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Grants for Small businesses - Federal

Explore 1,863 grant opportunities

Natural Product Multi-Site Clinical Trial Data Coordinating Center (Collaborative U24 Clinical Trial Required)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 14, 2026

Date Added

Oct 31, 2024

This funding opportunity supports the establishment of a Data Coordinating Center to manage and oversee multi-site clinical trials evaluating the effectiveness of natural products, aimed at U.S.-based research institutions and organizations.

Health
State governments
Fiscal Year (FY) 2025 Mississippi Conservation Delivery for Outreach, Education, and Technical Assistance
$999,999
U.S. Department of Agriculture (Natural Resources Conservation Service)
Federal

Application Deadline

Mar 16, 2025

Date Added

Jan 15, 2025

This funding opportunity provides financial support for conservation projects in Mississippi, focusing on outreach, education, and technical assistance to help socially disadvantaged and beginning farmers adopt sustainable agricultural practices.

Agriculture
State governments
National Center on Health, Behavioral Health, and Safety
$7,800,000
U.S. Department of Health & Human Services (Administration for Children and Families - OHS)
Federal

Application Deadline

Jun 2, 2025

Date Added

Jul 31, 2024

This funding opportunity provides $7.8 million to organizations that improve health, safety, and behavioral outcomes for children and families in Head Start and Early Head Start programs through training and technical assistance.

Income Security and Social Services
Special district governments
ROSES 2024: C.12 Planetary Instrument Concepts for the Advancement of Solar System Observations
$3,000,000
National Aeronautics & Space Administration (NASA Headquarters)
Federal

Application Deadline

Mar 28, 2025

Date Added

Feb 15, 2024

This grant provides funding for the development of innovative instruments and technologies to enhance solar system observations, aimed at researchers and organizations involved in planetary science and exploration.

Science and Technology
Nonprofits
Initiative to Maximize Research Education in Genomics: Diversity Action Plan (R25 Clinical Trials Not Allowed)
$325,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 27, 2025

Date Added

Nov 1, 2024

This funding opportunity supports educational and mentorship programs that encourage undergraduate and post-baccalaureate students from diverse backgrounds to pursue careers in genomics research.

Health
State governments
Mapping Machine Learning to Physics (ML2P)
Contact for amount
U.S. Department of Defense
Federal

Application Deadline

Dec 9, 2025

Date Added

Sep 29, 2025

This grant provides funding to a diverse range of organizations, including businesses and research institutions, to develop energy-efficient machine learning technologies that can be applied in energy-constrained environments, particularly for national defense.

Science and Technology
Public and State controlled institutions of higher education
Rapid Response Rural Data Analysis and Issue Specific Rural Research Studies
$600,000
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Jul 8, 2026

Date Added

May 7, 2026

This funding opportunity provides financial support for organizations to conduct rapid data analysis and targeted research on rural health issues, helping improve healthcare access and quality in underserved rural areas across the United States.

Health
State governments
Imaging, Biomarkers and Digital Pathomics for the Early Detection of Premetastatic Cancer and Precancerous Lesions Associated with Lethal Phenotypes (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 5, 2025

Date Added

Apr 12, 2022

This grant provides funding for researchers and institutions to develop advanced imaging and biomarker technologies that improve the early detection of aggressive cancers and precancerous lesions, ultimately enhancing patient outcomes and clinical decision-making.

Education
State governments
KUH Predoctoral to Postdoctoral Fellow Transition Award (F99/K00 - Independent Clinical Trial Not Allowed)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Dec 4, 2024

Date Added

Mar 16, 2022

This grant provides funding to exceptional U.S.-based graduate students transitioning from predoctoral to postdoctoral research in kidney, urologic, or hematologic sciences, encouraging diverse talent to contribute to these fields.

Food and Nutrition
Public and State controlled institutions of higher education
Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)
$1,838,436
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 5, 2025

Date Added

Jun 21, 2022

This funding opportunity provides financial support for small businesses and researchers to develop innovative products and services aimed at preventing, diagnosing, and treating Alzheimer's disease and related dementias, ultimately improving care for affected individuals and their families.

Health
Small businesses
HIV Prevention and Alcohol (R34 Clinical Trials Optional)
$225,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

May 7, 2026

Date Added

Nov 26, 2024

This funding opportunity provides financial support for pilot studies that develop and test innovative interventions aimed at preventing HIV in populations significantly affected by alcohol use, such as men who have sex with men, sex workers, and individuals recently released from incarceration.

Health
State governments
DoD Parkinsons Investigator-Initiated Research Award
$12,000,000
Department of Defense - Dept. of the Army -- U.S.AMRAA
Federal

Application Deadline

Aug 6, 2024

Date Added

May 8, 2024

The PRP IIRA supports highly rigorous, multidisciplinary, high-impact research projects that have the potential to make an important contribution to Parkinsons research. This award mechanism supports the full spectrum of research from basic science through clinical research.

Science and Technology
Nonprofits
DRL Global Support Program on Disability Inclusion Practices
$400,000
DOS-DRL (Bureau of Democracy Human Rights and Labor)
Federal

Application Deadline

Jun 27, 2024

Date Added

May 2, 2024

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor announces an open competition for organizations interested in submitting applications for programs to bolster non-governmental organizations internal accessibility and inclusion policies and practices

International Development
Nonprofits
Building a Community of Practice for Women in Strategic Trade (WiST)
$641,225
DOS-ISN (Bureau of International Security-Nonproliferation)
Federal

Application Deadline

May 28, 2024

Date Added

Mar 27, 2024

To implement a project aimed at advancing U.S. foreign policy and national security priorities by supporting initiatives that make decision-making structures and processes in fragile, conflict, or crisis-affected contexts more reflective of and responsive to the needs and perspectives of partner states to ensure strategic trade control systems meet international standards and by engaging on bilateral, regional and multilateral levels with foreign governments to aid in the establishment of independent capabilities to regulate transfers of weapons of mass destruction, WMD-related items, conventional arms, and related dual-use items, and to detect, interdict, investigate, and prosecute illicit transfers of such items.

Law Justice and Legal Services
City or township governments
Title V Competitive Sexual Risk Avoidance Education
$450,000
U.S. Department of Health & Human Services (Administration for Children ; Families - ACYF/FYSB)
Federal

Application Deadline

Not specified

Date Added

Jun 7, 2025

This funding opportunity supports local organizations in underserved states and territories to implement educational programs that encourage youth aged 10 to 19 to avoid non-marital sexual activity and promote healthy life choices.

Youth
Nonprofits
Information Mastery in Cognitive Warfare
$24,120,000
U.S. Department of Defense (Air Force -- Research Lab)
Federal

Application Deadline

Sep 6, 2025

Date Added

Aug 8, 2025

This funding opportunity provides financial support for a wide range of organizations to develop innovative research and tools aimed at enhancing national security through advancements in cognitive and information warfare strategies.

Science and Technology
For profit organizations other than small businesses
Innovations to Optimize HIV Prevention and Care Continuum Outcomes (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 9, 2025

Date Added

Jan 10, 2023

This funding opportunity supports research projects that develop innovative strategies to improve HIV prevention and treatment outcomes, particularly for marginalized populations, by addressing barriers and enhancing community engagement.

Health
State governments
Mitochondrial-associated Mechanisms of Neuropathological and Immunodeficient Aging in the Context of HIV and SUD (R01 Clinical Trials Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 10, 2026

Date Added

Oct 1, 2024

This funding opportunity supports research projects that investigate how mitochondrial function affects brain health and immune aging in individuals living with HIV and substance use disorders, aiming to identify new therapeutic strategies.

Education
State governments
Resource-based Centers for Rheumatic Diseases Research
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 3, 2025

Date Added

May 28, 2025

This funding opportunity is designed to support the establishment of research centers that provide essential resources and infrastructure for advancing studies on rheumatic diseases, encouraging collaboration among researchers and institutions.

Health
State governments
Strengthening the HIV treatment and care program in Sierra Leone to accelerate progress to achieve epidemic control under the President's Emergency Plan for AIDS Relief (PEPFAR)
$12,000,000
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 17, 2026

Date Added

Oct 17, 2025

This funding opportunity provides financial support to a wide range of organizations working to improve HIV treatment and care services in Sierra Leone, aiming to enhance healthcare delivery and strengthen local health systems.

Health
For profit organizations other than small businesses