Grants for For profit organizations other than small businesses - Federal

This funding opportunity provides financial support for institutions and organizations to create and manage a resource that supplies human tissues and organs for biomedical research, benefiting studies on various diseases and health conditions.

This funding opportunity provides financial support to small businesses and organizations developing innovative medical technologies and digital health solutions to improve health outcomes.

The Bureau of Near Eastern Affairs Office of Assistance Coordination (NEA/AC) and Embassy Tunis Assistance Unit seek proposals to address the social and economic hurdles facing repatriated Tunisian migrants voluntarily or forcibly returning to their home country. The proposals should focus on women and youth who encounter barriers to education, social support systems, and employment.

This funding opportunity provides $10 million to academic institutions and their partners to develop and demonstrate innovative cybersecurity solutions for enhancing the resilience of the energy delivery systems in the United States.

This program provides funding to organizations and local governments to build broadband networks in rural areas lacking internet access, promoting economic development, education, and healthcare.

This funding opportunity provides financial support to states and organizations for developing a coordinated care model that improves health services for children with serious, long-term medical conditions.

This funding opportunity is designed to support public-private partnerships that leverage artificial intelligence to improve the resilience and competitiveness of U.S. manufacturing through innovative research and workforce development.

The SCIRP CTRA is intended to support high-impact and/or new/emerging clinical research that may not be ready for a larger-scale clinical trial and for which feasibility/pilot/optimization studies are necessary. Projects should demonstrate potential to impact the standard of care, both immediate and long term, or contribute to evidence-based guidelines for the evaluation and care of military Service Members, Veterans, and other individuals living with SCI. The U.S. Army Medical Research Acquisition Activity (USAMRAA) is soliciting applications to the fiscal year 2024 (FY24) Spinal Cord Injury Research Program (SCIRP) using delegated authority provided by United States Code, Title 10, Section 4001 (10 USC 4001). The Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC) is the program management agent for this funding opportunity. Congress initiated the SCIRP in 2009 to provide support for traumatic spinal cord injury (SCI)-related research of exceptional scientific merit that has the potential to make a significant impact on improving the health and well-being of military Service Members, Veterans, and other individuals living with SCI. Appropriations for the SCIRP from FY09 through FY23 totaled $437.85 million (M). The FY24 Defense Appropriations Act provides $40M to the SCIRP through the appropriation for peer-reviewed spinal cord research. The vision of the SCIRP is to advance the treatment and management of SCI and ameliorate its consequences. The FY24 SCIRP challenges the scientific community to design research that will advance the development or translation of health care solutions for people living with SCI. Innovative research that fosters new directions or addresses neglected issues in the field of traumatic SCI is also supported, although studies focused exclusively on target identification are discouraged. The SCIRP encourages impactful research across the continuum of care from time of injury and across the life span that is well reasoned and scientifically supported. Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, their Families and/or care partners.

The "Facilitating Preclinical and Early Phase Human Studies for New Therapeutics" grant aims to fund research that advances new treatments from preclinical stages to first-in-human trials for aging-related conditions, excluding neurodegenerative and Alzheimer's diseases, with a focus on improving injury repair in older adults and defining clear milestones for progress monitoring.

This grant provides funding for technology demonstrations of non-lithium long-duration energy storage solutions, targeting state energy offices, Indian Tribes, educational institutions, electric utilities, and private energy storage companies to advance these technologies towards commercial viability.

The STRIPE program grant is designed to fund pre-clinical research that explores how radiopharmaceutical therapy affects cancer cells and their environment, with the aim of developing new targeting strategies and informing the design of future RPT-based clinical trials.

This project will increase the capacity of countries to develop effective regulations preventing the proliferation and misuse of commercial spyware in alignment with international best practices and advocate for commercial spyware regulatory approaches that are technically sound and rights-respecting.

This funding opportunity supports collaborative research teams focused on innovative solutions to improve treatments and outcomes for patients with glioblastoma, particularly the IDH-wild type variant.

The Academy of Kidney Cancer Investigators (AKCI) is a unique, interactive virtual academy that provides, intensive mentoring, national networking, and a peer group for scientist and clinician junior faculty. The KCRP created the Academy of Kidney Cancer Investigators in FY19 to align with several program priorities, which include to build research capacity in kidney cancer; increase collaborations to advance kidney cancer research, and support innovative research conducted by the next generation of kidney cancer scientists and clinicians. The overarching goal of the AKCI is to increase research capacity in kidney cancer through the development of successful, highly productive kidney cancer researchers in a collaborative research and training environment. The AKCI is a virtual career development and research training platform that currently consists of 11 Early-Career Scholars (ECS)/Designated Mentor pairs from different institutions, and one Academy Director. It is expected that six Early-Career Scholars will graduate by the fall of 2025 and four FY23 AKCI Early-Career Scholars/Designated Mentor awards will be made by September 2024. In addition, Academy graduates will continue to participate in the annual Academy meetings. Information about the Academy is available on the KCRP webpage and in the Kidney Cancer Program Booklet at https://cdmrp.health.mil/kcrp. The AKCI leadership team will identify opportunities for engagement with KCRP AKCI Scholars-Designated Mentors and KCRP FY25 (and subsequent year awardees) Postdoctoral and Clinical Fellowship Awardees. The Academy Director and Deputy Director catalyze the growth and professional development of the Early-Career Scholars in collaboration with their Designated Mentors, assess the progress of the ECSs, and facilitate communication and collaboration among all of the Academy members. The AKCI leadership team will also identify and offer opportunities for engagement (e.g., invitations to seminar series and in-person meetings) with FY24 Postdoctoral and Clinical Fellowship Awardees with FY24 KCRP AKCI-ECS-Designated Mentors (and subsequent year awardees). This FY24 funding opportunity is soliciting applications for an Academy Director (Principal Investigator [PI]) and Deputy Director (Partnering PI) to lead the AKCI. The newly selected FY24 Academy Director and Deputy Director will initiate their responsibilities no later than October 2025. The Academy Director and Deputy Director (hereafter referred to as Academy Leadership) must be established kidney cancer researchers and can be at different institutions. The Academy Leadership must demonstrate a strong record of mentoring and training early career investigators, a commitment to leadership, the ability to articulate methods toward research collaborations, and the ability to objectively assess the progress of all Scholars with their Designated Mentors in the AKCI. Other objectives will include execution of research that will engage AKCI FY24 Scholars (including subsequent-year Scholars), develop tools for Scholars to enable success, and provide opportunities to broaden their knowledge in kidney and renal pelvis cancers. The leadership team will identify and offer occasion(s) for the AKCI to network with KCRP FY24 Postdoctoral and Clinical Fellowship Awardees (and subsequent year awardees). Designated Mentors on FY24 KCRP AKCI Early-Career Scholar Award applications and Designated Mentors on open FY19 through FY23 KCRP AKCI Early-Career Scholar Awards (with the exception of those graduating in 2024) are not eligible to apply for this award. Note: An invited oral presentation is a requirement for application review of the KCRP AKCI LA, as described in Section II.D.2.b.iv, Additional Application Components. Responsibilities of the Academy Leadership include, but are not limited to: Act as a resource for all Scholars and Designated Mentors in the Academy over the Scholars 4-year period of performance. Facilitate communication and collaboration among all Scholars and Designated Mentors (including periodic interactive communication among all Academy members). Develop assessment criteria to evaluate the research progress made by all Scholars, as well as their career progression and sustainment as independent investigators in kidney cancer research. Conduct collaborative kidney cancer pilot project(s) that include Academy Scholars. These pilot projects should have the potential to improve collaboration within the Academy, as well as impact kidney cancer research and/or kidney cancer patients/survivors. o Examples of pilot research projects may include but are not limited to (a) funding an extended statistical or bioinformatics analysis with AKCI Scholars, (b) performing a large-scale meta-analysis of human or animal datasets with AKCI scholars, (c) provide access to critical biorepositories or animal models to expand AKCI investigator analyses or increase study rigor. Provide constructive critiques with the goal of advancing the research and professional careers of the Scholars and strengthening the mentorship of the Designated Mentors. Provide avenues to increase the promotion of the Academy and visibility of Scholars within kidney cancer research and advocacy communities (e.g., peer review, conferences, editorial boards). Support the professional development, to include laboratory management skills, of the Scholars into leading researchers through invited presentations by experts outside of the AKCI LA. Plan and host an annual 1-day workshop and, biennially, a multi-day workshop for all Scholars/Designated Mentor pairs as well as Academy graduates to present their research, share knowledge, and develop collaborative efforts within the AKCI. Scholars will be responsible for their own travel costs to in-person Academy meetings. Include KCRP FY24 Postdoctoral and Clinical Fellowship Awardees in at least one meeting of the FY24 AKCI. These investigators will be responsible for their own travel costs, funds for which are included in their research awards. Establish a panel of patient advocates and Veteran(s) (i.e., the Patient Advocacy Panel) to inform the AKCI on the needs of the patient community. Establish the Designated Mentor Panel to facilitate collaborations among the AKCI participants including the Scholars, Academy Director/Deputy Director, and the Designated Mentors. The Academy of Kidney Cancer Investigators Leadership Award is structured to support two PIs. The Academy Director will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The Deputy Director will be identified as the Partnering PI. The collaboration between the Academy Director and the Deputy Director should be supported by complementary expertise and experience. Initiating and Partnering PIs each have different submission requirements, as described in Section II.D.2, Content and Form of the Application Submission; however, both PIs should contribute significantly to the development of the proposed research project. The application should clearly demonstrate that both PIs have equal levels of input on the proposed Academy Leadership and clearly define the components to be addressed by each to support the success of the Scholars. While it is up to the Academy Director and the Deputy Director to define their roles, both Academy Leaders should have interactions with each Scholar-Designated Mentor pair, (and the Scholars Designated Mentors); acting as administrative support does not fulfill the intent of the Director and Deputy Director. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PI(s), refer to Section II.D.2, Content and Form of the Application Submission. Organizational-Level Emphasis: The following areas of emphasis are broadly applicable to many CDMRP programs, not just the KCRP. Investigators are encouraged to consider addressing these areas in their applications if doing so is appropriate for their line of research, addresses the FY24 KCRP strategic priorities and/focus areas described in Section II.A.1 and Section II.A.2. Nuclear Medicine: Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies. Womens Health: CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in womens health outcomes and/or advancing knowledge for womens health. Metastatic Cancer Task Force: A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 KCRP priorities. Rigorous Study Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Military Service Involvement: Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Clinical trials are not allowed under this funding opportunity. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes. Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials. For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes: (1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies. (2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. (3) Outcomes research and health services research that do not fit under the definition of clinical trial. Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule. The funding instrument for awards made under the program announcement will be cooperative agreements (31 USC 6305). Substantial CDMRP programmatic involvement with recipients is anticipated during the performance of award activities. Substantial involvement means that, after award, CDMRP staff will assist, guide, coordinate, or participate in project activities including but not limited to: Participating in the Steering Committee that oversees study conduct. Make recommendations for continued funding based on (a) overall study progress, including sufficient patient and/or data accrual; (b) cooperation in carrying out the research (e.g., attendance at Steering Committee meetings, implementation of group decisions, compliance with the terms of award and reporting requirements); and/or (c) maintenance of a high quality of research. The anticipated combined direct costs budgeted for the entire period of performance for a FY24 KCRP AKCI LA should not exceed $1,500,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. Awards supported with FY24 funds will be made no later than September 30, 2025. The CDMRP expects to allot approximately $2.4M to fund approximately one KCRP Academy of Kidney Cancer Investigator Leadership Award application (consisting of an Initiating PI application and a Partnering PI application). Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 and FY26 funds, which will expire for use on September 30, 2030, and September 30, 2032, respectively.

The Program supports research on the sources, sinks, transport, and transformation of gases and aerosols in the atmosphere through models, observations, and experiments, including homogeneous and heterogeneous chemical reactions, emissions, deposition, atmospheric oxidation and photochemistry, aqueous-phase chemistry and aerosol processes; the formation of new particles and secondary organic aerosols, the modeling of atmospheric chemical processes, the study of chemical mechanisms in the atmosphere, optical properties of gases and aerosols, and improved methods for measuring the concentrations of trace species and their fluxes into and out of the atmosphere.The Program encourages principal investigators from a wide variety of institutions and backgrounds to submit proposals.

The U.S. Department of State, Bureau of Democracy, Human Rights and Labor (DRL) announces an open competition for organizations interested in submitting applications in response to to strengthen civil society resilience in Kyrgyz Republic. The U.S. Department of State, Bureau of Democracy, Human Rights and Labor (DRL) announces an open competition for organizations interested in submitting applications in response to the following solicitation.  DRL anticipates funding one proposal from this solicitation, pending availability of funding.      The Kyrgyz Republic has long had a reputation of having the most vibrant, active civil society and independent media in Central Asia.  In recent years however, concerning trends have put that reputation at risk.  Harassment of activists, independent media and CSOs has intensified, with peaceful rallies limited to specific places, with authorities extending restrictions every few months.       Kyrgyz CSOs now face systematic attacks including arbitrary criminal and administrative prosecutions, deportations, and anonymous offline and online threats. They routinely endure unannounced tax inspections and smear campaigns on social media. Additionally, draft anti-democratic legislation currently for consideration in the Kyrgyz parliament threatens to seriously undermine freedom of association and further restrict CSO operating space.     In this challenging environment, DRL aims to maintain civil space and build civil society resiliency. This project’s primary objective is ensuring Kyrgyz CSOs have the tools, training, resources, and support to remain safely and effectively engaged in their work amid increasing repressions.       Elements of useful programming could include digital and physical security trainings, financial audits, flexible small-grants, legal support, advocacy strategy development, cyber bullying response tactics, or building solidarity networks domestically and internationally. The focus should be holistic, addressing security, legal, financial, operational, and psychosocial needs given the multilayered pressures civil society faces.    Program outcomes could include one or more of the following but are not limited to:    Civil society and community actors operate and coordinate safely to navigate the new/emerging legal operating environment in Kyrgyz Republic.     Kyrgyz civil society organizations have the tools, resources, and support to safely and more effectively remain engaged in their work amid increasing restrictions and repressions that challenge the civic space.  Kyrgyz civil society engages in advocacy on human rights issues.  All programs should aim to have impact that leads to reforms and have the potential for sustainability beyond DRL resources.  DRL’s preference is to avoid duplicating past efforts by supporting new and creative approaches.  This does not exclude from consideration projects that improve upon or expand existing successful projects in a new and complementary way.  DRL is committed to advancing equity and support for underserved and underrepresented communities. In accordance with the Executive Order on Advancing Racial Equity and Underserved Communities, programs should implement strategies for integration and inclusion of individuals/organizations/beneficiaries that can bring perspectives based on their religion, sex, disability, race, ethnicity, sexual orientation, gender identity, gender expression, sex characteristics, national origin, age, genetic information, marital status, parental status, pregnancy, political affiliation, or veteran’s status.  Programs should be demand-driven and locally led to the extent possible.  DRL requires all programs to be non-discriminatory and expects implementers to include strategies for nondiscrimination of individuals/organizations/beneficiaries based on race, color, religion, sex, gender identity, gender expression, sex characteristics, sexual orientation, pregnancy, national origin, disability, age, genetic information, marital status, parental status, political affiliation, or veteran’s status.  Competitive proposals may also include a summary budget and budget narrative for 12 additional months following the proposed period of performance, indicated above. This information should indicate what objective(s) and/or activities could be accomplished with additional time and/or funds beyond the proposed period of performance. Where appropriate, competitive proposals may include: Opportunities for beneficiaries to apply their new knowledge and skills in practical efforts; Solicitation of feedback and suggestions from beneficiaries when developing activities in order to strengthen the sustainability of programs and participant ownership of project outcomes; Input from participants on sustainability plans and systematic review of the plans throughout the life of the project, with adjustments made as necessary; Joint identification and definition of key concepts with relevant stakeholders and stakeholder input into project activities; Systematic follow-up with beneficiaries at specific intervals after the completion of activities to track how beneficiaries are retaining new knowledge as well as applying their new skills. Activities that are not typically allowed include, but are not limited to: The provision of humanitarian assistance; English language instruction; Development of high-tech computer or communications software and/or hardware; Purely academic exchanges or fellowships; External exchanges or fellowships lasting longer than six months; Off-shore activities that are not clearly linked to in-country initiatives and impact or are not necessary per security concerns; Theoretical explorations of human rights or democracy issues, including projects aimed primarily at research and evaluation that do not incorporate training or capacity-building for local civil society; Micro-loans or similar small business development initiatives; Initiatives directed towards a diaspora community rather than current residents of targeted countries.

This funding opportunity supports innovative research on rare cancers, providing up to $490,000 for early-stage projects that aim to improve diagnosis, understanding, and treatment, particularly benefiting military service members, veterans, and the general public.

This funding opportunity provides financial support for organizations to host an annual conference focused on improving the skills and strategies for implementing evidence-based practices in communication disorders, promoting inclusivity and diversity in the field.

This funding opportunity is designed to strengthen the Somali National Army's capabilities through operational mentorship and support, focusing on improving their ability to conduct independent military operations and enhance security in Somalia.

Naval Facilities Engineering Systems Command (NAVFAC) Atlantic desires to enter into a Cooperative Agreement with a U.S. based non-profit conservation organization (Recipient) that places interns, 18-years of age and older, who are enrolled or recently graduated from in an accredited natural resource or conservation program, in conservation management internships to assist in the completion of Integrated Natural Resources Management Plan (INRMP) and Integrated Cultural Resources Management Plan (ICRMP) projects at Department of Navy (DoN) and Marine Corps installations. Interns will work closely with Navy Natural and Cultural Resource Managers gaining valuable professional knowledge, skills, and abilities related to conservation management. The specific scope of projects will be outlined in the Performance Work Statement contained in each work order.Applicants/Recipients shall provide the following in their application:1. Narrative - Applicants/Recipients must provide a narrative that addresses the responsibilities and evaluation factors identified in Section 3.1 of the SOW. NAVFAC will consider and evaluate only those applications that address each of the responsibilities identified in section 3.1 (Responsibilities of Recipient) and the evaluation factors. Each applicants narrative must label the evaluation factors in the narrative. The narrative should demonstrate the Recipients capabilities to successfully meet the intended goals of the Cooperative Agreement. Please be as specific as possible.2. Cost Schedule Applicants/Recipients must submit a proposed Cost Schedule using the attached template (Attachment A). Do not deviate from the basic format of this form; however, columns and rows may be adjusted to include anticipated cost elements not included on the form. 3. Summary of Past Experience with Cooperative Agreements related to conservation projects, if any and not otherwise covered in narrative above. Identify organization, federal agency, dates, and type of work involved.4. Copies, or summary, of recruitment strategies, materials, and information related diversity of past interns, if any and not otherwise covered in narrative. 5. Additional Materials Requested:1. Name, Organization affiliation, and contact information2. Statement of credentials, qualifications, and roles/position and responsibilities of key personnel3. Copy of Liability Coverage4. Certificate of 501(c)(3) or other evidence demonstrating nonprofit status. Applications shall be submitted electronically via grants.gov or email to Elizabeth.s.eliason-carey.civ@us.navy.mil. Applications shall be submitted in Adobe Acrobat (.pdf) or MS Word format, except for Attachment A, which shall be submitted as an MS Excel file. Total page limit for all documentation is 40 pages. Completion of SF-424 Fields First. The Adobe Reader forms are designed to fill in common required fields such as the applicant name and address, Entity Identifier number, etc., on all Adobe Reader forms. To trigger this feature, an applicant must complete the SF-424 information first. Once it is completed the information will transfer to the other forms.Please see Statement of Work and Attachments in Attachment folder.