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Grants for Small businesses - Federal

Explore 1,962 grant opportunities

NOI to Issue Infrastructure Investment and Jobs Act (IIJA) Funding Opportunity Announcement No. DE-FOA-0003587 titled Rare Earth Elements Demonstration Facility.
$135,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Oct 13, 2025

Date Added

Aug 14, 2025

This funding opportunity provides financial support for the design and operation of a facility that extracts and refines rare earth elements from unconventional sources, aimed at strengthening domestic supply chains and reducing reliance on foreign materials.

Energy
For profit organizations other than small businesses
Strengthening Public Health Systems and Services through National Partnerships to Improve and Protect the Nation's Health
$95,000,000
U.S. Department of Health and Human Services (Centers for Disease Control-PHIC)
Federal

Application Deadline

Jul 10, 2026

Date Added

Jun 2, 2026

This funding opportunity provides financial support to organizations that have previously received CDC funding to strengthen public health systems through capacity-building, workforce development, and enhanced partnerships aimed at improving health outcomes and reducing health inequities.

Health
State governments
DoW Epilepsy Idea Development Award
$1,000,000
U.S. Department of Defense (Dept. of the Army -- USAMRAA)
Federal

Application Deadline

Aug 17, 2026

Date Added

May 22, 2026

This funding opportunity supports innovative research projects aimed at advancing the understanding and treatment of post-traumatic epilepsy, particularly for Service Members, Veterans, and their families.

Health
Nonprofits
Food Safety Outreach Program Technical Assistance-Grant Writing Skills Projects
$300,000
U.S. Department of Agriculture (National Institute of Food and Agriculture-eRA)
Federal

Application Deadline

Jul 20, 2026

Date Added

Jun 19, 2026

This funding opportunity provides financial support to organizations that help underserved communities and small agricultural producers improve their grant writing skills and food safety education initiatives.

Agriculture
Nonprofits
DRL Strengthening Taiwans Subnational Linkages with Central and Eastern Europe
$483,091
Department of State - Bureau of Democracy Human Rights and Labor
Federal

Application Deadline

Jul 22, 2024

Date Added

Jun 11, 2024

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL), in coordination with the Bureau of East Asian and Pacific Affairs (EAP), announces an open competition for organizations interested in submitting applications for a project that will increase sub-national, democratic, and people-to-people ties between Central and Eastern Europe (CEE) and Taiwan. For the purposes of this solicitation, applicable regions include Central and Eastern Europe, the Baltic states, and the Western Balkans.

Humanities
Nonprofits
Small Business Informatics Tools for the Pangenome (R43 Clinical Trial Not Allowed)
$400,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 3, 2025

Date Added

Dec 11, 2024

This funding opportunity supports small businesses in developing innovative informatics tools that enhance the use and accessibility of the human pangenome reference for genomic research and clinical applications.

Health
Small businesses
Small Business Transition Grant For Early Career Scientists (R41/R42 Clinical Trial Not Allowed)
$2,045,816
Department of Health and Human Services - National Institutes of Health
Federal

Application Deadline

Aug 21, 2024

Date Added

Apr 24, 2024

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to support early-career academic scientists interested in transitioning to entrepreneurship while also supporting the transfer of technology from academic laboratories into small businesses. Both small businesses and universities are drivers of technological innovation in the United States (U.S.), often working together to advance innovative ideas into products that can benefit the U.S. population. While most NIH funding supports basic research in university laboratories, the NIH also supports innovative technology development in U.S. small businesses through its SBIR and STTR programs. As technologies transition from academic discovery to small businesses, two common challenges arise, identifying the right team with the right expertise to take the product into a small business, and funding for early-stage technology development. This NOFO seeks to address both challenges simultaneously by having two equally important goals: entrepreneurial mentoring support, and product development support.

Education
Small businesses
F26AS00041 Yukon River Salmon Research and Management (R) Assistance
$100,000
U.S. Department of the Interior (Fish and Wildlife Service)
Federal

Application Deadline

May 18, 2026

Date Added

Mar 20, 2026

This funding opportunity provides financial support for research and management projects focused on conserving Chinook and Chum salmon in the Yukon River, with an emphasis on community engagement and capacity building among local residents.

Natural Resources
Individuals
Fertilizer Investment Expansion for Long-term Domestic Supply (FIELDS)
$150,000,000
U.S. Department of Agriculture (Rural Business-Cooperative Service )
Federal

Application Deadline

Aug 17, 2026

Date Added

Jul 2, 2026

This funding opportunity provides financial support to various organizations for expanding or establishing domestic fertilizer production capacity, ensuring U.S. farmers have reliable access to essential agricultural inputs.

Business and Commerce
Nonprofits
U.S. Army Combat Capabilities Development Command Broad Agency Announcement
Contact for amount
U.S. Department of Defense (ACC APG - Natick)
Federal

Application Deadline

Feb 28, 2025

Date Added

Jun 2, 2020

This grant provides funding for research and development projects aimed at improving the equipment and support systems for U.S. Army soldiers, focusing on enhancing their survivability, mobility, and overall effectiveness in the field.

Science and Technology
Public and State controlled institutions of higher education
DoD Military Burn, Patient-Centered Research Award
$1,700,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Sep 8, 2025

Date Added

May 2, 2025

This funding opportunity supports clinical research aimed at improving burn care for military personnel, focusing on practical applications that enhance treatment in challenging environments.

Science and Technology
Nonprofits
The State Physical Activity and Nutrition Program (SPAN)
$1,300,000
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention)
Federal

Application Deadline

Not specified

Date Added

Jan 27, 2023

This funding opportunity provides financial support to state and local governments, educational institutions, nonprofits, and other organizations to implement strategies that promote better nutrition and physical activity, ultimately reducing chronic disease risks in their communities.

Health
State governments
DoD Bone Marrow Failure, Investigator-Initiated Research Award
$2,440,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 9, 2024

Date Added

Jun 11, 2024

The "DoD Bone Marrow Failure, Investigator-Initiated Research Award" is a grant that provides two levels of funding: one for expanding mature research ideas and key discoveries in bone marrow failure, and another for supporting the development of new drugs for bone marrow failure treatment, with the ultimate goal of improving patient care and finding effective treatments and cures.

Science and Technology
Nonprofits
Notice of Intent to Publish a Funding Opportunity Announcement for New Institutional Training Programs for Aging Research (T32, Clinical Trial Not Allowed)
$1,188,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

May 25, 2025

Date Added

Oct 25, 2024

This funding opportunity supports institutions in developing training programs for predoctoral and postdoctoral researchers focused on advancing knowledge and skills in aging research, aiming to prepare a diverse group of scientists for careers in this critical field.

Health
State governments
Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R41/R42 Clinical Trials Not Allowed)
$400,000
Department of Health and Human Services - National Institutes of Health
Federal

Application Deadline

Jul 25, 2024

Date Added

Jan 30, 2024

The purpose of this funding opportunity is to develop artificial intelligence tools and experimental assays to identify new pharmacotherapeutics with lower toxicity and higher efficacy for substance use disorders (SUD) Areas of interest include but are not limited to: 1) Development of AI tools to identify potential target combinations, design new molecules, conduct virtual preclinical studies to predict efficacy and toxicity, and model in vitro and in vivo polypharmacology 2) Development of assays to assess the effects of compounds on multiple targets or functions

Education
Small businesses
Small Business Innovation Research and Small Business Technology Transfer Programs Phase I
$181,500
U.S. Department of Agriculture (National Institute of Food and Agriculture)
Federal

Application Deadline

Sep 17, 2024

Date Added

Jul 3, 2024

The USDA SBIR/STTR programs focus on transforming scientific discovery into products and services with commercial potential and/or societal benefit. Unlike fundamental research, the USDA SBIR/STTR programs support small businesses in the creation of innovative, disruptive technologies and enable the application of research advancements from conception into the market. The STTR program aims to foster technology transfer through formal cooperative R between small businesses and nonprofit research institutions.

Agriculture
Small businesses
National Bycatch Reduction Engineering Program (BREP) - FY2025
$350,000
U.S. Department of Commerce (DOC NOAA - ERA Production)
Federal

Application Deadline

Dec 13, 2024

Date Added

Oct 10, 2024

The National Bycatch Reduction Engineering Program (BREP) - FY2025 aims to fund innovative research and development projects that reduce bycatch of non-target species in fisheries, promoting sustainable practices and protecting marine ecosystems.

Environment
Public and State controlled institutions of higher education
Title V Competitive Sexual Risk Avoidance Education
$450,000
U.S. Department of Health and Human Services (Administration for Children ; Families - ACYF/FYSB)
Federal

Application Deadline

Aug 17, 2026

Date Added

Apr 30, 2026

This funding opportunity provides financial support to a wide range of organizations, including schools and nonprofits, to develop and implement educational programs that encourage youth aged 10 to 19 to abstain from nonmarital sexual activity and promote healthy decision-making.

Income Security and Social Services
County governments
DoD Kidney Cancer, Academy of Kidney Cancer Investigators - Early-Career Scholar Award
$725,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 15, 2024

Date Added

Jul 12, 2024

The DoD Kidney Cancer, Academy of Kidney Cancer Investigators - Early-Career Scholar Award is a grant aimed at supporting early-career scholars in conducting kidney cancer research, providing them with funding, networking, and collaborative opportunities, and mentorship for a period of four years, with the ultimate goal of advancing kidney cancer research and developing highly productive kidney cancer researchers.

Science and Technology
Nonprofits
Biological Technologies
Contact for amount
U.S. Department of Defense (DARPA - Biological Technologies Office)
Federal

Application Deadline

Oct 1, 2025

Date Added

Sep 12, 2024

This funding opportunity supports innovative research and development in biological technologies that enhance national security, targeting universities, nonprofits, small businesses, and industry participants, particularly those with commercial potential.

Science and Technology
For profit organizations other than small businesses