Grants for Native American tribal organizations - Federal

This funding opportunity is designed to support research centers in developing innovative vaccines against hepatitis C virus, targeting a wide range of applicants including universities, nonprofits, and government entities.

Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications for support of investigator-initiated studies addressing mechanisms by which bariatric surgery impacts cancer risk, and seeks to draw in talented scientists who study bariatric surgery to investigate its effects on cancer, rather than shorter-term outcomes such as weight loss and diabetes.Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications for support of investigator-initiated studies addressing mechanisms by which bariatric surgery impacts cancer risk, and seeks to draw in talented scientists who study bariatric surgery to investigate its effects on cancer, rather than shorter-term outcomes such as weight loss and diabetes. Background Obesity: Obesity will soon surpass smoking tobacco as the number one cause of preventable death both in the United States and worldwide. Bariatric (metabolic) surgery is the most effective strategy to achieve significant initial and sustained weight loss among individuals who are morbidly obese. Bariatric surgery provides dramatic improvement in metabolic function, associated with a reduction in type 2 diabetes mellitus (T2DM) and cardiovascular (CV) risk. Bariatric surgery also appears to reduce the risk of certain obesity-related cancers, although which cancers are favorably impacted vary by study, and the mechanism(s) driving this risk reduction is mostly speculative. Bariatric surgery is performed in over 250,000 people in the U.S. annually, and the frequency is rising. Studies evaluating which bariatric surgery procedure(s) are most effective in cancer risk reduction could help bring to light new pathways to target for cancer prevention. Bariatric Surgery: Importantly, it is not yet clear from clinical and preclinical studies if the benefit from bariatric surgery arises from weight loss alone or if there is also a surgery-specific benefit. One mechanism for a possible surgery-specific effect is elevated bile acids (BA), both intestinal and circulating, after gastric bypass surgery such as Roux-en-Y gastric bypass (RYGB) that are proposed to be central to weight loss and other metabolic benefits. The interaction between BA and intestinal microbes is also an area of intense interest. Studies have identified important changes after bariatric surgery in the composition and function of the gut microbiome, which may mediate bariatric surgery effects. Fecal microbiota transplantation (FMT) from humans or mice that had undergone bariatric surgery to germ-free recipient mice showed decreased weight gain and decreased adiposity are both transmissible traits. In addition, FMT induced important host metabolic changes including decreased energy harvest from the diet, increased resting energy expenditure, and increased lipid utilization. The data suggest a causal link between gut microbiota and the metabolic and weight loss effects of bariatric surgery. If validated, the findings will provide insight into the mechanisms driving the benefit of bariatric surgery on cancer risk and would be useful to further scientific understanding and patient care. Animal Models: Several diets or genetically induced animal models of obesity have consistently demonstrated the benefits of weight loss on cancer risk, and these obesity-induced tumor models may be adaptable to bariatric surgery studies, such as the Kras model of pancreatic cancer. Animal models have been developed to study the effects of bariatric surgery. Rodent animal models are most often used due to feasibility (low cost, ease of housing) and have been used extensively to study the mechanism(s) of bariatric surgery responsible for the reduction or elimination of T2DM and CV risk. However, very little has been reported on bariatric surgery and cancer risk despite the fact that both rat and murine models of mammary and other cancers develop in 6 months or less, making it feasible to assess mechanistic changes that influence cancer risk. Bariatric Surgery and Cancer Risk: Obese patients undergo bariatric surgery for a variety of reasons, including weight loss and improvement in metabolic dysfunction. Physician advice regarding the potential benefit of bariatric surgery and cancer risk reduction can currently only be given in generalities based on large-scale studies and not targeted to the individual. Many but not all bariatric surgery investigations document an overall cancer risk reduction among women but not men. Some but not all bariatric surgery studies have found that both women and men undergoing bariatric surgery have an increased risk of colorectal cancer (CRC). Older studies which assessed bariatric surgery and cancer risk may not be useful to guide targeted advice to patients, as one of the most common procedures performed in the past, gastric banding, is only performed in 1% of bariatric surgery procedures today. The two most common bariatric surgery procedures currently performed are sleeve gastrectomy and RYGB. As such, planned animal and/or human studies should focus on the mechanistic effects of the two procedures that are currently in common use. Human biospecimens and/or data may be available from cohorts to enhance the studies proposed including the Longitudinal Assessment of Bariatric Surgery (LABS), Adolescent Bariatrics: Assessing Health Benefits & Risks (Teen-LABS), and NCI Cohort Consortium Members. Applications that include collaborators from fields outside of cancer research will be given special programmatic consideration. Responsive applications may investigate animal models, human studies, or a combination of both. General Area of Research and Scope of Work for this FOA General Area of Research Examples of relevant areas of research include but are not limited to: Do alterations in cancer risk biomarkers occur before weight loss? If so, in what organ, tissue, or cell type do they originate? Is maximum weight loss or long-term weight loss more important for cancer risk reduction? If so, how do the two differ at a cellular and/or biochemical level? What mechanism(s) explain the evidence that bariatric surgery is more beneficial in cancer risk reduction in women than men? Does bariatric surgery increase or decrease the risk of CRC, and if so, what are the mechanism(s)? Which cancers are decreased in incidence by bariatric surgery, and what are the mechanism(s) that explain the effect? Are any cancers increased in incidence by bariatric surgery? If so, through what mechanism(s)? Does the specific bariatric surgery procedure have an impact on cancer risk? If so, what are the mechanism(s) driving the difference in impact? Does racial or ethnic background influence the impact of bariatric surgery on cancer risk, and if so, what are the mechanism(s) involved? How does bariatric surgery affect the penetrance of high-risk genetic predisposition to cancer? Scope of Work and Additional Guidance It is anticipated that studies will evaluate bariatric surgery animal models where a significant proportion of the animals develop cancer. Similarly, human studies involving individuals who will or have undergone bariatric surgery are also encouraged, so long as within the cohort to be studied the number of enrolled subjects who develop cancer is adequate to for a statistically powered endpoint linking cancer (and not a biomarker of cancer) to a molecular mechanism as the driver of cancer. When appropriate and feasible, the investigators may want to evaluate mechanisms influenced by bariatric surgery in animal models of cancer and evaluate potential changes that might correlate with humans due to bariatric surgery. We define mechanism as a biologic endpoint based on analyzed samples from bariatric surgery animal models or from subjects who have or are planned to undergo bariatric surgery. This FOA does not support studies where an epidemiologic endpoint is the primary aim of the project. The mechanism(s) to be studied should evaluate samples collected from animals or humans who have undergone bariatric surgery who did or did not develop cancer. If both animals and humans are studied, the mechanisms chosen should be based on a cancer endpoint. Applications Not Responsive to This FOA The following types of activities remain outside the scope of this FOA, and applications proposing them are non-responsive to this FOA and will not be reviewed. This FOA is not intended for epidemiologic studies, where the primary endpoint is the assessment of cancer in a cohort of animals or humans, which has undergone bariatric surgery and mechanistic studies evaluating bodily fluid or tissue samples are nonexistent or of secondary endpoints. Application that focuses entirely on in vitro investigations. Epidemiologic investigations as the primary focus of the application. Animal or human studies that do not evaluate tissue and/or bodily fluid samples collected from participants who have undergone bariatric surgery, some of which developed cancer after surgery. Application, which includes a clinical trial that does not have a bariatric surgeon as a key investigator on the team. NOTE: Applicants to this FOA are strongly encouraged to contact NCI staff as soon as possible in the development of the application (preferably no later than 12 weeks prior to the application due date) to discuss the details of their proposed clinical trial, so that NCI staff can help the applicant understand whether the proposed clinical trial is within the goals and mission of the NCI and is appropriate for this FOA.

This funding opportunity provides financial support for research projects that aim to improve the adoption and sustainability of effective health interventions, particularly in underrepresented communities, by addressing barriers and promoting equitable health outcomes.

This funding opportunity supports clinical trials for innovative treatments and interventions targeting Alzheimer's disease, related dementias, and age-related cognitive decline, inviting applications from a wide range of eligible organizations, including universities, nonprofits, and small businesses.

This funding opportunity supports a wide range of organizations in developing and sharing innovative neuroscience technologies to enhance research and understanding of brain function.

This funding opportunity provides financial support to state and local governments, tribal entities, and planning organizations for bridge replacement, rehabilitation, and planning projects to improve transportation infrastructure across the nation.

The Distributed Array of Small Instruments (DASI) solicitation is designed to address the increasing need for high spatial and temporal resolution measurements to determine the local, regional, and global scale processes that are essential for addressing the fundamental questions insolar and space physics. This solicitation will be formally divided into two tracks: 1) development of instrumentation for future deployment in arrays and 2) deployment and operation of existing instruments in distributed arrays.This DASI solicitation emphasizes both strong scientific merit and a well-developed plan for student training and involvement of a diverse workforce.

This funding opportunity provides financial support for educational and non-profit institutions to conduct innovative energy-related research that benefits Air and Space Force operations, with a focus on emerging technologies in areas like bio-agile energy, metamaterials, electrochemistry, and space architectures.

This grant provides funding for research and management projects focused on improving the understanding and conservation of salmon populations in the Yukon River, particularly benefiting local communities that rely on these fish for sustenance.

This grant provides funding to health organizations in Cameroon to strengthen their ability to prevent, detect, and respond to public health threats and improve overall health security.

This funding opportunity supports research institutions and organizations conducting experimental studies with human participants to explore new brain stimulation techniques for treating substance use disorders.

This funding opportunity supports U.S.-based businesses, academic institutions, and non-profits in developing innovative solutions for sustainable supply chains that reduce waste and promote recycling, while also fostering community benefits and workforce development.

This funding opportunity provides financial support to Indian Tribes and related organizations to develop clean energy solutions and enhance energy independence on Tribal Lands.

This funding opportunity provides financial support to organizations that will promote and implement employment research for individuals with disabilities, enhancing collaboration among stakeholders like employers and policymakers.

A. Program Need: The Historic Preservation Training Center (HPTC) is dedicated to the preservation and maintenance of historic buildings, structures, and features of the NPS and its partners. The HPTC executes this commitment by demonstrating outstanding leadership through field preservation schooling for basic hands-on craft skills development in masonry, carpentry, wood crafting, and architectural building identification, evaluation, and condition assessment techniques. The HPTC utilizes historic preservation projects as its main instrument for teaching preservation philosophy and progressive development of building crafts knowledge, exposure to the newest stabilization practices, techniques and applications, and enriching project management skills. This structure lends itself to accommodate on projects additional individuals looking to learn and practice new skills through hands-on projects. The HPTC is continuing to grow significantly across the NPS in scope and scale. Additional technical assistance on projects from skilled individuals will assist it in more responsively meeting the demand for project work at NPS sites across the country, and thus better accomplish the HPTC and overall NPS mission to preserve cultural resources for future generations to experience, learn from, and enjoy.B. Program Objectives: The program objective is to support and stimulate preservation trades and project work on NPS cultural resources through hosting pre-apprentice-style and pre-professional experiences for emerging professionals in the fields of facility management and cultural resource restoration and rehabilitation. Specifically, the program focuses on engaging existing students and graduates of trade schools focused on historic preservation skills and knowledge (such as those listed on The Campaign for Historic Trades website) or other facility relevant trades and fields (e.g. water/wastewater management, engineering, architecture, project management, etc.) and degree programs applicable to public land facility management who are looking for opportunities to apply their education to real-life projects. The program will promote greater public and private participation in historic preservation and facility programs and activities while simultaneously building resource stewardship ethics in its participants. An ancillary benefit and objective is to provide the National Park Service with trained individuals to help complete critical historic preservation and facility projects. The program will combine an intensive, immersive work atmosphere with tailored classroom and field-based curriculum to provide participants with any additionally necessary training related to the maintenance, restoration, and preservation of the infrastructure (buildings, bridges, monuments, memorials, culverts, etc.) found on public lands. The work completed will be on active NPS backlogged preventative maintenance and other projects alongside NPS maintenance and preservation professionals. Any curriculum provided by NPS will support this hands-on experience through reinforcement of the importance of trade skills, ethics of conservation and preservation on public lands.The program will strive to engage emerging student or recent graduations (2 years) historic trades and facility professionals from diverse backgrounds currently underrepresented in this field of work. The goal is to interest these skilled individuals in NPS career opportunities and thus diversify the NPS Facilities workforce.

This funding opportunity is designed to help schools collect and utilize data to improve the health and well-being of adolescents by tracking their behaviors and experiences over time.

Amendment 000001 - Remove the references to Letter of Intent. A Letter of Intent is not required for this FOA. Amendment 000002 - Update Section I.D. Applications Specifically Not of Interest. "Applications that are not led by a State, municipal entity, transit authority, or non-profit (See Section III.A.)" are specifically not of interest. Amendment 000003 - Extend the Concept Paper Submission Deadline from June 19, 2024 at 5:00PM ET to June 20, 2024 at 5:00PM ET in observance of the Juneteenth National Independence Day Federal Holiday. Amendment 000004 - Extend the following deadlines: Submission Deadline for Full Applications, Expected Submission Deadline for Replies to Reviewer Comments, Expected Date for EERE Selection Notifications, and Expected Timeframe for Award Negotiations. Section II.A.i. Update Anticipated Period of Performance for Topic Areas 1 and 2 (Phase 1). Section IV.D.xvi. The research and development (R) activities to be funded under this FOA will support the government-wide approach to the climate crisis by driving the innovation that can lead to the deployment of clean energy technologies, which are critical for climate protection. Specifically, this FOA will aid communities with resource and energy recovery strategies associated with their organic waste streams. Organic waste streams represent major sources of fugitive methane emissions, volatile organic compounds, and other pollutants. The White House set a goal of reducing methane emissions by 30% by 2030. By developing strategies that can prevent the landfilling of these wastes, one of the major sources of fugitive methane can be mitigated. Holistic waste management strategies can also benefit communities by reducing other impacts associated with waste collection and processing infrastructure including reducing truck traffic, odors, litter, and other air, water, and health impacts. Topic Area 1 is focused specifically on helping communities beyond a conceptualization phase by supporting more in-depth feasibility or scoping analysis. Oftentimes, staff and organizational capacity in communities (particularly in rural, remote, Tribal, or smaller communities) is limited. While technical assistance programs can accomplish some of these objectives, direct financial assistance can close this capacity gap. Topic Area 2 is targeted towards communities that have previously completed feasibility analysis and are seeking funding to further refine their project concept. Municipal and non-profit staff capacity and availability of funding often makes detailed design work out of reach for many communities and this topic aims to close that gap. Projects selected under Topic Area 2 will have an opportunity to construct and operate their designed pilot facility based on the down-select process described in the FOA. The eXCHANGE system is currently designed to enforce hard deadlines for Concept Paper and Full Application submissions. The APPLY and SUBMIT buttons automatically disable at the defined submission deadlines. The intention of this design is to consistently enforce a standard deadline for all applicants. Applicants that experience issues with submissions PRIOR to the FOA Deadline: In the event that an Applicant experiences technical difficulties with a submission, the Applicant should contact the eXCHANGE helpdesk for assistance (exchangehelp@hq.doe.gov). The eXCHANGE helpdesk and/or the EERE eXCHANGE System Administrators (eXCHANGE@ee.doe.gov) will assist the Applicant in resolving all issues. Applicants that experience issues with submissions that result in a late submission: In the event that an Applicant experiences technical difficulties with a submission that results in a late submission, the Applicant should contact the eXCHANGE helpdesk for assistance (exchangehelp@hq.doe.gov). The eXCHANGE helpdesk and/or the EERE eXCHANGE System Administrators (eXCHANGE@ee.doe.gov) will assist the Applicant in resolving all issues (including finalizing the submission on behalf of, and with the Applicant's concurrence). DOE will only accept late applications when the Applicant has a) encountered technical difficulties beyond their control; b) has contacted the eXCHANGE helpdesk for assistance; and c) has submitted the application through eXCHANGE within 24 hours of the FOA's posted deadline. Please see the full FOA at EERE-Exchange.energy.gov. The required Concept Paper due date for this FOA is 06/20/2024 at 5PM ET. The Full Application due date for this FOA is 8/14/2024 at 5PM ET. Interested parties are directed to visit the Energy Efficiency and Renewable Energys eXCHANGE system at https://eere-Exchange.energy.gov for the full Funding Opportunity Announcement DE-FOA-0003072. Questions regarding the FOA must be submitted to FY24WASTEFOA@ee.doe.gov.

This program provides funding to accredited universities and tribal entities to develop training centers that enhance the skills of the maternal and child health workforce through partnerships and comprehensive education initiatives.

This funding opportunity provides financial support to federally recognized Indian tribes and their representative organizations for projects that remove barriers to fish passage, benefiting tribal communities and enhancing native fish populations.

This funding opportunity supports researchers and organizations in developing advanced tissue-engineered technologies that mimic cancer biology to improve cancer detection, treatment, and prevention.