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NIH Pathway to Independence Award (Parent K99/R00 Independent Basic Experimental Studies with Humans Required)
$249,000
HHS-NIH11 (National Institutes of Health)
Federal

Application Deadline

May 7, 2024

Date Added

May 5, 2020

The purpose of the NIH Pathway to Independence Award (K99/R00) program is to increase and maintain a strong cohort of new and talented, NIH-supported, independent investigators. This program is designed to facilitate a timely transition of outstanding postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition in order to help awardees to launch competitive, independent research careers. Frequently Asked Questions for NOT-HL-23-083 General Questions Q: What is the purpose of the Notice of Special Interest (NOSI) NOT-HL-23-083? The NOSI on Assessing Real-World Effectiveness and Implementation of Telehealth-Guided Provider-to-Provider Communication among Rural Communities (NOT-HL-23-083) aims to support research that generates evidence on the real-world effectiveness of telehealth collaboration among healthcare providers for consultation, second opinions, and other purposes, referred to as provider-to-provider telehealth (PPT). The NOSI is intended to support the use of telehealth interventions and tools for the prevention, management and treatment of heart, lung, blood, and sleep conditions, as well as cancer, in rural communities. Q: Are foreign applications allowed under this NOSI? Yes. Non-domestic entities (Foreign Institutions) and Non-domestic components of U.S. Organizations are eligible to apply under the Notice of Funding Opportunities (NOFOs) relevant to this NOSI (PA-20-185; PAR-22-105; PAR-21-035; PAR-21-341) – additional information regarding eligibility is available in Section III. Eligibility Information of each NOFO. Q: How is “rural” defined for the purposes of this NOSI? Different definitions of “rural” are used by various entities for different purposes. Rurality can be conceptualized based on administrative boundaries, land-use patterns, or economic influence; can reflect several different dimensions, such as population density, population size, and degree of remoteness; and can be delineated at different spatial scales (e.g., zip code, county, census district). Applicants should operationalize “rural” in the way that best serves the aims of their study. However, applicants should clearly state how they are defining rural in their application and provide a justification for the criteria they are using. A few widely used classification systems for defining rural and urban areas are provided below. Additionally, the Health Resources and Services Administration (HRSA) provides a tool on their website that enables users to see whether a specified geographic area is considered “rural” for the purposes of HRSA Rural Health Grant eligibility: https://data.hrsa.gov/tools/rural-healthexternal link. This may be a good starting point for assessing whether an area of interest might be considered “rural”. Census Bureau Urban-Rural Classificationsexternal link - The Census Bureau delineates urban areas by applying specified criteria to the decennial census and other data. For the 2020 Census, an urban area comprises a densely settled core of census blocks that meet minimum housing unit density and/or population density requirements of having at least 2,000 housing units or a population of at least 5,000. This includes adjacent territory containing non-residential urban land uses. Rural areas encompass all population, housing, and territory not included within an urban area. National Center for Health Statistics (NCHS) Urban-Rural Classification Scheme for Countiesexternal link – NCHS has developed a six-level urban-rural classification scheme for U.S. counties and county-equivalent entities. The scheme is based on the Office of Management and Budget’s (OMB) delineation of metropolitan statistical areas (MSA) and micropolitan statistical areas, as well as Vintage postcensal estimates of the resident U.S. population. The scheme has two levels nonmetropolitan counties. USDA Rural Urban Continuum Codes (RUCC)external link - Rural-Urban Continuum Codes are a 9-level classification scheme that categorizes metropolitan counties by the population size of their metro area, and nonmetropolitan counties by their degree of urbanization and adjacency to a metro area. USDA Rural Urban Commuting Area (RUCA) Codesexternal link - RUCA codes categorize census tracts based on measures of population density, urbanization, and daily commuting patterns. This classification system consists of 10 levels that delineate metropolitan, micropolitan, small town, and rural commuting areas based on the size and direction of the primary (largest) commuting flows. These 10 codes are further subdivided based on secondary commuting flows. USDA Urban Influence Codesexternal link (UIC) – Urban influence codes are a 12-level classification scheme that distinguishes metropolitan counties by the population size of their metro area, and nonmetropolitan counties by the size of the largest city or town and proximity to metro and micropolitan areas. There are two metro and ten nonmetro categories. Frontier and Remote Area (FAR) Codesexternal link – Developed by the USDA Economic Research Service, Frontier and Remote Area codes are based on ZIP-codes. The term "frontier and remote" is used to describe territory characterized by some combination of low population size and high geographic remoteness. FAR areas are defined in relation to the time it takes to travel by car to the edges of nearby Urban Areas (UAs)external link. Four levels are necessary because rural areas experience degrees of remoteness at higher or lower population levels that affect access to different types of goods and services. Q: My project focuses on “direct-to-consumer/ direct-to-patient” telehealth, would it still be responsive to this NOSI? No. This NOSI focuses on “provider-to-provider” telehealth (PPT), which is a telehealth modality that fosters collaboration among healthcare providers for consultation, second opinions, and other purposes. Please refer to the “Background” section of the NOSI for some examples of PPT in heart, lung blood, sleep and cancer conditions. Q. My university/institution is located in an urban area, would I still qualify for this NOSI? There is no restriction regarding the location of the Principal Investigator’s university, institution, or center and if it is in an urban or rural area. The limiting factor is the population of interest. The focus of this NOSI is the use of provider-to-provider telehealth (PPT) to benefit rural communities. For the definition of rural areas, please refer to the previous questions “How is “rural” defined for the purposes of this NOSI?” Q. One of the components of my research involves a center or hospital located in an urban center/hospital, would I still qualify for this NOSI? It depends. The focus of this NOSI is the use of provider-to-provider telehealth (PPT) to benefit rural communities. As such, considering a hub-and-spoke telehealth model, the healthcare providers who require consultation and their patients (spoke component) must be in a rural area, assuring that the benefited population served by the PPT intervention is rural. Example 1: If both communicating sides of providers (hub and spoke) are in urban areas, it is not responsive to this NOSI. Example 2: If the provider receiving the consultation or training (spoke) is in a rural area, and the consulted team (hub or hub-less provider) is in an urban area, it is responsive to this NOSI, given that the population of interest benefitted by the PPT intervention is still in a rural area. For the definition of rural areas, please refer to the previous questions “How is “rural” defined for the purposes of this NOSI?” Q. Is the NOSI restricted to telemedicine between physicians? No. The focus of the NOSI is not just telemedicine, but telehealth, which goes beyond the communication between physicians, and would include a series of healthcare providers, allied health providers, and their teams. For some examples, please refer to the “ Background” section of the NOSI. Q: What are some of the research examples that might be responsive to this NOSI? There are a series of research projects that might be of interest for this NOSI. For some examples, please refer to the ones listed in the “Selected Research Examples ” section of the NOSI. Please be aware that these are meant to illustrate some of the projects of interest for this NOSI, and other research projects not exemplified here might still be of interest. Investigators are encouraged to reach out to the Scientific and Research Contacts listed in the NOSI to discuss their research ideas and their relevance to the NOSI as well as institute funding priorities. Q. Who do I contact for more information from specific participating Institutes, Centers, and Offices? To whom should I direct my questions regarding this NOSI? To access the complete list of contacts, please refer to the “Inquiries” Section of the NOSI, which includes Scientific and Research Contacts and Financial/Grants Management Contacts. For programmatic questions at NHLBI, please contact Dr. Fernando P. Bruno fernando.bruno@nih.govmailto:, for programmatic questions at NCI, please contact Dr. Robin C. Vanderpool robin.vanderpool@nih.govmailto:. If you have submission questions, please contact the eRA Service Desk. Application Preparation and Submission Questions Q: NHLBI and NCI are collaborating on this NOSI. If an applicant has a proposal that is relevant to both cancer and to heart, lung, blood, and sleep conditions, which institute will the application be assigned to? Applicants are advised to make use of the Assignment Request Form to request the institute they would prefer to act as the “Awarding Component.” These requests are taken into consideration. Applicants are further advised to consider the institute they plan to choose on the Assignment Request Form when framing their specific aims. The Awarding Component Section of the PHS Assignment Request Form * All assignment suggestions will be considered; however, not all assignment suggestions can be honored. Applications are assigned based on relevance of the application to an individual awarding component mission and scientific interests in addition to administrative requirements. * Applicants may enter up to three preferences for primary assignment in the boxes in the "Suggested Awarding Component(s)" row. Note: the application will be assigned based on the most appropriate match between it, the terms of the FOA, and the mission of each possible awarding component, with your preference(s) taken into consideration when possible. Applicants do not need to make entries in all three boxes of the "Awarding Component Assignment Suggestions" section. Q: If a proposal has aims that might be responsive to more than one eligible Notice of Funding Opportunity (NOFO) – should an investigator submit an application that is targeted at two different eligible funding opportunities, or separate those aims into two different applications and submit one to each corresponding NOFO? Each application in response to this NOSI must target only one of the eligible NOFOs. An applicant can elect to submit two different applications to two different NOFOs as long as the specific aims are sufficiently distinct. If the Division of Receipt and Referral determines there is significant overlap between the two applications, the applicant could be asked to withdraw one of them.

Education
State governments
Mentored Career Enhancement Awards to Build Cross-Disciplinary Knowledge and Skills for Comparative Studies of Human and Nonhuman Primate Species with Differing Life Spans (K18 Clinical Trial Not Allowed)
$1,500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 1, 2024

Date Added

Jul 5, 2024

This funding opportunity supports experienced researchers in expanding their expertise and collaborations across various fields related to the study of aging and lifespan differences between humans and nonhuman primates.

Health
State governments
Drug Development Tools Research Grants (U01) Clinical Trials Optional
$500,000
U.S. Department of Health and Human Services (Food and Drug Administration)
Federal

Application Deadline

May 13, 2025

Date Added

Feb 12, 2024

This funding opportunity supports researchers in developing innovative tools that can speed up drug development and improve regulatory processes, ultimately enhancing public health by facilitating faster access to effective treatments.

Agriculture
State governments
Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)
$375,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2025

Date Added

Jan 10, 2022

This funding opportunity is designed to support small-scale research projects at health professional and graduate schools that have limited NIH funding, helping to enhance research capabilities and engage students in meaningful research experiences.

Education
State governments
NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required)
$1,515,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 5, 2025

Date Added

Dec 10, 2024

This funding opportunity supports researchers conducting early-phase clinical trials for new treatments and diagnostics related to heart, lung, blood, and sleep disorders in both adults and children.

Health
State governments
Novel Approaches for Radiation Biodosimetry Assays and Devices Development (U01 Clinical Trial Not Allowed)
$350,000
HHS-NIH11 (National Institutes of Health)
Federal

Application Deadline

May 31, 2024

Date Added

Jan 26, 2024

The purpose of this notice of funding opportunity (NOFO) is to support radiation research at all stages of development for the identification of biomarkers of injury and the development of assays or devices for the purpose of triage, including assessing absorbed dose or predicting health outcomes of acute or delayed injuries resulting from radiation exposure during a public health emergency. This NOFO will support the development of these approaches, with the goal of future regulatory approval. The focus of this NOFO is the development and validation of rapid, reliable, inexpensive, and easy-to-use techniques/assays and devices for use in all segments of the civilian population including geriatric, pediatric, and immune-compromised individuals. Thus, research activities ranging from immediate, early, and delayed changes in radiation-related biomarkers, studies exploring the biokinetics of the proposed biomarker signature, and studies to predict the acute or chronic health outcome in one or more organs are requested. The selection of radiation exposure type, dose level, and dose rates proposed for studies should be relevant to a radiological or nuclear incident and verified by appropriate dosimetry assessments. The ideal radiation signature will be measurable in a non-invasive or minimally invasive way (e.g., finger stick, urine, saliva, or skin scraping as opposed to spinal fluid or complex imaging) that will allow for repeated assays over time, is sensitive to incremental differences in radiation exposure, is specific over a wide range of radiation doses and dose rates and has utility for different qualities of radiation (high and low linear energy transfer).

Health
State governments
Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 5, 2025

Date Added

Nov 22, 2024

This funding opportunity supports researchers exploring the use of microorganisms for innovative cancer therapies and imaging techniques, particularly in areas where traditional treatments fall short.

Education
State governments
IIJA/IRA Bureau of Land Management National Operations Center (NOC) Plant Conservation and Restoration Management
$500,000
U.S. Department of the Interior (Bureau of Land Management)
Federal

Application Deadline

Sep 30, 2024

Date Added

Aug 26, 2024

The IIJA/IRA Bureau of Land Management National Operations Center (NOC) Plant Conservation and Restoration Management grant aims to fund projects that increase the use of locally adapted native seeds for public land restoration, enhance biodiversity, improve climate resilience, and involve underserved communities, with a total of $800,000 available for individual awards ranging from $25,000 to $500,000.

Natural Resources
State governments
Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2024

Date Added

Mar 1, 2023

This funding opportunity supports research aimed at improving drug safety and effectiveness for pregnant women, breastfeeding mothers, and children, encouraging innovative studies that address their unique health needs.

Health
State governments
Biological Testing Facility (X01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 2, 2025

Date Added

Apr 28, 2023

This funding opportunity provides access to a specialized facility for researchers developing innovative, safe, and effective non-hormonal contraceptive methods for men and women, supporting preclinical studies necessary for future clinical trials.

Health
State governments
Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 3, 2025

Date Added

Mar 21, 2023

This funding opportunity provides financial support for under-resourced U.S. institutions to acquire advanced scientific instruments that enhance biomedical research and education, particularly for students from diverse and underserved backgrounds.

Health
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 28, 2025

Date Added

Nov 26, 2024

This funding opportunity supports innovative research projects that aim to reduce health disparities and promote health equity in diverse populations across the United States.

Health
State governments
Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 5, 2025

Date Added

Sep 8, 2022

This funding opportunity supports small research teams in developing innovative biomedical technologies that address critical health challenges and improve healthcare accessibility.

Education
State governments
Interaction between ARVs and Hormones in HIV and Coinfections (R01 Clinical Trial Optional)
$4,800,000
U.S. Department of Health and Human Services - National Institutes of Health
Federal

Application Deadline

Jul 30, 2024

Date Added

Mar 29, 2024

This program will support projects to identify and characterize factors associated with gender-affirming hormone therapy (GAHT) that may impact/contribute significantly to the prevention and treatment of HIV and/or co-infections with other sexually transmitted infections (STI)s in transgender individuals. For this funding opportunity GAHT is defined as a medical intervention, including but not limited to estrogen and/or testosterone treatment, that results in acquisition of secondary sex characteristics that align with an individual's gender identity. A growing body of data indicates that GAHT may impact the effectiveness and implementation of biomedical HIV prevention or treatment strategies and/or co-infections with other STIs. A number of factors in transgender populations present research challenges including variability in GAHT regimens, use of auxiliary drugs during GAHT care, access to participants, and access to existing cohorts, datasets, and samples. Consideration of appropriate controls, including cis-gender men and women is also a barrier. Recent studies demonstrating recruitment and retention of participants undergoing GAHT provide the opportunity to build on those studies and provide confidence that these critical studies are feasible.Letter of Intent Due Date(s) 30 days prior to the application due date

Education
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)
$300,000
HHS-NIH11 (National Institutes of Health)
Federal

Application Deadline

May 30, 2024

Date Added

Sep 25, 2023

The NINDSintends to reissuePAR-23-027 to solicit applications for basic research projects on chemical warfare agents, toxic industrial chemicals, and pesticides that have primary or secondary effects on the nervous system. Chemical threats are toxic compounds that could be used in a terrorist attack or accidentally released from industrial production, storage, or shipping. Projects supported by this NOFO are expected to generate data that elucidate mechanisms of toxicity of these agents, possible new manifestations of toxic exposures, and potential new targets for therapeutic development. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in Winter 2024 with an expected application due date in Spring 2024. This NOFO will utilize the R01 activity code. Details of the planned NOFO are provided below.

Health
State governments
Workforce Opportunity for Rural Communities (WORC) Round 6: A Grant Initiative for the Appalachian, Delta, and Northern Border Regions
$1,500,000
DOL-ETA (Employment and Training Administration)
Federal

Application Deadline

Jun 20, 2024

Date Added

Mar 16, 2024

The WORC Initiative aims to fund grants that create economic mobility, address inequities for historically marginalized communities of color, rural areas, and other underserved and underrepresented communities. These grants are designed to produce high-quality employment outcomes for workers in the Appalachian, Delta, and Northern Border regions, enabling them to remain and thrive in their communities. The Initiative provides grant funds to help impacted communities develop local and regional workforce development solutions aligned with existing economic development strategies and community partnerships, promoting new, sustainable job opportunities and long-term economic vitality with a focus on equity and underserved populations. WORC Round 6 places a strong emphasis on three key focus areas: enhancing access to Good Jobs, prioritizing equity, and sustaining impact. Questions regarding this Funding Opportunity Announcement (FOA) Forecast may be emailed to DOL-ETA-DWG@dol.gov; however, please note there is limited information that may be shared with the public, as this FOA is currently under development. We encourage prospective applicants and interested parties to use the Grants.gov subscription option to register for future updates provided for this particular FOA.

Employment Labor and Training
State governments
Pancreatic Cancer Detection Consortium: Management and Data Coordination Unit (U24 Clinical Trial Not Allowed)
$500,000
HHS-NIH11 (National Institutes of Health)
Federal

Application Deadline

Jun 11, 2024

Date Added

Sep 16, 2021

The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Research Units (RUs), one of the two scientific components of the Pancreatic Cancer Detection Consortium (PCDC), to conduct research on early detection of pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions to identify those patients who are at high risk of progression to cancer. The PCDC will continue to address one of the four research priorities identified in the National Cancer Institute's 2014 Scientific Framework for Pancreatic Ductal Adenocarcinoma. The PCDC will support research for the development and testing of new molecular and imaging biomarkers for detecting PDAC early and for identifying those patients at high risk of PDAC (because of genetic factors or presence of precursor lesions) who could be candidates for early intervention. The PCDC-RUs will consist of multi-disciplinary teams and will undertake studies to: identify and test biomarkers measurable in bodily fluids for early detection of PDAC and/or its precursor lesions; determine which pancreatic cysts are likely to progress to cancer; develop molecular- and/or imaging-based approaches for screening populations at high risk of PDAC; use machine learning and computational approaches towards biomarker discovery and/or validation; and conduct biomarker validation studies. The PCDC-RUs will also collect longitudinal biospecimens for building a biorepository. Each PCDC-RU is expected to participate in collaborative activities with other PCDC-RUs and share ideas, biospecimens and data within the Consortium. The other scientific component of the PCDC will be the Management and Data Coordination Unit (MDCU). The PCDC-MDCU will provide support toward study design, protocol development, statistical analysis, coordination, harmonization, data management and stewardship for the trans-PCDC collaborative projects, including biorepository building effort.

Education
State governments
FY 2024 IIJA/IRA Bureau of Land Management Arizona Invasive and Noxious Plant Management Program
$500,000
DOI-BLM (Bureau of Land Management)
Federal

Application Deadline

Jun 28, 2024

Date Added

Apr 3, 2024

Department of the Interior - Bureau of Land Management Arizona Invasive and Noxious Plant Management

Natural Resources
State governments
Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 30, 2024

Date Added

Jun 18, 2024

This funding opportunity supports innovative research to improve personalized probiotic treatments by studying individual biological factors that influence how people respond to probiotics.

Education
State governments
U.S. Embassy in Finland Public Diplomacy Annual Program Statement
$20,000
U.S. Department of State (U.S. Mission to Finland)
Federal

Application Deadline

Mar 28, 2025

Date Added

Jan 22, 2025

This funding opportunity provides financial support for a variety of organizations and individuals to implement public diplomacy initiatives that promote cooperation and shared values between the United States and Finland, focusing on areas like economic prosperity, technology, global security, and youth exchanges.

Business and Commerce
State governments