Grants for Small businesses - Federal

The Appalachian Region Healthcare Support Program provides technical assistance (TA) to help rural healthcare organizations, including critical access hospitals (CAHs), small rural hospitals, rural health clinics, tribal healthcare facilities, and other healthcare organizations located in the rural counties served by the Appalachian Regional Commission (ARC) with planning and implementing health care service improvements. The goal of this program is to strengthen healthcare delivery in rural areas of the Appalachian Region by improving financial and operational performance as well as the quality of care in rural healthcare organizations. The TA provider funded under this cooperative agreement will work with individual healthcare organizations to meet the following program objectives: Provide objective analysis and assessment of healthcare organizations financial status, market share, quality indicators, locally available human services, and gaps in services so that organizations can make actionable change; Identify clinical areas where expansion of services within a rural healthcare organization would meet local need, keep health care services available locally, and build capacity to improve financial and operational performance as well as quality of care. Support healthcare organizations in implementing best practice recommendations prioritized in TA action plans. For purposes of this notice of funding opportunity, rural healthcare organization is a health care organization located in a rural area in the Appalachian Region. A healthcare organization includes critical access hospitals, small rural hospitals, rural health clinics, tribal healthcare facilities, and other healthcare organizations. To determine if a health care organization is located in a rural area, visit https://data.hrsa.gov/tools/rural-health. To determine if a county is in the Appalachian Region, visit https://www.arc.gov/appalachian-counties-served-by-arc.For more details, see Program Requirements and Expectations.

The intent of the FY24 ERP IDA is to solicit novel, innovative research that has the potential to increase our understanding of PTE to improve quality of life, especially in Service Members, Veterans, and/or their care partners. The work should innovatively challenge existing research paradigms or exhibit high levels of creativity. The FY24 ERP IDA offers two levels of funding dependent upon the level of experience of the Principal Investigator (PI). Funding Level I - Pathway to Independence Option: Early-career investigators ranging from the postdoctoral level (e.g., research associate, fellows, residents, or equivalent) to within 3 years of their first independent faculty position (or equivalent) may be named by the organization as the PI on the application (mentor required). Funding Level II - Innovative New Direction Option: Investigators at all career levels may be named by the organization as the PI on the application.

This funding opportunity is designed for U.S. small businesses to develop and commercialize innovative health-related technologies through clinically informed research projects that include a clinical trial.

This grant provides funding to civil society organizations in Uganda to strengthen their capacity and coordination in delivering comprehensive HIV prevention and treatment services to key and priority populations at high risk of HIV infection.

The purpose of this Funding Opportunity Announcement (FOA) is to 1) invite applications that propose to develop and implement early to late stage clinical trials of promising pharmacological and non-pharmacological interventions for cognitive and neuropsychiatric changes associated with age-related cognitive decline and Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD) across the spectrum from pre-symptomatic to more severe stages of disease, and 2) stimulate studies to enhance trial design and methods.

This funding opportunity supports U.S. colleges and universities with limited research funding to assess their biomedical research capabilities and develop strategic plans to enhance their research infrastructure and capacity.

This program provides funding to organizations that improve bison production and marketing, particularly benefiting small farms, tribal groups, and underserved communities across the United States.

The intent of the FY24 ERP LRA is to leverage ongoing or completed research studies for which PTE was not an original focus and to provide support to expand the research to develop such a focus and increase our understanding of PTE. The project may include basic, translational, and/or clinical research studies. The study must be associated with an ongoing or completed research effort in which PTE is/was not a research priority and for which addition of cohorts, outcomes, assessments, or analysis specific to PTE would be scientifically justified to increase our understanding of PTE. Examples of allowable research include but are not limited to: Secondary analysis of epilepsy surveillance data to evaluate PTE risk; Addition of a chronic TBI cohort in an ongoing preclinical animal study to evaluate seizure outcomes and epileptogenesis; Recruitment/Analysis of a PTE cohort within an ongoing observational longitudinal study for a known concomitant comorbidity of PTE such as depression, cognitive deficits, sleep disorder, etc.

With this solicitation, BJA seeks to fund four national training and technical assistance (TTA) programs to support law enforcement and criminal justice stakeholders in Task Force Leadership, Operations and Management (Category 1), Specialized Units TTA (Category 2), Crime Gun Intelligence Center TTA (Category 3) and Police Recruiting and Retention Among Underrepresented Groups (Category 4).

Please note that this program requests optional Notices of Intent, which are due via NSPIRES by June 27, 2024. See the full posting on NSPIRES for details. Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at sara@nasa.gov, but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

This funding opportunity provides support for federally-recognized American Indian and Alaska Native Tribes and Tribal entities to plan and prepare competitive health research proposals.

The FY24 ASUDRP CA supports the establishment of a Consortium whose purpose is to identify, evaluate, and advance pharmacotherapies for alcohol, opioid, and other substance use disorders, with an emphasis on other co-occurring mental health conditions, through rigorous, collaborative research efforts that translate basic knowledge and early-stage clinical products into evidence-based treatments. The goal of this research is to maximize functioning and quality of life for Service Members, their Families, Veterans, and the American public.The proposed research must be relevant to Service Members, Veterans, military beneficiaries, and/or the American public.Each individual organization must apply to this program announcement as a Consortium Management Core (CMC) by means of a single application, and may also serve as a future research and/or trial site. The CMC will be responsible for coordinating with the Consortium Steering Committee (CSC) and Consortium Executive Committee (CEC) to prioritize, propose, conduct, and analyze basic research and clinical trials, and developing a roadmap to translate basic science knowledge into evidence-based treatments for ASUD. Clinical trials that include military and Veteran populations are encouraged.

Microbes and communities of microbes have remarkable genetic, physiological and biochemical diversity, allowing them to flourish in environments all over the planet and in a variety of substrates and hosts. Given their relative importance to ecosystems around the world, to the economy and to health, researchers have studied microbial systems extensively and have a better understanding of their capabilities and impacts on hosts and the environment. In recent years, researchers have increasingly turned to microbes and their diverse capabilities for bioremediation and applications in biotechnology, agriculture, and medicine. Because of advances in molecular biology, synthetic biology and bioengineering, researchers now have the ability to assemble synthetic microbial communities that have novel compositions, genetics and phenotypes and to use these communities to address both fundamental biological questions and a range of societal problems. The goal of this solicitation is to support research that addresses one or more of the three themes: 1) define the underlying mechanisms or rules that drive the formation, maintenance or evolution of synthetic microbial communities, 2) use synthetic microbial communities to address fundamental biological questions, including questions in molecular biology, cellular/organismal biology, ecology and evolution and/or 3) build synthetic communities with biotechnology, bioeconomy or environmental engineering applications, including but not limited to the production of novel biorenewable chemicals, biodegradation of recalcitrant or forever chemicals, enabling a circular bioeconomy, fostering sustainable agriculture and mitigating the impacts of climate change. For theme 3, the emphasis should be on designing communities with novel capabilities and understanding the underlying mechanisms that lead to these novel capabilities. Proposals must address one or more of the three themes noted above. Highest funding priority is given to proposals that have outstanding intellectual merit and broader impacts, while proposals with weaknesses in either category (or those that are perceived as likely to have an incremental impact) will not be competitive. The most competitive broader impacts include assessment plans. Well-conceived broader impacts activities take time and resources; thus, proposers are encouraged to include appropriate costs for broader impacts in the budget. To better understand the societal benefits and risks, as well as the potential for misuse or unintended damage to natural biological systems, synthetic microbial communities proposals should include a careful consideration of the social, ethical, and biosafety/security dimensions of the research. Investigators may choose to address these issues either as part of intellectual merit or broader impacts. Reproducibility in research leads to data that is amenable to more powerful analysis and the potential for reuse of data and greater generation of knowledge. Reproducibility in biological research that is prone to context dependent biological variation presents a unique challenge for the synthetic microbial communities researchers. Investigators must follow or advance best practices in sample collection and preparation, experimental design, data analysis, model generation, and/or validation of mathematical and computational methods to produce scientifically defensible results.

This funding opportunity supports researchers investigating the harmful effects of high-risk chemical exposures on lung and eye health, particularly in relation to public health emergencies.

This funding opportunity supports researchers exploring the mechanisms and effects of trained immunity in the immune system, particularly its implications for infectious diseases and immune-related conditions.

NIA intends to publish a Notice of Funding Opportunity (NOFO) soliciting applications that aim to develop Common Data Elements (CDEs) for Alzheimers disease (AD) and AD-Related Dementias (ADRD) using Real-World Data (RWD) from electronic health records and Centers for Medicare Medicaid Services (CMS) claims. The CDEs will foster data harmonization and interoperability among data systems that involve disparate and unaligned RWD. By reducing the efforts required for data harmonization in using RWD for cross-sectional and longitudinal analysis, the NOFO may enable researchers to utilize RWD more efficiently and produce real-world evidence in a faster manner. The NOFO is expected to be published in March 2024 with an expected application due date in June 2024. Please note that these time frames are simply estimations, and they may change. The NOFO is expected to utilize the Resource-Related Research Projects Cooperative Agreements (U24) activity code. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Additional details regarding the planned NOFO are below.

This grant provides funding for innovative preclinical research on radionuclide-based cancer therapies, focusing on their biological effects and potential combinations with other treatments, aimed at institutions and researchers in cancer biology and radiopharmaceuticals.

GTOs mission is to increase geothermal energy deployment through research, development, and demonstration (RD) of innovative technologies that enhance exploration and production. Its vision is a vibrant domestic geothermal sector that contributes to a carbon-pollution free electric sector by 2035 and a net-zero emission economy by 2050 while providing economic opportunities and environmental benefits for all Americans. GTO supports geothermal energy RD activities in six research areas aimed at increased access, reduced costs and improved economics, and improved education and outreach about geothermal resources. DOEs 2023 Enhanced Geothermal ShotTM analysis concludes that with aggressive technology improvements in areas relevant to enhanced geothermal systems (EGS), geothermal electricity generation could provide 90 GWe of firm, flexible power to the U.S. electric grid by 2050. Building a clean and equitable energy economy and addressing the climate crisis is a top priority of the Biden-Harris Administration. This FOA will advance the Biden-Harris Administrations goals to achieve carbon pollution-free electricity by 2035 and to deliver an equitable, clean energy future, and put the United States on a path to achieve net-zero emissions, economy-wide, by no later than 2050 to the benefit of all Americans. DOE is committed to pushing the frontiers of science and engineering, catalyzing clean energy jobs through research, development, demonstration, and deployment (RDD), and ensuring environmental justice and inclusion of underserved communities. Geothermal power offers a unique value proposition to support the United States target of 100% carbon-pollution-free electricity by 2035 and a net-zero emissions economy by 2050. Traditionally, geothermal power is well understood as a clean, firm generation resource with a high capacity factor, 24/7 availability, and minimal land use footprint. Moreover, the advent of flexible geothermal operations and geothermal power coupled with storage technologies broadens the breadth of services that geothermal power could provide to a decarbonizing grid. This FOA supports the administration goals laid out above by catalyzing regional grid modeling studies that quantify the potential contribution of geothermal power in supporting an equitable4 transition to a future decarbonized grid and economy. The research and development (R) activities to be funded under this FOA will support the government-wide approach to the climate crisis by driving innovation that can lead to the deployment of clean energy technologies, which are critical for climate protection. Specifically, this FOA will quantify the value of geothermal power to a decarbonized grid.

This funding opportunity provides financial support to organizations in U.S. territories and freely associated states to implement strategies that prevent and control chronic diseases, focusing on tobacco use, diabetes management, and oral health disparities.

The "Fiscal Year 2025 Phase II Continuation Consolidated Innovative Nuclear Research" grant aims to fund innovative research and development projects that enhance nuclear energy technology, with the goal of improving U.S. energy, environmental, and economic needs, maintaining current nuclear reactors, deploying new ones, securing our nuclear fuel cycle, and expanding international cooperation in the nuclear energy sector.