Grants for Nonprofits - Federal

This funding opportunity provides financial support to state and tribal agencies, community organizations, and collaborations focused on improving safety and well-being for families affected by domestic violence and child welfare issues.

This grant provides funding for research projects focused on improving health outcomes through lifestyle medicine for individuals affected by the 9/11 attacks, including responders and survivors receiving care under the WTC Health Program.

The "Blueprint Medtech: Small Business Translator" grant aims to support small businesses in developing and testing therapeutic and diagnostic devices for nervous or neuromuscular disorders, with funding and expert assistance provided for activities such as clinical studies, safety testing, and design validation, ultimately leading to FDA or IRB approval.

The REDI: NIA Entrepreneurship Enhancement Award (R25) is a grant aimed at providing entrepreneurial training to graduate students, postdocs, and early career scientists in fields related to aging and Alzheimer's disease research, to prepare them for diverse career paths.

The Office of Native American Affairs (ONAA) mission is to ensure that American Indian, Alaska Natives and Native Hawaiians (referred to collectively as Native American) seeking to create, develop and expand small businesses have full access to the business development and expansion tools available through the Agency’s entrepreneurial development, lending and procurement programs. ONAA’s overarching goal is to promote and support American Indians, Alaska Natives and Native Hawaiian entrepreneurs. In recent years, ONAA has successfully sponsored and managed nation- wide contractor-led workshops and roundtables, co-sponsored agreements, interagency agreements, and tribal consultations; developed and distributed promotional materials; and attended and participated in national and regional economic development conferences as subject matter experts for these groups. The focus of this pilot program initiative is to award a grant to a Native American serving business to carry out projects that support developing exports by eligible Native small businesses. The objective of NATEP is to increase (1) the number of Native small businesses that export, (2) the dollar value of exports, and (3) the number of Native small businesses exploring significant new trade opportunities. Such empowerment will serve to maximize economic impact and improve quality of life for the targeted underserved communities. Section 7(j) of the Small Business Act authorizes the U.S. Small Business Administration to provide management and technical assistance to eligible individuals and businesses. To be eligible for 7(j) services, a client must be: a socially and economically disadvantaged individual whose firm is a participant in the 8(a) Business Development Program; a business that is eligible to receive 8(a) contracts; or a business which qualifies as small under 13 CFR subpart 121 – Small Business size Regulations, and which is located in an urban or rural area with a high proportion of unemployed or low-income individuals, or which is owned by low-income individuals. The term “high proportion of unemployed” means the urban or rural county’s unemployment rate is not less than 140 percent of average unemployment rate for the United States or for the State in which such county is located, whichever is less, based on the most recent data available in the annual Local Area Unemployment Statistics report from the U.S. Department of Labor, Bureau of Labor Statistics. The term “low- income individual” means an individual whose family’s taxable income for the preceding year did not exceed 150 percent of the poverty level amount established by the Bureau of Census, U.S. Department of Commerce, for determining poverty status.

This funding opportunity supports clinical trials aimed at developing new therapies for rare neurodegenerative diseases, such as ALS, and is open to a wide range of eligible organizations, including universities and nonprofits.

With this solicitation, OJJDP seeks to provide funding to communities to develop intervention and supervision services for youth with problematic or illegal sexual behavior, and to provide treatment services for their victims and families/caregivers. Under this initiative, successful applicants are expected to have an established multidisciplinary team that (1) supports a comprehensive holistic approach to treating youth with problematic or illegal sexual behavior and (2) provides support services to victims and families/caregivers.

This funding opportunity supports promising predoctoral students from diverse backgrounds to conduct research in translational studies related to Alzheimer's disease and related dementias, fostering skills essential for advancing this critical field.

Notice of Funding Opportunity Description Background Although vaccines are among the most effective approaches to control viral diseases, developing a prophylactic or therapeutic HIV vaccine has proven elusive. There are no licensed vaccines for HIV. Strategies for induction of HIV broadly neutralizing antibodies will likely require repeated exposures over long periods, including immunization with distinct antigens in sequential order. Such immunization strategies will require development of technologies for controlled vaccine release. Recent advances in materials-based science, controlled release technologies, delivery systems, and immunology provide opportunities to enhance the quality, potency and durability of vaccine-induced T cell and antibody responses to HIV-1. Materials-based approaches can be engineered to improve the stability, spatiotemporal release, and presentation of multiple vaccine components; for example, by controlling the time frame and dose of vaccine delivery over days to weeks. Recent studies have shown that a slow-release vaccine is superior to bolus administration at inducing breadth, potency, and durability of antibody responses to HIV antigens by prolonging antigen exposure in the germinal centers, thereby enhancing the maturation of B cells and generating stronger humoral immune responses. Further research is needed to elucidate the mechanisms underlying the immunological improvements observed with slow-release vaccine delivery and to translate such concepts into clinical application. It will be crucial to determine how the duration of exposure to vaccine components impacts immune cell biology, and how to calibrate vaccine release to improve responses while avoiding immune exhaustion and over-activation. Advancing safe, effective, and well-tolerated controlled release vaccines is an unmet need that may enhance vaccine effectiveness and practicality, leading to better adherence to complex regimens, fewer adverse reactions, and cost savings. Finally, iterative behavioral studies during product development to determine vaccine/provider product expectation/preferences are critical to facilitate product uptake and use.

This funding opportunity supports postdoctoral researchers conducting studies on the impact of early environmental factors on child health using a large national dataset.

The U.S. Embassy of Amman of the U.S. Department of State is pleased to announce that the Embassy invites not-for-profit organizations to submit applications to carry out a year-long slate of cultural activities, U.S. Embassy alumni activities, job skills training, U.S. higher education opportunities, climate change awareness sessions, media literacy development activities, and technical skill activities for Jordanian youth. Programming will take place in the three established American Corners in Jordan (e.g. in Amman, Zarqa, and Irbid), as well as pop up spaces throughout Jordan. The information below outlines the thematic and programmatic priorities, as well as procedures for submitting requests for funding.

This funding opportunity provides up to $100 million to various organizations for innovative projects aimed at developing vaccines, therapeutics, and research strategies to combat highly pathogenic avian influenza in the U.S. poultry industry.

This funding opportunity supports primary care centers in implementing genomic screening for common genetic conditions to improve disease prevention and care, particularly in underrepresented communities.

The DoD Breast Cancer, Transformative Breast Cancer Consortium Development Award is a funding opportunity aimed at providing resources to establish a multi-institutional research team, including scientists, clinicians, and breast cancer advocates, to conduct preliminary research and develop a consortium framework for future application to a full Transformative Breast Cancer Consortium Award, with a focus on innovative research for early diagnosis and effective treatment of breast cancer relevant to active-duty Service Members, Veterans, military beneficiaries, and the American public.

This funding opportunity supports projects that create collaborative digital editions of historical documents, particularly those highlighting underrepresented communities in U.S. history, democracy, and culture.

The U.S. Department of State announces an Open Competition for organizations interested in submitting applications for projects that support understanding and raising awareness of the Peoples Republic of Chinas sub-national diplomacy in Europe.

This funding opportunity supports U.S. and Moroccan organizations in creating innovative educational programs that engage Moroccan youth in space science and technology, fostering skills in leadership and teamwork.

The DoD Reconstructive Transplant Research Investigator-Initiated Research Award is a funding opportunity aimed at supporting innovative and impactful research projects that contribute to reconstructive transplant science, improve patient care, and enhance the quality of life, with a particular focus on addressing the healthcare needs of military service members, veterans, and their families.

The U.S. Department of Justice (DOJ), Office of Justice Programs (OJP), Office for Victims of Crime (OVC) is seeking applications for funding. OJP is committed to advancing work that promotes civil rights and equity, increases access to justice, supports crime victims and individuals impacted by the justice system, strengthens community safety, protects the public from crime and evolving threats, and builds trust between law enforcement and the community. With this solicitation, OVC seeks to enable an organization to provide financial and technical assistance to approximately 300 communities (100 each year) nationwide to conduct public education and awareness activities on crime victims rights and services in their jurisdictions during the 20252027 National Crime Victims Rights Weeks (NCVRW). This program furthers the DOJs mission to uphold the rule of law, to keep our country safe, and to protect civil rights.

This program provides funding for alumni of U.S. government-sponsored exchange programs in North Macedonia to implement innovative projects that promote democratic values, social cohesion, and U.S.-North Macedonia relations.