Grants for Special district governments - Federal

Notice of Funding Opportunity Description Background Although vaccines are among the most effective approaches to control viral diseases, developing a prophylactic or therapeutic HIV vaccine has proven elusive. There are no licensed vaccines for HIV. Strategies for induction of HIV broadly neutralizing antibodies will likely require repeated exposures over long periods, including immunization with distinct antigens in sequential order. Such immunization strategies will require development of technologies for controlled vaccine release. Recent advances in materials-based science, controlled release technologies, delivery systems, and immunology provide opportunities to enhance the quality, potency and durability of vaccine-induced T cell and antibody responses to HIV-1. Materials-based approaches can be engineered to improve the stability, spatiotemporal release, and presentation of multiple vaccine components; for example, by controlling the time frame and dose of vaccine delivery over days to weeks. Recent studies have shown that a slow-release vaccine is superior to bolus administration at inducing breadth, potency, and durability of antibody responses to HIV antigens by prolonging antigen exposure in the germinal centers, thereby enhancing the maturation of B cells and generating stronger humoral immune responses. Further research is needed to elucidate the mechanisms underlying the immunological improvements observed with slow-release vaccine delivery and to translate such concepts into clinical application. It will be crucial to determine how the duration of exposure to vaccine components impacts immune cell biology, and how to calibrate vaccine release to improve responses while avoiding immune exhaustion and over-activation. Advancing safe, effective, and well-tolerated controlled release vaccines is an unmet need that may enhance vaccine effectiveness and practicality, leading to better adherence to complex regimens, fewer adverse reactions, and cost savings. Finally, iterative behavioral studies during product development to determine vaccine/provider product expectation/preferences are critical to facilitate product uptake and use.

This funding opportunity provides up to $100 million to various organizations for innovative projects aimed at developing vaccines, therapeutics, and research strategies to combat highly pathogenic avian influenza in the U.S. poultry industry.

This funding opportunity supports primary care centers in implementing genomic screening for common genetic conditions to improve disease prevention and care, particularly in underrepresented communities.

The U.S. Department of Justice (DOJ), Office of Justice Programs (OJP), Office for Victims of Crime (OVC) is seeking applications for funding. OJP is committed to advancing work that promotes civil rights and equity, increases access to justice, supports crime victims and individuals impacted by the justice system, strengthens community safety, protects the public from crime and evolving threats, and builds trust between law enforcement and the community. With this solicitation, OVC seeks to enable an organization to provide financial and technical assistance to approximately 300 communities (100 each year) nationwide to conduct public education and awareness activities on crime victims rights and services in their jurisdictions during the 20252027 National Crime Victims Rights Weeks (NCVRW). This program furthers the DOJs mission to uphold the rule of law, to keep our country safe, and to protect civil rights.

This funding opportunity provides financial support to state, local, and tribal governments, educational institutions, and nonprofits to improve recreational access and services on public lands in Alaska, particularly for underserved communities and in alignment with climate resilience and environmental stewardship goals.

This funding opportunity supports research initiatives focused on non-communicable diseases related to HIV at institutions in low- and middle-income countries, encouraging innovative projects and collaborations to improve health outcomes for people living with HIV.

This funding opportunity provides financial support to education and health agencies for developing and implementing sustainable school-based strategies to prevent HIV and STDs among middle and high school students in the United States.

This funding opportunity provides financial support for research projects that address the information and practice needs of caregivers and professionals working with children who experience delays in language development, particularly focusing on diverse communities.

This funding opportunity provides financial support to organizations working in Malawi to improve health information systems and enhance care for individuals affected by HIV/AIDS.

This Notice of Funding Opportunity (NOFO) seeks to foster new multi-disciplinary teams to address how HIV Comorbidities and co-infections within the missions of NIDDK and NIAID interact with viral reservoirs, potentially confounding cure strategies aimed at either sustained viral suppression or elimination from the body. These teams will mechanistically interrogate the impact of inflammation, metabolic perturbations, or other pathophysiological processes associated with these comorbidities or co-infections on reservoir dynamics, and/or the interplay of these conditions and co-infections on HIV reservoir biology in ways that are likely to interact with potential cure strategies.

This funding opportunity provides financial support to organizations working in Lesotho to strengthen health systems and improve services for HIV and TB prevention, treatment, and care, with a focus on achieving health equity and sustainability.

This funding opportunity provides financial support for organizations to develop and evaluate innovative technologies and environments that promote accessibility and usability for individuals with disabilities.

This funding opportunity supports initiatives in Michigan that educate and assist Medicare beneficiaries in preventing and reporting healthcare fraud, particularly targeting those with the greatest economic and social needs.

This funding opportunity provides rapid financial support for researchers to study health outcomes related to urgent events like pandemics, natural disasters, or sudden policy changes, allowing them to gather critical data quickly.

This grant provides funding for early stage investigators to pursue innovative and high-risk research projects involving human participants, without the need for preliminary data.

This funding opportunity supports innovative research aimed at understanding and improving treatment for schizophrenia and related disorders in individuals aged 35 and older.

This grant provides funding to law enforcement agencies at various levels to help them achieve accreditation and strengthen their community policing practices.

This funding opportunity provides resources to rural health networks to improve access, coordination, and quality of essential health services for underserved populations in rural communities.

This funding opportunity provides $6.4 million to organizations that support family engagement and community partnerships in early childhood education, specifically targeting programs that assist children and families in Head Start and Early Head Start.

This Notice of Funding Opportunity (NFO) is being released prior to appropriation and/or apportionment of funds for fiscal year 2024. Enactment of additional continuing resolutions or an appropriations act may affect the availability or level of funding for this program. The purpose of this NFO is to encourage and promote conservation planning and conservation practice implementation in urban, suburban, and other small-scale type agricultural operations. Emphasis will be placed on projects that establish new demonstration community gardens, or enhance and expand existing community agriculture projects. Proposals should seek to: 1. Provide conservation learning experiences to urban, suburban, and Tribal communities. 2. Address concerns regarding food deserts. 3. Advance Tribal food sovereignty. 4. Achieve positive and measurable natural resources conservation outcomes. For new users of Grants.gov, see Section D. of the full Notice of Funding Opportunity for information about steps required before submitting an application via Grants.gov. Key Dates Applicants must submit their applications via Grants.gov by 11:59 pm Eastern Time on May 22, 2024. For technical issues with Grants.gov, contact Grants.gov Applicant Support at 1-800-518-4726 or support@grants.gov. Awarding agency staff cannot support applicants regarding Grants.gov accounts. For inquiries specific to the content of the NFO requirements, contact the federal awarding agency contact (section G of this NFO). Please limit questions to those regarding specific information contained in this NFO (such as dates, page numbers, clarification of discrepancies, etc.). Questions related to eligibility or the merits of a specific proposal will not be addressed. The agency anticipates making selections by June 21, 2024 and expects to execute awards by September 1, 2024. These dates are estimates and are subject to change.