young) and Oklahoma (Comanche, Cotton, Jackson, Jefferson, Stephens, and Tillman). Expected outcomes and measurable results are integral to the Priddy Foundation's grantmaking. Program grants require organizations to evaluate results against defined standards, and organizational development grants mandate a comprehensive plan with clear linkages between leadership development and the ability to achieve and sustain the organization's mission effectively. For capital grants, organizations must attain their fundraising goal and document sufficient funds to complete the project before funding. This reflects the foundation's strategic priority to invest in initiatives that demonstrate clear objectives, a plan for execution, and a mechanism for accountability and impact measurement. The foundation's theory of change emphasizes empowering organizations to achieve greater effectiveness and self-sufficiency, ultimately leading to enhanced individual and community well-being in its target regions.

This grant provides financial support to Texas law enforcement agencies for collaborative efforts to combat motor vehicle crimes, including theft and fraud, through targeted enforcement and prevention strategies.

The DOE SC program in Advanced Scientific Computing Research (ASCR) hereby announces its interest in basic computer science and applied mathematics research in the fundamentals of Artificial Intelligence (AI) for science. Specifically, advancements in this area are sought that can enable the development of: Foundation models for computational science; Automated scientific workflows and laboratories; Scientific programming and scientific-knowledge-management systems; Federated and privacy-preserving training for foundation and other AI models for science; and Energy-efficient AI algorithms and hardware for science. The development of new AI techniques applicable to multiple scientific domains can accelerate progress, increase transparency, and open new areas of exploration across the scientific enterprise. SUPPLEMENTARY INFORMATION AI is one of the most powerful technologies of our time[1] and DOE is at the forefront of research and development in AI technologies for enabling scientific discovery and innovation. Core components of the scientific method remain unchanged: Observation, Hypothesis, Experiments, and Analysis. However, DOE recognizes that abundant sources of data, high-performance computing (HPC) and networking, energy-efficient algorithms, and AI-related technologies can be harnessed to significantly accelerate and expand the impact of scientific research. The breadth of applications spans climate science, cybersecurity and electric grid resilience, biotechnology, microelectronics, disaster response, and beyond. Research to address national priorities will require advances and AI innovations in high-level capabilities such as: monitoring and predicting the onset of real-world anomalies and extreme events; adaptive strategies to control the real-time behavior of complex systems, infrastructure, and processes; approaches for the optimal development and design of physical systems; decision-support for planning, risk, and policy formulation; and tools that synthesize scientific knowledge and accelerate the design, manufacturing, testing, and optimization of new technologies. The focus of ASCR research and development investments is on the underlying approaches for AI-enhanced scientific and engineering capabilities and to significantly transform the scientific method for accelerated discovery and innovation. Realizing the next generation of AI for science will require innovations in both hardware and algorithms. Future AI-enabled scientific workflows are expected to use Machine Learning (ML) to enhance numerical modeling and data analysis along with technologies that process natural and computer-programming languages. DOEs exascale supercomputers[2] are some of the Nations most powerful systems for large-scale AI training and for tasks integrating AI, modeling, simulation, and data analysis. These exascale and future systems complement the vast array of other AI-enabled HPC and edge systems, including automated laboratories and facilities, that will significantly accelerate scientific progress in the coming decades. DOEs scientific community has collectively articulated important research directions toward realizing the promise of AI for science and other DOE missions in the recently-released AI For Science, Energy, and Security report [1], building on the preceding AI for Science report [2], and complementing the report on Opportunities and Challenges from Artificial Intelligence and Machine Learning for the Advancement of Science, Technology, and the Office of Science Missions [3]. The research directions highlighted in these reports, and others, appear prominently in the National Artificial Intelligence Research and Development Strategic Plan [4]. This FOA addresses a broad spectrum of research priorities described in these documents that are critical to enabling trustworthy AI for scientific applications advancing human understanding and addressing national needs. [1] For additional background on the promise and importance of AI R, see the OMB/OSTP Memorandum on Multi-Agency Research and Development Priorities for the FY 2025 Budget (August 2023) https://www.whitehouse.gov/wp-content/uploads/2023/08/FY2025-OMB-OSTP-RD-Budget-Priorities-Memo.pdf, and the Executive Order on the Safe, Secure, and Trustworthy Development and Use of Artificial Intelligence (October 2023) https://www.whitehouse.gov/briefing-room/presidential-actions/2023/10/30/executive-order-on-the-safe-secure-and-trustworthy-development-and-use-of-artificial-intelligence/ [2] For more information on ASCRs exascale supercomputers, and other HPC resources, available as national user facilities, see https://science.osti.gov/ascr/Facilities/User-Facilities

Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at sara@nasa.gov, but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

The O’Connor Fund for Historic Preservation, established in 2000 by Pam and Terry O’Connor, is administered by the City of Kalamazoo to support historic preservation activities within the city. Its core mission aligns with the Kalamazoo Historic Preservation Commission (KHPC)'s goals, aiming to safeguard and enhance Kalamazoo's historical resources. The fund provides grants between $2,000 and $10,000 to eligible projects that contribute to the preservation of buildings, areas, and other resources more than 50 years old. The primary beneficiaries of this grant program are 501(c)(3) or other non-profit organizations, public agencies, and governmental units operating within the city of Kalamazoo that own historic properties. The impact goals are centered on fostering a vibrant historical landscape, ensuring the longevity of significant structures, and promoting an understanding of the city's heritage. The fund seeks to prevent dilapidation, encourage respectful rehabilitation, and support comprehensive planning efforts that contribute to the overall historic preservation strategy of Kalamazoo. The fund prioritizes projects that fall into two main categories: Rehabilitation Projects and Preservation Planning Projects. Rehabilitation projects focus on the physical restoration and repair of exterior components of historic resources, including roofs, chimneys, walls, windows, doors, fire escapes, elevators, and foundations. Preservation Planning Projects encompass a broader range of activities such as Economic Feasibility Studies, Historic Building Condition Reports, architectural rehabilitation plans, historic district study reports, under-represented communities surveys, and designation nominations. All projects must be carried out or supervised by qualified professionals. Expected outcomes include the successful preservation and rehabilitation of historic structures, the creation of robust preservation plans, and increased community engagement with Kalamazoo’s historical assets. Measurable results could include the number of historic properties successfully rehabilitated, the completion of planning documents that inform future preservation efforts, and the designation of new historic sites or districts. The fund's strategic priorities are deeply integrated with the KHPC Annual Work Plan, goals and plans of Imagine Kalamazoo, Kalamazoo County Housing Plan, and the Michigan Statewide Historic Preservation Plan, signifying a comprehensive approach to historic preservation as a component of broader community development and cultural enrichment.

United Way of Dane County is offering 2025-2026 Impact Grants, an open and competitive funding opportunity for organizations working in Youth Opportunity, Financial Security, and Healthy Communities. This grant program is deeply aligned with United Way of Dane County’s Plan for Community Well-Being, which seeks to measurably increase individual and family well-being in Dane County, ensuring every person leads a healthy, thriving, and secure life unimpacted by systemic racism, discrimination, and poverty. The total investment available is approximately $2-$3 million, with minimum awards of $15,000 per year for a two-year funding cycle (January 1, 2025 – December 31, 2026), contingent on Campaign results. The target beneficiaries of these grants are individuals and families in Dane County, particularly those impacted by systemic racism, discrimination, and poverty. The impact goals are centered on fostering healthy, thriving, and secure lives for all residents. United Way of Dane County is looking to support organizations whose work aligns with their collective vision and demonstrates the greatest potential for impact in helping to achieve these community goals. The program's priorities and focuses are clearly defined through a multi-generational approach. This includes engaging in sustainable, long-term work on systems change with a clear focus on youth opportunity, financial security, and healthy communities. Furthermore, the grants emphasize modeling equitable, anti-racist practices across all aspects of work, including investments, partnerships, innovation, public policy advocacy, data and research, and connection to resources. Another key priority is cultivating a stronger nonprofit ecosystem through trust-based collaborations to drive positive community change. Expected outcomes include a measurable increase in individual and family well-being throughout Dane County. This involves supporting organizations that directly contribute to the defined goals of the Plan for Community Well-Being, ultimately aiming for a community where experiences of systemic racism, discrimination, and poverty no longer impact a person's ability to lead a healthy, thriving, and secure life. The foundation's strategic priorities and theory of change are rooted in a holistic approach to community well-being, focusing on systemic change and equitable practices to achieve lasting positive impact.

The Community Foundation of Greater Greensboro is offering its Economic Mobility Grant Program, aligning with its mission to foster a strong economic foundation for residents. The foundation is committed to funding organizations that focus on key areas designed to promote economic stability and advancement within Guilford County. This grant program is a direct reflection of the foundation's strategic priority to advance economic mobility. The target beneficiaries of this program are residents of Guilford County who require support to become economically mobile. The impact goals are to support organizations whose work encompasses workforce development and education, small business and entrepreneurship, and access to workforce housing. By investing in these areas, the foundation aims to create a more equitable and opportunity-rich environment for individuals and families in the community. The program's priorities and focuses are clearly defined. Priority is given to grant proposals that concentrate on long-term strategies to advance and sustain economic mobility in Guilford County. This emphasizes a commitment to lasting change rather than short-term fixes. While the description doesn't explicitly state expected outcomes and measurable results in a quantitative sense, the focus on "long-term strategies to advance and sustain economic mobility" implies a desire for measurable improvements in employment rates, business creation, and access to affordable housing as indirect outcomes. The foundation's strategic priorities and theory of change are centered on the belief that a strong economic foundation is crucial for residents to achieve economic mobility. By funding organizations engaged in workforce development, supporting small businesses, and ensuring access to housing, the foundation seeks to address systemic barriers to economic progress. The consideration of board and staff diversity and total operating budget in the grantmaking process also highlights a commitment to equity and inclusivity in achieving its goals, demonstrating a holistic approach to community development.

It is the policy of my Administration to advance womens health research, close health disparities, and ensure that the gains we make in research laboratories are translated into real-world clinical benefits for women. It is also the policy of my Administration to ensure that women have access to high-quality, evidence-based health care and to improve health outcomes for women across their lifespans and throughout the country. President Joseph R. Biden, Jr., Executive Order 14120 on Advancing Womens Health Research and Innovation, 18 March 2024.In support of the Presidents Executive Order to advance womens health research, the PRORP is releasing this WHRA funding opportunity. The intent of the FY24 PRORP WHRA is to support research focused on orthopaedic issues faced by women serving in military settings, such as infantry and other physically demanding roles, who have sustained orthopaedic injuries. The overall goal of the WHRA is to address factors that contribute to the health and retention of women in military service. Although use of military populations, datasets, or samples are not required, the application should demonstrate how the proposed research relates to issues faced by women serving in military settings. The proposed research project should also include a well-formulated, testable hypothesis based on sound scientific rationale and logical reasoning.Although the PRORP is interested in supporting military-focused research, research supported by the PRORP is expected to also apply to all individuals who have sustained a major orthopaedic injury.The PRORP encourages applications from a spectrum of research areas, including but not limited to translational and clinical research. The PRORP also welcomes qualitative research, population science, and health care services research specifically designed to understand the impact of orthopaedic injuries on female Service Members.With the initiation of the Arthritis Research Program, the FY24 PRORP may not fund arthritis research; however, research that addresses conditions or health abnormalities related to arthritis is permitted provided the proposed research addresses the PRORP WHRAs focus on orthopaedic injuries in women.A key feature of the PRORP WHRA is the relevance to female military and/or Veteran populations following orthopaedic injury. Inclusion of female military and/or Veteran populations is highly encouraged for applications proposing clinical research. Applicants proposing clinical studies in non-military and/or non-Veteran populations must justify the relevance of the proposed research to the military and/or Veteran communities. All applicants should clearly describe how their study design, including recruitment strategies and access to appropriate populations, as applicable, will enable them to meet this intent.Research involving human subjects, human datasets, and human anatomical substances is permitted; however, the WHRA may not be used to conduct clinical trials. Applicants seeking support for a clinical trial should consider the FY24 PRORP Clinical Trial Award (Funding Opportunity Number HT942524PRORPCTA).Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.Rigor of Experimental Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Projects that include research on animal models are required to submit Attachment 7, Animal Research Plan, as part of the application package to describe how these standards will be addressed. Applicants should consult the ARRIVE guidelines 2.0 (Animal Research: Reporting In Vivo Experiments) to ensure relevant aspects of rigorous animal research are adequately planned for and, ultimately, reported. The ARRIVE guidelines 2.0 can be found at https://arriveguidelines.org/arrive-guidelines.Encouraged Department of Defense (DOD) and/or VA Collaboration: Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the VA, and other federal government agencies are encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated total costs budgeted for the entire period of performance for an FY24 PRORP WHRA should not exceed $1.5M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $3.0M to fund approximately two WHRA applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

Orthopaedic injuries have a profound impact on military readiness and return to work/activity/duty. In the military, extremity battle wounds comprise approximately 50% of injuries reported in the Department of Defense Trauma Registry. Additionally, orthopaedic injuries and conditions that occur outside of combat (e.g., during training, leisure activities, resultant from old injuries) present one of the greatest threats to the readiness of our Service Members and military. Early stabilization, treatment, and rehabilitation of orthopaedic injuries in both civilian and military populations have led to better outcomes, particularly in the prevention of secondary complications and in minimizing morbidity. Availability of orthopaedic care and treatment as early as possible, or as close to the point of injury as possible, also minimizes limb loss and affects military readiness.Although the PRORP is interested in supporting military-focused research, research supported by the PRORP is expected to also apply to all individuals who have sustained a major orthopaedic injury.With the initiation of the Arthritis Research Program, the FY24 PRORP may not fund arthritis research; however, research that addresses conditions or health abnormalities related to arthritis is permitted provided the proposed research addresses the selected Focus Area.The PRORP CTA supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of military combat or service-related orthopaedic injuries that significantly impact unit readiness and return-to-duty/work rates. Applicants are encouraged to address how the proposed research will support patient care closer to the point of injury and/or allow patients to more quickly return to duty/work. Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept trials (e.g., pilot, first-in-human, phase 0) to demonstrate the feasibility or inform the design of more advanced trials, through large-scale trials to determine efficacy in relevant patient populations.The FY24 PRORP CTA differs from the FY24 PRORP Clinical Translational Research Award (CTRA) in that the CTRA allows for clinical research projects that may or may not include a clinical trial, whereas the CTA is restricted to clinical trials only.Funding from this award mechanism must support a clinical trial and may not be used for animal or preclinical studies. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.All applications submitted to this program announcement, regardless of the selected Focus Area, are eligible for Research Level 1.Collaborative Care Option (Research Level 2): Applications submitted to the FY24 PRORP CTA, with Focus Area Translation of Early Findings Soft Tissue Trauma, are eligible for a Collaborative Care Option (Research Level 2); refer to Section II.D.5, Funding Restrictions. The Collaborative Care Option provides additional support to encourage collaborative interdisciplinary research among physical therapists, occupational therapists, prosthetists, surgeons, and other orthopaedic care providers. The proposed research should include both surgical and rehabilitation strategies that create a cohesive project. Surgical strategies are reconstruction and repair and/or application of biologics, pharmaceuticals, and devices for the purpose of restoration of native architecture, composition, and function of traumatically injured tissues. Rehabilitative strategies are those that restore function following injury or illness, with the goal of optimal health and independence. Projects should integrate principles and approaches from surgical and rehabilitative strategies, beyond what each approach would provide by itself, with the goal of optimizing form, function, and independence for those who have sustained traumatic orthopaedic injuries. The rehabilitation strategy and the standard of care must be specified. Projects that follow patients across the continuum of care are highly encouraged. To encourage meaningful and productive multidisciplinary collaborations, projects submitted for this option must include at least one investigator with orthopaedic rehabilitation expertise and at least one clinician who specializes in orthopaedic or trauma care. A Letter of Collaboration is required from each specialist (i.e., rehabilitation expert and surgeon) who is serving as Key Personnel, excluding the Principal Investigator (PI), on the application. A clinician is defined as an individual who is credentialed (possesses the necessary degrees, licenses, and other certifications) and practicing as a care provider in a relevant capacity.If the proposed research includes a clinical trial of an investigational product to be conducted at international sites, an application to the relevant national Regulatory Agency of each host country must be submitted within 6 months of the award date.The government reserves the right to withdraw funding if an Investigational New Drug (IND) or Investigational Device Exemption (IDE) application and/or international regulatory application is necessary but has not been submitted within 6 months of the award date.For more information, a Human Subject Resource Document is provided at https://cdmrp.health.mil/pubs/pdf/Human%20Subjects%20Resource%20Document_DEC2022.pdf.Key aspects of the PRORP CTA mechanism: Clinical Trial Start Date: The proposed clinical trial is expected to begin no later than 6 months after the award date, or 12 months after the award date for studies regulated by the Regulatory Agency. Preliminary Data Are Required: Inclusion of preliminary data relevant to the proposed clinical trial is required. Study Population: The application should demonstrate the availability of and access to a suitable patient population that will support a meaningful outcome for the study. The application should include a discussion of how accrual goals will be achieved, as well as the strategy for inclusion of women and minorities in the clinical trial appropriate to the objectives of the study. Studies utilizing human biospecimens or datasets that cannot be linked to a specific individual, gender, ethnicity, or race (typically classified as exempt from Institutional Review Board [IRB] review) are exempt from this requirement. Intervention Availability: The application should demonstrate the documented availability of and access to the drug/compound, device, and/or other materials needed, as appropriate, for the proposed duration of the study. Personnel and Environment: The application should demonstrate the study teams expertise and experience in all aspects of conducting clinical trials, including appropriate statistical analysis, knowledge of U.S. Food and Drug Administration (FDA) processes (if applicable), and data management. The application should include a study coordinator(s) who will guide the clinical protocol through the local IRB of record and other federal agency regulatory approval processes, coordinate activities from all sites participating in the trial, and coordinate participant accrual. The application should show strong institutional support and, if applicable, a commitment to serve as the FDA regulatory sponsor, ensuring all sponsor responsibilities described in 21 CFR 312, Subpart D, are fulfilled. Statistical Analysis and Data Management Plans: The application should include a clearly articulated statistical analysis plan, a power analysis reflecting sample size projections that will answer the objectives of the study, and a data management plan that includes use of an appropriate database to safeguard and maintain the integrity of the data. If required by a Regulatory Agency, the trial must use a 21 CFR 11-compliant database and appropriate data standards.Womens Health Research: The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health.Use of DOD or VA Resources: If the proposed research involves access to DOD or VA resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Refer to Section II.D.2.b.ii, Full Application Submission Components, for detailed information. Refer to the General Application Instructions, Appendix 1, for additional information.For the purposes of this funding opportunity, Regulatory Agency refers to the FDA or any relevant international Regulatory Agency unless otherwise noted.If the proposed clinical trial involves the use of a drug that has not been approved by the relevant Regulatory Agency for the country where the research will be conducted, then submission of an IND application, or equivalent, that meets all requirements under 21 CFR 312 may be required. It is the responsibility of the applicant to provide evidence from the IRB of record or the relevant Regulatory Agency if an IND, or equivalent, is not required. If an IND, or equivalent, is required, the regulatory application must be submitted to the relevant Regulatory Agency within 6 months of the CTA award start date. The IND, or equivalent, should be specific for the product and indication to be tested in the proposed clinical trial. For more information on IND applications specifically, the FDA has provided guidance at https://www.fda.gov/drugs/types-applications/investigational-new-drug-ind-application.If the investigational product is a device, then submission of an IDE, or equivalent, application that meets all requirements under 21 CFR 812 may be required. It is the responsibility of the applicant to provide evidence if an IDE, or equivalent, is not required. If an IDE, or equivalent, is required, the IDE application, or equivalent, must be submitted to the relevant Regulatory Agency within 6 months of the CTA award start date. The IDE, or equivalent, should be specific for the device and indication to be tested in the proposed clinical trial.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated total costs budgeted for the entire period of performance for an FY24 PRORP CTA should not exceed $2.5M (Research Level 1) or $3.25M (Research Level 2). Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $13.25M to fund approximately four Research Level 1 and one Research Level 2 CTA applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

Priority Program Areas: A successful proposal will include a robust calendar of activities through serial programming spanning at least two months and directly address at least one of the three key programming areas: Digital Policy, STEM Education and Workforce Development: Programming to expand understanding of emerging technologies and digital policy challenges such as cybersecurity, Intellectual Property Rights, artificial intelligence, fintech, and quantum computing, as well as initiatives to expand technical and soft skills through participatory and interactive workshops on STEM fields, digital trade, digital arts, gaming, and related business practices for online activities for SMEs and/or use of the existing makerspaces at the American Centers. Climate Solutions, Health Security and Sustainability: Programming to achieve measurable goals to improve environmental protection and preservation, climate change adaptation, pollution reduction, renewable energy, climate-smart agriculture, transboundary water challenges, clean energy, and health security and public health preparedness. Information Literacy and Research Skills: Workshops to build critical thinking skills to find, evaluate, organize, use, and communicate information in all its various formats, including through the use of data, digital media, and AI, and develop audiences ability to conduct research and evaluate and use information responsibly and ethically using American Spaces databases and open education resources.

Orthopaedic injuries have a profound impact on military readiness and return to work/activity/duty. In the military, extremity battle wounds comprise approximately 50% of injuries reported in the Department of Defense Trauma Registry. Additionally, orthopaedic injuries and conditions that occur outside of combat (e.g., during training, leisure activities, resultant from old injuries, etc.) present one of the greatest threats to the readiness of our Service Members and military. Early stabilization, treatment, and rehabilitation of orthopaedic injuries in both civilian and military populations have led to better outcomes, particularly in the prevention of secondary complications and in minimizing morbidity. Availability of orthopaedic care and treatment as early as possible, or as close to the point of injury as possible, also minimizes limb loss and affects military readiness.Although the PRORP is interested in supporting military-focused research, research supported by the PRORP is expected to also apply to all individuals who have sustained a major orthopaedic injury.With the initiation of the Arthritis Research Program, the FY24 PRORP may not fund arthritis research; however, research that addresses conditions or health abnormalities related to arthritis is permitted provided the proposed research addresses the selected Focus Area.The FY24 PRORP ARA seeks applied research applications focused on advancing optimal treatment and restoration of function for individuals with orthopaedic injuries sustained during combat and service-related activities. Applicants are encouraged to address how the proposed research will support patient care and allow patients to more quickly return to duty/work. It is expected that any research findings would also provide benefit to the general population. To meet the intent of the award mechanism, applications must specifically address an FY24 PRORP ARA Focus Area, listed in Section II.A.1, above.The FY24 PRORP ARA is focused on applied research, defined as work that refines concepts and ideas into potential solutions with a view toward evaluating technical feasibility of promising new knowledge products, pharmacologic agents, behavioral and rehabilitation interventions, diagnostic and therapeutic techniques, clinical guidance, and/or emerging approaches and technologies.Awards may not be used to support fundamental basic research. Basic research is defined as research directed toward greater knowledge or understanding of the fundamental aspects of phenomena and of observable facts without specific applications toward process or products in mind.Research Scope: Research proposed under the FY24 PRORP ARA may include small- to large-scale projects. Upon successful completion, the proposed research is expected to yield knowledge products, approaches, or technologies that have the potential to advance toward clinical translation. Strong transition plans are expected.Inclusion of preliminary and/or published data relevant to the proposed research is required. Applicants must demonstrate logical reasoning for the proposed work. To be competitive, the application must include a sound scientific rationale and a well-formulated, testable hypothesis established through a critical review and analysis of the literature.Studies allowed under the FY24 PRORP ARA may include, but are not limited to: Refinement of concepts and ideas into potential solutions, or research tools, with a view toward evaluating technical feasibility of emerging approaches, technologies, and promising new knowledge products. Evaluation, maturation, and/or down-selection of potential product candidates (drugs, biologic constructs, or devices/systems) in vitro and/or in vivo. Preparation activities needed to support a future clinical trial or regulatory submission.Applications to the FY24 PRORP ARA mechanism must support preclinical applied research and may not be used for clinical research studies. Applicants seeking support for clinical research projects should consider the FY24 PRORP Clinical Translational Research Award (Funding Opportunity Number HT942524PRORPCTRA), Clinical Trial Award (Funding Opportunity Number HT942524PRORPCTA), or Womens Health Research Award (Funding Opportunity Number HT942524PRORPWHRA) mechanisms.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).Rigor of Experimental Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Projects that include research on animal models are required to submit Attachment 8, Animal Research Plan, as part of the application package to describe how these standards will be addressed. Applicants should consult the ARRIVE guidelines 2.0 (Animal Research: Reporting In Vivo Experiments) to ensure relevant aspects of rigorous animal research are adequately planned for and, ultimately, reported. The ARRIVE guidelines 2.0 can be found at https://arriveguidelines.org/arrive-guidelines.Womens Health Research: The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health. Applications proposing research that solely address womens health may also consider the FY24 PRORP WHRA mechanism, Funding Opportunity Number HT942524PRORPWHRA.Encouraged Department of Defense (DOD) and/or VA Collaboration: Military relevance is a key feature of this award. Principal Investigators (PIs) are encouraged, but not required, to collaborate with DOD or VA researchers and clinicians.Use of DOD or VA Resources: If the proposed research involves access to DOD or VA resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Refer to Section II.D.2.b.ii, Full Application Submission Components, for detailed information. Refer to the General Application Instructions, Appendix 1, for additional information.The anticipated total costs budgeted for the entire period of performance for an FY24 PRORP Applied Research Award should not exceed $750,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $3.75M to fund approximately five ARA applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

Orthopaedic injuries have a profound impact on military readiness and return to work/activity/duty. In the military, extremity battle wounds comprise approximately 50% of injuries reported in the Department of Defense Trauma Registry. Additionally, orthopaedic injuries and conditions that occur outside of combat (e.g., during training, leisure activities, resultant from old injuries) present one of the greatest threats to the readiness of our Service Members and military. Early stabilization, treatment, and rehabilitation of orthopaedic injuries in both civilian and military populations have led to better outcomes, particularly in the prevention of secondary complications and in minimizing morbidity. Availability of orthopaedic care and treatment as early as possible, or as close to the point of injury as possible, also minimizes limb loss and affects military readiness.Although the PRORP is interested in supporting military-focused research, research supported by the PRORP is expected to also apply to all individuals who have sustained a major orthopaedic injury.With the initiation of the Arthritis Research Program, the FY24 PRORP may not fund arthritis research; however, research that addresses conditions or health abnormalities related to arthritis is permitted provided the proposed research addresses the selected Focus Area.The PRORP CTRA is intended to support high-impact and/or emerging clinical research that may not be ready for a full-scale randomized controlled clinical trial. Projects should demonstrate potential to impact the standard of care, both immediate and long-term, as well as contribute to evidence-based guidelines for the evaluation and care of military, Veterans, and all patients with orthopaedic injuries. One goal of the FY24 PRORP CTRA is to translate current and emerging techniques and interventions into the clinical space to better serve military and non-military patients. A holistic approach that takes into account the health, functional abilities, and quality of life of individuals who have sustained an orthopaedic injury should be considered. Another goal is to identify the most effective diagnosis, treatment, rehabilitation, and prevention options available to support critical decision-making for patients, clinicians, other caregivers, and policymakers.The FY24 PRORP CTRA differs from the FY24 PRORP Clinical Trial Award (CTA) in that the CTRA allows for clinical research projects that may or may not include a clinical trial, whereas the CTA is restricted to clinical trials only.Funding from this award mechanism must support clinical research and may not be used for animal research.Clinical research encompasses research with patient samples, data, and interaction with patients that may or may not be considered a clinical trial. Clinical research is observational in nature and includes: (1) Research that does not seek to evaluate the effects of interventions. Research conducted with human subjects (or on material of human origin such as data, tissues, specimens, and cognitive phenomena) for which an investigator (or colleague) directly interacts with human subjects but does not seek to assess the effects of an intervention, qualifies as clinical research. Patient-oriented research may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies. (2) Epidemiologic and behavioral studies that do not seek to study the safety, effectiveness, and/or efficacy outcomes of an intervention. (3) Outcomes research and health services research that do not fit under the definition of clinical trial. Excluded from the definition of clinical research are in vitro studies that utilize human tissues that cannot be linked to a living individual. Note: Studies that meet the requirements for exemption under 46.104(d)(4) of the Common Rule are not considered clinical research as defined by the CDMRP. Exemption category 4 refers to secondary research for which consent is not required.A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For more information, a Human Subject Resource Document is provided at https://cdmrp.health.mil/pubs/pdf/Human%20Subjects%20Resource%20Document_DEC2022.pdf.Proposed studies submitted to the CTRA may be interventional and may involve some retrospective data analysis. Note that purely retrospective or database-related research is not allowed under this funding opportunity. Small pilot clinical trials with human subjects are allowable.Key aspects of the PRORP CTRA mechanism: Preliminary Data Are Required: Inclusion of preliminary data relevant to the proposed clinical research is required. Study Population: The application should demonstrate the availability of and access to a suitable patient population that will support a meaningful outcome for the study. The application should include a discussion of how accrual goals will be achieved, as well as the strategy for inclusion of women and minorities in the clinical research appropriate to the objectives of the study. Studies utilizing human biospecimens or datasets that cannot be linked to a specific individual, gender, ethnicity, or race (typically classified as exempt from Institutional Review Board [IRB] review) are exempt from this requirement. Intervention Availability: The application should demonstrate the documented availability of and access to the drug/compound, device, and/or other materials needed, as appropriate, for the proposed duration of the study. Statistical Analysis and Data Management Plans: The application should include a clearly articulated statistical analysis plan, a power analysis reflecting sample size projections that will answer the objectives of the study, and a data management plan that includes use of an appropriate database to safeguard and maintain the integrity of the data. If proposing a clinical trial that requires oversight by a Regulatory Agency, the trial must use a 21 CFR 11-compliant database and appropriate data standards.For the purposes of this funding opportunity, Regulatory Agency refers to the U.S. Food and Drug Administration (FDA) or any relevant international regulatory agency unless otherwise noted.If the proposed clinical research involves the use of a drug that has not been approved by the relevant Regulatory Agency for the country where the research will be conducted, then submission of an Investigational New Drug (IND) application, or equivalent, that meets all requirements under 21 CFR 312 may be required. It is the responsibility of the applicant to provide evidence from the IRB of record or the relevant Regulatory Agency if an IND, or equivalent, is not required. If an IND, or equivalent, is required, the regulatory application must be submitted to the relevant Regulatory Agency within 12 months of the CTRA award start date. The IND, or equivalent, should be specific for the product and indication to be tested in the proposed clinical trial. For more information on IND applications specifically, the FDA has provided guidance at https://www.fda.gov/drugs/types-applications/investigational-new-drug-ind-application.If the investigational product is a device, then submission of an Investigational Device Exemption (IDE), or equivalent, application that meets all requirements under 21 CFR 812 may be required. It is the responsibility of the applicant to provide evidence if an IDE, or equivalent, is not required. If an IDE, or equivalent, is required, the IDE application, or equivalent, must be submitted to the relevant Regulatory Agency within 12 months of the CTRA award start date. The IDE, or equivalent, should be specific for the device and indication to be tested in the proposed clinical trial.Womens Health: The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health. Applications proposing research that solely address womens health may also consider the FY24 PRORP WHRA mechanism, Funding Opportunity Number HT942524PRORPWHRA.Use of Department of Defense (DOD) or VA Resources: If the proposed research involves access to DOD or VA resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Refer to Section II.D.2.b.ii, Full Application Submission Components, for detailed information.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated total costs budgeted for the entire period of performance for an FY24 PRORP CTRA should not exceed $1.5M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $6.0M to fund approximately four CTRA applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.