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Grants for Small businesses - Federal

Explore 1,748 grant opportunities

Targeted Genome Editor Delivery (TARGETED) Challenge
$1,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Dec 24, 2025

This grant provides funding to researchers and innovators developing advanced delivery systems for genome editing technologies, particularly targeting hard-to-reach tissues and overcoming the blood-brain barrier.

Science and Technology
For profit organizations other than small businesses
Science of Organizations
$3,270,000
National Science Foundation
Federal

Application Deadline

Not specified

Date Added

Feb 18, 2024

This program provides funding for researchers to explore and enhance the understanding of organizations across various sectors, focusing on theoretical contributions and rigorous methodologies.

Science and Technology
Public and State controlled institutions of higher education
Mechanistic Exploration of Therapeutic Targets and Treatable Traits to Improve CNS Outcomes in People with HIV
$3,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Jun 10, 2025

This funding opportunity supports innovative research to identify and develop treatments for central nervous system complications in individuals living with HIV, inviting a diverse range of applicants including governments, nonprofits, and educational institutions.

Health
State governments
Advancing Research on Empirically-Supported Interventions for Older Adults Living with Serious Mental Illness (SMI)
$3,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Jun 18, 2025

This funding opportunity supports research to improve mental health care for older adults with serious mental illness by developing and evaluating effective interventions across various healthcare settings.

Health
Nonprofits
Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01 Clinical Trials Required)
Contact for amount
U.S. Department of Health & Human Services (Food and Drug Administration)
Federal

Application Deadline

Not specified

Date Added

Jul 12, 2025

This funding opportunity supports clinical research aimed at developing new treatments for rare diseases, targeting a wide range of eligible organizations, including universities, nonprofits, and small businesses.

Health
Public and State controlled institutions of higher education
Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Dec 10, 2024

This funding opportunity supports researchers conducting observational studies to improve understanding and treatment of musculoskeletal, rheumatic, and skin diseases, ultimately informing future clinical trials.

Health
State governments
NIH Research Project Grant (Parent R01 Clinical Trial Required)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Dec 19, 2024

This funding opportunity supports research projects that involve clinical trials to improve health outcomes, targeting a wide range of eligible applicants including universities, nonprofits, and international organizations.

Education
State governments
Mass Market Solutions for Leveraging Robotics and AI Technologies for Home Construction Demonstration
$10,000,000
U.S. Department of Housing and Urban Development
Federal

Application Deadline

Aug 3, 2026

Date Added

May 13, 2026

This funding opportunity provides financial support for projects that utilize robotics and AI technologies to improve the efficiency and affordability of home construction in the United States.

Housing
Public and State controlled institutions of higher education
Spinal Cord Injury (SCI) Model Systems National Data and Statistical Center
$800,000
U.S. Department of Health and Human Services (Administration for Community Living)
Federal

Application Deadline

Not specified

Date Added

Sep 8, 2025

This funding opportunity provides financial support to a wide range of organizations for establishing a national data center focused on improving rehabilitation and independent living outcomes for individuals with spinal cord injuries through enhanced research and data management.

Science and Technology
State governments
Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Nov 25, 2024

This grant provides funding for researchers to study the neurobiological and behavioral mechanisms of mood and psychosis symptoms in women undergoing menopause, with the goal of developing new interventions and improving mental health outcomes.

Health
State governments
Improving Working Conditions in the Processing of Waste from Electrical and Electronic Equipment (E-Waste)
Contact for amount
U.S. Department of Labor (Bureau of International Labor Affairs)
Federal

Application Deadline

Not specified

Date Added

Apr 7, 2026

This initiative seeks insights from various stakeholders to improve labor conditions and promote decent work in the global e-waste processing sector, which involves millions of workers often in hazardous environments.

Employment Labor and Training
Nonprofits
Forecast for BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

May 28, 2025

This funding opportunity supports research projects that develop innovative technologies for mapping brain connectivity, targeting a wide range of institutions and organizations involved in neuroscience.

Health
For profit organizations other than small businesses
PRIMED-AI: Validation Center (U54 Clinical Trial Not Allowed)
$3,900,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Jun 7, 2025

This funding opportunity supports the establishment of a center dedicated to validating AI-based clinical decision support tools that integrate imaging and health data, aimed at improving personalized healthcare for individuals with significant health conditions.

Health
County governments
Radar Signal Processing Improvements for Probability of Detection
$250,000
U.S. Department of Defense (DoD)
Federal

Application Deadline

Not specified

Date Added

Feb 19, 2025

This grant provides funding for small businesses to develop innovative radar signal processing techniques that improve the detection of long-range projectiles for the U.S. Army, while maintaining current operational performance.

Science and Technology
Small businesses
Advancement and Innovation in Measurement of Language Development and Predictors (R21 Clinical Trial Not Allowed)
$200,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Nov 19, 2024

This funding opportunity supports research projects that develop innovative and culturally responsive tools for measuring children's language development and identifying predictors of language impairments, with a focus on community engagement and inclusivity.

Health
State governments
AIM-AHEAD & NCATS Training Program
$10,000
U.S. Department of Health and Human Services (National Center for Advancing Translational Sciences)
Federal

Application Deadline

Not specified

Date Added

Sep 11, 2025

This program provides training and financial support for researchers from diverse backgrounds to learn how to analyze real-world clinical data using artificial intelligence and machine learning methods.

Health
Nonprofits
Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers
$1,500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 27, 2027

Date Added

Mar 17, 2026

This funding opportunity supports research centers that develop and implement innovative mental health treatments for youth and adults, aiming to improve access and outcomes in mental health care across diverse communities.

Health
State governments
Magnetic Acceleration Generating New Innovations and Tactical Outcomes (MAGNITO)
$3,000,000
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Not specified

Date Added

Aug 26, 2025

This grant provides funding for innovative projects focused on developing advanced magnetic materials that exceed current performance standards, targeting a wide range of applicants including universities, nonprofits, and businesses in the U.S.

Energy
Individuals
Lead-Safe and Healthy Homes Financing Demonstration
$10,000,000
U.S. Department of Housing and Urban Development
Federal

Application Deadline

Not specified

Date Added

May 13, 2026

This funding opportunity provides financial support to organizations that will create a national fund to reduce lead hazards and improve housing health, particularly for low-income families and communities.

Housing
Nonprofits
Avant Garde/Avenir award for Investigators conducting high risk/high reward research on HIV and Substance Use (or Substance Use Disorders)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

May 29, 2025

This funding opportunity supports innovative researchers tackling the complex issues of HIV and substance use disorders, encouraging high-risk, high-reward projects that could lead to significant advancements in public health.

Health
For profit organizations other than small businesses