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Grants for Small businesses - Federal

Explore 1,854 grant opportunities

Engineering Next-Generation Human Nervous System Microphysiological Systems (R21 Clinical Trials Not Allowed)
$275,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 5, 2024

Date Added

Nov 10, 2022

This grant provides funding for researchers to develop advanced human cell-based systems that better mimic the complex functions of the nervous system, aiming to improve the understanding and treatment of brain and spinal cord disorders.

Health
State governments
PROtein SEquencing (PROSE) Program Announcement
Contact for amount
Defense Advanced Research Projects Agency
Federal

Application Deadline

Aug 28, 2025

Date Added

Jul 16, 2025

This program provides funding for researchers and innovators to develop advanced technologies for rapidly identifying and sequencing complex protein-based biothreats, enhancing national security and defense capabilities.

Science and Technology
For profit organizations other than small businesses
Cellular Models of HIV Pathogenesis within NIDDK Mission Areas (R01 Clinical Trial Not Allowed)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 20, 2025

Date Added

Sep 18, 2024

This funding opportunity supports research using advanced cellular models to investigate HIV interactions with tissues related to diabetes, digestive, and kidney diseases, particularly focusing on HIV persistence, latency, and related health issues.

Food and Nutrition
State governments
Limited Competition: AIDS Malignancy Consortium (AMC; UM1 Clinical Trial Required)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 10, 2025

Date Added

Aug 14, 2024

This funding opportunity supports collaborative research efforts to improve the prevention, treatment, and understanding of cancers associated with HIV, involving various specialized teams and clinical trials accessible to diverse populations.

Education
Small businesses
Kidney Precision Medicine Project Recruitment Sites (U01 Clinical Trial Not Allowed)
$450,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 10, 2026

Date Added

Sep 11, 2025

This funding opportunity supports various organizations in recruiting and managing participants with kidney diseases for a national study aimed at improving understanding and treatment of these conditions.

Health
State governments
NIDCR Research Grants for Analyses of Existing Genomics Data (R01) (Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2025

Date Added

Mar 28, 2023

This funding opportunity supports researchers analyzing existing genomic data related to dental, oral, and craniofacial health to address research gaps and improve health outcomes.

Health
State governments
NOI to Issue Infrastructure Investment and Jobs Act (IIJA) Funding Opportunity Announcement DE-FOA-0003585 Battery Materials Processing and Battery Manufacturing and Recycling Grant Program
$200,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Oct 13, 2025

Date Added

Aug 14, 2025

This funding opportunity provides financial support for projects that enhance the domestic processing, manufacturing, and recycling of critical battery materials to strengthen U.S. supply chains and reduce reliance on foreign sources.

Energy
For profit organizations other than small businesses
Notice of Intent to Publish a Funding Opportunity Announcement for NCI Continuing Umbrella of Research Experiences (CURE) Academic Career Excellence (ACE) Award (K32 Independent Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 12, 2025

Date Added

Dec 27, 2024

This funding opportunity supports early postdoctoral fellows from diverse backgrounds in cancer research, providing them with mentorship and training to advance their careers in addressing health disparities and enhancing the cancer research workforce.

Health
State governments
Bil: Carbon Capture Technology Program, Front-End Engineering And Design For Carbon Dioxide (Co2) Transport
$3,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Feb 12, 2025

Date Added

Dec 16, 2024

This funding opportunity provides financial support for engineering studies to develop infrastructure for transporting captured carbon dioxide, targeting private companies, governments, non-profits, and educational institutions committed to reducing greenhouse gas emissions and promoting community benefits.

Energy
Nonprofits
Small Business Innovation Research and Small Business Technology Transfer Programs Phase II
$650,000
U.S. Department of Agriculture (National Institute of Food and Agriculture)
Federal

Application Deadline

Sep 23, 2025

Date Added

Jul 17, 2025

This funding opportunity provides financial support to U.S.-based small businesses that have previously received Phase I awards to further develop and commercialize innovative research in agriculture, food systems, and environmental sustainability.

Science and Technology
Small businesses
NSF/CASIS Transport Phenomena Research at the International Space Station to Benefit Life on Earth
$400,000
National Science Foundation
Federal

Application Deadline

Mar 4, 2026

Date Added

Sep 23, 2025

This grant provides funding for U.S.-based researchers and organizations to conduct innovative studies in microgravity that explore transport phenomena, with the goal of developing solutions that benefit life on Earth.

Science and Technology
Public and State controlled institutions of higher education
Global Brain and Nervous System Disorders Research Across the Lifespan - Exploratory Grants
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 24, 2026

Date Added

Sep 27, 2025

This grant provides funding for innovative research on brain and nervous system disorders, encouraging collaboration between U.S. and low- and middle-income country researchers to improve global health outcomes.

Health
City or township governments
National Center on Early Childhood Development, Teaching, and Learning
$8,800,000
U.S. Department of Health & Human Services (Administration for Children and Families - OHS)
Federal

Application Deadline

Jun 2, 2025

Date Added

Jul 31, 2024

This grant provides funding to organizations that will deliver training and support to improve early childhood education and development practices for children from birth to age five in Head Start and Early Head Start programs.

Income Security and Social Services
Special district governments
Capacity-building support for the environmentally sound end-of-life management of lead-acid batteries in Africa.
$739,875
U.S. Department of State - Bureau of Oceans - Int. Environmental - Scientific
Federal

Application Deadline

Jul 29, 2024

Date Added

Jun 13, 2024

The U.S. Department of State, Bureau of Oceans and International Environmental and Scientific Affairs (OES) announces an open competition (see eligibility information in Funding Announcement), under the Toxic Chemicals earmark to reduce and mitigate environmental contamination and human exposures to lead by supporting capacity-building efforts for environmentally sound end-of-life management of lead-acid batteries (LABs) and used lead-acid batteries (ULABs) in Africa. This program aims to reduce lead pollution as well as promote and advance environmentally sustainable consumption and production at international, national, and subnational levels.

Environment
Nonprofits
NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Clinical Trials and Clinical Research (R44 Clinical Trial Optional)
$3,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Nov 18, 2025

This funding opportunity supports small businesses that have completed a Phase II SBIR or STTR award in advancing clinical trials and research projects for medical products, particularly those requiring federal regulatory approval, while encouraging partnerships with investors to ensure commercial viability.

Health
Small businesses
A Strategic Approach to Advancing Health Equity for Priority Populations with or at Risk for Diabetes—Subject Matter Expertise, Training, and Technical Assistance
$10,000,000
U.S. Department of Health & Human Services (Centers for Disease Control and Prevention)
Federal

Application Deadline

Mar 14, 2023

Date Added

Jul 17, 2025

This funding opportunity provides financial support to organizations that will help improve diabetes prevention and management for underserved populations by offering expertise, training, and resources to enhance health equity.

Health
Nonprofits
Limited Competition: High Impact Specialized Innovation Programs in Clinical and Translational Science for UM1 CTSA Hub Awards (RC2 Clinical Trials Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Dec 10, 2024

Date Added

Nov 7, 2023

This funding opportunity provides financial support to institutions with active Clinical and Translational Science Awards to develop innovative programs that address critical challenges in clinical research and improve the efficiency of translating scientific discoveries into practical applications.

Health
Small businesses
NIJ FY25 Research and Evaluation on Drugs and Crime: Nexus with Firearms and Violence
$2,000,000
U.S. Department of Justice (National Institute of Justice)
Federal

Application Deadline

Jun 8, 2026

Date Added

May 5, 2026

This funding opportunity provides financial support for research projects that explore the connections between drug markets, firearm-related violence, and effective law enforcement strategies, targeting a wide range of eligible applicants including governments, educational institutions, and nonprofit organizations.

Law Justice and Legal Services
State governments
Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (UT1/UT2) Clinical Trial Not Allowed
$1,972,828
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 6, 2025

Date Added

Jun 7, 2025

This funding opportunity supports U.S.-based small businesses in developing and manufacturing therapeutic extracellular vesicles for regenerative medicine applications, focusing on tissue and organ repair.

Health
Small businesses
Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R21 - Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 16, 2025

Date Added

Oct 18, 2024

This funding opportunity provides financial support for innovative research projects aimed at understanding the neurological and mental health effects of chronic illnesses linked to infections, such as Long COVID and chronic fatigue syndrome, encouraging studies that explore their underlying mechanisms.

Health
State governments