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Grants for State governments - Federal

Explore 4,190 grant opportunities

Rural Surface Transportation Grant Progam
$780,000,000
DOT-DOT X-50 (69A345 Office of the Under Secretary for Policy)
Federal

Application Deadline

May 6, 2024

Date Added

Mar 26, 2024

The Department is combining three major discretionary grant programs and two fiscal years of funding into one Multimodal Projects Discretionary Grant (MPDG) opportunity to reduce the burden for state and local applicants and increase the pipeline of shovel-worthy projects that are now possible because of the Bipartisan Infrastructure Law. The Rural Surface Transportation Grant Program (Rural) program was created in the Bipartisan Infrastructure Law to fund will support projects to improve and expand the surface transportation infrastructure in rural areas to increase connectivity, improve the safety and reliability of the movement of people and freight, and generate regional economic growth and improve quality of life. It is a highly competitive program. The Bipartisan Infrastructure Law provides approximately $1.7 billion for Rural over 5 years, of which approximately $780 million will be made available through this NOFO. At least 90% of rural funding must be awarded in amounts of $25 million or more. If you are seeking less than $25 million, you are competing for only about $78 million nationwide this round. Applications will be evaluated on six outcome criteria, economic analysis, project readiness, and statutory requirements. The six outcome criteria are: (1) safety; (2) state of good repair; (3) economic impacts, freight movement, and job creation; (4) climate change, resilience, and the environment; (5) equity, multimodal options, and quality of life; and (6) innovation areas: technology, project delivery, and financing. Applicants that wish to submit the same application to be considered for more than one grant program under the MPDG combined NOFO only need to submit their application through one Grants.gov opportunity number and that application will be considered for all programs for which it is not opted-out or ineligible. It is not necessary to submit multiple of the same application under the other MPDG Grants.gov opportunities.

Infrastructure
City or township governments
NIH Neuroscience Development for Advancing the Careers of a Diverse Research Workforce (R25 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 21, 2025

Date Added

Feb 12, 2025

This funding opportunity supports educational programs that promote diversity in neuroscience research by providing mentoring, research experiences, and skill development for underrepresented individuals in the field.

Education
State governments
Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Data Mining and Functional Validation (R21 Clinical Trial Not Allowed)
$275,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 20, 2025

Date Added

Aug 15, 2024

This funding opportunity supports researchers in exploring and validating the biological mechanisms linking HIV, substance use disorders, and opioid exposure at a single-cell level, with a focus on data mining existing datasets and conducting functional validation studies.

Education
State governments
Behavioral and Integrative Treatment Development Program (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 5, 2025

Date Added

Sep 25, 2024

This grant provides funding for researchers to develop and test innovative behavioral treatments for individuals struggling with drug and alcohol misuse, particularly focusing on improving treatment effectiveness and accessibility for diverse populations.

Education
State governments
Rural Hospital Stabilization Pilot Program
$20,000,000
HHS-HRSA (Health Resources and Services Administration)
Federal

Application Deadline

Jul 7, 2024

Date Added

Apr 25, 2024

This program will help rural hospitals expand their services to meet community health needs while increasing their revenues. The program will achieve these goals by providing expert technical assistance to rural hospitals to conduct market assessments, determine ways to enhance existing service lines, and start new service lines to keep services locally. The program will also provide direct financial support to help with associate costs of service lines. This program will also have the affect of helping facilities address long-standing rural disparities.

Health
State governments
FY25 Safer Outcomes: Enhancing De-Escalation and Crisis Response Training for Law Enforcement Support for Law Enforcement Agencies
$500,000
U.S. Department of Justice (Community Oriented Policing Services)
Federal

Application Deadline

Jun 24, 2025

Date Added

May 15, 2025

This grant provides funding to law enforcement agencies across the U.S. to develop and implement training programs focused on de-escalation and crisis response, enhancing community policing efforts.

Law Justice and Legal Services
State governments
Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed)
$275,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 25, 2024

Date Added

Jul 5, 2023

This notice of funding opportunity (NOFO) provides funding to conduct efficacy studies in an established rare disease preclinical model to demonstrate that a proposed therapeutic agent warrants further development. In addition to preclinical efficacy, accompanying pharmacodynamic and pharmacokinetic studies would be supported. Therapeutic agents include small molecules, biologics or biotechnology-derived products. The goal of this NOFO is to spur therapeutic development for rare diseases by advancing projects to the point where they would attract subsequent investment supporting full Investigational New Drug (IND) application development or progression to clinical trials in the case of repurposing or repositioning.

Health
State governments
Title X Family Planning Services Grants
$22,000,000
U.S. Department of Health and Human Services (Office of Population Affairs)
Federal

Application Deadline

Jan 11, 2022

Date Added

Sep 17, 2025

This grant provides funding to nonprofit organizations and government entities to deliver essential family planning and reproductive health services to low-income and underserved populations across the United States.

Health
Nonprofits
Fiscal Year 2024 Community Assistance Program-State Support Services Element (CAP-SSSE)
$900,000
DHS-DHS (Department of Homeland Security - FEMA)
Federal

Application Deadline

Jun 14, 2024

Date Added

May 2, 2024

The Community Assistance Program - State Support Services Element (CAP-SSSE) program provides funding to states to provide technical assistance to communities in the National Flood Insurance Program (NFIP) and to evaluate community performance in implementing NFIP floodplain management activities. Designation, duties and responsibilities of State Coordinating Agencies are found in 44 CFR 60.25. These regulations identify the states commitment to the minimum floodplain management criteria and to demonstrate the capability and responsibility to implement the program. In this way, CAP-SSSE helps to; ensure that the flood loss reduction goals of the NFIP are met, build state and community floodplain management expertise and capability, and leverage state knowledge and expertise in working with their communities.Applicants can submit applications for this funding opportunity through FEMA Grants Outcomes (GO). Access the system at https://go.fema.gov/

Business and Commerce
State governments
Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01 Independent Clinical Trial Required)
$150,000
HHS-NIH11 (National Institutes of Health)
Federal

Application Deadline

May 7, 2024

Date Added

May 25, 2021

This Funding Opportunity Announcement (FOA) invites applications to enhance the pool of highly trained investigators from diverse backgrounds, including those from groups underrepresented in research areas of interest to the NHLBI. The career development will take place under the guidance of an experienced mentor in the biomedical, behavioral or clinical sciences leading to research independence. It is targeted toward individuals whose basic, clinical, and translational research interests are grounded in the advanced methods and experimental approaches needed to solve problems related to cardiovascular, pulmonary, and hematologic diseases and sleep disorders in the general and health disparities populations. This FOA invites applications from institutions with eligible faculty members to undertake special study and supervised research under a mentor who is an accomplished investigator in the research area proposed and has experience in developing independent investigators. This FOA is designed specifically for candidates proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary clinical trial, as part of their research and career development. Applicants not planning an independent clinical trial, or proposing to gain research experience in a clinical trial led by another investigator, must apply to the companion FOA (see RFA-HL-22-011).

Health
State governments
Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Required)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 12, 2024

Date Added

Sep 10, 2021

The Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Required) aims to support licensed neurologists and neurosurgeons in the NINDS intramural program as they transition to independent academic positions while leading clinical trials and advancing their research careers in neuroscience.

Health
State governments
Cooperative Agreements for the Garrett Lee Smith State/Tribal Youth Suicide Prevention and Early Intervention Program
$16,652,528
HHS-SAMHS-SAMHSA (Substance AbU.S.e and Mental Health Services Adminis)
Federal
Rolling

Application Deadline

Not specified

Date Added

Aug 2, 2023

The purpose of this program is to support states and tribes with implementing youth suicide prevention and early intervention strategies in schools, institutions of higher education juvenile justice systems, substance use and mental health programs, foster care systems, and other child and youth-serving organizations. SAMHSA was given the authority to address priority substance abuse treatment, prevention and mental health needs of regional and national significance through assistance (grants and cooperative agreements) to States, political subdivisions of States, Indian tribes and tribal organizations, and other public or nonprofit private entities. Under these sections, CSAT, CMHS and CSAP seek to expand the availability of effective substance abuse treatment and recovery services available to Americans to improve the lives of those affected by alcohol and drug additions, and to reduce the impact of alcohol and drug abuse on individuals, families, communities and societies and to address priority mental health needs of regional and national significance and assist children in dealing with violence and traumatic events through by funding grant and cooperative agreement projects. Grants and cooperative agreements may be for (1) knowledge and development and application projects for treatment and rehabilitation and the conduct or support of evaluations of such projects; (2) training and technical assistance; (3) targeted capacity response programs (4) systems change grants including statewide family network grants and client-oriented and consumer run self-help activities and (5) programs to foster health and development of children; (6) coordination and integration of primary care services into publicly-funded community mental health centers and other community-based behavioral health settings.

Health
State governments
Long-Term Effects of Disasters on Healthcare Systems in Populations with Health Disparities (R01- Clinical Trial Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 24, 2025

Date Added

Feb 22, 2024

This funding opportunity supports research projects that investigate the long-term impacts of disasters on healthcare systems serving vulnerable populations in the U.S., aiming to improve access and reduce health disparities.

Education
State governments
Clinical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Jan 24, 2024

This funding opportunity supports U.S.-based small businesses in the clinical validation of biomarkers for neurological or neuromuscular disorders, promoting inclusivity and collaboration while ensuring rigorous scientific standards for potential diagnostic and therapeutic applications.

Health
State governments
Development and Maintenance of the Animal Food Regulatory Program Standards (U19) Clinical Trial Not Allowed
$300,000
HHS-FDA (Food and Drug Administration)
Federal

Application Deadline

May 20, 2024

Date Added

Mar 15, 2024

Notice of Funding Opportunity Description The Food and Drug Administration (FDA), Office of Regulatory Affairs (ORA)is announcing the availability of up to $1,125,000 in FY 2024 to be awarded under Limited Competition to State animal food regulatory programs. The intended outcome of this NOFO is to advance efforts for a nationally integrated animal food safety system through the implementation and advancement of the Animal Food Regulatory Program Standards (AFRPS) by State animal food regulatory programs. Applicants must refer to the Eligibility section of this NOFO to determine which funding track they should apply for: AFRPS Development or AFRPS Maintenance. Applicants should take sustainability into account when designing projects proposed under this cooperative agreement to maximize the longevity of resulting outcomes, resources, and program infrastructure beyond the end of the project period. The AFRPS allows for the development of risk-based animal food safety programs by establishing a uniform basis for measuring, evaluating, and improving the performance of State animal food regulatory programs in the Unites States. By achieving and maintaining implementation of these program Standards, Federal and State food regulatory programs can better direct their regulatory activities toward preventing animal food safety hazards, that can cause illness or injury to animals or humans, in facilities that manufacture, process, pack, or hold animal food materials/supplies. Consequently, the safety and security of the United States animal food supply and protection of human public health will improve. The AFRPS are comprised of eleven Standards (See link below in Program Goals Section) which establish foundations for the critical elements that serve as an objective framework to evaluate and improve components of a State animal food program. These elements cover the State animal food program's regulatory foundation, training, inspection program, auditing, animal food-related illness or death and emergency response, enforcement program, outreach activities, planning and resources, laboratory services, sampling program, and assessment and improvement of Standard implementation. Achieving and maintaining implementation of the program Standards will require comprehensive self-assessment on the part of a State program and will encourage continuous improvement and innovation. FDA recognizes that the time required for achieving full implementation of the AFRPS will vary between States. However, all State animal food regulatory programs will be expected to implement improvement plans to ensure continuous improvement and demonstrate that they are moving towards full implementation. State animal food regulatory programs receiving funds under this cooperative agreement will be expected to achieve and maintain full implementation within 5 total year or less of funding under an AFRPS Cooperative Agreement(s). Grantees will achieve and maintain implementation with the AFRPS (most recent published version). For the purpose of this funding opportunity, "full implementation" is defined as the State animal food regulatory program having all elements, systems, and programs, as required in the Program Elements and Documentation sections of the AFRPS; and can demonstrate the use of those elements, systems, or programs. If implementation is not achieved by the end of funding year 5, the State program will provide a detailed improvement plan on how the remaining AFRPS elements and documentation requirements will be fully implemented and demonstrated. The improvement plan will include: A detailed timeline including what needs to be accomplished to implement the element and/or documentation requirement, and when the work will be completed. The outcomes of the work provided under this cooperative agreement are as follows: 1. State animal food regulatory programs will take significant steps to achieve and maintain implementation of the AFRPS, which is recognized as a critical element to creating a national, fully integrated food safety system. 2. State animal food regulatory programs will contribute to the continuous improvement of the AFRPS through attendance at an annual face-to-face meeting, active participation in committees, and other initiatives supporting the AFRPS. 3. Develop strategies for achieving and maintaining implementation of the AFRPS that can be replicated or leveraged across state programs to promote national consistency. 4. Provide a foundation for supporting advisory/regulatory action based upon findings of regulatory activities conducted by State animal food regulatory programs. Only the following State animal food programs will be eligible to apply: State animal food regulatory programs with current FDA animal food safety inspection contracts (providing funding to State animal food regulatory programs) and are also enrolled in the AFRPS, or those that apply for an FDA animal food safety inspection contract and enroll in the AFRPS, are eligible to apply for funding under this cooperative agreement. An animal food safety inspection contract must be executed prior to this cooperative agreement being awarded. A condition of the award will be maintaining a current FDA animal food safety inspection contract in satisfactory condition throughout the cooperative agreement project period. The FDA will provide one year of funding for this project with the hopes of making another NOFO in FY 2025 to help align project objectives, outputs, reporting, terms and conditions, and project periods for all AFRPS project awardees, and to provide continued funding for awardees under this project to achieve the objectives of the project. The anticipated release of another NOFO in FY2025 will also help align project periods for awardees under this NOFO as well as those currently awarded under PAR-20-132 (for which the project period and funding will end on 6/30/2025). For AFRPS, it is anticipated that full implementation of the AFRPS will be achieved within 5 total funding years under an AFRPS Cooperative Agreement(s), based on a verification audit of your program to ensure the elements have been implemented.

Agriculture
State governments
EPA Region 3 Solid Waste Infrastructure Grant
$150,000
Environmental Protection Agency
Federal

Application Deadline

Aug 30, 2024

Date Added

Jun 3, 2024

The Notice of Funding Opportunity (NOFO) solicits applications designed to increase the ability of EPA Region 3 states (Delaware, Maryland, Pennsylvania, Virginia, and West Virginia and the District of Columbia) to manage food scraps more sustainably through composting. In particular, the NOFO seeks to increase capacity for food scraps composting in the region through the upgrade of yard waste composting facilities. The upgraded yard waste composting facilities will be capable of processing waste food which increases the capacity for wasted food composting in the region. For further details see the NOFO.

Environment
State governments
National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders or Alcohol Use Disorder (U01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 15, 2025

Date Added

May 6, 2022

Reissue of PAR-20-118. This FOA encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This FOA using the U01 mechanism supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies Projects seeking support for a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach should consider the companion U19 FOA.

Health
State governments
Kentucky NRCS Agricultural Conservation Easement Program Reserve Easement (ACEP WRE) Acquisition Services Agreement
$5,000,000
USDA-NRCS (Natural Resources Conservation Service)
Federal

Application Deadline

Jun 28, 2024

Date Added

May 29, 2024

SUMMARY INFORMATION Federal Awarding Agency Name: U.S. Department of Agriculture NRCS Notice of Funding Opportunity Title: Kentucky NRCS Agricultural Conservation Easement Program Wetland Reserve Easement (ACEP WRE) Acquisition Services Agreement Notice of Funding Opportunity Number: USDA-NRCS-KY-ACEP- 24-NOFO0001367 Assistance Listing: This program is listed in the Assistance Listings (previously referred to as the Catalog of Federal Financial Assistance) on Sam.gov under 10.931 Agricultural Conservation Easement Program, which can be found at: https://sam.gove/content/home. SAM is a web-based, government-wide application that collects, validates, stores, and disseminates business information about the federal government's trading partners in support of the contract awards, grants, and electronic payment processes. Notice of Funding Opportunity Summary The Natural Resources Conservation Service (NRCS) is seeking proposals to assist with due diligence for acquiring Agricultural Conservation Easement Program (ACEP) Wetland Reserve Easements (WRE), including contracting for title exams, updates, and closing services; boundary surveys; appraisals and cultural resource investigations. ACEP WRE provides funding for the purchase of conservation easements held by NRCS, and to restore, protect, and enhance wetlands on eligible land. Proposals are requested for consideration of cooperative agreements with a period of performance not to exceed five years. For new users of Grants.gov, see Section D. of the full Notice of Funding Opportunity for information about steps required before submitting an application via Grants.gov. Key Dates Applicants must submit their applications via Grants.gov by 11:59 pm Eastern Time on TBD. For technical issues with Grants.gov, contact Grants.gov Applicant Support at 1-800-518-4726 or support@grants.gov. Awarding agency staff cannot support applicants regarding Grants.gov accounts. For inquiries specific to the content of the NFO requirements, contact the federal awarding agency contact (section G of this NFO). Please limit questions to those regarding specific information contained in this NFO (such as dates, page numbers, clarification of discrepancies, etc.). Questions related to eligibility, or the merits of a specific proposal will not be addressed.

Agriculture
State governments
Interplay of Autophagy Regulated Cell Death and HIV Pathogenesis in Substance Use Disorders (R21 Clinical Trial Not Allowed)
$275,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 14, 2024

Date Added

Dec 6, 2023

This grant provides funding for research studies that explore the relationship between autophagy, HIV infection, and substance use disorders, aiming to uncover mechanisms that could lead to new therapeutic strategies for affected individuals.

Education
State governments
FY26 Guidelines for Brownfield Assessment Grants (Assessment Coalition Grants)
$1,500,000
U.S. Environmental Protection Agency
Federal

Application Deadline

Jan 28, 2026

Date Added

Nov 21, 2025

This grant provides funding to coalitions of local governments and nonprofit organizations to assess and plan for the redevelopment of contaminated properties, helping communities revitalize brownfield sites safely.

Environment
State governments