Grants for Nonprofits - Federal

A. PROGRAM DESCRIPTION Executive Summary: U.S. Embassy Dushanbes Public Diplomacy Section (PDS) announces an open competition to implement the Academy for Women Entrepreneurs (AWE) in Tajikistan, a program that seeks to elevate the economic livelihood of 25 women in Panjakent District. The Academy of Women Entrepreneurs (AWE) is a global program that was established by the U.S. State Department's Bureau of Educational and Cultural Affairs in 2019 to provide women with the knowledge, networks, and access to launch or scale successful businesses. By promoting womens economic opportunities and ensuring that women have the capabilities and resources needed to participate in the economy, the AWE program directly supports the U.S. National Strategy on Gender Equity and Equality. Background: Due to the high rate of male labor migration and unemployment, more Tajik women are considering how to financially support their households. However, womens entrepreneurial activities are highly dependent on the effectiveness of the business environment in the country. Successful small business development creates new employment opportunities in Tajikistan and helps women support themselves and their families. Small businesses are fast becoming the main source of income for women in Tajikistan. Panjakent, a former trading city on the ancient Silk Road, is located in a strategic geographic area bordering Uzbekistan. After a 25-year hiatus, Tajikistan and Uzbekistan have restrengthened bilateral ties, and both countries are working to expand trade and economic cooperation with each other. In this manner, they have established free economic zones where businesspeople can put their ventures to work. The city of Panjakent and its surroundings is home to unique natural beauty, newly recognized UNESCO cultural heritage sites, and agricultural projects - all of which makes it a strategic location to empower women to advance economic and human development. The skills that women will learn through AWE will not only be valuable to establish stronger economic independence for themselves but also to contribute to more cross-border trade with neighboring Uzbekistan. Project Audience(s): The primary audience is approximately 25 Tajik women in Panjakent District who have some entrepreneurial skills, either with the capacity to scale-up current ventures in hospitality management, eco-tourism, and trade, or with experience working at local markets, such as in the areas of agricultural products, handicrafts, artisan products, or in service industries such as beauty parlors and sewing. Recruitment Criteria: a) Women aged 18 to 45. b) Holding high school and/or university degrees. c) Approximately 1-2 years business experience. d) Motivation to engage in long-term business or entrepreneurial activity. e) Must reside in the district of Panjakent or nearby villages. f) Womens leadership experience. g) Community service experience. h) Some English proficiency preferred, but not a requirement. In coordination with PDS Dushanbe, the implementer will organize informational meetings to spread the word about the project, its goals, objectives, and vision, and identify current or aspiring entrepreneurs in Panjakent District. This could include information sessions at American Space Panjakent and other relevant NGO offices and entities, but also outreach with flyers provided to target women working in local markets in the specified fields. Project Goal: To elevate the economic livelihood of current or aspiring women entrepreneurs in hospitality management, eco-tourism, trade, and handicrafts in Panjakent to support the tourism infrastructure of Panjakent District. Project Objectives: Objective 1: Improve women entrepreneurs confidence and motivation in pursuing and growing their businesses. Objective 2: Increase the ability of women from the Panjakent region to create and grow their businesses in hospitality management, eco-tourism, and trade through targeted training and mentorship activities. Training topics may include but are not limited to: U.S. small business best practices, business plan development, marketing, accounting, financial management, investment and financing, leadership, strategic planning, business registration, and more. Objective 3: Increase women entrepreneurs awareness and knowledge of tourism initiatives and business opportunities in Panjakent. Objective 4: Increase women entrepreneurs abilities to apply for funding opportunities, including grants, loans, and investments, to fuel their business growth and attract potential investors. Project Activities: Select 25 women entrepreneurs for the AWE project in Panjakent. Provide women entrepreneurs with the knowledge, networks, and access to launch or scale successful businesses in Panjakent through online and in-person trainings. This could include a mentoring program or other form of connection with the business community. Use the online training platform DreamBuilder to teach participants the fundamentals of starting or growing a small business from a U.S. perspective, offering modules on marketing, pricing, and bookkeeping, and includes a built-in business plan generator. Organize sessions to increase entrepreneurs understanding of the tourism potential of the region; this could include a three-day business tour to the city of Samarkand in Uzbekistan, which holds high potential for cross-border tourism and trade. Organize and hold a final pitch event, inviting potential investors to provide feedback. B. FEDERAL AWARD INFORMATION Length of performance period: 12 months Number of awards anticipated: 1 Award amounts: awards may range from a minimum of $25,000 to a maximum of Total available funding: $39,504 Award Ceiling: $39,504 Award Floor: $25,000 Type of Funding: ECA Anticipated program start date: September 1, 2024 This notice is subject to availability of funding. Funding Instrument Type: Cooperative Agreement Cooperative agreements are different from grants in that Embassy staff are more actively involved in the grant implementation. The Department of State will be substantially involved in carrying out the following aspects of this cooperative agreement: 1) Selection of AWE personnel. 2) Selection of AWE participants. 3) Monitor AWE programming. 4) Connect recipient with the U.S. Alumni Network of Tajikistan (USANT) 5) Connect regional AWE alumni with the first cohort of 25 Tajik women entrepreneurs. 6) Publish a press release on project completion. 7) Produce a video on project accomplishments. Recipient Responsibilities: 1) Collaborate with PDS Dushanbe in selecting the participants for AWE programming. 2) Coordinate all logistics for the events including promotion, venue arrangements, set up and take down, monitoring and evaluation of the events. 3) Engage ECA exchange alumni in AWE programming. 4) Translate Dreambuilder Online Learning Platform from English into Tajik to conduct mentoring and facilitation in local languages (fundamentals of starting or growing a small business from a U.S. perspective, offering modules on marketing, pricing, and bookkeeping, and includes a built-in business plan generator.) 5) Strengthen communication, media, and outreach plans in collaboration with USANT. 6) Connect AWE alumni across the globe with dynamic U.S. experts who can engage both virtually and in person on entrepreneurship and innovation-related topics.t 7) Submit 2024-2025 AWE alumni data to PDS Dushanbe. Program Performance Period: Proposed programs should be completed in 12 months or less. The Department of State will entertain applications for continuation grants funded under these awards beyond the initial budget period on a non-competitive basis subject to availability of funds, satisfactory progress of the program, and a determination that continued funding would be in the best interest of the U.S. Department of State. Support for Diversity, Equity, Inclusion, and Accessibility (DEIA): All programs should consider strategies for expanding the pool of individuals/organizations/beneficiaries to afford opportunities for as diverse and inclusive population as is feasible to bring diverse perspectives based on religion, sex, disability, race, ethnicity, sexual orientation, gender identity, gender expression, sex characteristics, national origin, and age to implementation of the program. The Public Diplomacy Section reserves the right to award less or more than the funds described under circumstances deemed to be in the best interest of the U.S. government, pending the availability of funds and approval of the designated Grants Officer. C. ELIGIBILTY INFORMATION 1. Eligible Applicants The following not-for-profit organizations are eligible to apply: Not-for-profit organizations Civil society/non-governmental organizations Public and private educational institutions Applicants are only allowed to submit one proposal per organization. If more than one proposal is submitted from an organization, all proposals from that institution will be considered ineligible for funding. 2. Cost Sharing or Matching Cost sharing or matching is not required for this funding opportunity, but is encouraged, as well as potential public private partnerships.

Microbes and communities of microbes have remarkable genetic, physiological and biochemical diversity, allowing them to flourish in environments all over the planet and in a variety of substrates and hosts. Given their relative importance to ecosystems around the world, to the economy and to health, researchers have studied microbial systems extensively and have a better understanding of their capabilities and impacts on hosts and the environment. In recent years, researchers have increasingly turned to microbes and their diverse capabilities for bioremediation and applications in biotechnology, agriculture, and medicine. Because of advances in molecular biology, synthetic biology and bioengineering, researchers now have the ability to assemble synthetic microbial communities that have novel compositions, genetics and phenotypes and to use these communities to address both fundamental biological questions and a range of societal problems. The goal of this solicitation is to support research that addresses one or more of the three themes: 1) define the underlying mechanisms or rules that drive the formation, maintenance or evolution of synthetic microbial communities, 2) use synthetic microbial communities to address fundamental biological questions, including questions in molecular biology, cellular/organismal biology, ecology and evolution and/or 3) build synthetic communities with biotechnology, bioeconomy or environmental engineering applications, including but not limited to the production of novel biorenewable chemicals, biodegradation of recalcitrant or forever chemicals, enabling a circular bioeconomy, fostering sustainable agriculture and mitigating the impacts of climate change. For theme 3, the emphasis should be on designing communities with novel capabilities and understanding the underlying mechanisms that lead to these novel capabilities. Proposals must address one or more of the three themes noted above. Highest funding priority is given to proposals that have outstanding intellectual merit and broader impacts, while proposals with weaknesses in either category (or those that are perceived as likely to have an incremental impact) will not be competitive. The most competitive broader impacts include assessment plans. Well-conceived broader impacts activities take time and resources; thus, proposers are encouraged to include appropriate costs for broader impacts in the budget. To better understand the societal benefits and risks, as well as the potential for misuse or unintended damage to natural biological systems, synthetic microbial communities proposals should include a careful consideration of the social, ethical, and biosafety/security dimensions of the research. Investigators may choose to address these issues either as part of intellectual merit or broader impacts. Reproducibility in research leads to data that is amenable to more powerful analysis and the potential for reuse of data and greater generation of knowledge. Reproducibility in biological research that is prone to context dependent biological variation presents a unique challenge for the synthetic microbial communities researchers. Investigators must follow or advance best practices in sample collection and preparation, experimental design, data analysis, model generation, and/or validation of mathematical and computational methods to produce scientifically defensible results.

Walla Walla DistrictThis announcement represents an opportunity to enter into a cooperative agreement with an organization for outdoor education and training while accomplishing maintenance on public lands consisting of park maintenance, vegetation management, prescribed burns, landscaping, and similar services. The U.S. Army Corps of Engineers (USACE) is seeking organizations that offer challenging education and job-training experience that helps young adults develop the skills they need to lead full and productive lives and offer opportunity for aid with formal post high school education. Statutory Authority: Water Resources Development Act of 2000, Title 33, Part 2339, Section 213(a), Public Law 106-106-541, 114 Stat. 2593 (codified as amended at 33 U.S.C. 2339).

This funding opportunity supports researchers investigating the harmful effects of high-risk chemical exposures on lung and eye health, particularly in relation to public health emergencies.

This funding opportunity supports predoctoral students in dual-degree programs at institutions without NIH-funded training programs, helping them pursue research and clinical training to become future physician-scientists.

This funding opportunity is designed to support local governments, nonprofits, and educational institutions in Nebraska in providing culturally and linguistically appropriate health outreach and support services for newly arrived refugees.

This funding opportunity announcement (FOA) focuses on sensitivity and tolerance mechanisms underlying the development of alcohol use disorder. The intent of this FOA is to: (1) develop hypotheses about cellular, molecular or network mechanisms that regulate sensitivity and tolerance to alcohol, and (2) develop quantitative models to predict the development of tolerance and the progression to alcohol use disorder. These objectives will be accomplished with a Phased Innovation (R21/R33) mechanism, clinical trial optional, in which secondary data analysis or pilot studies can occur during the R21 phase, and research testing the hypotheses can be expanded in the R33 phase. The transition to the R33 phase will be determined by NIAAA program staff after evaluation of the achievement of specific milestones set for the R21 phase.

This initiative will support national service centers for molecular structure determination by high resolution cryoelectron microscopy (cryoEM). The centers will provide access to state-of-the-art equipment, technical support, and training for the production and analysis of high-resolution data and offer equal-opportunity nationwide access to services through an open application process.

This funding opportunity provides financial support to various organizations for delivering essential services to victims of crime, including children, the elderly, and other affected individuals, across the United States.

This funding initiative provides financial support to African scientists and institutions, along with global partners, to advance the development of an effective HIV vaccine through collaborative research and clinical trials.

The Embassy of the United States of America in Paraguays Public Diplomacy (PD) section of the U.S. Department of State announces an open competition for organizations to submit applications to carry out a program to implement the Academy of Women Entrepreneurs (AWE) FY-2024 program in Paraguay. The AWE program is an initiative to support and empower women entrepreneurs around the world. Through a hybrid learning experience, Paraguayan women will have the opportunity to explore the fundamentals of business, such as preparing business plans and raising capital, with the goal of building a better future for themselves, their families, and their communities. The AWE program is supported with the DreamBuilder platform developed by Thunderbird University, an online course that reinforces entrepreneurship components. This year, the AWE Paraguay program seeks to reach all 17 departments of Paraguay, empowering 100 women through the DreamBuilder platform, and virtual meetings.

This funding opportunity supports researchers exploring the mechanisms and effects of trained immunity in the immune system, particularly its implications for infectious diseases and immune-related conditions.

NIA intends to publish a Notice of Funding Opportunity (NOFO) soliciting applications that aim to develop Common Data Elements (CDEs) for Alzheimers disease (AD) and AD-Related Dementias (ADRD) using Real-World Data (RWD) from electronic health records and Centers for Medicare Medicaid Services (CMS) claims. The CDEs will foster data harmonization and interoperability among data systems that involve disparate and unaligned RWD. By reducing the efforts required for data harmonization in using RWD for cross-sectional and longitudinal analysis, the NOFO may enable researchers to utilize RWD more efficiently and produce real-world evidence in a faster manner. The NOFO is expected to be published in March 2024 with an expected application due date in June 2024. Please note that these time frames are simply estimations, and they may change. The NOFO is expected to utilize the Resource-Related Research Projects Cooperative Agreements (U24) activity code. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Additional details regarding the planned NOFO are below.

This project seeks to enhance detainees rights in Tunisia by expanding access to legal aid and improving enforcement of detainee rights in Tunisia. In 2016, Tunisia passed wide-ranging reforms of its Criminal Procedure Code (CPC). Act 2016-5 (Law 5) enacting article 13 of the CPC gave arrestees in police custody the right to legal counsel and significantly reduced the duration of legal pre-charge detention from 72 to 48 hours. By the order of public prosecutor and when justified, pre-charge detention could be extended with 48 hours for felonies and 24 hours for misdemeanors. In parallel, the anti-terrorism law of 2015 allows prosecutors and police to hold suspects for the first 48 hours without access to a lawyer and extends the duration of pre-charge custody to five days extendable two times for a total of 15 days. Since Law 5 came into force, its application has been uneven. This project seeks to ensure that the rights granted to civilians in Tunisia by Law 5 and criminal procedures proposing alternatives to detention, inter alia, bail provisions, are enforced consistently during the pre-trial phase.

This grant provides funding for innovative preclinical research on radionuclide-based cancer therapies, focusing on their biological effects and potential combinations with other treatments, aimed at institutions and researchers in cancer biology and radiopharmaceuticals.

The purpose of this Notice of Funding Opportunity (NOFO) is to support the continuation of NIDA's HIV Cohorts Program, encouraging existing and new sites to address new emerging and/or high priority research on multidisciplinary aspects of HIV/AIDS and substance abuse in alignment with NIH-HIV research priorities in order to inform policy or practice. Purpose The National Institute on Drug Abuse (NIDA) supports a program of longitudinal cohort studies that addresses the intersection of HIV and substance use. This program is a multidisciplinary platform to support basic, epidemiologic, and clinical research on HIV and HIV-associated co-morbidities and co-infections among populations with substance use and substance use disorders (SUDs) and to address research questions at the individual and population level. The purpose of this notice of funding opportunity (NOFO) is to support the continuation of NIDA's HIV Cohorts Program, encouraging existing and new sites to address new emerging and/or high priority research on multidisciplinary aspects of HIV/AIDS and substance use in alignment with NIH-HIV research priorities in order to inform policy or practice. Cohort sites supported under this program are required to report to and collaborate with a NIDA funded Coordinating Center, including participating in research agendas addressing NIDA’s high priority areas. Background Since the start of the HIV epidemic, cohort studies of people living with HIV (PLWH) and key populations at risk for HIV acquisition have made important contributions to the understanding of HIV virology, seroconversion dynamics, the natural and treated histories of HIV infection, the impact of HIV-associated co-morbidities (e.g., HCV) and complications including the role of substance use and SUDs. Longitudinal cohorts of at-risk individuals can provide crucial information about acute or early phases of infection, as well as disease transmission. Cohort studies provide a continuous source of data collection with the ability to address new or emergent public health problems, changes in drug use patterns and uptake of screening, prevention, or new treatments. Cohorts can also add to the understanding of processes such as aging, co-morbidities, social dimensions of HIV and substance use epidemics, as well as structural factors such as state and local policies, health insurance, and availability of relevant services. Research Objectives and Scope Research by each site should focus on high-risk populations or PLWH, who use substances. This RFA will seek applications from investigators working with HIV populations most affected by HIV (i.e., those at highest risk or living with HIV) in the United States. These can include sexual and gender minorities, racial/ethnic minorities, people involved in the criminal justice system and sex workers. Cohort populations should reflect social and economic characteristics of affected populations. Rural and metropolitan populations are welcome. This initiative also targets priority jurisdictions identified by the Ending the HIV Epidemic (EHE) initiative, although other jurisdictions will be considered with an epidemiologic justification (e.g., rural counties affected by opioid epidemics). Applicants must demonstrate the capacity to: Be responsive to changes to substance use and HIV epidemics, such as new substance use patterns, introduction of new substances; emergent co-morbidities including infectious diseases such as Mpox, COVID-19 and others, changes to public health policies, or to HIV/substance use treatments or prevention strategies. Applicants are strongly encouraged to include research that focuses on HIV-associated infectious co-morbidities (e.g., HCV, other sexual-transmitted disorders [STD]) and HIV-associated non-infectious co-morbidities, such as neurocognitive or other central nervous system impairment, mental health disorders and relevant medical disorders. [Note: The main focus of research should be the intersection of HIV and Substance Use, with co-morbidities as co-factors.] Partner with the end-user of the knowledge/data that would be generated (e.g., prevention specialists, Public Health officials, health departments, justice systems, policymakers, community organizations, etc.) and should thoroughly explain how the knowledge would be used to inform decisions and implement change. The involvement of the end-user is to ensure that the proposed data and methods will be useful. The partnerships with key end-users can be existing, or new relationships initiated based on success of previous stakeholder engagement and preparation to implement proposed work in a new setting. Collect data that can be used to inform policy and practice and include collaborations with potential end-users of cohort data such as those involved in HIV planning processes (e.g., EHE, Ryan White, CDC prevention funding) as well as service providers and provider organizations (e.g., health systems, federally qualified health centers [FQHCs], harm reduction sites). Participate in the collection of common data elements and biospecimens and participate in activities related to multi-site research such as data harmonization by working in concordance with the Data Coordinating Center. All sites are expected to collaborate and share all their data at least twice a year with the Data Coordinating Center. Assess variables that reflect system and structural factors that can affect HIV acquisition, utilization of prevention or treatment services, HIV viral suppression, substance use and/or factors that can influence dissemination of emergent prevention and care interventions. Research projects should address populations and research questions not captured by other HIV studies currently funded by NIH, including those co-funded by NIDA such as the WIHS/MACS Combined Cohort Study (MWCCS), the Center for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) or the NIAID Limited Interaction Targeted Epidemiology (LITE) cohorts while also being able to work with these outside cohorts on research questions where complementary of age, patterns of substance use, etc., may be desirable. Common Scientific Agenda and Collaboration with Data Coordinating Center: All sites are expected to collaborate and share all their data, at least twice a year, with the Data Coordinating Center at the University of Washington which will provide technical assistance, support, and resources. Clinical data and biological samples collected via the cohort(s) are expected to be available for sharing and use by the scientific community. Sites will also be expected to participate in collaborative activities including at least one annual meeting and monthly/quarterly conference calls with the Data Coordinating Center. Common Scientific Agenda All sites are also expected to participate in a common scientific agenda. The scientific areas listed below outline high priority research areas for NIDA that should be accomplished by each site during the five-year award period. There needs to be a clear justification of the clinical assessments, specimen collections, surveys and other measures, the frequency of participant visits and sampling from the cohort studies. Applications may propose additional research areas that are contemporary and are of high significance to the cooccurring HIV and substance use epidemics. Substance use and SUDs: drug use trends, types of drug use and frequency in relation to HIV risk and outcomes, risks associated with overdose related death HIV-related co-morbidities (HCV, Neurocognitive disorders) COVID-19; MPox and other sexually transmitted disorders), medical consequences, epidemiology, prevention, treatment, and outcomes in acute and chronic HIV Implementation: HIV and SUD services, uptake, and delivery. Point-of-care rapid testing, referral, and treatment, geocoding HIV viral loads: in relation to substance use, treatment, and co-morbidities Treatment: HIV and SUD treatment uptake and adherence, linkage to care Social determinants of health: socioeconomic factors, social support, trauma/violence, stigma, discrimination, life transitions, and food insecurity and the mechanisms of action through which they may affect health outcomes among people living with or at risk of HIV acquisition Brain and CNS: behavioral and psychiatric abnormalities, neurocognitive alterations in the context of substance use and HIV Genomic and phenotypic data in the context of HIV, co-morbidities, and substance use Research Strategy: Sites funded under this RFA will serve as a national resource for research addressing the intersection of HIV and substance use in the United States. Applications should include multidisciplinary teams and should select key populations at risk for HIV acquisition or populations of PLWH. Variables should reflect substance use in the study population with particular attention to its relevance for HIV acquisition, transmission, response to HIV treatment and/or viral suppression. Studies should address variables related to policy and practice such as HIV, substance use and other health care/public health service utilization, health insurance, key HIV risk populations and PLWH, people who experience marginalized social and sexual identities. Data collection should address stigma and discrimination as well as resource constraints (e.g., food, shelter, access to reliable transportation, access to reliable and private internet connectivity), particularly those which may limit participation in public health or health care services. Data collection should reflect current best clinical and methodologic practices and can include biospecimen collection, behavioral data from surveys or interviews, electronic health records and other methods that are consistent with study aims and objectives. The research strategy should include collaborations with potential end-users of cohort data such as those involved in HIV planning processes (e.g., EHE, Ryan White, CDC prevention funding) as well as service providers and provider organizations (e.g., health systems, FQHCs, harm reduction sites) or others (prevention specialists, Public Health officials, health departments, justice systems, policymakers, community organizations, etc.). Applications must thoroughly explain how the knowledge/data would be used to inform decisions, policy, practice and/or implement change. Applications need to address NIH and NIDA’s highest priority areas of research: Research Priorities | NIH Office of AIDS Research NIDA HIV Priority Areas Sites should consider their capacity to address areas of interest such as the following: System and structural level factors that lead to HIV acquisition Social determinants of HIV and substance use, including factors that increase exposure to HIV and substance use New or emerging substance use patterns and recovery approaches Long-term HIV/substance use outcomes and medical consequences such as those associated with aging and HIV Capturing the effects of systemic interventions to increase prevention, diagnosis, and treatment, including differences in HIV testing service, utilization, etc. that occur in different settings such as community organizations, FQHCs, and health systems. In addition, sites are strongly encouraged to: Expand existing populations: Increasing the representation of PLWH, ensuring the representation of sexual and gender minorities, ethnic/racial minorities and people with lived experiences, factors that contribute to HIV risk and poor treatment outcomes such as homelessness, engaging in sex work, and criminal justice involvement. EHE priority jurisdictions should be addressed in the application with epidemiologic justification provided for non-EHE jurisdictions such as rural areas affected by opioid epidemics. Demonstrate their capacity to recruit and follow populations of adequate sample size and power (i.e., >500). Smaller sample sizes need justification with respect to local epidemiology and factors such as population and service density. Sites with established cohorts should demonstrate their capacity to, and describe plans to, refresh samples and continue to recruit participants and comply with the NIH data sharing policy. The Research Strategy should: Describe how substance use in the population will be characterized i.e., specific drugs used, level and history of use, form of administration, continuum cascade of substance use, and/or changing patterns over time including initiation. Describe methods for the recruitment, enrollment, and retention of cohort participants, describing previous experience with recruitment and retention of longitudinal samples. Describe the data collection methods and their appropriateness for the variables of interest, as well as the primary analyses of data, providing a rationale for the analytic methods selected and the statistical power for major analyses. Include specific proposed data elements, such as clinical data, summary health histories, biologic specimens, socio-behavioral data, or treatment variables that will support the study aims Given the requirement of data sharing across cohort sites, the discussion should address how proposed data elements could incorporate common or shared platforms. Provide justification of the priority research domains for the cohort study and for the approaches to achieving the study aims. The study rationale should indicate how the cohort will address gaps in current NIH-funded HIV cohort research (e.g., MWCCS, CNICS, LITE) and indicate where it might complement existing cohort research. Describe experience with participation in multi-site research, particularly where data sharing was integrated into the research. Applications also should describe the administrative and organizational structure for the project and how it will facilitate attainment of the aims and objective of the proposed research. Where biospecimens are routinely collected, applications should describe procedures for processing, storage, and sharing for use by the scientific community. Document alignment with EHE plans or other appropriate HIV service plans (e.g., CDC/Ryan White planning processes) and provide a plan for engaging local decision makers, as well as document how cohort data can inform local decisions about resource allocation and service delivery. For renewal applications, applicants should provide a rationale for continued funding including information regarding any new data collection. Renewal applicants must provide plans to demonstrate program relevance and to ensure representation of current HIV/substance use epidemic patterns. Applications Not Responsive to this NOFO include: The following types of applications will be considered non-responsive and will be returned without review: Studies that do not have the capacity to adhere to data sharing requirements and data harmonizing activities with the data coordinating center (transferring data, common data elements or biorepository data sharing) as specified above. Studies with less than 500 participants without adequate justification. Applications with a primary focus on research related to end organ or systemic disease related to comorbidities such as cardiac, liver, or chronic kidney diseases, hypertension, and bone disorders. Studies that do not focus on HIV infection and substance use and/or outcomes. Plan for Enhancing Diverse Perspectives (PEDP) This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP) as described in NOT-MH-21-310, submitted as Other Project Information as an attachment (see Section IV). Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material. The PEDP will be assessed as part of the scientific and technical peer review evaluation, as well as considered among programmatic matters with respect to funding decisions.

This grant provides financial assistance to Native American tribes, Native Hawaiian organizations, and museums for the repatriation of human remains and cultural items to their rightful communities.

The National Earthquake Hazards Reduction Program NEHRP seeks to mitigate earthquake losses in the United States through basic and directed research and implementation activities in the fields of earthquake science and engineering. NEHRP is a multi-agency program consisting of the National Institute of Standards and Technology (NIST), FEMA, the United States Geological Survey (USGS), and the National Science Foundation (NSF). The NEHRP program supports the mission area of the FY20-24 DHS Strategic Plan titled "Strengthen Preparedness and Resilience," as well as the national preparedness goal of mitigation, as provided in the Presidential Policy Directive (PPD-8). NEHRP also supports the FEMA 2022-2026 Strategic Plan, by contributing to the accomplishment of Strategic Goal 3: Promote and Sustain a Ready FEMA and Prepared Nation. The purpose of this Notice of Funding Opportunity is to provide grant funding to non-profit organizations and institutions of higher education who possess the expertise and experience necessary to develop and deliver multi-State and National earthquake mitigation and preparedness products and services (See Appendix A.), on behalf of States participating in the FEMA NEHRP State Assistance program (See Appendix D.). This NOFO funds Multi-State and National activities and is not intended to provide assistance to any one particular State or Territory. Those activities are funded through the FEMA NEHRP Individual State Earthquake Assistance grant program and require individual States to provide a 25% Cost Share. All activities funded by the FEMA NEHRP, Multi-State and National Earthquake Assistance grant program must be consistent with NEHRP Vision, Mission, Goals and FEMA Program Responsibilities (See Appendix C.), and ultimately result in a measurable enhancement of National seismic safety and earthquake risk awareness.Applicants can submit applications for this funding opportunity through FEMA Grants Outcomes (GO). Access the system at https://go.fema.gov/

The "Mechanistic Investigations into ADRD Multiple Etiology Dementias" grant aims to fund research into how interactions between multiple brain pathologies contribute to the worsening of neurodegenerative diseases, with a focus on understanding the cellular and molecular mechanisms involved.

This funding opportunity provides financial support for large-scale habitat restoration projects that enhance coastal and Great Lakes ecosystems while promoting community resilience to climate-related hazards, particularly benefiting underserved and Indigenous communities.