Grants for City or township governments - Federal

This Notice of Funding Opportunity (NOFO) requests applications to explore human pancreatic tissues and the immune compartment for the discovery of specific signaling or processing pathways that may contribute to the asymptomatic phase of T1D, the discovery of early biomarkers of T1D pathogenesis, the development of diagnostic tools for the detection and staging of early T1D in at-risk or recently-diagnosed individuals, and/or the identification and biological validation of therapeutic targets for the development of preventative or early treatment strategies. Successful applicants will join the Consortium on Beta Cell Death and Survival (CBDS), whose mission is to better define and detect the mechanisms of beta cell stress and destruction central to the development of T1D in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and of preventing the progression to autoimmunity. The CBDS is part of a collaborative research framework, the Human Islet Research Network (HIRN, https://hirnetwork.org/), whose overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This NOFO will only support studies with a primary focus on increasing our understanding of human disease biology (as opposed to rodent or other animal models). This NOFO will not accept applications proposing a clinical trial.

Notice of Funding Opportunity Description Background The Food and Drug Administration (FDA) protects the public health by ensuring that medical products intended to be marketed in the United States are safe and effective for their intended use. FDA stakeholders are exploring innovative ways to produce scientific evidence in support of regulatory submissions, including the development of new data sources, study designs, methodologies, and technologies. FDA encourages and facilitates the use of such innovative approaches while ensuring that the scientific evidence supporting marketing approvals meet our high evidentiary standards. The Prescription Drug User Fee Act VII (PDUFA VII) commitment letter represents the product of discussions between the FDA, regulated industry, and public stakeholders, as mandated by Congress. The performance and procedural goals and other commitments specified in the PDUFA VII commitment letter apply to aspects of the human drug review program that are important for facilitating timely access to safe, effective, and innovative new medicines for patients. The commitment letter includes goals relating to the use of digital health technologies (DHTs) to support drug development and review. A DHT is a system that uses computing platforms, connectivity, software, and/or sensors, for health care and related uses. DHTs for remote data acquisition in clinical investigations can include hardware and/or software to perform one or more functions. DHTs may rely on or work with other technologies that support their operation, such as general-purpose computing platforms (e.g., smartphones) and communication networks. Among other activities relating to the use of DHTs, FDA has established a Framework for the Use of DHTs in Drug and Biological Product Development to guide the use of DHT-derived data in regulatory decision-making for drugs (hereinafter Framework ). The Framework highlights FDA’s DHT efforts including workshops and demonstration projects; engagement with stakeholders; establishment of internal processes to support the evaluation of DHTs for use in drug development; promotion of shared learning and consistency regarding DHT-based policy, procedure, and analytic tool development; and publication of guidance documents. In addition, FDA’s webpage DHTs for Drug Development (available at: https://www.fda.gov/science-research/science-and-research-special-topics/digital-health-technologies-dhts-drug-development) provides an overview of the ongoing DHT efforts, including demonstration projects. A variety of project types are welcomed under this NOFO, applicable to drugs and biologics (not devices). FDA is particularly interested in projects that evaluate the use of DHTs in drug development. Project Objectives The overarching goal of this notice of funding opportunity (NOFO) is to explore the role of DHTs (e.g., actigraphy, photography, environmental sensors) in the evaluation of new drugs. These projects may involve engagement with researchers from academia, the biopharmaceutical industry, patient groups, and other stakeholders. The objectives of these projects are to advance DHTs for clinical drug development, expand the ability to capture early manifestations of chronic diseases, determine outcomes in populations with unmet medical needs and enhance convenience for trial participants by allowing for remote data acquisition in clinical investigations. The scope includes, but is not limited to, projects that focus on: Comparing digital measurements to traditional measurements in clinical trials to evaluate drugs Developing and evaluating novel endpoints using DHTs to address unmet needs for drug clinical trials (e.g., use of environmental sensors to capture apnea in pediatric patients) Comparing metrics to evaluate continuous measurements (e.g., maximum activity and stamina) Capturing early manifestations of chronic diseases (e.g., dementia) through the use of DHTs

With this solicitation, BJA seeks to support law enforcement agencies that have an intellectual property (IP) enforcement task force or plan to create one. The Intellectual Property Enforcement Program assists state, local, and tribal jurisdictions in preventing and reducing intellectual property theft and related crime as well as supporting law enforcement in investigating and prosecuting IP crimes and reducing violent crime associated with IP cases and investigations. Any awards under this solicitation would be made under statutory authority provided by the Consolidated Appropriations Act, 2024. As of the writing of this solicitation, the Department of Justice is operating under a short-term Continuing Resolution with no full-year appropriation for the Department being enacted for FY 2024 currently. Specific Information The Intellectual Property Enforcement Program: Protecting Public Health, Safety, and the Economy from Counterfeit Goods and Product Piracy is specifically designed to support jurisdictions in investigating and prosecuting intellectual property crimes. This will be accomplished by assisting state, local, and tribal jurisdictions to build partnerships with federal agencies and prosecutors through IP enforcement task forces. This program also works to prevent and reduce intellectual property theft and related crimes by improving community and buyer awareness. IPEP includes an educational component to assist buyers in determining the authenticity of seemingly legitimate websites that instead deceive consumers into purchasing counterfeit goods. Solicitation Goals and Objectives Goals The goal of this program is to improve the coordination of IP enforcement efforts among federal, state, local, tribal, and territorial authorities. This coordination will include IP task force members and federal agencies meeting to update, discuss, and collaborate on IP investigations, prosecutions, training, and public awareness activities. The information to be shared through these task forces must include information about targeting, investigating, analyzing, and prosecuting matters involving IP crimes as they relate to violations of state and local criminal statutes and federal prosecutions. Objectives • Improve coordination of IP enforcement efforts among federal, state, local, tribal, and territorial authorities. • Establish and/or enhance state, local, tribal, or territorial IP enforcement task forces, to include campus law enforcement agencies. Deliverables • Provide information to update the United States Department of Justice’s Prioritizing Resources and Organization for Intellectual Property (PRO IP) Act Annual Report. • Provide updates to the OJP Program Plan. Page 7 O-BJA-2024-172080 For information about what the applicant needs to submit regarding Goals, Objectives, and Deliverables, please see the How to Apply section on the Application Goals, Objectives, Deliverables, and Timeline Web-Based Form. Priority Areas In order to further OJP’s mission, OJP will provide priority consideration when making award decisions to the following: The Inventory of Federal Priorities for Policing will help the U.S. Department of Justice evaluate the possibility for priority consideration, where appropriate, and identify potential gaps in training and technical assistance. To receive this additional priority consideration, applicants will complete the Inventory as a survey within JustGrants. For additional information, see the Data Requested with Application section.

This funding opportunity supports a wide range of research projects aimed at improving the understanding, prevention, diagnosis, and treatment of Alzheimer's Disease and related dementias, particularly focusing on underserved populations and health disparities.

ACL recognizes senior centers as valued partners in the Aging Network that support community living by keeping older adults active, informed, and healthy. Many senior centers serve as important focal points for the delivery of comprehensive services. In 2021, to better ensure that senior centers have the tools and resources necessary to develop and implement programs that meet the current and future needs of the Nations older adults, ACL established a Modernizing Senior Centers Resource Center.ACL is seeking applications to fund one cooperative agreement that will continue the operation of the Modernizing Senior Centers Resource Center to provide technical assistance and training to senior centers as well as serve as a clearinghouse for innovative programs and strategies that can be successfully replicated at the local level.

This funding opportunity supports research partnerships between technology developers and academic researchers to optimize and evaluate digital mental health interventions, particularly for underserved populations.

This funding opportunity supports research projects aimed at developing safe and effective medications for treating substance use disorders, particularly for substances like cocaine, methamphetamine, and cannabis, and is open to a wide range of eligible institutions and organizations.

This funding opportunity provides financial support for projects that protect cultural heritage and prevent the illicit trade of artifacts in Tunisia, targeting educational institutions, NGOs, and public entities involved in cultural preservation.

This grant provides funding to early-career researchers focused on melanoma to support their independent research and professional development while fostering collaboration within a network of experts.

This grant provides funding for research aimed at developing new therapies for amyotrophic lateral sclerosis (ALS), specifically targeting projects that have already shown promise in preclinical studies and emphasize the use of biomarkers for therapeutic development.

The purpose of the NIH Independent Scientist Award (K02) is to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research. The K02 award provides three to five years of salary support and "protected time" for newly independent scientists who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. Each independent scientist career award program must be tailored to meet the individual needs of the candidate. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or a separate ancillary clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by another investigator. Applicants proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion FOA

Application website will be open starting August 1, 2024 Award amount is based on availability of funding. Award amount is not to exceed $300,000. Award will be based on the merit of the proposal. Proposals are due September 13, 2024. Project is to be completed by January 30, 2026 Application Website: https://nucfac-ten-year-action-plan-grant.urbanandcommunityforests.org Link to RFP: https://nucfac.org/forms/Final%20%20NUCFAC%20RFP%206_17_2024%20ADA%20V05_.pdf Congress established the National Urban and Community Forestry Advisory Council (Council) to advise the Secretary of Agriculture on issues related to the nations urban and community forests and related natural resources. The Council is charged by law (P.L. 95-313 Section 9 as amended through PL 110-246, [16 U.S.C. 2105](g)(1)(A)) with developing a ten-year action plan; providing annual accomplishments for the action plan and assisting the U.S. Forest Service in establishing categories and recommendations for award to the agencys competitive National Urban and Community Forestry Challenge Cost-Share Grant Program . The current National Urban and Community Forestry Ten-year Action plan (Action Plan) will expire at the end of 2026. To prepare for the next ten-year action plan, the Forest Service is requesting proposals from qualified organizations/entities to coordinate, facilitate and manage a collaborative and comprehensive process for the development of the next ten-year Action Plan. PROPOSAL REQUEST: Coordinate, facilitate, and manage a collaborative and comprehensive process for the development of the next National Urban and Community Forestry Ten Year Action Plan (2027-2037). This includes publishing and rollout assistance. The National Urban and Community Forestry Advisory Councils authorizing legislation requires the Council to prepare a National Urban and Community Forestry Action Plan every ten years. The current Action Plan, 2016-2026, is to be updated by January 30, 2026, for the Council to meet its mandate. The Forest Service is seeking proposals from qualified organizations/entities to conduct a current assessment, and review and identify emerging issues of the nations urban forest resources and the urban and community forestry programs and activities conducted by Federal and State agencies, nonprofit organizations, community and civic organizations and other interested parties across the country. Funds are to support the development of a National Urban and Community Forestry Advisory Councils Ten-Year Action Plan, 2027-2037 as mandated by Congress. The award will be based on the availability of funding, which may be subject to change. The maximum award amount may not to exceed $300,000. Proposals will be expected to address the following key elements, through implementation of the scope and criteria below. This will also include incorporating the Councils comments and recommendations. Key Elements: 1) Work with the National Urban and Community Forestry Advisory Council and the Forest Service Urban and Community Forestry staff throughout the process for input and guidance. 2) Assess the current Action Plans accomplishments, gaps, and items to carry over into the next Action Plan. 3) Summarize the status of urban forest resources in the United States. This is to include the human dimension of urban forestry as well as the urban natural resources. 4) A review of urban and community forestry related programs and activities in the United States, including education and technical assistance activities conducted by: - the Department of Agriculture, and other Federal agencies, - the State forestry organizations, - private industry, - nonprofit organizations, community and civic organizations - Indian Nation and Indigenous communities, and - interested others. 5) Facilitate and integrate applicable public engagement recommendations for improving the status of the Nations urban and community forest resources, including education and technical assistance and modifications required in existing programs and policies of relevant Federal agencies. 6) A review of the urban and community forestry research, documents including-- a) a review of all past five years of research and ongoing research associated with urban and community forests, arboricultural practices, urban forest management, work with disadvantaged communities, and the economic, social, and psychological benefits of trees and forest cover in urban and community environments being conducted by the Forest Service, other Federal agencies, and associated land grant colleges and universities. b) recommendations for new and expanded research efforts directed to and by the Forest Service Research, other Federal agencies, and associated land grant colleges and universities; around urban and community forestry concerns identified by this Action Plan; and c) a summary of research priorities and an estimate of the funds needed to implement such research, on an annual basis, by the Forest Service Research, other Federal agencies, and associated land grant colleges and universities; for the next ten years. 7) An estimate of the financial and technical resources needed to implement the National Urban and Community Forestry Action Plan and the Urban and Community Forestry Program for the succeeding 10 fiscal years.

This funding opportunity supports innovative research that investigates how aging affects individuals living with HIV, focusing on improving their health outcomes and addressing related challenges.

This funding opportunity provides financial support for state and local governments, tribal organizations, educational institutions, and nonprofits to implement wildfire risk reduction projects and community fire preparedness initiatives across various regions, excluding Nevada and Wyoming.

This funding opportunity provides financial support for state and local governments, tribal organizations, higher education institutions, and nonprofit organizations to monitor and improve the health of coastal wetlands in the Great Lakes region.

This notice of funding opportunity (NOFO) will support development, adaptation, and/or applications of computational tools to aggregate and analyze orthogonal chemical and/or biological data sets related to natural products with the aim of generating novel testable hypotheses regarding their biological activity and role in the context of whole person health research. Projects must leverage and merge multiple compatible or interoperable sources and/or types of data. Use of artificial intelligence and machine learning approaches is encouraged. This NOFO is part of the Consortium Advancing Research on Botanicals and Other Natural Products (CARBON) Program. Other components of this Program include the Botanical Dietary Supplements Translational Research Teams (RM1) and Limited Competition: Research Resource for Natural Product Nuclear Magnetic Resonance Data (R24).

This grant provides funding to state and local governments, tribal organizations, and nonprofits for the recovery and preservation of historic sites damaged by natural disasters in 2023 and 2024.

This funding opportunity supports research on how sex differences influence the risk and treatment responses of Alzheimer's Disease and related dementias, inviting applications from a wide range of organizations, including universities, nonprofits, and businesses.

This grant provides financial support for early-career clinician-scientists to conduct patient-oriented research in pain management, focusing on developing effective strategies to address chronic pain and the opioid crisis.

This funding opportunity provides financial support for faculty and students at under-resourced academic institutions to collaborate with NASA on research projects, fostering mentorship and skill development in STEM fields.