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Grants for Nonprofits - Federal

Explore 5,295 grant opportunities

Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK (R01 Clinical Trial Required)
$200,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2025

Date Added

Feb 1, 2023

This funding opportunity provides financial support for small clinical trials focused on preventing and treating diseases related to diabetes, digestive, kidney, and urologic health, particularly targeting underserved populations to improve health outcomes.

Food and Nutrition
State governments
Office of Elementary and Secondary Education (OESE): Innovation and Early Learning Programs: Education Innovation and Research (EIR) Program Expansion Grants Assistance Listing Number 84.411A
$15,000,000
U.S. Department of Education
Federal

Application Deadline

Oct 14, 2025

Date Added

Sep 13, 2025

This grant provides funding to educational organizations and institutions to develop and implement innovative programs that enhance early learning and improve educational outcomes for students in elementary and secondary education.

Education
Independent school districts
Enabling Technologies for Electronic Warfare and Surveillance
Contact for amount
U.S. Department of Defense (Office of Naval Research)
Federal

Application Deadline

Dec 20, 2024

Date Added

Aug 15, 2024

This grant provides funding for innovative technologies that improve the Navy and Marine Corps' electronic warfare and surveillance capabilities, targeting researchers and companies developing advanced signal processing, countermeasures, and ISR systems.

Science and Technology
Nonprofits
FY 2025 Future Leaders Exchange (FLEX) Program Placement Components
$10,240,000
U.S. Department of State (Bureau Of Educational and Cultural Affairs)
Federal

Application Deadline

Oct 21, 2024

Date Added

Aug 21, 2024

The FY 2025 Future Leaders Exchange (FLEX) Program Placement Components grant aims to foster mutual understanding and enhance U.S. relations with various European and Eurasian countries by enabling high school students from these regions to live, study, and develop leadership skills in the U.S., while also sharing their own cultures with their host communities.

Education
Public and State controlled institutions of higher education
Rare Earth Elements Demonstration Facility
$134,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Jan 20, 2026

Date Added

Dec 2, 2025

This funding opportunity supports partnerships that include domestic academic institutions to develop innovative technologies for extracting and refining rare earth elements from unconventional sources, enhancing the U.S. supply chain and reducing environmental impact.

Energy
Public and State controlled institutions of higher education
Ambassadors Fund For Cultural Preservation(Afcp) 2025
$500,000
U.S. Department of State (U.S. Mission to Nigeria)
Federal

Application Deadline

Jan 10, 2025

Date Added

Nov 13, 2024

This funding opportunity provides financial support for organizations in Nigeria to preserve and protect cultural heritage sites, collections, and expressions that are important to local communities.

International Development
Nonprofits
The National Center for Mental Health Dissemination, Implementation and Sustainment (MHDIS)
$7,467,006
HHS-SAMHS-SAMHSA (Substance AbU.S.e and Mental Health Services Adminis)
Federal

Application Deadline

Jun 10, 2024

Date Added

Jan 30, 2024

The purpose of this SAMHSA program is to create a National Center for Mental Health Dissemination, Implementation, and Sustainment (MHDIS) to build the capacity of CMHS grant recipients, as well as organizations that oversee or directly provide mental health services to improve the implementation of evidence-based change management processes that guide mental health services. This will be accomplished by establishing five bi-regional Mental Health Technical Assistance Centers (MTACs) that provide localized, targeted and intensive technical assistance (TA) to CMHS grant recipients and other mental health providers.

Health
State governments
U.S. Embassy Windhoek PDS Annual Program Statement
$10,000
DOS-NAM (U.S. Mission to Namibia)
Federal

Application Deadline

Jun 30, 2024

Date Added

Jan 8, 2024

Public Diplomacy Section in Windhoek invites proposals for programs that strengthen cultural ties between the United States and Namibia through cultural and exchange programming that highlights shared values and promotes bilateral cooperation. All programs must include an American cultural element, or connection with American expert/s, organization/s, or institution/s in a specific field that will promote increased understanding of U.S. policy and perspectives.Directly support U.S. treaty or bilateral agreement obligations.Directly support U.S. policies, strategies, and objectives in a country as stated in the Integrated Country Strategy (ICS) (ICS is the four-year strategy that articulates the U.S. priorities in a given country and is led by the Chief of Mission.) These priorities are Empowering an Inclusive, Rules-Based Democracy, Catalyzing a Resilient, Sustainable Economy and Cultivating Equitable Access to Service to help Unleash Namibias Human Resources.Support disaster risk reduction for cultural heritage in disaster-prone areas, or post-disaster cultural heritage recovery.Complement the Cultural Heritage Center in the Bureau of Educational and Cultural Affairs (ECA) or Public Diplomacy programs.

International Development
Nonprofits
FY 2024 Online Professional English Network (OPEN) Program
$6,000,000
DOS-ECalifornia (Bureau Of Educational and Cultural Affairs)
Federal

Application Deadline

May 30, 2024

Date Added

May 9, 2024

The Office of English Language Programs (ECA/A/L) of the Bureau of Educational and Cultural Affairs announces an open competition for the FY 2024 Online Professional English Network (OPEN) Program, which offers foreign English teaching professionals and language learners the opportunity for professional development through high-quality, accessible, and openly licensed virtual resources, including online English language teacher development courses, online English language learning courses, virtual exchanges, webinars, an alumni community of practice (CoP), multiple social media channels, and other types of engaging and innovative online learning. In cooperation with ECA/A/L, the award recipient will manage the selection, development, and delivery of appropriate online TESOL (Teaching English to Speakers of Other Languages) learning courses which will be offered to English language educators or learners on an easily accessible online learning management system (LMS). Courses, webinars, and other virtual programming may be offered globally, regionally, or to specific countries at the request of U.S. embassies. Courses and exchanges are developed by U.S. academic institutions, educational NGOs, or TESOL professional associations, while webinars and other social media programming are developed by U.S.-based TESOL professionals. All content produced for this program should be accessible according to Section 508 compliance standards, openly licensed with a Creative Commons Attribution (CC BY) License, and follow best practices for diversity, equity, inclusion, and accessibility (DEIA). ECA/A/L anticipates an unlimited number of English language professionals, educators, and learners will benefit from the openly licensed virtual programming, webinars, massive open online courses (MOOCs), and content developed under this award. U.S. public and private non-profit organizations meeting the provisions described in Internal Revenue Code, Section 26 U.S.C 501 (c) (3) may submit proposals to administer and manage the FY 2024 OPEN Program. It is ECA/A/Ls intent to award one cooperative agreement in the amount of $6,000,000, pending the availability of FY 2024 funds, to an applicant that has the ability to achieve these objectives and provide the necessary infrastructure and experience. ECA/A/L reserves the right to reduce, revise, or increase proposal budgets and participant numbers in accordance with the needs of the program and the availability of funds. Please see the full announcement for additional information.

International Development
Public and State controlled institutions of higher education
Assay development and screening for discovery of chemical probes, drugs or immunomodulators (R01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 5, 2024

Date Added

Aug 10, 2023

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for identification of small molecules that function to elucidate the biology of disease as chemical probes or function as agonists or antagonists of disease target(s) for therapy or immunotherapy. The NOFO is intended to support discovery research for the identification of validated hits relevant to health-related outcomes of participating NIH Institutes. Stages of discovery research covered by this NOFO include: 1) assay development for specific biological targets and disease mechanisms relevant to the mission of participating NIH Institutes with the intent to screen for small molecule compounds that show potential as probes for use in advancing knowledge about the known targets, identifying new targets, or as pre-therapeutic leads; 2) screen implementation high throughput target-focused approaches or moderate throughput phenotypic- and fragment-based approaches to identify initial screening hits; 3) hit validation, including implementation of secondary assays that are orthogonal to the primary assay, advanced cheminformatics analysis and initial medicinal chemistry inspection to prioritize the hit set, and follow-up assays to characterize mode and mechanism of action of the validated hits; 4) hit-to-lead optimization, including SAR to optimize target engagement, selectivity and to minimize chemical liabilities, ADME, PK and PD studies, and, if appropriate, in vivo modeling to test efficacy or biological effects.

Education
State governments
Leveraging Extant Data to Understand Developmental Trajectories of Late Talking Children (R21 Clinical Trial Not Allowed)
$200,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 20, 2024

Date Added

Oct 17, 2023

This funding opportunity provides financial support for researchers to analyze existing data on late talking children, particularly focusing on underrepresented populations, to better understand their developmental trajectories and improve language outcomes.

Health
State governments
Social disconnection and Suicide Risk in Late Life (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2024

Date Added

Jul 19, 2023

This funding opportunity supports research projects that explore the link between social isolation and suicide risk in older adults, encouraging innovative interventions and service delivery models to enhance social connections and mental health.

Health
State governments
Translating Socioenvironmental Influences on Neurocognitive Development and Addiction Risk (TranSINDA) (U01 Clinical Trial Not Allowed)
$4,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 7, 2024

Date Added

Jul 19, 2024

This grant provides funding for research teams to study how early-life social and environmental factors influence brain development and addiction risk using animal models and advanced neuroscience techniques.

Education
State governments
Hepatitis C Training and Implementation Centers (HC-TIC) Network
$200,000,000
U.S. Department of Health and Human Services (Centers for Disease Control - NCHHSTP)
Federal

Application Deadline

Aug 30, 2024

Date Added

Mar 2, 2024

This cooperative agreement establishes the Hepatitis C Training and Implementation Center (HC-TIC) Network, which aims to accelerate the integration of hepatitis C prevention, testing, care coordination, and treatment interventions (program implementation) in priority high-impact settings through training and implementation TA. This cooperative agreement will improve and sustain the quality, availability, and reach of hepatitis C prevention and care activities in priority high-impact settings. Protection of public health and safety through the control and prevention of disease, injury, and disability in the U.S. and worldwide with attention to infectious disease, food borne pathogens, environmental health, occupational safety and health, health promotion, injury prevention and educational activities.

Health
State governments
F24AS00062 National Fish Passage Program Bipartisan Infrastructure Law: Restoring River, Floodplain, and Coastal Connectivity and Resiliency
$10,000,000
U.S. Department of the Interior (Fish and Wildlife Service)
Federal

Application Deadline

Dec 31, 2024

Date Added

Oct 11, 2023

This funding opportunity provides financial and technical assistance to partners for projects that restore aquatic connectivity and improve fish passage in rivers, floodplains, and coastal habitats, benefiting ecosystems and local communities.

Natural Resources
State governments
Collaborations Advancing Rapid Load Additions (CARLA)
$28,000,000
ConnectWerx
Federal

Application Deadline

May 8, 2025

Date Added

Mar 12, 2025

This funding opportunity provides financial support to collaborations involving state utility commissions, grid operators, and large electricity users to develop innovative solutions for managing increasing electricity demand while keeping costs low for consumers.

Energy
Nonprofits
OJJDP FY24 Juvenile Justice System Reform and Reinvestment Initiative
$1,500,000
USDOJ-OJP-OJJDP (Office of Juvenile Justice Delinquency Prevention )
Federal

Application Deadline

May 28, 2024

Date Added

Apr 10, 2024

With this solicitation, OJJDP seeks to support states implementation of innovative and/or research-based, data-informed policies to improve juvenile justice system outcomes and sustainable strategies for reinvesting resulting costs saved or averted into effective delinquency prevention and intervention programs.Eligibility This solicitation is composed of two grant categories. Applicants must clearly designate the category for which they are applying. Category 1: Juvenile Justice System Reform State governments Category 2: Juvenile Justice System Reform Training and Technical Assistance Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public- and state-controlled institutions of higher education Private institutions of higher education For-profit organizations other than small businesses Small businesses

Law Justice and Legal Services
State governments
Engaging Students in English
$15,000
DOS-LUX (U.S. Mission to Luxembourg)
Federal

Application Deadline

May 5, 2024

Date Added

Jan 11, 2024

The Public Diplomacy Section (PD) of the U.S. Embassy in Luxembourg announces an open competition for organizations to submit applications to carry out programs strengthening bilateral ties between the United States and Luxembourg on Engaging Students in English. The U.S. Embassy Luxembourg invites proposals from non-governmental organizations, think tanks, government institutions, academic institutions, and individuals for programs strengthening the bilateral ties between the United States and Luxembourg and Engaging Students in English, including, but not limited to: Programs focused on strengthening specific English language skills or professional English capacity of students, such as public-speaking, debate, theater/drama Programs that enhance and promote the English-teaching profession and community, such as trainings, workshops, conferences, or presentations for English educators in Luxembourg. English-language programs for underprivileged groups including but not limited to patrons of organizations, such as shelters for refugees, women, abuse victims or childrens organizations. Educational programs such as English language camps, academic competitions, international exchanges, conferences, workshops, courses, exhibits, hackathons, online projects, or performances. Projects that share American best practices in English-language education by bringing U.S. experts to engage with students and teachers in Luxembourg. All programs must engage Luxembourg audiences. All programs must include a U.S. element or connection with U.S. experts that will promote increased understanding of U.S. policy and perspectives. Any speaker paid with grant funding must hold U.S. citizenship. Please review the complete NOFO on the Funding Opportunities page on our website: https://lu.usembassy.gov/grants-program/ or in the related documents tab on the announcement on grants.gov to find more information on how to submit a Statement of Interest.

International Development
City or township governments
ROSES 2025: C.5 Planetary Science Early Career Award
$200,000
National Aeronautics and Space Administration (NASA Headquarters)
Federal

Application Deadline

Jan 12, 2026

Date Added

Jul 15, 2025

This funding opportunity supports early career scientists in the U.S. who are working on planetary science research, helping them advance their projects and professional development through financial support.

Science and Technology
Nonprofits
Tajikistan: Early Detection and Response Pilot
$1,497,975
U.S. Department of State (Bureau of Counterterrorism)
Federal

Application Deadline

Aug 7, 2025

Date Added

Aug 1, 2025

This funding opportunity provides financial support to organizations working to empower Tajik communities in detecting and responding to terrorist recruitment and activities, enhancing regional security in Central Asia.

International Development
For profit organizations other than small businesses