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Grants for Small businesses - Federal

Explore 1,965 grant opportunities

HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed)
$400,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 5, 2025

Date Added

Jan 3, 2023

The purpose of this Funding Opportunity Announcement (FOA) is to facilitate the transition of previously funded SBIR and STTR Phase II and Phase IIB projects in pain management to the commercialization stage by providing additional assistance for private partnering activities through the Commercialization Readiness Pilot (CRP) program. Specifically, this FOA supports the addition of entrepreneurial expertise into small business leadership teams along with supporting partnering activities to aid in commercialization through private third-party funding or partnership with industry.

Health
Small businesses
Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24 Clinical Trial Not Allowed)
$6,600,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 30, 2025

Date Added

May 15, 2025

This funding opportunity provides financial support for a variety of organizations to advance genomic research in pediatric cancers and congenital anomalies, fostering collaboration and innovation in understanding and treating these conditions.

Health
State governments
Strengthening economic analysis and capacity in support of program management for HIV, TB, and related health threats in South Africa (SA) under the President's Emergency Plan for AIDS Relief (PEPFAR)
$400,000
U.S. Department of Health & Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 20, 2025

Date Added

Jul 26, 2024

This grant provides funding to organizations in South Africa to improve economic analysis and capacity for managing HIV, tuberculosis, and related health issues, ultimately enhancing public health program efficiency and resource allocation.

Health
State governments
PHS 2024-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 5, 2025

Date Added

Jul 5, 2024

This funding opportunity supports U.S.-based small businesses in health-related fields to develop innovative technologies, with a focus on projects that can successfully transition to commercialization.

Education
Small businesses
Creutzfeldt-Jakob Disease (CJD) Increasing Educational Support for CJD Families and the Nation
$100,000
U.S. Department of Health & Human Services (Centers for Disease Control - NCEZID)
Federal

Application Deadline

Mar 18, 2025

Date Added

Aug 23, 2024

This funding opportunity provides financial support to organizations that aim to improve educational resources and public awareness for families affected by Creutzfeldt-Jakob disease and enhance national surveillance efforts for this rare neurological condition.

Health
State governments
Clinical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 22, 2026

Date Added

Oct 3, 2024

This funding opportunity supports U.S.-based institutions and organizations in validating candidate biomarkers for neurological and neuromuscular disorders to improve clinical decision-making and therapeutic development.

Health
State governments
FAA Aircraft Pilots Workforce Development Grant Program
$1,000,000
U.S. Department of Transportation (FAA - Aviation Next Gen)
Federal

Application Deadline

Jun 22, 2026

Date Added

May 20, 2026

This program provides funding to educational institutions, flight schools, and organizations to develop training initiatives that address the national shortage of qualified pilots and unmanned aircraft systems operators.

Workforce Development
Nonprofits
HEAL Initiative: Research to Increase Implementation of Substance Use Preventive Services (R61/R33 Clinical Trial Optional)
$750,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 17, 2025

Date Added

Sep 22, 2023

This funding opportunity provides support for U.S.-based organizations to develop and implement effective substance use prevention services within various community systems, targeting individuals at risk or already misusing substances.

Education
State governments
Counterproliferation Finance
$256,537
DOS-ISN (Bureau of International Security-Nonproliferation)
Federal

Application Deadline

Jun 21, 2024

Date Added

May 16, 2024

To implement a project aimed at advancing U.S. foreign policy and national security priorities by supporting initiatives that is more reflective of and responsive to the needs and perspectives of partner states to ensure strategic trade control systems meet international standards and by engaging on bilateral, regional and multilateral levels with foreign governments to aid in the establishment of independent capabilities to regulate transfers of weapons of mass destruction, WMD-related items, conventional arms, and related dual-use items, and to detect, interdict, investigate, and prosecute illicit transfers of such items.

Law Justice and Legal Services
Nonprofits
Biology of Bladder Cancer (R21 Clinical Trial Optional)
$200,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 16, 2025

Date Added

Nov 21, 2024

This funding opportunity supports innovative research into the biology and mechanisms of bladder cancer, particularly focusing on non-muscle-invasive bladder cancer, to improve understanding and develop new prevention or treatment strategies.

Education
State governments
OJJDP FY25 Family Treatment Court Training and Technical Assistance
$3,000,000
U.S. Department of Justice (Office of Juvenile Justice Delinquency Prevention )
Federal

Application Deadline

Mar 6, 2025

Date Added

Jan 17, 2025

This funding opportunity provides financial support to organizations that help family treatment courts improve services for parents facing substance use and mental health challenges in child welfare cases.

Law Justice and Legal Services
Public and State controlled institutions of higher education
University Leadership Initiative (ULI)
Contact for amount
NASA-HQ (NASA Headquarters)
Federal

Application Deadline

May 29, 2024

Date Added

Mar 1, 2024

Amendment 2 to the NASA ARMD Research Opportunities in Aeronautics (ROA) 2024 NRA has been posted on the NSPIRES web site. University Leadership Initiative (ULI) provides the opportunity for university teams to exercise technical and organizational leadership in proposing unique technical challenges in aeronautics, defining multi-disciplinary solutions, establishing peer review mechanisms, and applying innovative teaming strategies to strengthen the research impact.Research proposals are sought in six ULI topic areas in Appendix D.4.Topic 1: Safe, Efficient Growth in Global Operations (Strategic Thrust 1)Topic 2: Innovation in Commercial High-Speed Aircraft (Strategic Thrust 2)Topic 3: Ultra-Efficient Subsonic Transports (Strategic Thrust 3) Topic 4: Safe, Quiet, and Affordable Vertical Lift Air Vehicles (Strategic Thrust 4)Topic 5: In-Time System-Wide Safety Assurance (Strategic Thrust 5)Topic 6: Assured Autonomy for Aviation Transformation (Strategic Thrust 6)This NRA will utilize a two-step proposal submission and evaluation process. The initial step is a short mandatory Step-A proposal due May 29, 2024. Those offerors submitting the most highly rated Step-A proposals will be invited to submit a Step-B proposal. All proposals must be submitted electronically through NSPIRES at https://nspires.nasaprs.com.An Applicants Workshop will be held on Thursday Apr 3, 2024; 1:00-3:00 p.m. ET (https://uli.arc.nasa.gov/applicants-workshops/workshop8).An interested partners list for this ULI is at https://uli.arc.nasa.gov/partners. To be listed as an interested lead or partner, please send electronic mail to hq-univpartnerships@mail.nasa.gov with "ULI Partnerships" in the subject line and include the information required for the table in that web page.

Science and Technology
Nonprofits
Strengthening Community-Backed Governance to Advance Stability and Peace in Burma
$1,973,359
U.S. Department of State (Bureau of Democracy Human Rights and Labor)
Federal

Application Deadline

Aug 31, 2026

Date Added

Aug 17, 2026

This funding opportunity provides financial support to U.S. and foreign nonprofit organizations and NGOs to strengthen community governance and peace efforts in Burma by enhancing coordination among ethnic resistance groups and improving early warning systems for civilian protection.

International Development
Nonprofits
Biological Technologies
Contact for amount
DOD-DARPA-BTO (DARPA - Biological Technologies Office)
Federal

Application Deadline

Jun 20, 2024

Date Added

Jun 22, 2023

This announcement seeks revolutionary research ideas for topics not being addressed by ongoing BTO programs or other published solicitations. This publication constitutes a Broad Agency Announcement (BAA) as contemplated in Federal Acquisition Regulation (FAR) 6.102(d)(2) and 35.016 and 2 CFR § 200.203. Any resultant award negotiations will follow all pertinent law and regulation, and any negotiations and/or awards for procurement contracts will use procedures under FAR 15.4, Contract Pricing, as specified in the BAA. BTO's mission is to develop capabilities that leverage the unique properties of biology - adaption, replication, resilience and complexity, to revolutionize how the United States defends the homeland and prepares and protects its Warfighters. Research in BTO creates biotechnological capabilities that provide tactical care and restore function to injured warfighters, increase operational resilience, develop novel functional materials, and detect and protect against threats to maintain force readiness.

Science and Technology
Public and State controlled institutions of higher education
State Offices of Rural Health Coordination and Development Program (SORHCDP)
$950,000
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Dec 9, 2024

Date Added

Jul 15, 2024

This funding opportunity provides financial support to organizations that aim to strengthen the capacity and collaboration of State Offices of Rural Health and improve healthcare services in rural communities across the United States.

Health
State governments
Mentored Career Development Program for Early Stage Investigators Using Nonhuman Primate Research Models (K01 Independent Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Jan 10, 2023

This funding opportunity supports early-stage researchers in the U.S. to develop expertise in using nonhuman primate models for biomedical research, with a focus on infectious diseases, neuroscience, and aging, through a structured mentorship program.

Health
State governments
Division of Chemistry: Disciplinary Research Programs
$105,000,000
National Science Foundation
Federal

Application Deadline

Not specified

Date Added

Apr 26, 2023

This funding opportunity supports foundational research in various chemistry subfields at U.S. higher education institutions and nonprofit organizations, promoting innovative projects that align with national priorities like sustainability and advanced manufacturing.

Science and Technology
Public and State controlled institutions of higher education
Cancer Epidemiology Cohorts: Building the Next Generation of Research Cohorts (U01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 28, 2025

Date Added

Feb 12, 2025

Through this funding opportunity announcement, the National Cancer Institute (NCI) solicits applications to Cancer Epidemiology Cohorts: Building the Next Generation of Research Cohorts PAR. This funding opportunity announcement seeks to support initiating and building the next generation of population-based cancer epidemiology cohorts to address specific knowledge gaps in cancer etiology and survivorship. Specifically, it will support methodological work necessary to initiate and build cancer epidemiology cohorts that can address critical scientific gaps concerning (i) new or unique exposures in relation to cancer risks and outcomes and (ii) achievement of diverse populations in cohorts with the inclusion of understudied populations (e.g., racial/ethnic groups, rural populations, and persistent poverty areas) with substantial community engagement.

Education
State governments
Understanding the mechanisms underlying the age-related changes in gait biomechanics and the impact on the increased metabolic cost of walking (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 7, 2024

Date Added

Aug 27, 2024

This grant provides funding for researchers to investigate how aging affects walking mechanics and increases the energy cost of walking, encouraging innovative studies that combine various scientific disciplines and technologies.

Health
State governments
Disability and Rehabilitation Research Projects (DRRP) Program: Model Systems Knowledge Translation Center
$850,000
U.S. Department of Health and Human Services (Administration for Community Living)
Federal

Application Deadline

Jul 29, 2026

Date Added

Sep 8, 2025

This funding opportunity provides financial support to organizations that will create a centralized center to translate and share important research findings related to spinal cord injuries, traumatic brain injuries, and burn injuries, ensuring that individuals with disabilities, caregivers, and healthcare professionals can effectively use this information.

Science and Technology
State governments