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Grants for Nonprofits - Federal

Explore 6,095 grant opportunities

Behavioral and Integrative Treatment Development Program (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 20, 2024

Date Added

May 9, 2022

This funding opportunity supports researchers developing and testing behavioral interventions for drug abuse treatment, including those addressing comorbidities and utilizing technology to improve outcomes.

Education
State governments
Rural Housing Preservation Grant 2025
$100,000
U.S. Department of Agriculture (Rural Housing Service)
Federal

Application Deadline

Sep 4, 2025

Date Added

Aug 6, 2025

This funding opportunity provides financial support to public agencies, nonprofit organizations, and tribes for home repairs and rehabilitation projects aimed at assisting very-low and low-income homeowners in rural areas.

Housing
Nonprofits
Pragmatic Trials across the Cancer Control Continuum (UG3/UH3 Clinical Trial Required)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 17, 2025

Date Added

Nov 19, 2024

This funding opportunity supports the development and testing of cancer-related interventions through real-world clinical trials, particularly targeting diverse populations and addressing health disparities in the United States.

Education
State governments
Alumni Engagement Innovation Fund (AEIF) 2026
$30,000
U.S. Department of State (U.S. Mission to Guinea)
Federal

Application Deadline

May 7, 2026

Date Added

Apr 9, 2026

This funding opportunity provides financial support for alumni of U.S. government-funded exchange programs in Guinea to implement community-based projects that promote shared values and address local challenges, particularly in celebration of the United States' 250th anniversary.

International Development
Nonprofits
Research to Advance the Science of Primary Care (R01)
$2,500,000
U.S. Department of Health and Human Services (Agency for Health Care Research and Quality)
Federal

Application Deadline

Mar 25, 2026

Date Added

Mar 30, 2024

This funding opportunity supports research projects that aim to improve the quality and effectiveness of primary care by addressing real-world challenges and promoting health equity, particularly for vulnerable populations.

Health
State governments
Regional Childrens Advocacy Centers Program
$1,125,000
U.S. Department of Justice (Office of Juvenile Justice Delinquency Prevention )
Federal

Application Deadline

Oct 6, 2025

Date Added

Sep 13, 2025

This funding opportunity is designed to support local nonprofit children's advocacy centers in enhancing their services and training related to the investigation and prosecution of child abuse and neglect cases across four U.S. regions.

Law Justice and Legal Services
Nonprofits
OJJDP FY24 Juvenile Justice Evidence Translation Project
$1,000,000
USDOJ-OJP-OJJDP (Office of Juvenile Justice Delinquency Prevention )
Federal

Application Deadline

Jun 18, 2024

Date Added

May 2, 2024

With this solicitation, OJJDP seeks to support the development and dissemination of translational tools and resources current knowledge about what works packaged in accessible, comprehensible, actionable form for use by everyday youth serving (nonresearcher) practitioners, and lay persons to effect and sustain positive change on key topics spanning the juvenile justice continuum in order to improve the juvenile justice system and prevent juvenile delinquency.

Law Justice and Legal Services
Public and State controlled institutions of higher education
2025 Human Exploration Research Opportunities (HERO) NOFO
$1,500,000
National Aeronautics & Space Administration (NASA Johnson Space Center)
Federal

Application Deadline

Oct 31, 2025

Date Added

Nov 6, 2024

This funding opportunity supports U.S. institutions conducting research to improve health and performance for astronauts during human space exploration missions.

Science and Technology
Public and State controlled institutions of higher education
NIJ FY24 Research and Evaluation of Policing Practices
$3,500,000
USDOJ-OJP-NIJ (National Institute of Justice)
Federal

Application Deadline

May 20, 2024

Date Added

Mar 6, 2024

With this solicitation, NIJ seeks rigorous, applied evaluative research on: (1) police training; (2) police accountability policies and practices; (3) investigative practices to enhance clearance rates; and (4) police officer health and wellness programs. Successful applicants should propose the most rigorous design to answer their proposed research questions. NIJ will consider research designs that include qualitative, quantitative, and mixed methods designs. Randomized controlled trials (RCTs) and strong quasi-experimental designs are required for proposals to conduct outcome evaluations. NIJ will give special consideration to proposals with methods that include meaningful engagement with the people closest to the subject of study, including practitioners as well as community members representing crime victims, people under criminal justice supervision, and members of high-crime communities. Applicants are encouraged to propose multidisciplinary research teams to build on the complementary strengths of different methods and areas of subject matter expertise. NIJ also seeks proposals that include consideration and measurement of issues of diversity, discrimination, and bias across age, gender, race, ethnicity, religion, and sexual orientation, as applicable. Applications proposing research involving partnerships with juvenile justice, criminal justice or other agencies should include a strong letter of support, signed by an appropriate decisionmaking authority from each proposed, partnering agency. A letter of support should include the partnering agency’s acknowledgment that de-identified data derived from, provided to, or obtained through an award funded by NIJ will be archived by the grant recipient with the National Archive of Criminal Justice Data (NACJD) at the conclusion of the award. Applicants and their potential partners are encouraged to review NIJ’s data archiving guidance. If selected for an award, grantees will be expected to have a formal agreement in place with partnering agencies by January 1, 2025. That formal agreement must include a provision to meet the data archiving requirements of the award. NIJ seeks proposals that include robust, creative, and multi-pronged dissemination strategies that include strategic partnerships with organizations and associations that are best equipped to ensure that research findings lead to changes in policies and practices. Special consideration will be given to proposals that dedicate at least 15% of the requested project award funding toward implementing such strategies, as demonstrated in the “Budget Worksheet and Budget Narrative.” In the case of partnerships that will involve the use of federal award funds by multiple partnering agencies to carry out the proposed project, only one entity/partnering agency may be the applicant (as is the case with any application submitted in response to this solicitation); any Page 8 O-NIJ-2024-172011 others must be proposed as subrecipients. The applicant is expected to conduct the preponderance of the work proposed.

Science and Technology
State governments
Rehabilitation Research and Training Center (RRTC) on Improving Employment Outcomes Among People with Serious Mental Illness
$875,000
HHS-ACL (Administration for Community Living)
Federal

Application Deadline

May 7, 2024

Date Added

Jul 19, 2023

The purpose of the RRTCs, which are funded through the Disability and Rehabilitation Research Projects and Centers Program, is to achieve the goals of, and improve the effectiveness of, services authorized under the Rehabilitation Act through well-designed research, training, technical assistance, and dissemination activities in important topical areas as specified by NIDILRR. These activities are designed to benefit people with disabilities, family members, rehabilitation service providers, policymakers and other research stakeholders. The purpose of this particular RRTC is to conduct research, training, technical assistance, and related activities to contribute to improved employment outcomes of adults with Serious Mental Illness. NIDILRR plans to make one grant under this opportunity. The grant will have a 60-month project period, with five 12-month budget periods.

Science and Technology
State governments
Community Economic Development Focus on Energy Communities
$800,000
HHS-ACF-OCS (Administration for Children and Families - OCS)
Federal

Application Deadline

May 20, 2024

Date Added

Jan 28, 2024

This NOFO will be canceled, however there will be a focus on energy communities within HHS-2024-ACF-OCS-EE-1965.The Administration for Children and Families, Office of Community Services will solicit applications to award approximately $3.2 million in Community Economic Development (CED) discretionary award funds to Community Development Corporations for CED projects that will be located in and serve energy communities communities that have either experienced employment loss and/or economic dislocation events as a result of declines in the fossil fuel industry and/or are disproportionately reliant on fossil fuel energy production or distribution, including coal, oil, gas, and power plant communities across the country. Projects may include the creation or expansion of business(es) that reduce emissions of toxic substances and greenhouse gases from existing and abandoned infrastructure and that prevent environmental damage that harms communities and poses a risk to public health and safety. Projects may also employ individuals from energy communities but focus on a range of other industries. The overall goal of this effort will be to create good-paying jobs, spur economic revitalization, remediate environmental degradation, and support energy workers.

Income Security and Social Services
Nonprofits
Clinical Studies of Mental Illness (Collaborative R01) (Clinical Trial Optional)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2025

Date Added

Dec 13, 2022

This funding opportunity supports collaborative clinical studies on mental illness across multiple research sites, encouraging diverse participation and innovative research into genetics, biomarkers, and treatment responses.

Health
State governments
Advisory Committee Coordination Support for the Chesapeake Bay Program Partnership
$2,450,000
U.S. Environmental Protection Agency
Federal

Application Deadline

May 1, 2026

Date Added

Mar 11, 2026

This funding opportunity provides financial support for organizations to coordinate and support advisory committees that contribute to the restoration and protection of the Chesapeake Bay, benefiting diverse stakeholders across the watershed.

Environment
Native American tribal organizations
Notice of Intent to Publish a Funding Opportunity Announcement for BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)
$750,000
HHS-NIH11 (National Institutes of Health)
Federal

Application Deadline

May 25, 2024

Date Added

Nov 24, 2023

This Notice of Intent to Publish is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects for the following Notice of Funding Opportunity (NOFO), which is expected to be published in January 2024, with an anticipatedapplication receipt date in May 2024. The Brain Research through Advancing Innovative Neurotechnologies(BRAIN) Initiative intends to promote a new initiative by publishing a NOFO to solicit applications that would support development and preclinical testing, beginning withproof of concept,of next-generation recording and/or modulation devices for human use to further our understanding of the human central nervous system and treat nervous system disorders. This NOFO will utilize the R18 activity code. Details of the planned NOFO are provided below.

Health
State governments
Alumni Engagement Innovation Fund (AEIF) 2026
$35,000
U.S. Department of State (U.S. Mission to Burundi)
Federal

Application Deadline

May 4, 2026

Date Added

Apr 3, 2026

This funding opportunity supports alumni of U.S. government-sponsored exchange programs in Burundi to implement innovative projects that promote youth engagement, entrepreneurship, and educational access while strengthening ties with the United States.

International Development
Individuals
DoD Vision Research, Mentored Clinical Research Award
$225,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Aug 23, 2024

Date Added

Mar 27, 2024

The FY24 VRP MCRA is intended to support patient-oriented vision injury research and develop research expertise of highly motivated military or civilian clinicians in training. Research supported by the MCRA can be a standalone study of high impact to vision injury care or the generation of clinical research data in preparation for a more expansive study.Each MCRA must be led by an established clinician or Ph.D. clinical scientist who will serve as Principal Investigator (PI) of the award. Key personnel must include a clinician in training (e.g., a fellow, resident, junior clinician, clinician in a Ph.D. program). The clinician in training should have sufficient time remaining in their training program to complete the research proposed under the MCRA. The clinician in training will conduct the proposed research under the mentorship of the PI, with support from supporting personnel as appropriate. While additional junior scientists or clinicians may participate in the research, only one clinician in training may be designated as mentee. A Letter of Organizational Support and Mentee Eligibility, signed by the Department Chair or appropriate organization official, and a Letter of Commitment, signed by the mentee, should be submitted as part of Attachment 2: Supporting Documentation.For the purposes of this award mechanism, clinical research is defined as research conducted with human subjects or research on material of human origin, such as tissues or specimens or data obtained from human subjects. Documentation of Institutional Review Board (IRB)/ Ethics Committee (EC) approval or exemption by December 1, 2024, is required for an MCRA application to be considered for funding. See Attachment 2: Supporting Documentation for additional detail.The MCRA may not be used to conduct preclinical research (including animal research) or clinical trials.A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.Studies that retrospectively analyze data generated from previously conducted clinical trial(s) are not considered a clinical trial.

Science and Technology
Nonprofits
AFCEC Land Management Mapping for CONUS/Europe/PACAF Air Force Installations
$59,332,041
U.S. Department of Defense (Fort Worth District)
Federal

Application Deadline

May 26, 2026

Date Added

Apr 24, 2026

This funding opportunity is designed to support organizations involved in environmental conservation and land management by providing resources for geospatial data collection and analysis across U.S. Air Force installations in the continental U.S., Europe, and the Pacific.

Natural Resources
Public and State controlled institutions of higher education
Lewis Houghton Civics and Democracy Initiative - Continuing Awards
$250,000
Library of Congress
Federal

Application Deadline

May 18, 2026

Date Added

Apr 21, 2026

This funding opportunity provides financial support to existing partner organizations of the Library of Congress to enhance and expand civic education programs using the Library's digital collections.

Education
Nonprofits
Innovative Health Practices
$1,000,000,000
U.S. Agency for International Development
Federal

Application Deadline

Feb 20, 2028

Date Added

Feb 21, 2023

The United States Agency for International Development (USAID) is issuing this Broad Agency Announcement (BAA) to seek participants to co-create, co-design, co-invest, and collaborate on creating, piloting, and scaling innovative research and development interventions utilizing innovative health practices to help reduce disease and mortality rates worldwide. USAID invites organizations and companies to submit an Expression of Interest (EOI) and participate in generating novel tools and approaches that accelerate and sustain improved health outcomes in low-and-middle-income countries (LMICs). The intent of the BAA is to allow co-creation and co-design to the maximum extent to create high quality, effective partnerships with great efficiency in time and resources. USAID is seeking new applications of research development, science, partnerships, and innovative practices in global health that provide the best value to the Government. USAID will invite selected for-profit and non-profit, public and private organizations, as detailed below, to co-create innovative research and development (R) solutions to the Problem and Challenge Statements stated in this BAA, including those organizations that have ideas, expertise, resources, and/or funding to add to potential solutions. In particular, this BAA welcomes co-creation from local partners based in LMICs, including the private sector, faith-based organizations, and other non-traditional USAID partners, to increase the presence and voices of local populations in solving their own health challenges.The intent of the BAA is to enable and encourage co-creation and co-design in order to generate high quality ideas and effective partnerships with improved efficiency in time and resources. Other types of collaboration can also include co-investing:Co-Investing: USAID wants to align goals with the partners under this BAA, to facilitate shared responsibility, shared risk, and shared resourcing. Shared resourcing requires that cash and other resources, both tangible and intangible, such as in-kind contributions, expertise, intellectual property, brand value, high-value coordination, and access to key people, places, and information, are directed towards reaching the solution to the Problem/Challenge. Co-investing does not require equal shared resources (such as 1:1 leverage), but rather resource contributions that are appropriate to the specific projects objectives, considering the comparative advantages brought by the participation of each party.

Science and Technology
Nonprofits
Molecular Imaging of Inflammation in Cancer (R01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 5, 2024

Date Added

Jul 22, 2021

This funding opportunity invites researchers to develop and apply advanced imaging techniques to better understand the role of inflammation in cancer, fostering collaboration between cancer scientists and imaging experts.

Education
State governments