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Grants for Small businesses - Federal

Explore 1,517 grant opportunities

Epitranscriptomics Crosstalks and Toxicants (EPCOT) (R01 Clinical Trials Not Allowed)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 6, 2025

Date Added

Nov 15, 2024

This funding opportunity supports innovative research on how environmental toxicants impact RNA modifications and their role in health issues, targeting universities, nonprofits, and for-profit organizations involved in related studies.

Environment
State governments
Strengthening the Botswana Ministry of Health (MOH) laboratory and health systems through technical assistance (TA) to effectively manage and sustain a quality HIV/TB program in Botswana under the Presidents Emergency Plan for AIDS Relief (PEPFAR)
$3,000,000
U.S. Department of Health & Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 19, 2025

Date Added

Jul 26, 2024

This funding opportunity provides financial support to organizations working in Botswana to strengthen laboratory and health systems for effective management of HIV and TB programs.

Health
State governments
Elder Justice Innovation Grants FY2025
$500,000
U.S. Department of Health & Human Services (Administration for Community Living)
Federal

Application Deadline

Aug 11, 2025

Date Added

Jul 1, 2025

This funding opportunity provides financial support for organizations to develop and evaluate innovative strategies aimed at preventing and addressing elder abuse and neglect among older adults and individuals with disabilities.

Health
City or township governments
ROSES 2024: C.9 Mars Data Analysis Program
$4,500,000
National Aeronautics & Space Administration (NASA Headquarters)
Federal

Application Deadline

Nov 14, 2024

Date Added

Sep 25, 2024

This grant provides funding for researchers and organizations to analyze data from Mars missions, supporting advancements in our understanding of the planet's geology, climate, and potential for life.

Science and Technology
Nonprofits
Cognitive Terrain Flight Model Development
$250,000
U.S. Department of Defense (DoD)
Federal

Application Deadline

Not specified

Date Added

Feb 19, 2025

This funding opportunity is designed to support small businesses in developing advanced AI and machine learning technologies that enhance the safety and effectiveness of Army aviation operations in challenging terrain.

Science and Technology
Small businesses
Leadership and Coordination Center (LACC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed)
$2,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

May 2, 2025

Date Added

Jan 17, 2025

This funding opportunity is designed to support a centralized leadership and coordination center that will oversee a comprehensive study on the health of adults living with HIV and similar individuals, focusing on improving health outcomes and addressing disparities through community engagement and scientific research.

Education
State governments
High Energy Cost Grants
$3,000,000
U.S. Department of Agriculture (Rural Utilities Service)
Federal

Application Deadline

Feb 28, 2025

Date Added

Dec 30, 2024

This program provides funding to communities facing extremely high energy costs to improve their energy infrastructure and promote renewable energy solutions.

Business and Commerce
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for Precision Medicine for Type 1 Diabetic Nephropathy (U01 Clinical Trial Not Allowed)
$1,300,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Dec 10, 2024

Date Added

Sep 27, 2024

This funding opportunity is designed to support research sites that will enroll patients with Type 1 Diabetes at risk of kidney disease, enabling the study of kidney biopsies to advance understanding and treatment of diabetic nephropathy.

Health
State governments
Infrastructure Investment and Jobs Act (IIJA): Mine of the Future - Proving Ground Initiative
$40,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Jan 30, 2026

Date Added

Nov 17, 2025

This funding opportunity provides financial support for the establishment of national-scale testing facilities for innovative mining technologies, aimed at enhancing the U.S. critical minerals supply chain through collaborative projects among academia, industry, and other stakeholders.

Natural Resources
Public and State controlled institutions of higher education
Private Sector Collaboration Pathway (PSCP) Jordan Addendum
$10,000,000
Agency for International Development (Jordan USAID-Amman)
Federal

Application Deadline

Apr 26, 2025

Date Added

Apr 17, 2024

This initiative provides funding opportunities for private sector entities in Jordan to collaborate with USAID in addressing key development challenges, focusing on economic growth, water security, governance, education, and the empowerment of women and youth.

Business and Commerce
For profit organizations other than small businesses
ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed)
$220,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 25, 2025

Date Added

Jun 6, 2023

This funding opportunity provides financial support for research organizations to establish expert panels that will evaluate and curate genomic variants linked to important diseases, enhancing clinical understanding and treatment options.

Education
State governments
Solutions to Enable Regional Genomic Medicine eConsult Services (R43/R44 Clinical Trial Optional)
$400,000
HHS-NIH11 (National Institutes of Health)
Federal

Application Deadline

May 30, 2024

Date Added

Jan 9, 2024

This Notice of Funding Opportunity (NOFO) invites applications from eligible small businesses to develop solutions for commercialization that can be used to enable regional clinician-to-clinician genomic medicine eConsult services. Specifically, we seek products, such as technologies or services, that will allow for the development and sustainment of eConsult services. Eligible United States small business concerns (SBCs) may submit Small Business Innovation Research (SBIR) Phase I, Direct to Phase II, and Fast-Track grant applications. Small business applicants interested in submitting a Small Business Technology Transfer (STTR) grant application should submit to the related funding opportunity, PAR-24-107. SBIR and STTR are phased programs. The main objective in SBIR and STTR Phase I is to establish the technical merit and feasibility of the proposed research and development efforts. An SBIR and STTR Phase II continues the R&D efforts to advance the technology toward ultimate commercialization. At the conclusion of an SBIR/STTR Phase II, it is expected that the small business will fully commercialize their product or technology using non-SBIR/STTR funds (either federal or non-federal). Small businesses that are eligible to submit Phase II applications for projects that were supported with a Phase I SBIR or STTR award are expected to submit the regular Phase II application as a "Renewal" application based on the awarded Phase I SBIR or STTR project. Only one Phase II application may be awarded for a specific project supported by a Phase I award. NIH Fast-Track: An NIH SBIR Fast-Track incorporates a submission and review process in which both Phase I and Phase II applications are submitted and reviewed together as one application to reduce or eliminate the funding gap between phases. NIH Direct to Phase II: For small businesses that have already demonstrated scientific and technical merit and feasibility but have not received a Phase I SBIR or STTR for that project, NIH can issue a Direct to Phase II award. The NIH will accept Direct to Phase II applications regardless of the funding source for the proof of principle work on which the proposed Phase II research is based. Direct to Phase II awards should be submitted as “New” applications and not continuations ("Renewal") of Phase I SBIR or STTR projects.

Health
Small businesses
FY2025 Commercial Motor Vehicle Operator Safety Training Program (CMVOST)
$200,000
U.S. Department of Transportation (DOT-Federal Motor Carrier Safety Administration)
Federal

Application Deadline

Jun 20, 2025

Date Added

May 22, 2025

This funding opportunity provides financial support to educational institutions and training providers for training individuals, especially veterans and their families, in the safe operation of commercial motor vehicles to help them obtain their Commercial Driver’s Licenses.

Transportation
State governments
Strengthening comprehensive HIV prevention interventions in Malawi under the President's Emergency Plan for AIDS Relief (PEPFAR)
$5,000,000
U.S. Department of Health & Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 18, 2025

Date Added

Jul 18, 2024

This funding opportunity provides financial support to organizations working in Malawi to implement comprehensive HIV prevention strategies, focusing on reducing new infections and improving health outcomes for targeted populations.

Health
State governments
NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Jan 30, 2024

This funding opportunity provides financial support for small businesses to conduct innovative clinical trials related to allergy and infectious diseases, focusing on high-risk studies and unlicensed products.

Health
Small businesses
DoD Melanoma, Team Science Award
$2,100,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 1, 2025

Date Added

May 27, 2025

This grant provides funding for collaborative research teams of independent investigators to advance innovative solutions in melanoma prevention, treatment, and survivorship, with a focus on improving patient outcomes.

Science and Technology
Nonprofits
Community-led Monitoring of Integrated Primary Health Care Services Activity (INTEG-CLM-PHC) in Togo
$2,400,000
U.S. Agency for International Development (Ghana USAID-Accra)
Federal

Application Deadline

Not specified

Date Added

Aug 22, 2024

This grant provides funding to improve primary health care services in Togo by enhancing their quality and community responsiveness, particularly for vulnerable groups like women, children, and people living with HIV/AIDS.

Health
Individuals
DoD Tick-Borne Disease, Idea Development Award
$3,640,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 3, 2024

Date Added

Apr 24, 2024

The DoD Tick-Borne Disease, Idea Development Award is a grant aimed at funding innovative research that could significantly advance the understanding and treatment of Lyme disease and other tick-borne diseases, ultimately improving the lives of military personnel, veterans, their families, and the general public.

Science and Technology
Nonprofits
ROSES 2024: F.9 Citizen Science Seed Funding Program
$700,000
National Aeronautics & Space Administration (NASA Headquarters)
Federal

Application Deadline

Nov 19, 2024

Date Added

Feb 15, 2024

This funding opportunity is designed to support innovative citizen science projects that engage the public in space and Earth science research, encouraging collaboration between scientists and community members.

Science and Technology
Nonprofits
Sedimentary Geology and Paleobiology
$10,400,000
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

May 14, 2022

This grant provides funding for researchers studying ancient sediments and fossils to better understand the Earth's history, environmental changes, and the evolution of life before the Holocene epoch.

Science and Technology
For profit organizations other than small businesses