Grants for Nonprofits - Federal

This funding opportunity supports innovative, early-stage research involving human participants to advance biomedical and clinical science, targeting a wide range of eligible applicants including universities, nonprofits, and small businesses.

This grant provides funding to support postdoctoral researchers from diverse backgrounds as they transition into independent faculty positions in biomedical research.

The purpose of this research is to systematically evaluate the diastereomeric composition of LEQVIO (Inclisiran), an FDA-approved, N-acetyl galactosamine (GalNAc)-conjugated siRNA drug, and to understand the biological/pharmacological activity of each diastereomer in LEQVIO through stereo chemically controlled synthesis and biological activity assessment using in vitro and animal models. The proposed studies will focus on 1) synthesis of each diastereomer of LEQVIO (Inclisiran) in stereo chemically pure form; 2) assessment of the biological activity of each stereo chemically pure diastereomer in inhibiting PCSK9 activity using in vitro assays and in a transgenic mouse model; 3) development of analytical methods to identify and characterize the stereochemical structure of each diastereomer in LEQVIO; and 4) assessment of the individual contribution of each diastereomer to the overall pharmacological activity of LEQVIO. Tools developed in this research can also be applied to other similar GalNAc-conjugated siRNAs specifically, and other siRNAs in general. Knowledge gained from this research will also contribute to the sameness evaluation of generic siRNAs, and to the quality control of oligonucleotide drugs.

This opportunity seeks input from organizations involved in maternal and child health projects to help improve healthcare quality for the poorest and most vulnerable populations in Indonesia.

This grant provides funding to civil society organizations in Uganda to strengthen their capacity and coordination in delivering comprehensive HIV prevention and treatment services to key and priority populations at high risk of HIV infection.

The purpose of this Funding Opportunity Announcement (FOA) is to 1) invite applications that propose to develop and implement early to late stage clinical trials of promising pharmacological and non-pharmacological interventions for cognitive and neuropsychiatric changes associated with age-related cognitive decline and Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD) across the spectrum from pre-symptomatic to more severe stages of disease, and 2) stimulate studies to enhance trial design and methods.

This funding provides financial support to organizations that help improve job training, employment opportunities, and housing conditions for migrant and seasonal farmworkers and their families across the United States.

This funding opportunity supports U.S. colleges and universities with limited research funding to assess their biomedical research capabilities and develop strategic plans to enhance their research infrastructure and capacity.

This funding opportunity provides $125,000 to organizations that will create a STEM learning lab for Indian students aged 13 to 21, promoting innovative education and future partnerships with U.S. institutions.

This grant provides funding to nonprofit organizations and educational institutions to improve transparency and governance in Malawi's mining sector and public debt management.

This notice is not a mechanism to fund existing NOAA awards. The purpose of this notice is to request applications for special projects and programs associated with NOAA's strategic plan and mission goals, as well as to provide the general public with information and guidelines on how NOAA will select applications and administer discretionary Federal assistance under this Broad Agency Announcement (BAA).This Broad Agency Announcement is a mechanism to encourage research, education and outreach, innovative projects, or sponsorships that are not addressed through NOAA’s competitive discretionary programs. This announcement is not soliciting goods or services for the direct benefit of NOAA. Funding for activities described in this notice is contingent upon the availability of Fiscal Year 2021, Fiscal Year 2022, and Fiscal Year 2023 appropriations. Applicants are hereby given notice that funds have not yet been appropriated for any activities described in this notice. Publication of this announcement does not oblige NOAA to review an application beyond an initial administrative review, or to award any specific project, or to obligate any available funds. As an agency with responsibilities for maintaining and improving the viability of marine and coastal ecosystems, for delivering valuable weather, climate, and water information and services, for understanding the science and consequences of climate change, and for supporting the global commerce and transportation upon which we all depend, NOAA must remain current and responsive in an ever-changing world. We do this in concert with our partners and stakeholders in Federal, state, and local governments and private organizations, applying a systematic approach that links our strategic goals through multi-year plans to the daily activities of our employees. Every year we are committed to re-evaluate our progress and priorities, look for efficiencies, and take advantage of new opportunities to improve our information, products, and services. In furtherance of this objective, NOAA issues this BAA for extramural research, innovative projects, and sponsorships (e.g., conferences, newsletters, etc.) that address one or more of the following four mission goal descriptions contained in the NOAA Strategic Plan: Climate Adaptation and Mitigation Weather-Ready Nation Healthy Oceans Resilient Coastal Communities and Economies

The U.S. Department of States Consulate General of the United States in Hyderabad announces an open competition to implement a program, Countering Disinformation Training for Vernacular Language Journalists, in four consular regions and the embassy region. Based on funding availability, this project will provide 20 to 25 journalists in five regional languages of Telugu, Tamil, Marathi, Bengali, and Hindi from media outlets and digital platforms in Hyderabad, Chennai, Mumbai, Kolkata, and New Delhi with 18-month-long, hands-on training in countering disinformation, consulting multiple sources, and utilizing fact checking resources. This project will build skills among local language journalists to verify news, views, photos, and videos prior to release. This project will also help build a network of responsible journalists in India who will advocate for fact checking, and recognize that the need to build audience trust outweighs being first to break the news.

This funding opportunity supports complex clinical trials aimed at improving screening, diagnosis, prevention, or treatment of vision disorders, targeting researchers and institutions capable of leading high-risk studies with significant public health impact.

This program provides funding to organizations that improve bison production and marketing, particularly benefiting small farms, tribal groups, and underserved communities across the United States.

This program provides funding to U.S. colleges, universities, and certain non-academic organizations to implement strategies that promote gender equity and inclusion in STEM academic careers.

This grant provides funding for research projects that enhance cadet education, support faculty development, and improve the operational capabilities of the Air Force, while fostering collaboration with industry partners.

The intent of the FY24 ERP LRA is to leverage ongoing or completed research studies for which PTE was not an original focus and to provide support to expand the research to develop such a focus and increase our understanding of PTE. The project may include basic, translational, and/or clinical research studies. The study must be associated with an ongoing or completed research effort in which PTE is/was not a research priority and for which addition of cohorts, outcomes, assessments, or analysis specific to PTE would be scientifically justified to increase our understanding of PTE. Examples of allowable research include but are not limited to: Secondary analysis of epilepsy surveillance data to evaluate PTE risk; Addition of a chronic TBI cohort in an ongoing preclinical animal study to evaluate seizure outcomes and epileptogenesis; Recruitment/Analysis of a PTE cohort within an ongoing observational longitudinal study for a known concomitant comorbidity of PTE such as depression, cognitive deficits, sleep disorder, etc.

U.S. DEPARTMENT OF STATE U.S. EMBASSY Nouakchott Notice of Funding Opportunity (NOFO) Section A. Funding Opportunity Program Description Assistance Instrument Type: Grant Funding Opportunity Title: PGO Request for SSH Proposals Funding Opportunity Number: PGO-MRT-FY2023 Catalog of Federal Domestic Assistance Number: 19.220 Funding Amount: $60,000 Number of Awards: 5 Key Dates: 1. Applications must be submitted by 11:59PM EDT on August 06, 2024. 2. Questions must be submitted by 11:59PM EDT on July 24, 2024. 3. Notification of project approval and award signing expected by September 2024. Eligibility Category: Local communities, cooperatives, associations, local NGOs, municipalities. Executive Summary: The U.S. Embassy Nouakchott / Program and Grants Office (PGO) at the U.S. Department of State (DOS), announces this Notice of Funding Opportunity (NOFO) for Request of Full Proposals from organizations interested in applying for funding for program proposals that promote socioeconomic activities. Five to ten grants, with a combined total of $60,000 U.S. Dollars (USD) in FY 2023 Special Self-Help program (SSH)/source of funding will be awarded (pending availability of funds) for work that will support socioeconomic activities. The period of performance is 12 to 16 months. Funding authority rests in the Foreign Assistance Act of 1961, as amended. Contact Person: For questions on the application and technical content please contact Nouakchottgrants@state.gov Please read carefully the entire solicitation package if you plan to submit an application; there are steps that you should take immediately in order to make your submissions by the deadline. A.1. Background: U.S. Embassy Nouakchotts Program and Grants Office (PGO) announces a request for full proposals from organizations interested in applying for funding for program proposals that promote socioeconomic activities under its Ambassadors Special Self Help program (SSH). PGO invites organizations interested in potential funding to submit their proposals that reflect the below goals - pending funding availability. Please carefully follow all instructions below. A.2. The Special Self-Help Program Objectives: Programming supported with SSH resources should address the following program objective: The purpose of the Special Self-Help program is to fund grants for small development activities that generate public awareness of U.S. foreign assistance efforts but that fall outside the structure of other established U.S. assistance projects. The program is intended to be flexible and allow the Ambassador to respond directly to requests from local communities for assistance with small community projects that have immediate impact, and further mission policies and objectives. Equally important, the Special Self-Help program is structured to encourage communities to be self-reliant and undertake similar activities on their own in the future. All Special Self-Help projects are community-based, initiated locally, administered at the local level, and include significant community contributions in cash, labor or materials. The implementation period for individual self-help projects is short - less than one year, and projects are small ranging in cost from $6,000 to $12,000. Projects proposed should not exceed $12,000.

With this solicitation, BJA seeks to fund four national training and technical assistance (TTA) programs to support law enforcement and criminal justice stakeholders in Task Force Leadership, Operations and Management (Category 1), Specialized Units TTA (Category 2), Crime Gun Intelligence Center TTA (Category 3) and Police Recruiting and Retention Among Underrepresented Groups (Category 4).

Please note that this program requests optional Notices of Intent, which are due via NSPIRES by June 27, 2024. See the full posting on NSPIRES for details. Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at sara@nasa.gov, but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).