Grants for Small businesses - Federal

This funding opportunity provides financial support to organizations working in Zambia to improve HIV and TB prevention, care, and treatment services through innovative and sustainable quality improvement strategies.

This funding opportunity provides financial support for research projects that enhance data collection and analysis related to breast cancer, specifically targeting gaps in existing clinical studies and involving consumer advocates in the research process.

The "Puerto Rico Energy Resilience Fund: Resilient Communities Program" grant aims to use $1B in funding to enhance Puerto Rico's energy resilience and clean energy economy, particularly focusing on mitigating power outage impacts on low-income residents, ensuring energy reliability for healthcare services in disadvantaged communities, and supporting the growth of the clean energy workforce, through the installation of solar PV and battery storage in subsidized multi-family properties and community healthcare facilities.

This funding opportunity provides financial support for research projects that implement effective treatments for opioid and stimulant use disorders, focusing on improving care systems and addressing health disparities.

This funding opportunity supports small U.S.-based businesses in developing innovative solutions for population genomic screening to improve primary care practices and enhance patient outcomes.

This funding opportunity is designed for U.S.-based small businesses to develop innovative, cost-effective drug detection devices that can quickly identify both known and new drugs without relying on traditional antibody-based methods.

This funding opportunity is designed to establish a center that will coordinate and manage data for collaborative research on rare diseases, supporting various research consortia and engaging stakeholders to improve diagnosis and treatment.

This program funds projects that improve the safety, efficiency, and reliability of intercity passenger and freight rail. The Consolidated Rail Infrastructure and Safety Improvements (CRISI) Program is authorized under 49 U.S.C. 22907. The purpose of the CRISI Program is to invest in a wide range of projects within the United States to improve railroad safety, efficiency, and reliability; mitigate congestion at both intercity passenger rail and freight rail chokepoints to support more efficient travel and goods movement; enhance multi-modal connections; and lead to new or substantially improved Intercity Passenger Rail Transportation corridors. This program invests in railroad infrastructure projects that improve safety, support economic vitality (including through opportunities for small businesses), create good-paying jobs with the free and fair choice to join a union, increase capacity and supply chain resilience, apply innovative technology, and explicitly address climate change, gender equity and racial equity. The purpose of this notice is to solicit applications for the competitive CRISI Program provided in Consolidated Appropriations Act, 2023, division L, title I, Public Law 117–328 (2023 Appropriation), Consolidated Appropriations Act, 2024, division F, title I, Public Law 118–42 (2024 Appropriation) and the 2023 and 2024 advance appropriation in the Infrastructure Investment and Jobs Act, division J, title II, Public Law 117–58 (2021).

OVC seeks field-generated proposals that offer innovative solutions that will increase access to victim services and expand the options available to crime victims, especially in underserved communities. This solicitation encourages prospective applicants to partner with nontraditional partners that may not be typically associated with the victim services field.

This ISO seeks solution summaries and proposals for projects that fall within the general scope of the ARPA-H Scalable Solutions mission office. SSO expands what is technically possible by developing approaches that will leverage an interdisciplinary approach and collaborative networks to address challenges of geography, distribution, manufacturing, data and information, thereby improving health care access and affordability. In the United States, many communities and remote areas lack access to timely and quality health care, which leads to disparities in health outcomes for those populations. Bottlenecks during the manufacturing processes of products and health technologies also lead to delays and limited availability, preventing effective distribution of health care solutions to areas of need, especially in emergencies.ARPA-H SSO seeks solutions to improve the scalability and affordability of health care solutions, bridge gaps in underserved areas, and extend remote access to expertise by developing location-specific interventions, telemedicine solutions, and mobile health clinics. Solutions should focus on rapid innovation and the use of partnerships, as well as flexible distribution networks and streamlined manufacturing processes. The following SSO interest areas categorize the ground-breaking solutions we seek to support:Scalable Technologies and Interventions: Approaches to improve affordability and equitable access to health care that are adaptable to various geographic, demographic, economic contexts and can be rapidly deployed at scale (e.g., drug-repurposing*, telemedicine, point-of-care diagnostics, and modular health care infrastructure). Tailored solutions for the pediatric population that provide parity in access to treatments and other health care interventions with the adult population and adapt to the pediatric patients changing physiology and developmental status over the course of years. Transformational approaches to reduce or eliminate health disparities, including tools and models for product design and care delivery that scale novel approaches in human factors and human-centered design to respond to full diversity of patients. Tools to enable the scaling of provider and institutional capabilities (e.g., school nurses and schools, walk-in clinics, homesteading care) to address unmet health care access needs and expand availability of critical services. Foundational capabilities to accelerate diagnoses and reduce the cost of treatments for rare diseases wherever patients are, without the need for specialized facilities or healthcare expertise.* Solution summaries and proposals that focus on testing drugs for effectiveness for other disease states or use cases, are unlikely to be funded unless including additional R, or providing gains in cost reduction, accessibility, and/or equity.Collaborative Distribution Networks: Methods for standardization, automation, and democratization of complex procedures 5 including, but not limited to, histopathology, rare disease diagnosis and treatment, and surgical interventions to ensure access and delivery to populations diverse in demographics, geographies, and resources at scale. Approaches to enhance delivery of effective healthcare solutions in rural or low resource settings, including but not limited to "last mile delivery, at-home monitoring, imaging, drug delivery, telehealth augmentation, and support for remote medical procedures with limited need for specialized training. Technologies to enable the deployment of critical healthcare resources rapidly, equitably, and securely at scale to the point of need in permissive and non-permissive (i.e., damaged infrastructure, cyber-denied) environments during a public health crisis or natural disaster. Solutions to scale education and training of critical healthcare resources for health care providers and patients to ensure information integrity to prevent negative impacts to resource use/uptake. Innovative information technology, data and analytic products and technologies to enable ordering, inventory management, situational awareness, allocation planning and demand forecasting of critical healthcare resources during a public health crisis or natural disaster.Biomanufacturing Innovations*: Innovative manufacturing technologies and approaches that reduce cost, shorten the timeline for production, advance domestic competitiveness and reduce supply chain risk of biologics, cellular and gene therapies, pharmaceuticals, medical devices and personal protective equipment. New approaches to support predictable, programable biological production of conventional and novel materials reliability at scale in a cost-effective sustainable manner. Novel solutions to reduce the reliance on specialized handling and cold chain management of pharmaceuticals and biologics. Scalable innovations to advance and strengthen biomanufacturing supply chain and resolve bottlenecks including:o Advances in production of active pharmaceutical ingredients, process consumables, and other critical materials (i.e., enzymes, cell lines, etc);o Novel biomanufacturing-related data products, technologies or models to integrate into supply chain situational awareness systems;o Alternative materials and new manufacturing capabilities for personal protective equipment; ando Improvement of capabilities sustainably re-shore manufacturing and utilize a broad array of readily accessible and cost-efficient feedstocks as part of strengthening the local and national industry base. Analytics and novel sensor systems to precisely manage bioproduction, real-time release assays, and predictive capabilities to inform tuning of biological chassis for efficient and effective scale-up of manufacturing to industrial scale.*ARPA-H is not interested in approaches that merely increase capacity reservation.Other high-quality submissions that propose revolutionary technologies that meet the goals of SSO will be considered even if they do not address the topics listed above.Proposals are expected to use innovative approaches to enable revolutionary advances in medicine and healthcare, and the science and technology underlying these areas. While approaches that are disease agnostic are encouraged, ARPA-H welcomes proposals that bring radically new insights to address specific diseases including, but not limited to, cancer, diabetes, neurological diseases, pediatric and maternal/fetal health, infectious diseases, and cardiovascular disease.Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art or technology that has reached the clinical trial stage. An example of this type of proposal might include the request to fund clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

The "Single Source for the Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D)" grant is intended to fund the University of Pennsylvania's ongoing research into understanding and combating Type 1 Diabetes, by studying human pancreatic tissues and immune cells, and sharing their findings through an open-access database.

The GEL-ICS program will build a cohesive group of leaders working on issues in cyberspace who are committed to the UN-affirmed Framework of Responsible State Behavior and will be equipped with the necessary knowledge and global connections to be effective advocates and champions of the Framework through the fellowship and other activities.

This funding opportunity provides financial support to non-profits, local and tribal governments, and businesses for projects that promote renewable wood energy and innovative wood products, particularly in underserved communities and areas with high unemployment.

This grant provides funding to a wide range of organizations, including NGOs and private sector entities, to strengthen local health systems in Guinea, focusing on improving healthcare quality and accessibility in targeted regions.

This funding opportunity supports innovative research projects that aim to improve HIV prevention and care strategies, targeting a wide range of organizations and individuals involved in health and social sciences.

This grant provides funding to organizations in India to improve the quality and accessibility of HIV and STI testing services through enhanced laboratory networks and continuous quality improvement initiatives.

This funding opportunity supports a variety of organizations in developing technology-based training programs for healthcare providers to improve patient care and workforce capacity in underserved communities.

The Public Affairs Section of the U.S. Embassy in Kuala Lumpur announces an open competition for a cooperative agreement to develop, organize, and oversee the 2025 Young Southeast Asian Leaders Initiative (YSEALI) Summit, pending the availability of funds. The four-day Summit (exclusive of arrival and departure dates) in 2025 will gather over 150 YSEALI exchange program alumni from across ASEAN countries and Timor-Leste. The award recipient is expected to design a youth-focused, high-energy, and dynamic Summit that will provide the next generation of Southeast Asian leaders the opportunity to build networks, discuss ideas, and develop solutions to contemporary challenges. The YSEALI Summit in Malaysia will be conducted in English. The content of the program should touch on each of the four pillars of YSEALI and include leadership, mentorship, and teamwork training. The Summit will enable participants to see how YSEALI members have become leaders in Southeast Asian communities through community service, entrepreneurship, civic engagement, and education. The Summit should feature panels and presentations by prior YSEALI participants from each country who have become changemakers in their fields. The Summit should feature sessions giving participants the opportunity to work together to develop possible solutions to current environmental, social, political, and economic challenges in the region. Participants should learn innovative approaches to promote relations among ASEAN countries and with the United States through presentation, case studies and simulations. The Summit will also provide leadership and other soft skills training on topics such as advocacy, negotiation, and personal branding, which are core soft skills YSEALI alumni need to become successful leaders. Participants will also have a chance to join cultural activities, and other site visits that support the Summits theme. The Summit will include a mix of informational sessions, discussions and challenges, and break-out sessions on different topics and group presentations, as well as site and cultural visits.

This funding opportunity provides financial support to organizations working to improve HIV prevention, care, and treatment services for key populations in Central America, aiming to achieve significant health outcomes by 2030.

This funding opportunity supports innovative research projects that address social factors affecting health to reduce disparities and promote health equity among underserved populations in the U.S.