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Grants for Small businesses - Federal

Explore 1,854 grant opportunities

SMART FY25 Maintenance and Operation of the Dru Sjodin National Sex Offender Public Website
$1,000,000
U.S. Department of Justice (SMART)
Federal

Application Deadline

Feb 24, 2025

Date Added

Jan 9, 2025

This funding opportunity provides financial support for organizations to maintain and enhance a national website that helps the public and law enforcement access information about registered sex offenders across the United States.

Law Justice and Legal Services
Nonprofits
Functional Validation and/or Characterization of Genes or Variants Implicated in Substance Use Disorders (R21/R33 Clinical Trial Not Allowed)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 28, 2025

Date Added

Aug 7, 2024

This funding opportunity supports research projects that use genome editing techniques to explore the genetic factors contributing to substance use disorders, encouraging diverse organizations to participate in advancing addiction science.

Health
Public and State controlled institutions of higher education
Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 10, 2025

Date Added

May 22, 2025

This funding opportunity supports researchers in conducting single-site clinical trials focused on heart, lung, and blood health, encouraging innovative trial designs and community engagement.

Health
State governments
OJJDP FY24 Child Victimization and Juvenile Justice Prosecution Training and Technical Assistance Program
$2,000,000
Department of Justice - Office of Juvenile Justice Delinquency Prevention
Federal

Application Deadline

Jul 18, 2024

Date Added

Jun 11, 2024

With this solicitation, OJJDP seeks to select organization(s) to provide training and technical assistance geared toward strengthening prosecution efforts as listed below: Prosecution of cases of child victimization while in custodial care. These are cases in which children or youth report that they have been victimized while in out-of-home placement, whether that is foster care, group home, shelter care, or a custodial setting. These cases are far less likely to result in prosecution than cases in which a child or youth has been victimized while not in out-of-home placement.

Law Justice and Legal Services
Nonprofits
Advancing Nutrition-related Research Across the Lifespan
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 27, 2026

Date Added

May 29, 2025

This funding opportunity supports a wide range of organizations in conducting research to improve nutrition-related health outcomes and reduce health disparities across all life stages by addressing social factors that influence nutrition.

Health
State governments
Applied Regulatory Science Research to Evaluate Cardiotoxicity of Oncology Therapeutics (U01) Clinical Trial Optional
$500,000
U.S. Department of Health & Human Services (Food and Drug Administration)
Federal

Application Deadline

Aug 8, 2025

Date Added

Jul 24, 2025

This funding opportunity supports U.S.-based organizations in conducting research to better understand and manage heart-related side effects of cancer treatments, with a focus on improving detection, monitoring, and data sharing.

Agriculture
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for Investigational New Drug (IND)-enabling and Early-Stage Development of Medications to Treat Alcohol Use disorder and Alcohol-Associated Organ Damage (R43/R44 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 5, 2025

Date Added

Nov 26, 2024

This funding opportunity is designed to support small businesses in developing new medications for treating alcohol use disorder and related organ damage, helping them advance their therapeutic candidates toward FDA approval.

Health
Small businesses
Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Oct 2, 2024

This grant provides funding to U.S. small businesses for developing biologics-based therapies aimed at treating neurological and neuromuscular disorders.

Education
Small businesses
Formative and Pilot Intervention Research to Optimize HIV Prevention and Care Continuum Outcomes (R34 Clinical Trial Optional)
$225,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 9, 2025

Date Added

Jan 10, 2023

This grant provides funding for research projects that develop and test new strategies to improve HIV prevention and treatment outcomes, particularly by involving communities affected by HIV.

Health
State governments
Alfalfa Seed and Alfalfa Forage Systems
$900,000
U.S. Department of Agriculture (National Institute of Food and Agriculture)
Federal

Application Deadline

Jun 12, 2026

Date Added

Apr 29, 2026

This program provides funding to support research and extension projects that improve alfalfa seed and forage production systems, benefiting farmers, ranchers, and agricultural institutions across the U.S.

Agriculture
Public and State controlled institutions of higher education
Preventing global health threats by strengthening surveillance systems to accelerate outbreak detection, notification, and response
$1,500,000
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Jul 15, 2026

Date Added

Sep 19, 2025

This funding opportunity provides financial support to a wide range of organizations, including governments and nonprofits, to strengthen global health surveillance systems for faster detection and response to infectious disease outbreaks in various regions around the world.

Health
State governments
Sustaining HIV services for key and priority populations through enhanced differentiated testing, innovative treatment and prevention approaches, and continuous support to Ukraine Ministry of Health, Public Health Center, and communities under PEPFAR
$8,000,000
U.S. Department of Health & Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 21, 2025

Date Added

Aug 8, 2024

This grant provides funding to organizations in Ukraine to improve HIV testing, prevention, and treatment services for vulnerable populations affected by the ongoing war.

Health
State governments
Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 5, 2024

Date Added

Aug 18, 2023

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. With this NOFO, the NCI intends to encourage submission of projects devoted to demonstrating that mammalian models or their derivatives used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patients' benefit. These practical goals contrast with the goals of many mechanistic, NCI-supported R01 projects that employ mammals, or develop and use mammalian cancer models, transplantation tumor models, or models derived from mammalian or human tissues or cells for hypothesis-testing, non-clinical research. Among many other possible endeavors, applicants in response to this FOA could propose demonstrations of how to overcome translational deficiencies of mammalian oncology models, define new uses of mammalian models or their genetics for unexplored translational challenges, advance standard practices for use of translational models, test approaches to validate and credential models, or challenge current practices for how models are used translationally

Education
State governments
BJS FY25 National Victimization Statistical Support Program (NVSSP)
$2,000,000
U.S. Department of Justice (Bureau of Justice Statistics)
Federal

Application Deadline

Feb 10, 2026

Date Added

Jan 16, 2026

This funding opportunity provides financial support for research and statistical analysis related to crime and victimization, primarily aimed at enhancing the National Crime Victimization Survey and its methodologies.

Information and Statistics
Independent school districts
Energy Frontier Research Centers (EFRCs)
$18,000,000
U.S. Department of Energy (Office of Science)
Federal

Application Deadline

Jul 1, 2026

Date Added

Feb 18, 2026

This funding opportunity supports interdisciplinary research teams in the U.S. to conduct foundational studies in energy, environment, and national security, fostering scientific innovation and training the next generation of energy-focused researchers.

Science and Technology
State governments
Funding Opportunity Announcement (FOA) Number DE-FOA-0002785: Exploratory Topics (SBIR/STTR)
$2,500,000
DOE-ARPAE (Advanced Research Projects Agency Energy )
Federal

Application Deadline

May 7, 2024

Date Added

Mar 22, 2024

To obtain a copy of the Funding Opportunity Announcement (FOA) please go to the ARPA-E website at https://arpa-e-foa.energy.gov. To apply to this FOA, Applicants must register with and submit application materials through ARPA-E eXCHANGE (https://arpa-e-foa.energy.gov/Registration.aspx). For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). ARPA-E will not review or consider concept papers submitted through other means. For problems with ARPA-E eXCHANGE, email ExchangeHelp@hq.doe.gov (with FOA name and number in the subject line). Questions about this FOA? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email ARPA-E-CO@hq.doe.gov. To read this FOA in its entirety, please go to the ARPA-E website at https://arpa-e-foa.energy.gov. Questions about this FOA? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email ARPA-E-CO@hq.doe.gov. The purpose of this modification is to incorporate changes to Funding Opportunity Announcement. Accordingly, this modification, Inserted new Exploratory Topic, Topic L: Plant HYperaccumulators TO MIne Nickel-Enriched Soils (PHYTOMINES). See Table 1. Exploratory Topics, Appendix L, and Total Amounts to be awarded on Cover Page.

Opportunity Zone Benefits
Small businesses
FY24 Solar Energy Supply Chain Incubator Funding Opportunity Announcement
$6,000,000
U.S. Department of Energy (Office of Energy Efficiency and Renewable Energy (EERE))
Federal

Application Deadline

Oct 7, 2024

Date Added

Jul 17, 2024

The anticipated funding opportunity announcement (FOA) aims to support research and development projects under the Vehicle Technologies Office (VTO). The goals include the demonstration of smart charge management for electric vehicles, improvement of 12-volt lead-acid batteries for safety-critical electric vehicle applications, development of strategies to reduce the likelihood of cascading effects of electric vehicle fires, reduction in battery electrode, cell, and pack manufacturing costs, advancement of silicon-based anodes for lithium-ion batteries, and development of high-energy density conversion cathodes. The FOA emphasizes advancing equity, addressing the climate crisis, and achieving net-zero emissions by 2050. Eligible applicants are encouraged to include underrepresented groups and underserved communities in their project teams. The FOA will fund activities related to electric vehicle (EV) technologies, focusing on areas such as smart charge management, safety improvements in EV batteries, cost reduction in battery manufacturing, and the development of advanced battery materials. The Department of Energy aims to drive innovation in clean energy technologies, ensuring environmental justice and inclusion. Specific areas of interest include wide-scale demonstrations of smart charge management, enhancement of safety-critical 12-volt lead-acid batteries, reduction of cascading effects of battery fires, cost reduction in battery manufacturing, and the development of high-energy-density battery components.

Science and Technology
Small businesses
Defense Sciences Office (DSO) Office-wide BAA
Contact for amount
U.S. Department of Defense (DARPA - Defense Sciences Office)
Federal

Application Deadline

Jun 2, 2026

Date Added

Jun 4, 2025

This grant provides funding for innovative research proposals that advance scientific and technological breakthroughs to enhance national security, targeting a wide range of applicants including private institutions, nonprofits, and small businesses.

Science and Technology
For profit organizations other than small businesses
Metal Casting BAA0001-21
Contact for amount
Defense Logistics Agency (DLA), Department of Defense (DoD)
Federal

Application Deadline

Jun 30, 2026

Date Added

Mar 20, 2025

This funding opportunity supports research and development in metal casting technologies to enhance military applications and meet national defense needs.

Science and Technology
For profit organizations other than small businesses
Rehabilitation Research and Training Center (RRTC): National Research Center for Parents with Disabilities
$925,000
U.S. Department of Health and Human Services (Administration for Community Living)
Federal

Application Deadline

Not specified

Date Added

Sep 8, 2025

This funding opportunity provides resources to organizations conducting research and training to improve support and services for parents with disabilities, helping them navigate their parenting roles effectively.

Science and Technology
State governments